MVD1

Diphosphomevalonate decarboxylase 1

417 amino acids

Performs the first committed step in the biosynthesis of isoprene-containing compounds such as sterols and terpenoids (By similarity). Component of the triterpene saponins (e.g. ginsenosides or panaxosides) and phytosterols biosynthetic pathways (PubMed:29378087). Catalyzes the conversion of mevalonate diphosphate to isopentenyl diphosphate (IPP) (PubMed:29509695).

Belongs to the diphosphomevalonate decarboxylase family.

46.266 kDa

MAESWVIMVTAQTPINIAVIKYWGKRDETLILPINDSIRVSLDPDHLCTTTTVSVRPSFEQDRMWLNGKEISLLGGRFQSCLREIRSRARDLEDEKKGIVIKKMDWEKLHFHIASYNNFPTAAGLASSAAGLACFVFALAKLLTLQEDNGQLSAIARRGSGSACRSLYGGFVKWIMGKEENGSDSIAVQLADEKHWDDLVIVIAVVSARQKETSSTTGMQDSCKTSMLIQHRAKEVVPKRILQMEDAIEKRDFPSFARLACADSNQFHAVCLDTSPPIFYINDTSHKIISCVEKWNRSVGTPQVAYTFDAGPNAVLIARDRKIAALLLRRLLFHFPPHSNTDSNSYVIGDKSILQDVGVQDTKDIESLPPPPEIKDNIPAQKSNGDVSYFICTRPGRGPVLLPDSRALLNPETGLPK

MVD1

Diphosphomevalonate decarboxylase MVD1, peroxisomal

412 amino acids

Performs the first committed step in the biosynthesis of isoprene-containing compounds such as sterols and terpenoids (PubMed:10344201, PubMed:26216978). Is specific for (R)-5-diphosphomevalonate (MVAPP). The catalytic efficiency with (R)-5-phosphomevalonate (MVAP) as substrate is 10000-fold lower than for MVAPP (PubMed:26216978). Can complement a yeast mutant defective in MVD activity (PubMed:10344201).

Belongs to the diphosphomevalonate decarboxylase family.

45.586 kDa

MAEEKWVVMVTAQTPTNIAVIKYWGKRDEVRILPINDSISVTLDPDHLCTLTTVAVSPSFDRDRMWLNGKEISLSGSRYQNCLREIRSRADDVEDKEKGIKIAKKDWEKLHLHIASHNNFPTAAGLASSAAGFACLVFALAKLMNVNEDPSQLSAIARQGSGSACRSLFGGFVKWNMGNKEDGSDSVAVQLVDDKHWDDLVIIIAVVSSRQKETSSTSGMRESVETSLLLQHRAKEVVPVRILQMEEAIKNRDFTSFTKLTCSDSNQFHAVCMDTSPPIFYMNDTSHRIISLVEKWNRSAGTPEIAYTFDAGPNAVMIARNRKVAVELLQGLLYCFPPKPDTDMKSYVLGDTSIVKEAGLEGELPQGIKDKIGSQDQKGEVSYFICSRPGRGPVVLQDQTQALLHPQTGLPK

MVD1

Diphosphomevalonate decarboxylase

397 amino acids

Belongs to the diphosphomevalonate decarboxylase family.

43.535 kDa

MSIYVASTTAPVNIATLKYWGKRDSMLNLPTNSSISVTLSQEDLRTLTSAATGPELAEDRLWLNGKPESLGNARTQQCLADLRALRRALETEEPDLPRMSEWKLHIVSENNFPTAAGLASSAAGFAALVVAVAKLYGLPQDYSEISKIARKGSGSACRSLYGGYVAWEMGAEADGSDSRAVQIADVEHWPEMRAAILVVSADRKDTPSTSGMQQTVHTSDLFKERVATVVPRRYGEMAAAIRARDFATFARLTMQDSNSFHATCLDSFPPIFYMNDTSRRIVKLCHLINEFYNETIVAYTFDAGPNAVLYYLAENEARLCGFLSAVFGANDGWETTFSTEQRATFAAQFDECVRGKLATDLDDELHRGVARLIFTKVGPGPQDTKSSLIDPETGLPR

MVD1

Diphosphomevalonate decarboxylase

396 amino acids

Belongs to the diphosphomevalonate decarboxylase family.

44.116 kDa

MTVYTASVTAPVNIATLKYWGKRDTKLNLPTNSSISVTLSQDDLRTLTSAATAPEFERDTLWLNGEPHSIDNERTQNCLRDLRQLRKEMESKDASLPTLSQWKLHIVSENNFPTAAGLASSAAGFAALVSAIAKLYQLPQSTSEISRIARKGSGSACRSLFGGYVAWEMGKAEDGHDSMAVQIADSSDWPQMKACVLVVSDIKKDVSSTQGMQLTVATSELFKERIEHVVPKRFEVMRKAIVEKDFATFAKETMMDSNSFHATCLDSFPPIFYMNDTSKRIISWCHTINQFYGETIVAYTFDAGPNAVLYYLAENESKLFAFIYKLFGSVPGWDKKFTTEQLEAFNHQFESSNFTARELDLELQKDVARVILTQVGSGPQETNESLIDAKTGLPKE

mvd1

Diphosphomevalonate decarboxylase

393 amino acids

Belongs to the diphosphomevalonate decarboxylase family.

42.755 kDa

MDKKVYQCTVSAPVNIAVIKYWGKRDVALNLPTNSSISVTLSQDDLRTVTTASCSEKFENDTLWLNGNAEEIFANKRLRVCVEELRKARLDLEEENDDLDKIGALKLHVVSENNFPTAAGLASSAAGYAAFCEAIARLYDLPWTPTQLSRIARQGSGSACRSLFGGYVAWEMGELHSGADSVAVQVEPVENWPEIRVAVLVASAAKKGVSSTAGMQATVASSTLFQHRIQNIVPQRIQEMKTAIRERDFETFAKLTMTDSNQFHACCLDTFPPIFYLNDTSRAVIRVVENINATAGKTIAAYTFDAGPNAVIYFLEENSEIVLNTLYAVTKNAEGWSKQYGSSPVTVDSAAANIVSSGISRVILTRVGNGPRVLTIDESLIDASGNPKFIGSH

MVD1

Diphosphomevalonate decarboxylase

388 amino acids

Belongs to the diphosphomevalonate decarboxylase family.

42.538 kDa

MTVYTSSATAPVNIATLKYWGKRDKSLNLPTNSSISVTLSQNDLRTLTSVAASEDFKEDKLWLNGKLESLESERTKACLADLRTLRKELESNDSSIPKLSQFGVHIVSENNFPTAAGLASSAAGFAALVVSIAKLYELPQNMSEISKIARKGSGSACRSLFGGYVAWEMGQETNGEDSKAVEVAPLSHWPNMKAAILVVSDDKKDTPSTSGMQTTVATSDLFQWRIKEVVPKRFDDMKDSILRKDFATFGDLTMKDSNSFHAVCLDSTPPIFYLNDTSKKIIKLIHELNKREGKIIAAYTFDAGPNAVIYYEQENESKVLGVIYKYFSKVSGWEKLDTKTLDTTSDIQADPELYKGVSKIILTEVGQGPQGSSESLINDKGLPKAVAN