Transcription factor that specifically recognizes the sequence 5'-YAAC[GT]G-3' (PubMed:7813437, PubMed:23523368). Acts as a master regulator of male meiosis by promoting expression of piRNAs: activates expression of both piRNA precursor RNAs and expression of protein-coding genes involved in piRNA metabolism, such as PIWIL1 (PubMed:21750041, PubMed:23523368). The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons, which is essential for the germline integrity (PubMed:23523368).

751 amino acids

MAKRSRSEDEDDDLQYADHDYEVPQQKGLKKLWNRVKWTRDEDDKLKKLVEQHGTDDWTLIASHLQNRSDFQCQHRWQKVLNPELIKGPWTKEEDQRVIELVQKYGPKRWSLIAKHLKGRIGKQCRERWHNHLNPEVKKSSWTEEEDRIIYEAHKRLGNRWAEIAKLLPGRTDNSIKNHWNSTMRRKVEQEGYLQDGIKSERSSSKLQHKPCATMDHLQTQNQFYIPVQIPGYQYVSPDGNCVEHVQTSAFIQQPFVDEDPDKEKKIKELELLLMSAENEVRRKRLPPQPGSFSSWSGSFLMDDSMSNTLNNLEEHTTEFYSMDENQTVSAQQNSPTKFLAVEANAVLSSLQTIPEFPRTLELIESDPVAWSDVTSFDLSDAAASPVKSTPVKLMRIQHNEGAMECQFNVSLVLEGKKNSRNGGDSEAIPLTSPNVVKFSTPPTISRKKKRIRVGQSAGSELGSASLSEVGNRRIKHTPVKTLPFSPSQFFNTCPGNEQLNIENPSFTSTPICGQKVLITTPLQKEATPKDQKENVGFRTPTIRRSILGTTPRTPTPFKNALAAQEKKYGPLKIVSQPLAFLEEDIREVLKEETGTDIFLKEEDEPAYKSCKQEHSASVKKVRKSLALESWDKEEPGTQLLTEDISDMQSENILTTSLLMIPLLEIHDNRCNLTPEKQDINSANKTYTLNKKRPNPNPCKAVKLEKSLQSNCEWETVVYGKTEDQLIMTEQARRYLSTYTATSSTSRALIL

85.7 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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