msh3

DNA mismatch repair protein Msh3

1428 amino acids

Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with msh2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. MutS beta recognizes large insertion-deletion loops (IDL) up to 13 nucleotides long. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis (By similarity).

Belongs to the DNA mismatch repair MutS family. MSH3 subfamily.

161.57 kDa

MPRLKLPKSFKDELESEKTTTTSSRKKAPVVDPKQTLMSSFFTPVSKSTDTKEINNKEDKDEDKDKDKDNKKTKKSKDTSDNEDMVDDNNKQQKEKKATPNKSNSPQSPQTSKSPLTRRSSANGNSDSKIDNKEKEKEKEKEKEKDKSTPTKTTSSRVKKDTEVSKSIPPKLSKQTKKKQISSDNDIYDDEKDSEEEDLEDDHDDEEEKVVVKKPSKPTSKSITAKPASTKATTTTTTTTTTTSTGRTRVNRVNLDISFSSESEEDEKPKKKIIGKKRKKKDDSDFDSESESDTISEASEVEPESEEDLDSFKFNSKKKNNNKNNNNKKKNDEYEDEEEDEDDELFKDIEMKDKPEEEEKEEEGDPIVIGSGRVVLPKGTPDFQPDPKAGKKLLKAHLEIQSKEEAKRLQQANGGGGDGGGGQIKGSDDEDEEVKKPTKGGSKASAKKKGPAYTPLEQQYIAIKKENPDTVLMVECGYKYKFFGEDAEVANKVLNIYSYVAKNFLNCSIPTQRLFFHLRRLVMAGYKVGIVEQTETAALKAISSSKSQPFERKLTRVYTSSTFIDDDIDDQLTSSSPQFLVSFYESTPKNKNDDVIKKQRDNEEEGIDSSNESSTSTISFVAVSVKTGEIIYDTFKDNVMRSQLETILTHIKPSEILIPPTTTTVNKQKVNNGIGTNHYYFSNLTSKCLKTYTKSTNVRTQAMDSQLYDYEYSLGKLIDFYEDESNNNNNNNNCEDVLKFVKSTLNKEQIICLGILLSYLNEFIHFGSILKVESNFKAFRVSNHLVLPHSTIVNLELLVNESDNKEKGSLIWLMNRTSTFSGSRMFINWICKPLNQLELIKERQDAVEELVNGIKTNSPPIVSIISLFKSHIPDLQRNLSRIYYKVQCTPKEFLNTMTSLQRIVELFKEINNNNSSYKFNSTLLNSIFKLQNDNKDGDSDSFDYIGGEDKLSKRIKYFLSNINKETAKEYGTVGCDKSNLWVDLEKYEKIRETKEKIEQVEKEFKNVLKNIRKELSKPSLEYHHMPGLGLEYLLELPPSFKAVPKSWIKVNSTQKMARYHAPEVLEQLKILSQSRETLKIQSQESWISFLGEFSVDYSLFSNFVNKISNLDCLFSLAKVSSLEGYIRPQFVKEKKDGGIQIENGRHPVVEAILSGSDGSYVPNTIELRESACKSMIITGPNMGGKSSLLRQTALIVIMAQVGCFVPATSCSLSVFDAIYTRMGARDSIGTGKSTFFIELEETSDILKNSTQNTLVILDELGRGTSTNDGVAIAYSTLKYIVEVMKCYCLFVTHYPLLAQLELQYPTQVGNFHMGYLEEKQDQQLQKSVIPKVIFLYKLVKGAAQNSYGLNIARLAGLPMEVIADALKKSNEMKESITRRANLSDGKDQQQIENEIKSIIKNWNSNRTTLNSNDLLQFIEKFKSIQLKL

MSH3

DNA mismatch repair protein MSH3

1191 amino acids

Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair. MSH3 provides substrate-binding and substrate specificity to the complex. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions (By similarity).

Belongs to the DNA mismatch repair MutS family. MSH3 subfamily.

132.701 kDa

MPSEGSQQPSLDSFFKRKNPRVEPYSRTGNNAIIDLTDSPPNKKIKLDDEGSQKNRSMTQTSSSYFKGHPTARPLSVDKRLPRKPSAAIQAYKLQDVIPPQPSHSGLAFETCSLVPQASFVPDSQPEPSASPAPQRTTEQLKRHEEWKTRILAMSGSFRRKRSLALDEAVAAEAREAAGLEDEGTPFDGSDGDDYKSESEKNAEEVGKQLKKYVAKELAGKGKSKGKKKEEIGPSGLAYTPLEKQFMEIKEQNRDVLLLMEVGYKYKFHGEDAKTASRELGIVAFPNRNFFTASIPTHRLHIHVKKLLSLGYKVGVITQTETAALKKIGDNRNAPFARKLTHLFTAATYVEDPSLSSSSSSSSSVRFDDPVVPGTAPPPTNALVAIVEQPVDRASDDRVKVGLVCVVPGTGDITWDEFDDSQIRTELETRLAHLSPAELLLPKQRLTKATEKVLTYFAGEPKHRGRNAVRIERIDNIPEYDAAFDFLTNFYHCKEHKATVSKGDVNDERHLMTEGNKQWSLQPKLSQDGADISLDEEIYLASGVSSSKAILTLVDFPKQVVISMAVAIRYMKRFGLENAFKHTSSFVRFANRSHMLLSSNTLANLEIYQNQTDGGLYGSLIWLLDHCKTRMGKRLLREWVGRPLLDVAALKARADAIEEIMENNSYHMEKLRSLLINMPDLVRGLTRVQYGKATPNELATLLITLVRLASEFKPNMGNVFRSCLLNNIPNTLPTILDTSQRFLNALNLKQARENDVANLWADPDRFPDIQDVKDCISVCEMELNEHLMELRKILKKPTLRYITVSGIEYLVEVPIRDTKIVPAQWMKISATRTVNRYHTPKILAITKERTQHLEKLSIVAREAFIAFQSEVAEYHELVVVSKQIAVIDCLMSLAQTAAASGYCKPKFVAEPELKILAGRHPMVEMLREESYVPFDIHFSKEEGTTKIITGPNMAGKSSTVRAMALIVCMAQIGSFVPAASVTLSVHDSVQTRMGASDEIGRGKSTFMVELSETSDILQTITPRSLVVLDELGRGTSTYDGIAIAYATLSHIAEIGCNTLFVTHYPTVAQDLAREKPDKISNWHMSFDEIQMPDGGAEITFLYQLTRGLQEASFGVWCARLAGLPKPILDTAQMRSSSLKAETQERLRGIVARRVGWMLHNLFDNKTSSSQVLRNVEMLHNSLSSSSISFSQ

MSH3

DNA mismatch repair protein MSH3

1191 amino acids

Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair. MSH3 provides substrate-binding and substrate specificity to the complex. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions (By similarity).

Belongs to the DNA mismatch repair MutS family. MSH3 subfamily.

132.687 kDa

MPSEGSQQPSLDSFFKRKNPRVEPYSRTGNNAIIDLTDSPPNKKIKLDDEGSQKNRSMTQTSSSYFKGHPTARPLSVDKRLPRKPSAAIQAYKLQDVIPPQPSHSGLAFETCSLVPQASFVPDSQPEPSASPAPQRTTEQLKRHEEWKTRILAMSGSFRRKRSLALDEAVAAEAREAAGLEDEGTPFDGSDGDDYKSESEKNAEEVGKQLKKYVAKELAGKGKSKGKKKEEIGPSGLAYTPLEKQFMEIKEQNRDVLLLMEVGYKYKFHGEDAKTASRELGIVAFPNRNFFTASIPTHRLHIHVKKLLSLGYKVGVITQTETAALKKIGDNRNAPFARKLTHLFTAATYVEDPSLSSSSSSSSSVRFDDPVVPGTAPPPTNALVAIVEQPVDRASDDRVKVGLVCVVPGTGDITWDEFDDSQIRTELETRLAHLSPAELLLPKQRLSKATEKVLTYFAGEPKHRGRNAVRIERIDNIPEYDAAFDFLTNFYHCKEHKATVSKGDVNDERHLMTEGNKQWSLQPKLSQDGADISLDEEIYLASGVSSSKAILTLVDFPKQVVISMAVAIRYMKRFGLENAFKHTSSFVRFANRSHMLLSSNTLANLEIYQNQTDGGLYGSLIWLLDHCKTRMGKRLLREWVGRPLLDVAALKARADAIEEIMENNSYHMEKLRSLLINMPDLVRGLTRVQYGKATPNELATLLITLVRLASEFKPNMGNVFRSCLLNNIPNTLPTILDTSQRFLNALNLKQARENDVANLWADPDRFPDIQDVKDCISVCEMELNEHLMELRKILKKPTLRYITVSGIEYLVEVPIRDTKIVPAQWMKISATRTVNRYHTPKILAITKERTQHLEKLSIVAREAFIAFQSEVAEYHELVVVSKQIAVIDCLMSLAQTAAASGYCKPKFVAEPELKILAGRHPMVEMLREESYVPFDIHFSKEEGTTKIITGPNMAGKSSTVRAMALIVCMAQIGSFVPAASVTLSVHDSVQTRMGASDEIGRGKSTFMVELSETSDILQTITPRSLVVLDELGRGTSTYDGIAIAYATLSHIAEIGCNTLFVTHYPTVAQDLAREKPDKISNWHMSFDEIQMPDGGAEITFLYQLTRGLQEASFGVWCARLAGLPKPILDTAQMRSSSLKAETQERLRGIVARRVGWMLHNLFDNKTSSSQVLRNVEMLHNSLSSSSISFSQ

MSH3

DNA mismatch repair protein MSH3

1166 amino acids

Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair. MSH3 provides substrate-binding and substrate specificity to the complex. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions (By similarity).

Belongs to the DNA mismatch repair MutS family. MSH3 subfamily.

128.382 kDa

MSSSQSTSQLKRKQQTISSFFSKKPVAPNGSTTTTPKDGHVKKTIGHARVHEAPSSEMDVVDGAHDAAVRPDEEGDDDYQIILPSRKRIRSNGEVSTLQRGTLADIDNGHSSKGENELQTGIMGSSDSDRAEQPVKIKSGSSRTEKFRFSSSSLPSSSDPKGNGGCDVLYAISADGDASEDGDEEQKRKQALHQKFVKRLGGPDCLPFSVSRVDAGDAEEAEGAESDAEAEAEIVPVPQKGRGGKKTTTGKLTPMERQIIDIKKKHMDTLLVVEVGYKFRFFGEDARVAAKELSIVCIPGKLRFDEHPSEAHLSRFASASIPVHRLHVHVKRLVEAGYKVGVVRQLETAALKAAGENRNAPFVRKLTNLYTKGTYIDDVEGLEESSGNSGSASTSTGYLLCMAESNAKGWGNDEKVHVGIVAVQPATGDVIYDDFEDGFMRSEIEMRLLHIAPCEFLIVGEMSKATEKLVQHLSGSKTNVFGDKIRVERVSKSKTAAAESHSHVSSFYAGRMNAKGTTGDVAASNLLEKVLTLPEDVTICLSSMIKHMSEFGLEYVFDLTKYFQPFSARSHMLLNGNTLTNLEIYQNQTDHTSKGSLFWTLDRTKTRFGQRLLRKWVGRPLLDKTELEERVSAVEELQDPSKTVQIERLKGLLSKIRADLEKSLIRIYYGRCTRPELLTVLQTLQLIADEYVHLKSPADLGFSSPTITTAIAALPAIRDDVVTYLNKINEEAAKKDDKYCFFREVEETDEITESNLGIADVQHRLQEHCAVAAEILGKKKVQYTTVAGIEYLIEVENSPYNLKKVPASWRKISGTKKVSRFHTPEVVQYMRERDQYKEALAAACDKAFHALLADISTKYQSFRDCILALATLDCLLSLANIASQPGYIKPAYTDKTRISVQRGRHPMVEQLLLDTYVPNDIELHTDETRALLVTGPNMGGKSSYVRQVALISIMGQIGSYVPADSATLGMLDAVYTRMGAFDNMLAGESTFMVELSETADILKQATPRSLVILDELGRGTSTHDGVAIAQAVLDYMVRNLRSLTLFITHYQNLSSMAREFPKGELRNVHMKFTESGMDGQDITFLYEVGEGVAHRSYGLNVARLANVPDSVLEVARAKSAELEEKIRKKKMLALAKVAKGFINTDGDAGGPAPALLERVMVGLEQL

MSH3

DNA mismatch repair protein MSH3

1156 amino acids

Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair. MSH3 provides substrate-binding and substrate specificity to the complex. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions (By similarity).

Belongs to the DNA mismatch repair MutS family. MSH3 subfamily.

125.976 kDa

MAGPSRAPVKKQASLTSFFTANISSKKHANSPGGGSAANRNKDETEDENTQKIIGKGKEKDESSPITLSVLESNRKRPLQDNNSNGNGRSSRAAKRAKSVVSEDDSEEVSSPPVQASTGRTPIPEPPSSSSRTERYAYDADRLASDPSGLNEDEDAATRRKKEELHRKFVKKLGHPDSLASLRRRELLGQNESPGLDGEGEEEGGDAEEDETPLPSKTKKKGAKTGKLTPMEIQFLDIKRKHMDTVLVVEVGYKFRFFGEDARIAAKELSIVCIPGKFRYDEPHIDRFASASIPVHRLSVHVKRLVAAGHKVGVVRQLETAALKKAGDNRNAPFVRKLTNIYTKGTYIDETGELDQPGEGAGASAGGYLLCLTESPVKGLGTDENVHIGVMAVQPATGDIIYDDFEDGFMRREIETRLLHISPCELLVVGELSKATNKLVQHLAGSSTNVFGDRSRVERVPKSKTMAAEASSHVTQFYAGKVKGDDERSASLLDKVLKLPESVTVCLSAMITHLTEYGLEHIFDLTKYFQSFTTRQHMLINGTTLESLEVYRNATDQSEKGSLLWALDKTRTRPGRRLLRKWIGRPLLDRERLEERVTAVEELLEHQSNFKVDRLGGVLNSIKADLERSLIRIYYGKCTRPELLSTLQTLQRISIEFSRVKTPEDTGFNSSLIVEAIYALPGIGTIVSAYLDKINPEAARKDDKYTFFRDDEETEDITNHKLGIAAVEADLDVHRKDAATKLSKKTPVTYVTVSGIEYLIEVPNTDLKHVPASWAKISGTKKLSRFHTPEVMRLMNERDQHKEALAAACDNAFTDLLKSIASEYQPLRDAVASLATLDCLLSLAQVASLPGYSKPTFLPTATPPTISITSGRHPIAEHTLPDGYIPFTTSLASPSPLAQLITGPNMGGKSSYVRAVALLVLLAQIGSYVPAEAMSLTLTDAIYTRMGARDNLFAGESTFMVEVSETAAILRGATARSLVVLDELGRGTSTHDGAAIAHAVLAHVARETRCLTLFITHYQNLARVADGLGGAVRCVHMRFEATGRQRDEAADGDADAAAADADEEITFLYEVADGVAHRSYGLNVARLARIPRRVLDVAARKSREMEEGVKARRLRGAVRLLEDVVAGGGGGGGGGGGDGDDGEDPLEHLVSSIEQL

MSH3

DNA mismatch repair protein MSH3

1154 amino acids

Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair. MSH3 provides substrate-binding and substrate specificity to the complex. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions (By similarity).

Belongs to the DNA mismatch repair MutS family. MSH3 subfamily.

127.005 kDa

MPPPPSQKPGQASISAFFKPKSSQRPITKSCQPDRAQVSNGYARTSNLLDTDTGASSSAQPPHKRSKLNNKDGPRRETIDRMSKWKFTALQPSDNVSSELDEAASQATPTERSQHDQARHDAFRKTLLGPNFAIDRHASNQMQIDDMSSAHTFSHSESRTSTGTKVDAMVVDDDDDDDDNQHEQAAQSVPGTWNRFTGLAAPESTPAPCSHRDSSMNKTKGKPKASGAGTGPSYTPLEKQILELKAEHPGVLLIIEVGYKLKFYGEDARIASKELSIMCFPERNLLTAMIPVHRLHIHVKRLIQAGHKVGVVRQIETRALKAASKNAYTPFVRKLTALYTASTWVDDLSSLDDLAANMGDAYTNQPKSLMAIVEQSERGNAQADRVSIGIVSVEVNTGHLTYDQFSDGHARSELETRIAHLAPAEVLIPPQLTKPTEKVISYLLGNGADGGVRIERLAAMPDYNQAFQSVTRFYRDRGLESPEVPEVPEVPGSSEADTTRLATTLADGADKRSSPLISLIVSLPQLSLIALAQIIQHLQAFQLESICTLSTNFRSFSSRTTMLLNSNTLANLEIFRTANEQTERGSLIWLLDKCKSAMGRRLLRKWVSRPLTDIDKLQERLDAVEALRDGKSYVLRRLDSVLHGLPDLERGLARMTYGRATPTELATVLLSLNRVTQEFKADEAATWKTQSSLIDTHLLSLASGKQVVQTYLNQISIKEARANNKADLYLDADVFPAIQASKDNMAIIDGELREHLREIRKLLHRPSLDYVSVAGVDYLVEVRVADAKKVPVEWLRVSATKSMVRFHTPEVMRLSKIRDQHKETLDAAAQEAFARFVRELCKSEYVVLRNVVASLAVLDVLLSLAHVARAAGYTRPVFLRQPQDAEASVPVEIIGMRHAILEVVSAMPYIPNDVSLSTGDSGAAILLSGCNMGGKSSVVRALGLVIIMAQIGSFVAADVARIGVHDAVYVRMGARDRMFSGRSTYMVEVSETADILGSLTSRSMVILDELGRGTSSRDGYCLAAGVLEYLLTLGCPPNTVFITHYLQLASMQRRYPHLRNMHMAFTSNSRNLLDPIHLVYKLRPGIAHSFGIHAAHLARLPLQIIHSASTISSALYAKHTNRSAFLVLKHAFANPPQLATVSTLQHLLFTHPPT

MSH3

DNA mismatch repair protein MSH3

1151 amino acids

Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair. MSH3 provides substrate-binding and substrate specificity to the complex. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions (By similarity).

Belongs to the DNA mismatch repair MutS family. MSH3 subfamily.

126.189 kDa

MAGPSGAAPKKQASLLGFFTPKTVNGLKRPTSSRPGTSEEDEERTADSSPSSRDNVRKRPLEQDPDAGNTRRPRASKRAKNVVIDDEDDEHDNDDDDDDFKLDAEAEADPEPVVAADDTAGVSQSSSISASRAGRYIYDESQPKGQAKTDENGDALDAATLRKKRELHDKFVKKLGHPDAMSRWGNAGRGEQETGAQEEEEDGDAAEEEPPPPPKGKKKGAKSGKLTPMELQFLEIKRKHMDTVLIVEVGYKFRFFGEDARIAGKELSIVCIPGKFRYDEHPSEAHLDRFASASIPVHRLPVHAKRLVAAGHKVGVVRQIETAALKKAGDNRNAPFVRKLCEVYTKGTYIDEMGEMDAQTGASGAHSGGYLLCLTETAAKGSGTDEKVDVGLVAVQPATGDIIYDSFEDGFMRSEIETRLLHISPCELLIVGQLSKATEKLVKHLSGSASNVFGDRTRVERVAKGKTTPAEASSHVTKFYAGKLKGSTQDDRAAALLDKVLNLPEPVTLCLSAMITHLTEFGLEHIFDLTKYFQSFSTRSHMCINGTTLESLEVYRNSTDHTEKGSLLWALDKTRTRFGQRMLRKWLGRPLLDKERLDDRVAAVEELFENRNGPQVEKLQKLLSSIKTDLERSLIRIFYGRCTRPELLAVLQTLQRIAVEYIVVKEPSQTGFKSNLVSEALASLPRIREIVVSYLNRINPDAARKNDKYEFFRDESDDTGDDGEDEITTQKMSIAAVEQELDAHRSDAAATLGRKKAVDYVTVAGIEYLIEVPNTEIRKVPASWAKISGTKKLSRFHTPEVVRLIAERDQHKEALAAACDAAFKAMLASIADQYQPLRDAVSSLATLDCLLSFAQVAALPGYSKPIILPDSHPPTIAVAGGRHPIAEHTLPSGYIPFSTTLSSPAPLAHLVTGPNMGGKSSFVRALALLVLLAQVGSFVPADSLRLTLSDAIYTRMGASDNLFAGESTFMVEVGETAAILRTATPRSLVLLDELGRGTSTHDGAAIAHAVLDHVVRNTRCLTLFITHYQSLARVAEGLGTGLVRNVHMRFTSSRDDNDDGDKDQDDDVGENITFLYEVADGVAHRSYGLNVARLARIPRKILEVAARKSRKMEEDVRTRRLRSATKLLEAVCRGDGSDDQLEHLLSSIEQL

MSH3

DNA mismatch repair protein Msh3

1137 amino acids

Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta which binds to DNA mismatches thereby initiating DNA repair. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. MutS beta recognizes large insertion-deletion loops (IDL) up to 13 nucleotides long. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis.

Belongs to the DNA mismatch repair MutS family. MSH3 subfamily.

127.412 kDa

MSRRKPASGGLAASSSAPARQAVLSRFFQSTGSLKSTSSSTGAADQVDPGAAAAAAAAAAAAPPAPPAPAFPPQLPPHIATEIDRRKKRPLENDGPVKKKVKKVQQKEGGSDLGMSGNSEPKKCLRTRNVSKSLEKLKEFCCDSALPQSRVQTESLQERFAVLPKCTDFDDISLLHAKNAVSSEDSKRQINQKDTTLFDLSQFGSSNTSHENLQKTASKSANKRSKSIYTPLELQYIEMKQQHKDAVLCVECGYKYRFFGEDAEIAARELNIYCHLDHNFMTASIPTHRLFVHVRRLVAKGYKVGVVKQTETAALKAIGDNRSSLFSRKLTALYTKSTLIGEDVNPLIKLDDAVNVDEIMTDTSTSYLLCISENKENVRDKKKGNIFIGIVGVQPATGEVVFDSFQDSASRSELETRMSSLQPVELLLPSALSEQTEALIHRATSVSVQDDRIRVERMDNIYFEYSHAFQAVTEFYAKDTVDIKGSQIISGIVNLEKPVICSLAAIIKYLKEFNLEKMLSKPENFKQLSSKMEFMTINGTTLRNLEILQNQTDMKTKGSLLWVLDHTKTSFGRRKLKKWVTQPLLKLREINARLDAVSEVLHSESSVFGQIENHLRKLPDIERGLCSIYHKKCSTQEFFLIVKTLYHLKSEFQAIIPAVNSHIQSDLLRTVILEIPELLSPVEHYLKILNEQAAKVGDKTELFKDLSDFPLIKKRKDEIQGVIDEIRMHLQEIRKILKNPSAQYVTVSGQEFMIEIKNSAVSCIPTDWVKVGSTKAVSRFHSPFIVENYRHLNQLREQLVLDCSAEWLDFLEKFSEHYHSLCKAVHHLATVDCIFSLAKVAKQGDYCRPTVQEERKIVIKNGRHPVIDVLLGEQDQYVPNNTDLSEDSERVMIITGPNMGGKSSYIKQVALITIMAQIGSYVPAEEATIGIVDGIFTRMGAADNIYKGQSTFMEELTDTAEIIRKATSQSLVILDELGRGTSTHDGIAIAYATLEYFIRDVKSLTLFVTHYPPVCELEKNYSHQVGNYHMGFLVSEDESKLDPGAAEQVPDFVTFLYQITRGIAARSYGLNVAKLADVPGEILKKAAHKSKELEGLINTKRKRLKYFAKLWTMHNAQDLQKWTEEFNMEETQTSLLH

msh3

DNA mismatch repair protein msh3

1133 amino acids

Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with msh2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair. Msh3 provides substrate-binding and substrate specificity to the complex. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions (By similarity).

Belongs to the DNA mismatch repair MutS family. MSH3 subfamily.

125.12 kDa

MGKPNSTPAKTQKSISSFFAPKSSQKPQDSSSPPASKAPGNLDDADSNEGTNEDAKITGNRLKRVLEEDENGGNTGAKERPSKRAKSVEVEEEDNESYALPAADSRKTSSSLTRGKSKPSLRTNKYMFSGSSQRATESLIEEEPEDELEKARKVELHKKFVKKLGHPDSLRRIIHEDDAALEVGDEEGEEDEEAPAPVKTKKKGAKTGKLTPMELQVIDIKRKHMDTLLIVEVGYKFKFFGEDARTAAKVLSIVCIPGKFRFDEHPSESHLNYFASASIPVHRLPVHAKRLVAAGYKIGIVRQTETAALKKAGDNRNAPFVRKLTNVYTKGTYIDDIDGLDTTDAPSGGAPATGYLLCITETKAKGWGTDEKVEVGILAVQPATGDVIYDNFEDGFMRGELETRLLHIAPCELLIVGELTKATDKLVQHLSGSSTNVFGDRIRVERVGKSKTMAAESYSRVAQFYADKLKAHQSSNNAREQELLEKVLKLTEPVTICLSAMITHMTEYGLEHVFDLTKYFQSFSARSHMLLNGNTLTSLEIYTNQTDYTQKGSLFWTLDKTQTKFGQRLLRKWVGRPLLDKQRLEERVAAVEELKDNANTPKVDKLNATLREVRSDLERSLLRIYYGKCTRPELLTVLQTMQRIANEFAHVKTPSDAGFESIALNEAVASLPAIGEIVISFLDKINAQAARNDDKYAFFLEHYETEAIGDHKCGIGAVEQDLEAHRMVAATKLSKKTPVTYVTIAGIEYLIEVPNTDLKNVPASWAKISGTKKMSRFHTPEVIKFLRERDQHKESLSSACDAAFSTFLSEISTHYALIRDTISHLATLDCLLSLATVASLPGYCKPTFTSSTEISVIGGRHPMVEQLLPSAYIPNDTSLSTSPDHTRALLLTGPNMGGKSSYVRQVALISILAQIGSYVPAESARLGLLDGIYTRMGAYDSLFTAQSTFMVELSETASILKSAGPRSLVILDELGRGTSTHDGVAIAEAVLDWVVRETKCLCLFITHYQTLASVARGFEKGKELRNVHMKFTAERNGRRVSNADADKDNEDFDEEITFLYEVGEGVAHRSYGLNVARLARVPKSVLDTAASKSRELETQVKQKKLLGLSNMISNVLENGTDQLDQLIIGMEQL

msh3

DNA mismatch repair protein msh3

1130 amino acids

Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with msh2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair. Msh3 provides substrate-binding and substrate specificity to the complex. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions (By similarity).

Belongs to the DNA mismatch repair MutS family. MSH3 subfamily.

124.666 kDa

MPLRSSQSSPPASQSFKRKQPTISSFFTKKPPTSQEKAQEPEDEPAASRRQFANALDKATRVKEHGAPAERDEEQEEEEEDIVAPAPKRIKTNGVHEKEPASAAKEVSSASRPAPPLASSQRTELYKFASSPADGAGAGVDRPEDPETKQRQAERERLHQLFVKKLGGADCAVGIGRSAGGDAPSGAEEAAEGDEDEEVAPAPAAKGRGSKKAGGGKLTPLEKQVIEIKRKHMDTVLVIEVGYKYRFFGEDARIAAKELSIVCIPGKMRFDEHPSEAHLDRFASASIPVHRLHVHVKRLVAAGYKVGVVRQLETAALKAAGDNRNAPFSRKLTNLYTKGTYVDDVEGLEGPTPAASGGASPATGYLLCITETNAKGWGNDERVHVGIVAVQPNTGDIIYDDFEDGFMRSEVETRLLHIAPCELVIVGELSKATEKLVQHLSGSKLNTFGDKVRVERVGKKKTAVAESHSHVANFYASKLKAASVDDTQTSNLLQKVLTLPEQVTVCLSAMIEHMTEYGLEHIFQLTKYFQHFSSRSHMLLNANTLVSLEIYQNQTDHSTKGSLFWTLDRTQTRFGQRLLRKWVGRPLLDKSRLEERVNAVEELKNPEKTVQVERLKRLLGRIKSDLEKNLIRIYYGKCTRPELLTVLQTLQTIAQEYADVKSPEDNGFASPVLGEAVASLPTILKDVVAFLNKINMHAARSDDKYEFFRESEETDEISEHKLGIASVEHELEEHRAVAAGILKWPKVVYVTSSGIEYLIEVENTSNAIKRVPASWVKVSGTKKLSRFHTPEVIQLLRQRDQHKEALAAACDKAFAALLAEIAVNYQLFRDCVQALATLDCLLSLAAIASQPGYVKPEYTDHTCICVEQGRHPMVEQLLLDSYVPNDTDLDTDQTRALLVTGPNMGGKSSYVRQVALIAIMGQIGSYVPARSAKLGMLDAVFTRMGAFDNMLAGESTFMVELSETADILKQATPRSLVILDELGRGTSTHDGVAIAQAVLDYMVRTIRSLTLFITHYQHLSNMTQSFPDHELRNVHMRFTESGAGQDEEITFLYEVGEGVAHRSYGLNVARLANLPAPLLDVAKLKSAELEEQIRRRRLARLLTAVGEVMSDPAKGDEDFLERLMSTAEQL

msh3

DNA mismatch repair protein msh3

1130 amino acids

Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with msh2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair. Msh3 provides substrate-binding and substrate specificity to the complex. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions (By similarity).

Belongs to the DNA mismatch repair MutS family. MSH3 subfamily.

124.78 kDa

MGKPKSTPVKTQKSISSFFTPKSSQKPQNSSPPPASNAPENLYDAQSDQETNETAEITGNSSKRTLEEDANGGNTGATERPSKRAKNVDVEEEDGEGSSLPAANARKAPSSSMLGKSKPSTRTNKYMFSGLSQSVAAEPTIEEELEEESEKARKADLHRKFVKKLGHPDSIKRSIPEDDAALEGDEDMEDEEEAPAPVKTKKKGAKTGKLTPMELQVLDIKRKHMDTLLIVEVGYKFKFFGEDARTAAKVLSIVCIPGKFRFDEQAHLNYFASASIPVHRLPIHAKRLVAAGHKIGIVRQTETAALKKAGDNRNTPFVRKLTNVYTKGTYIDDIEGLDSTDAPSGGAPATGYLLCITETKAKGWGTDEKVEVGILAVQPATGDFIYDNFEDGFMRSEIETRLLHIAPCEFLIVGELTKATEKLVQHLSGSTTNVFGDRIRVERVEKPKTMAAESYSRVAQFYADKLKAHQSSNNAREQELLEKVLRLTEPVTICLSAMITHMTEYGLEHVFDLTKYFQSFSARSHMLLNGNTLTSLEIYTNQTDHTEKGSLFWTLDKTQTRFGQRLLRKWVGRPLLDKQRLEERVAAVEELKDNVNTPKVDKLNATLREVRSDLERSLLRIYYGKCTRPELLTVLQTMQRIANEFAHVKIPSDAGFDSVLLNEAVASLPEIGGVVISFLEKINAQAARKDDKYAFFLEEYETEEIGEHKCGIGAVEQDLEAHRKEAASKLSKKTPVTYVTIAGIEYLIEVPNSDLKKVPASWAKISGTKSNSRFHTPEVIKFLRERDQHKESLSSACDTAFLAFLAEISTHYALIRDTISQLATLDCLLSLAAVASLPGYCKPTFTSTTEISVVGGRHPMVEQLLPSTYIPNDTSLSTDPDNTRALLITGPNMGGKSSYVRQVALISILAQIGSHVPAESARLGLLDGIYTRMGAYDSLFTAQSTFMVELSETASILKSASPRSLVILDELGRGTSTHDGVAIAEAVLDWVVRETKCLCLFITHYQTLASVARGFEKGKELRNVHMRFTAERNGKQVSNANADKDGEDVNEEITFLYEVGEGVAHRSYGLNVARLARVPKAVLDTAASKSRELEAEVKQKKLLGLSKMISNVLENDVDQLEQLIIGMEQL

MSH3

DNA mismatch repair protein MSH3

1125 amino acids

Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair. MSH3 provides substrate-binding and substrate specificity to the complex. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions (By similarity).

Belongs to the DNA mismatch repair MutS family. MSH3 subfamily.

124.644 kDa

MSQSSSLKRKQQPTISSFFGKTTSSSGESTNKKASLNGLGRAKQRIREEESNLSPSPEDKGEYLDDEDEDIVPPSRKRVKSSRISTDGANAAAKGNDDDLSQSPHRNVPASSRTERFRFQSSPVSSLDAEGSQVEGREAIDTERERKRKENLHQKFVRRLGGPGCLPSLEHGSNANTAMTEGGEDEDEALDEEDVAPPPSTKARGARKAASTKLTPLEKQVIDIKNKHKDAILVVEVGYKFRFFGEDARIAAKELSIVCIPGKLRFDEHPSEAHLNRFASASIPVHRLHVHVKRLVRAGHKVGVVRQLETAALKAAGDNRNAPFERKLTHLYTKGTYIDDTEELEGLNAVGANSAAPATGYLLCMTESNAKGWGNDEKVQVGILAVQPATGNIIHDSFEDGFMRTEIETRLLHIAPCEFLLIGDVSRATDKLVQHLSGSKMNVFGDKVRVERVSKSKTAAAESHSHVSSFYAGRMKATSTTQDERARDLLDKVLNLPEDVTICLSAMIKHLKEYNLENVFDLTKYFQPFSARSHMLLNGNTLINLEIYQNQTEQTSKGSLFWTLDRTKTRFGQRLLRKWVGRPLLDKQELEDRVAAVTELKDSDATPRVGRLKTLLSKVKTDLEKNLLRIYYGKCTRPELLTVLQTLQLIATEFSHVKSPADAGFDSPVINEAISQLPVVLDDVVSYLNKINLHSAKADDKFSFFQESEETDEITEQKLGIGSVEHDLEEYRNTAAEILCKKKVCYVTNAGIEYLIEVENSSLQMKKIPASWRKISGTKKVSRFHPPEVVNLMRERDQHKEALAAACDKAFLGLLADISTKYQPFRDCIQALATLDCFMSLAAVAAQPGYVRPTYADEARISVRGGRHPMVEQLLLDTYVPNDTELGTDGTRALLVTGPNMGGKSSYVRQVALISIMGQIGSYVPAESATLGMLDAVYTRMGAFDNMLAGESTFMVELSETSDILKQATPRSLVILDELGRGTSTHDGVAIAQAVLDYMVRDIRSLTLFITHYQHLSNLARTFPNGELRNVHMKFTESGKDGQDITFLYEVGEGVAHRSYGLNVARLANIPSSVLDVAYTKSAELEEKIKRKNLEGIAKGLSRVLENGENEGELMERLLSEVEQL

msh3

DNA mismatch repair protein msh3

1123 amino acids

Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with msh2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair. Msh3 provides substrate-binding and substrate specificity to the complex. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions (By similarity).

Belongs to the DNA mismatch repair MutS family. MSH3 subfamily.

124.367 kDa

MTLSSSQSSPPSTQNLKRKQQTISSFFTKRAPSAEKRSNDIEDGRATTQKGAEMPLRETAGDQNNLEDDEDGDVVVRAPKRVKTNGVDPENGFGRNIKEASNIARRPDPPLSSSQRTNLYKFASSQADDAGIEKTDDPEARQRQLEREKLHKLFVKKLGGADCLIGIGRDATTEAPSGTEDVAEGDEDDESPPQPRSKGKGLSKKGGSKLTPLEKQVIEIKRKHMDTILVVEVGYKFRFFGEDARIAAKELSIVCIPGKMRFDEHPSEAHLDRFASASIPVHRLHVHVKRLVSAGYKVGVVRQLETAALKAAGDNRNAPFSRKLTNLYTKGTYVDDVEGLDGATPAASGGASPATGYMLCITETNAKGWGNDEKVHVGIVAVQPNTGDVIYDDFDDGFMRSEVETRLLHIAPCELVIVGELSKATEKLVQHLSGSKLNTFGDKVRVDRVAKKKTAVAESHSHVANFYAAKLKAANTADDAPASNLLQKVLNLPEQVTVCLSAMIQHLTEYGLEHIFELTKYFQHFSSRSHMLLNANTLVSLEIYQNQTDHSAKGSLFWTLDRTQTRFGQRLLRKWVGRPLLDKERLEERVNAVEELKSPERTVQAERLKIMLGKIKSDLEKNLIRIYYGKCTRPELLTVLQTLQTIAQEYVDVKTPQDSGFTSPILGEAIARVPSILGDVVKFLNKINMHAARNDDKYEFFRESEETEGISEHKCGIASVEHELEEHRSVAAGILKWPKVTYVTSSGIEYLIEVENSAAAIKRVPASWVKVSGTKKVSRFHTPEVIQLLRQRDQHKEALAAACDQAFAALLAEIASNYQSFRDCVQSLATLDCLLSLAAIASQPGYVKPEYTDQTCIHVEQGRHPMVEQLLLDSYVPNDIDLDSDKTRALLVTGPNMGGKSSYVRQIALIAIMAQIGSYVPARSAKLGMLDAVFTRMGAFDNMLAGESTFMVELSETADILKQATPRSLVILDELGRGTSTHDGVAIAQAVLDYMVRTIRSLTLFITHYQHLSNMAQSFPDHELRNVHMRFTESGSGKDEEITFLYEVGEGVAHRSYGLNVARLANLPAPLLEVARQKSSELEERIRRRRLARLLADVGGLIEDPAKGDENFFQRLISNAEQL

msh3

DNA mismatch repair protein msh3

1123 amino acids

Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with msh2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair. Msh3 provides substrate-binding and substrate specificity to the complex. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions (By similarity).

Belongs to the DNA mismatch repair MutS family. MSH3 subfamily.

124.367 kDa

MTLSSSQSSPPSTQNLKRKQQTISSFFTKRAPSAEKRSNDIEDGRATTQKGAEMPLRETAGDQNNLEDDEDGDVVVRAPKRVKTNGVDPENGFGRNIKEASNIARRPDPPLSSSQRTNLYKFASSQADDAGIEKTDDPEARQRQLEREKLHKLFVKKLGGADCLIGIGRDATTEAPSGTEDVAEGDEDDESPPQPRSKGKGLSKKGGSKLTPLEKQVIEIKRKHMDTILVVEVGYKFRFFGEDARIAAKELSIVCIPGKMRFDEHPSEAHLDRFASASIPVHRLHVHVKRLVSAGYKVGVVRQLETAALKAAGDNRNAPFSRKLTNLYTKGTYVDDVEGLDGATPAASGGASPATGYMLCITETNAKGWGNDEKVHVGIVAVQPNTGDVIYDDFDDGFMRSEVETRLLHIAPCELVIVGELSKATEKLVQHLSGSKLNTFGDKVRVDRVAKKKTAVAESHSHVANFYAAKLKAANTADDAPASNLLQKVLNLPEQVTVCLSAMIQHLTEYGLEHIFELTKYFQHFSSRSHMLLNANTLVSLEIYQNQTDHSAKGSLFWTLDRTQTRFGQRLLRKWVGRPLLDKERLEERVNAVEELKSPERTVQAERLKIMLGKIKSDLEKNLIRIYYGKCTRPELLTVLQTLQTIAQEYVDVKTPQDSGFTSPILGEAIARVPSILGDVVKFLNKINMHAARNDDKYEFFRESEETEGISEHKCGIASVEHELEEHRSVAAGILKWPKVTYVTSSGIEYLIEVENSAAAIKRVPASWVKVSGTKKVSRFHTPEVIQLLRQRDQHKEALAAACDQAFAALLAEIASNYQSFRDCVQSLATLDCLLSLAAIASQPGYVKPEYTDQTCIHVEQGRHPMVEQLLLDSYVPNDIDLDSDKTRALLVTGPNMGGKSSYVRQIALIAIMAQIGSYVPARSAKLGMLDAVFTRMGAFDNMLAGESTFMVELSETADILKQATPRSLVILDELGRGTSTHDGVAIAQAVLDYMVRTIRSLTLFITHYQHLSNMAQSFPDHELRNVHMRFTESGSGKDEEITFLYEVGEGVAHRSYGLNVARLANLPAPLLEVARQKSSELEERIRRRRLARLLADVGGLIEDPAKGDENFFQRLISNAEQL

msh3

DNA mismatch repair protein msh3

1119 amino acids

Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with msh2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair. Msh3 provides substrate-binding and substrate specificity to the complex. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions (By similarity).

Belongs to the DNA mismatch repair MutS family. MSH3 subfamily.

123.133 kDa

MPLPSSQNSSSPGVKRKQSTLASFFTKKPQTAQQASVNVVEEKSPAATFDKADNQERAAKKDKALTDDEEDDIVAPAPKRVRTNGLYPASREEIPNSTSTTERPPALTSSQRTERFKFSSSPAVNTGVEGSQAAVELEAGQRQKEREELHHKFVRKLGGADCLIGIGRNAISEATPEEGAEPEDEEEAAPPPPAKGKAAAKKGGSKLTPMEKQVIDIKRKHMDTVLVVEVGYKFRFFGEDARVAAKELSIVCIPGKLRFDEHPSEASHLDRFASASIPVHRLHVHVKRLVAAGHKVGVVRQIETAALKAAGDNRNAPFVRKLTNLYTKGTYIDDAEGLGGPMPAASGGASPATGYLLCITETNAKGWGNDEKVQVGIVAVQPATGDIVYDDFEDGFMRSEIETRLLHIAPCELLIVGELSKATEKLVQHLSGSKLNVFGDKTRVERVLKSKTAAAESHSHVSSFYAGKMKTASAADDAQASSLLQKVLNLPEQVTICLSSMIEHMKEYGLEYVFELTKYFQHFSSRSHMLLNGNTLMSLEIYQNQTDHTTKGSLFWTLDRTQTRFGQRMLRKWVGRPLLDKSRLEERVNAVEELKNPEKTVMVERLKGLLGKVKSDLEKSLIRIYYGKCTRPELLTVLQTMQMIAQEFSDVKSPADTGFASTAINEAITCLPTILEDVVAFLDKINMHAAKSDDKYAFFREAEETEDISDQKLGIASVEHELEEHRSVAGQKLGKKTVEYKSVAGIDYLIEVENSSASIKRVPASWVKVSGTKKVSRFHTPEVIQLMRQRDQHKEALAAACDQAFISLLADIATKYQPFRDSVQALATLDCLIALATIASQPGYVKPEYTDHTCIQVDQGRHPMVEQLLLDSYVPNDIDLDSDKTRALLVTGPNMGGKSSYVRQVALIAIMGQIGSYVPAQSAKLGMLDAVFTRMGAFDNMLAGESTFMVELSETADILKQATPRSLVILDELGRGTSTHDGVAIAQAVLDYMVRSIRSLTLFITHYQHLSSMVHSFADQELRNVHMRFTESGTGTDEEITFLYEVGEGVAHRSYGLNVARLANLPGALLDQARQKSKELEEKIRRRKLAGLVTAVGEVIEGSKDENMIERLISSAEQL

MSH3

DNA mismatch repair protein MSH3

1119 amino acids

Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair. MSH3 provides substrate-binding and substrate specificity to the complex. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions (By similarity).

Belongs to the DNA mismatch repair MutS family. MSH3 subfamily.

124.391 kDa

MAPKSSQSSQGLSQRSKQQTISSFFTPKPSQTPKAPPKPAALAVPNGADQDDDDDEDEDIAPPRQLTPARKRSIDEQHEDEEAGRSSPPKRVRVANDEPRPSLGNASATTLNAAKPPKITERTSKFLFSSSPVVRDETDAKDDAAATQKLREKLHEKFVKKLGRPDSFAELRRRNKVISEDNGNGEEGEGEEDEEEEEPAPKPTKGRKGAATKKTSKLTPMELQYLDIKRKHMDTVIVMEVGYKFKFFGEDARTASKELGIVCIPGKFRYDEHPSEAHYDRFASASFPVHRLQVHVKRLVKANHKVGVVRQLETAALKAAGNNRNTPFVRKLTNLYTKGTYVDDIEGLETPTAGAQATGYLLCVTETNAKGWGTDEKVQVGLVAVQPATGDIIYDDFEDGFMRSEIETRLLHIAPAEFLIVGDLSKATDKLIHHLSASKTNVFGDRSRVERVEKPKTMAAQAYSHISNFYADKMKSSQEGGSEQGAILDKVHQLSEHVTICLSAMITYLSDYALEHVFDLTKYFQPFSARSYMLLNGNTLSSLEIYQNQTDYTSKGSLFWTMDRTKTRFGQRLLRKWVGRPLIDKERLEERIAAVEELKEGEHTIAVDKVKFLLGKIKTDLEKVLIRIYYKKCSRPELLAALQILQDIASQYLSAKTPEQSGFSSILLSEAVSNVPKIYEDVNSFLEKINAKAAKDDDKYGFFREEFEAEDINDLKLSIASVEDDLNTHRKDAAAKLGKTKVDYVTVAGIEYLIEVKRKSVEEKKVPASWQQISATKTTLRFHTPEVKRMLQERDQYKESLAAACDTAFKRLLDDIAAKYQSLRDCVSSLATLDALLSLATLANQPGYVKPTFVETTELDIVGGRHPMVEQLLLDAYVPNDVHLSGDATRALLVTGPNMGGKSSYVRSAALIAIMGQIGSYVPAESAKLGMLDAVFTRMGALDNMLKGESTFMVELNETADILRSATSRSLIILDELGRGTSTFDGVAIAEAVLDYVIRDVGALTLFITHYQHLARLQDRFNGELKNVHMSFEERDGGKEVVFLYEVAEGTSHRSYGLNVARLAKVPEKVIETAEVKSSELEESMGISRVANMARMVKGLLEDGGEEGLERLIEGIEQL

msh3

DNA mismatch repair protein msh3

1117 amino acids

Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with msh2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair. Msh3 provides substrate-binding and substrate specificity to the complex. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions (By similarity).

Belongs to the DNA mismatch repair MutS family. MSH3 subfamily.

123.742 kDa

MPLSSSQSSPPSSQNLKRKQQTISSFFTKKPQSTKPEESHGADEKQRTNGAEEVGNENRAPPHTADAAEEDDDDIVAPAPKRARTNAHRQKDTDQTSDGPPRIAEPPKSSQRTELAKFASSPAGAAEPEEMDEEEAQERKKEREKLHKQFVRRLGGPDCLIGINRHVSGEADPALEEAAEADEDEEAVQAPPAKGKAAAKKGGGKLTPMERQIIDMKRKHMDKILAVQVGYKFRFFGEDARVAAKELSIVCIPGKFRFDEHPSEAHLDRFASASIPVHKLHVHVKRLITAGHKVGIVRQIETAALKAAGDNRNAPFVRKLTNVYTKGTYIDDMEGLEGPTAGAGTTAATGYMLCITETNAKGWGNDEKVHVGIVAVQPATGDIVFDDFEDGFMRSEIETRLLHLAPCELLIVGDLSKASDKLVQHLAGSKMNVFGDKVRVERTTKSKTAAAEAHSHVSSFYADKVKSANASDDTQASNLLQKVLNLPEQVSICLSSMIKHMTEYGLEHVFDLTKYFQHFSSRSHMLLNGNTLMSLEIYQNQTDHSSRGSLFWTLDRTQTRFGQRLLRKWVGRPLLDKSKLEERVNAIEELKSMEKVAMVERLKGVLGKAKCDLEKILIRIYYGRCTRPELLTGLQTLQMIAQEFGDVKSPEDSGFTTPILNEAIASLPTILEDVLSFLNKINLHAARNDDKYEFFREAEETEDISEHKLGIASVEHELREYQSVAGKILGRSKIQYVTVAGIDYLIEVENNSSYLKRVPASWVKISGTKKLSRFHSPEVIKLLRQRDQHKEALAAACDHAYASLLAEIAANYQPFRDCVQSLATIDCLLSLSSIANQPGYVKPEYADNTCIHVEQGRHPMVEQLLLDSYVPNDINLDSEETRALLVTGPNMGGKSSYVRQIALIAIMGQVGSYVPAQSAKLGMLDAVFTRMGAFDNMLAGESTFMVELSETADILKQATPRSLVILDELGRGTSTHDGVAIAQAVLDYMVRSLRSLTLFITHYQHLSSMVHSFPNHELRNVHMRFTESGSGQDEEITFLYEVGEGVAHRSYGLNVARLANLPVPLIEVAKQKSAELEQKIRRRRLAGLMSTVENIMSDSAKNDEGLITRLISSAEQL

msh3

DNA mismatch repair protein msh3

1117 amino acids

Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with msh2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair. Msh3 provides substrate-binding and substrate specificity to the complex. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions (By similarity).

Belongs to the DNA mismatch repair MutS family. MSH3 subfamily.

123.663 kDa

MTLSSSQSSPPSSQNLKRKQQTISSFFTKRAPTAEKRSNDLEDGRATTQKGAEMPLRETTGDQDDLVDDEDGDIVVRAPKRVKTNRVDPENGFGRNVTRGPDPPSSSSQRTNLCKFASSPADDAGIEKADDPEARQRQLEREKLHKLFVKKLGGADCLIGIGRNATTEAPSGTEEVAEGDEDDESAPPPRSKGKGASKKGGSKLTPLEKQVIEIKRKHMDTVLVIEVGYKFRFFGEDARIAAKELSIVCIPGKMRFDEHPSEAHLDRFASASIPVHRLHVHVKRLVSAGYKVGVVRQLETAALKAVGDNRNAPFSRKLTNLYTKGTYVDDVEGLDGATPAASGGASPATGYMLCITETNAKGWGNDEKVHVGIVAVQPNTGDIIYDDFEDGFMRSEVEARLLHIAPCELVIVGELSKATEKLVQHLSGSKLNTFGDKVRVDRVAKKKTAVAESHSHVANFYAAKLKAANTADDAPASNLLQKVLNLPEQVTVCLSAMIEHLTEYGLEHIFELTKYFQHFSSRSHMLLNANTLVSLEIYQNQTDHSAKGSLFWTLDRTQTRFGQRLLRKWVGRPLLDKERLEERVNAVEELKSPDRTVQVERLKILLGRIKSDLEKNLIRIYYGKCTRPELLTVLQTLQTIAQEYVDVKTPEDSGFTSPILGEAIARVPSILEDVVKFLNKINMHAARNDDKYEFFRESEETEGISEHKCGIASVEHELEEHRSVAAGILKWPKVTYVTSSGIEYLIEVENTAAAIKRVPASWVKVSGTKKLSRFHTPEVIQLLRQRDQHKEALAAACDQAFAALLAEIATNYQSFRDSVQSLATLDCLLSLAAIASQPGYVKPEYTDQTCIHVEQGRHPMVEQLLLDSYVPNDIDLDSDRTRALLVTGPNMGGKSSYVRQIALIAIMAQIGSYVPARSAKLGMLDAVFTRMGAFDNMLAGESTFMVELSETADILKQATPRSLVILDELGRGTSTHDGVAIAQAVLDYMVRTIRSLTLFITHYQHLSNMAQSFPNHELRNVHMRFTESGSGKDEEITFLYEVGEGVAHRSYGLNVARLANLPAPLLEVARQKSSELEERIRRRRLAGLRADVGGLMEDPAKGDEDFFQRLISNAEQL

msh3

DNA mismatch repair protein msh3

1111 amino acids

Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with msh2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair. Msh3 provides substrate-binding and substrate specificity to the complex. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions (By similarity).

Belongs to the DNA mismatch repair MutS family. MSH3 subfamily.

123.542 kDa

MPLSSQPSSSNLKRKQPTISSFFTKKPQLSQESISNDVLEKEERDEEREEVAKQEEGLRENGGTRSNNVDDDEDDVVAPASKRARTNGSHSQNTIETPKEKHVERPLPSDSIQKTELSKFASSPATEGETKERTKERERLHQKFVRRLGGPDCLIGIGRNTAPEAVPEEVGEGDEDDEPSPPPAAKGKATAKKGARKLTPMEKQVIDIKRKHMDTVLVVEVGYKFRFFGEDARTAAKELNIVCIPGKFRFDEHPSEAHLDRFASASIPVHRLHVHVKRLVSAGHKVGVVRQMETAALKAAGDNRNAPFGRKLTNLYTKGTYIDDMEGLEGSTASMSATGTSMATGYMLCITETNTKGWGNDEKVLVGIVAVQPATGDIVYDEFEDGFMRSEIETRLLHLAPCEVLIVGDLSKATEKLVQHLSGNKTNAFGDEIRVERAPKAKTAAAESHSHVSSFYAERMKKVNATNDVQASSLLQKVLNLSEQATICLSSMIKHMSEYGLEHVFQLTKYFQHFSSRSHMLLNANTLNSLEIYHNQTDHSTKGSLFWTLDRTQTRFGQRMLRKWVGRPLLNKLGLEERVDAVEELKNLERVALVEQMKCLLGRIKTDLEKSLIRVYYGKCTRPELLTLLQTLQMIAQEFAGVQSPADTGFSSPLISKAVASLPTILEDVVRFLDKINMHAAKNDDKYEFFRESEETDEITEHKLGIGAVEHDLEEHRSTAGEILGKRKVDYVTVAGIEYLIAVENKSPSIKKVPASWVKISGTKAVSRFHTPEVIRLLRQRDQHKEALAAGCDKAYATFLAEISASYQSFRDSVQSLATLDCLISLATIANQPGYVKPEYTNHTCIQVDQGRHPMVEQLLLDSYVPNDIDLDSDKTRALLVTGPNMGGKSSYVRQVALIAIMGQIGSYVPARSAKLGMLDAVFTRMGAFDNMLAGESTFMVELSETADILKQATPRSLVILDELGRGTSTHDGVAIAQAVLDYMIRSIRSLTLFITHYQHLSSMVHSFPDHELRNVHMRFTESGPTEEEITFLYEVREGVAHRSYGLNVARLANLPAPLIELAKQKSAELEQKIHRRRLAGLVRTVGDILADSAKADESLIERLISSAEQL

msh3

DNA mismatch repair protein msh3

1105 amino acids

Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with msh2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair. Msh3 provides substrate-binding and substrate specificity to the complex. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions (By similarity).

Belongs to the DNA mismatch repair MutS family. MSH3 subfamily.

122.14 kDa

MPLPSSQPSASSSPNLKRKQPTISSFFTKKPQAPKQSTSNEGPAPIDNDSEITDKLAEDDEEDIVAPVPKRTKSNGSLTVNRPQSPKAKSVSRVEQESSQRTELSKFASSPAIETEGNEATELDGSAKVRQQEREKLHQRFVRKLGGPDCLVGIGRNCVGETTSIEEAAEGDEDDETPQPVQPKGKAGKKGGGKLTPMEKQVIEIKKKHMDTILLIEVGYKFRFFGEDARIAAKELSIVCIPGKFRYDEHPSEAHLDRFASASIPVQRLHVHVKRLVAAGHKVGVVRQLETAALKAAGDNRNAPFVRKLTNVYTKSTYIDDIESLEGSTAGASGASATGYILCITETNARGWGNDEKVHVGIVAVQPTTGDIVYDEFDDGFMRSEIETRLLHIAPCEMLIVGELSKATEKLVQHLSGSKMNVFGDKVRVERAPKAKTAAAESHSHVSSFYAEKMKSADAADDEVASNLLQKVLGLPDQVTICLSAMIKHMTEYGLEHVLQLTKYFQHFSSRSHMLLNGNTLTSLEIYQNQTDYSSKGSLFWTLDRTQTRFGQRMLRKWVGRPLLDRRQLEDRVNAVEELKDFRNVVMVERIKGLLGKIKHDLEKGLIRIYYGKCSRPELLTILQTMQMIAQEFADIESPADTGFSSPAISQAIMSLPTILKDVVFFLNKINMHAARNDDKYEFFREEEETEEISEHKLGIGAVEHELEEHRPVAGEALGKKMVTYVSVAGIDYLVEVENNSPAIKRVPASWMKISGTKKVSRFHTPEVVKMIRQRDQHREALAAACDKAFLALQAEIATNYQALRDCVQSLATLDCLVSLATLASQPGYVKPEYTEETCIHVEQGRHPMVEQLLLDSYVPNDINLDSSKTRALLVTGPNMGGKSSYVRQVALIAIMGQIGSYVPAQAAKLGMLDAVFTRMGAFDNMLAGESTFMVELSETADILKQATPRSLVILDELGRGTSTHDGVAIAQAVLDYMVRSIRSLTLFITHYQHLSAMVHSFPDGELRNVHMRFSESGTGADEDITFLYEIGEGVAHRSYGLNVARLANLPAPLLEMAKQKSAELEEKIRRRRLAGFVAAVGAVVQSNQADESVIERLVSSMEEL

Msh3

DNA mismatch repair protein Msh3

1091 amino acids

Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta which binds to DNA mismatches thereby initiating DNA repair. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. MutS beta recognizes large insertion-deletion loops (IDL) up to 13 nucleotides long. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis (By similarity).

Belongs to the DNA mismatch repair MutS family. MSH3 subfamily.

123.074 kDa

MPRGKSASGGSTAAGPGPGRQTVLSRFFRSAGSLRSSASSTEPAEKVTEGDSRKRSLGNGGPTKKKARKVPEKEEENISVASHHPEAKKCLRPRIVLKSLEKLKEFCCDSALPQNRVQTEALRERLEVLPRCTDFEDITLQRAKNAVLSEDSKSQANQKDSQFGPCPEVFQKTSDCKPFNKRSKSVYTPLELQYLDMKQQHKDAVLCVECGYKYRFFGEDAEIAARELNIYCHLDHNFMTASIPTHRLFVHVRRLVAKGYKVGVVKQTETAALKAIGDNKSSVFSRKLTALYTKSTLIGEDVNPLIRLDDSVNIDEVMTDTSTNYLLCIYEEKENIKDKKKGNLSVGVVGVQPATGEVVFDCFQDSASRLELETRISSLQPVELLLPSDLSEPTEMLIQRATNVSVRDDRIRVERMNNTYFEYSHAFQTVTEFYAREIVDSQGSQSLSGVINLEKPVICALAAVIRYLKEFNLEKMLSKPESFKQLSSGMEFMRINGTTLRNLEMVQNQTDMKTKGSLLWVLDHTKTSFGRRKLKNWVTQPLLKLREINARLDAVSDVLHSESSVFEQIENLLRKLPDVERGLCSIYHKKCSTQEFFLIVKSLCQLKSELQALMPAVNSHVQSDLLRALIVELLSPVEHYLKVLNGPAAKVGDKTELFKDLSDFPLIKKRKNEIQEVIHSIQMRLQEFRKILKLPSLQYVTVSGQEFMIEIKNSAVSCIPADWVKVGSTKAVSRFHPPFIVESYRRLNQLREQLVLDCNAEWLGFLENFGEHYHTLCKAVDHLATVDCIFSLAKVAKQGNYCRPTLQEEKKIIIKNGRHPMIDVLLGEQDQFVPNSTSLSDSERVMIITGPNMGGKSSYIKQVTLVTIMAQIGSYVPAEEATIGIVDGIFTRMGAADNIYKGRSTFMEQLTDTAEIIRRASPQSLVILDELGRGTSTHDGIAIAYATLEYFIRDVKSLTLFVTHYPPVCELEKCYPEQVGNYHMGFLVNEDESKQDSGDMEQMPDSVTFLYQITRGIAARSYGLNVAKLADVPREVLQKAAHKSKELEGLVSLRRKRLECFTDLWMTHSVKDLHTWADKLEMEEIQTSLPH

MSH3

DNA mismatch repair protein MSH3

1081 amino acids

Component of the post-replicative DNA mismatch repair system (MMR). Forms the heterodimer MutS beta (MSH2-MSH3 heterodimer) which binds to DNA mismatches thereby initiating DNA repair. MutS beta recognizes single base mismatches and trinucleotide insertion-deletion loops (IDL) in the DNA.

Belongs to the DNA mismatch repair MutS family. MSH3 subfamily.

119.366 kDa

MGKQKQQTISRFFAPKPKSPTHEPNPVAESSTPPPKISATVSFSPSKRKLLSDHLAAASPKKPKLSPHTQNPVPDPNLHQRFLQRFLEPSPEEYVPETSSSRKYTPLEQQVVELKSKYPDVVLMVEVGYRYRFFGEDAEIAARVLGIYAHMDHNFMTASVPTFRLNFHVRRLVNAGYKIGVVKQTETAAIKSHGANRTGPFFRGLSALYTKATLEAAEDISGGCGGEEGFGSQSNFLVCVVDERVKSETLGCGIEMSFDVRVGVVGVEISTGEVVYEEFNDNFMRSGLEAVILSLSPAELLLGQPLSQQTEKFLVAHAGPTSNVRVERASLDCFSNGNAVDEVISLCEKISAGNLEDDKEMKLEAAEKGMSCLTVHTIMNMPHLTVQALALTFCHLKQFGFERILYQGASFRSLSSNTEMTLSANTLQQLEVVKNNSDGSESGSLFHNMNHTLTVYGSRLLRHWVTHPLCDRNLISARLDAVSEISACMGSHSSSQLSSELVEEGSERAIVSPEFYLVLSSVLTAMSRSSDIQRGITRIFHRTAKATEFIAVMEAILLAGKQIQRLGIKQDSEMRSMQSATVRSTLLRKLISVISSPVVVDNAGKLLSALNKEAAVRGDLLDILITSSDQFPELAEARQAVLVIREKLDSSIASFRKKLAIRNLEFLQVSGITHLIELPVDSKVPMNWVKVNSTKKTIRYHPPEIVAGLDELALATEHLAIVNRASWDSFLKSFSRYYTDFKAAVQALAALDCLHSLSTLSRNKNYVRPEFVDDCEPVEINIQSGRHPVLETILQDNFVPNDTILHAEGEYCQIITGPNMGGKSCYIRQVALISIMAQVGSFVPASFAKLHVLDGVFTRMGASDSIQHGRSTFLEELSEASHIIRTCSSRSLVILDELGRGTSTHDGVAIAYATLQHLLAEKRCLVLFVTHYPEIAEISNGFPGSVGTYHVSYLTLQKDKGSYDHDDVTYLYKLVRGLCSRSFGFKVAQLAQIPPSCIRRAISMAAKLEAEVRARERNTRMGEPEGHEEPRGAEESISALGDLFADLKFALSEEDPWKAFEFLKHAWKIAGKIRLKPTCSF

MSH3

DNA mismatch repair protein MSH3

1037 amino acids

Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair. MSH3 provides substrate-binding and substrate specificity to the complex. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions (By similarity).

Belongs to the DNA mismatch repair MutS family. MSH3 subfamily.

118.896 kDa

MSSQKRQSTLSRFFTTIKPSQSTESTLTEKVSSKSPPLPPPPPPPTASPSLPSEKLLEFGFDGTKDSTSTRTTTTKSKDVEKRKSTTSSGSSFSSESKPKRPKEKRLTPLEKQILELTEQHQDKILLIQIGYKYKVFGINALKVSKILNIMYISNDIEDTRFHYCSIPDTRLHIHLQRILSHGYKVGVVKQIESTIVKQIEKTSKSSDVMRREVTGVYTKATYLGDESNENTKGSWDGLSSSSSSSSSDVPEYIVCINEVSEKQFAIVAVQPLIGEVIFDSFKDDISRQELETRLLYLRPVEVIVITNGSSEQISGPTLMTLKLINHNCNIIHKSGSPSENGNENENENENEAIEAIMSKYLNEKLVEYYSINFSIPIQQCFEYLLLYLNEFKLTNIFTIPENITNFQDSKKYMILPANTLNSLEIFTNTTDHTTKGSLFKLLNNTKTIFGSRLLQKWVSRPLVHIQDIKDRHQAIEDLQSEYNHVVDSISNFLTKIKYLDLEGLLSKIHYSSTNNNNNNLRINRKQVYLLLSNLQEILILVQKFEKSIKSFKFKSSLLIQIFDELLTISQTDIIIIENFLSMIDLSFIDCKESSEQCRKFFKRNSFDSIELQYQNIAQYQQQIEQEQLEIIRKELGNSKLKYVQKDGERYLIEIRNNQRDKLSKILDDKDYILIKSTQTITRYRKKSVTEYLKLLQYHEEMLIKTCDEEFQNFLKDLDSNYTLFYKIIKNLAIFDCLLSLTTTSSLPNYTRPTLIDDDLTILVKQARHPTIEQLRPNYVANDININIEYDKNRVLIITGPNMGGKSSYVKTVALLTVMTQIGCYLPCQNATMGIFDSIFIRMGANDNILKGYSTFMMEMLQCKNIISMMSNRSLIILDEIGRGTGTIDGISLAYSILKYLIESEFKPLVLFITHYPSIHVLEQEYPNQLVVNYHMGYQEIKNNTPGEIPEIIFLYNLCRGVVNNSYGLNVAKLAGISHDIIKQAYRVSEKVKSDIELKEYWKFAHSLNKALKEGGSSSPNQLDDIDYYILSKHSSL

MSH3

DNA mismatch repair protein MSH3

1032 amino acids

Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair. MSH3 provides substrate-binding and substrate specificity to the complex. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions (By similarity).

Belongs to the DNA mismatch repair MutS family. MSH3 subfamily.

117.14 kDa

MLQQPTISRFFKSSSTRKKSEQRTAKEEAELMQLLESDGENNSATVPSDRKPEAAPMHVGLGNKAAAGGAVPGQVKSATRGFEDFRFNRRREACGKEQEVGFAERLQRIMERREGGCVEEDETELDNEAPRSKRAKPNRLTELDQQFKDLKLQHMDKVLAVRVGYKYKFFAEDAVMVSRVLQIKLVPGKLTVHETDPADHKHKKFAYCTIPDTRLEVHLQRLMHHNLKVGVVEQTETSAVKKNSGTSSSVFSREVTNIFTRATYGINETFGTKDRRVLGDSASVWGLVCKRQPSYTRYFLVSVNLNSGEVIFDDFKEERFLTEALETRIKYTNPSEVVVGDGLGSEIEKVFHTSDSDITLNRIELVGLYEEIFSEPHPAFKGNVPLQTALMLVHGYLTNFKNESLLFFKENFKPFCSKTHMILPSSAIESLDIFENSTDRSSKGSLLWVLDHTRTNYGLRNLKNWIAKPLINIDQIQQRLDAVQCISTEVGNIFIESLNNMLRDGQDLERILNRIAYGKTSRREVYLFLRELTQLATLFSSHHRYIETNVLSANGKIRMQSSLLANIFTDLDEYWKQFPIPNFLAMINIDAALDKNPDRPYVEYFNLTKYDRAEPLISKQQDIEAVIGELRDELKNIRVILKRPMLNYKDEIDFLVEIRNTQVSSVPVDWVKVASTKAVSRFQTPGTAKLVAKLQYHKELLQDLALQEYESFIKRITGEYTSLRKAILHLSTYDCILSLAATSCNVDYVRPKFNTAPQCINVINGRNPIIESLDVRYMPNDVNLNREGKKIMIITGPNMGGKSSYIRQVALLVIMAQIGCYVPAQEAEFSIFDQIFTRIGAYDNLLRNDSTFKIEMTEMVQILRSSTENSLLLLDEVGRGTGTHDGISISYALLRYFIELHNACPLILFITHYASLGSIRSPILGNYHMSYIEEKRPGENWPSVVFLYKLKEGRAHNSYGLNVAKLADIQTGIINRAYKISTMLKQEMESNSSIAAICTIKHALAGNSAASLKSAIETLIESADHEQFVLNM

MSH3

DNA mismatch repair protein MSH3

1029 amino acids

Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair. MSH3 provides substrate-binding and substrate specificity to the complex. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions (By similarity).

Belongs to the DNA mismatch repair MutS family. MSH3 subfamily.

118.522 kDa

MYQPTISHFFKSSQPSSQTDTRQDEDQRLDIESHEQRGGANMNKDELINILGSDSESDQDLDEDLDQDQNNNQDQDQEQDRDLASKANNGRSTLSAERIERRPDFNEKLKTIMRKRNAGSMINTGSDDENDDNDDVKSTKRTKANNKKLTELDQQFKELKLKHMDTILCVRVGYKYKFFAKDAEIVSNILQIKLVPGKKTLDESDPNDRNYRKFQYCSIPDTRLHVHLQRLVFFNYKVAVVEQTETSALKKNNNSGSLFTREIKNIFTKVSYGINETFDKSEDRILGDLTSVWAISINETSKMRKVNLISVQLNSGEIVHDQFSDDILLNVNLEARIRYLNPTEIITEEELPPSIRTIFTKLNQDIQFYQSHKEACPNLFDALQGLDLNNELKRLLSVLHSYLSTFENTKVLYFASNYSSFTAKNFMVLPRNTIESLEIFENSTTNKTNGSLLWVMDHTRTQFGYRLLRKWISKPLIDLKSILDRQDAITCIMKEVHSIFFESFNELLRKSIDLERALNRIAYGSTSRKEVYFFLKQIATFASLFKSHHTFIHDQLHKENSALRKTSCLLFNILQNLDAFFSATDLPLFLQMINVDAALDKDSHKNVIEFFNLNKYDFPEGLLHKYRDIEEVKTELDDELQNIKRVLKRPTLSYKDTKDYLIEVRNTQAKTVPSNWVKVNSTKAVSRFRTPKTEELVGKLLYHNDLLNLLAEDEFKRFLQRIVDRYAEIKTCINNLATYDCILSLAATSSNVNYVKPKLTELHQKVKVKNGRNPIIESLDVNYVPNDVLMSSNSGKINIITGPNMGGKSSYIRQVALLVIMTQIGCYIPADSAEMSICDRIFTRIGSHDDLLNAKSTFQVEMSEVLHILNSSTPRSLLLLDEVGRGTGTHDGLSISFAILNYFVYLADNCPLVLFITHYSALCQIDSKLIANYHMSYIEKHQPGEKWTNVIFLYKLVLGQAHNSYGFNVAKLSNIPTEIINRAFEVSEEKILSSKHHNFLEIMKALKRVNERKLNKEALKKIQAFIEDI

MSH3

DNA mismatch repair protein MSH3

1028 amino acids

Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair. MSH3 provides substrate-binding and substrate specificity to the complex. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions (By similarity).

Belongs to the DNA mismatch repair MutS family. MSH3 subfamily.

117.54 kDa

MAPETKGQRSISHFFKSQSSSQKLNKDDTEYSGNIIDLTNGDEKVSSRLANFEHKPNKSSKSPNELDTSKRKSSKDNEHVDGDPEPVKKKPRTSQSLSRSKSKPQSVGSNSKKLTPLEKQFVEMKQSNLDKILAIQVGYKFKFFGEDAVIASKILSIMLIPGNIKLDEYQHDRFAYCSIPDNRLHIHLKRLLNQGLKVGVAKQTETAAIKSIDSTNKSGLFEREITGVYTKATYMGDELLTGDPNINRTSITDDEMGDYIFCIDESHSKDIGMIAIQPITGDIIYDTFNDNVTRDELETRLVYLNPSEILVINNSTEISKETIKMINIVNNKVNIIHRPRRQQTDYTNEIYNFFNTIDEGKYKDLGEHYLLKFPNNIQSCMIELIKYLEEFKLSNIFTIISNVSCFSNSKTCLVLPSSTVQALEIFQNMTDPNSNKGSLIWLLNHTRTRMGNRLLVKWISKPLIDKAQIEERLQGIEDLTFKFNHFIDSLKNQLDKIGKASIDLEKNLIKVHYSSTYQLDKISRKEVYLLLKCFDDILSMIKQFGKPTNNILESIHSPLLLRIFDELMQLAKEDTVRCLLDMISADALDDSNLNDQKIKFFNLNYFKDQQIISQLSEISNVESLLNDELIEIRKMLKRPQLNYITSSKETYLVEVRNGKMVDSLPKDWIKINGTKTVSRFRSPEITRLHKQLQYHNDMLIRNCDKAFNAYLFKIDNNYEFFSKIIRNLSTFDCLLSLSAVSSINSNYARPKIVEDKQIIQMKNSRNPIIENLSVNYSNYISNDINISYDEDRVLIITGPNMGGKSTYVKQVALLVIMAQIGSYIPCDEATVGIFDSIFIRMGARDNILQNQSTFMIEMLECSHILKNMTSNSLIILDEIGRGTGTNDGIAIAYSILNYLIEEPRKPLTLFITHFPSLHVLEDKFKGIATNYHMGFHEVSKSNQEFPEVVFLYNLVRGVVGNSYGLNVAKLAGIPNSIINNAYTKSTEIRDAIESDWPKKLIKMIKSLREQNDARVELLEIEQLCNNID

MSH3

DNA mismatch repair protein MSH3

1025 amino acids

Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair. MSH3 provides substrate-binding and substrate specificity to the complex. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions (By similarity).

Belongs to the DNA mismatch repair MutS family. MSH3 subfamily.

117.474 kDa

MKQASISRFFKKVSAVNKEKVDQVKEVEKEAEVDEVLDLTLDSENDEEQQQETPVLEPIDGEEHPTVSKVPDLNDSRLLQKQKILNASKDITNSVDVSAFNEKLKDIMNKRKLGRIKGSLIDESDEIAEQSEADEHNIKKKRKKSDQLTPLDRQVKDLKLGNMDKVLVIRVGYKYKIFAQDAIIASTILHLQLIPGKVTIDDSNPNDSKYKQFAYCSFPDVRLKVHLERLVRSGLKVAVVEQSETATTKKFDNSKAKTSVFERKITGTYSKATYATNCEFEVNHENILGTNNSIWALDIEVSDSIYKYYLWSIQLSNGEVIYDSFEESKDNFSKVETRMKYLNPSEIVSPVVDSFPIKLKKRFLDLQLCQKNYDILAEDLNIPKKELLNNRLIELWHILYRYLKEYSNEKLLNIGSNYRHFSQKISIQLQAQTINNLDLISNDDSKGTLFWILDHTRTPFGKRLLKEWLLRPLLSKDAIVDRLNAIDCILESANSIFFESLNQMMKGIPDLLRTINRVSFGKTSQREVYFLLKQLTGVIKHFEAHKDYIEVEINSNSGAIKTKSTKLASIMTQMFEFSLSSVIPQLLLMINVSAVMEKDQKKQLLGFFHLNNYDNSENIIKMQRDIDSVKAQLHDELQNIKKILKRPHLAYKDEVDFLIEVRNTQVKGIPSDWVKVNNTKMISRFLTPRTKELVELLEYQNDLLYNEISKEYDQFLNRIASYYNEVKTFIMNLAEYDCLLSLAAVSCNVGYTRPVFTDSNEQLIIAKQARNPIIESLGVDYVPNDIEMEKDSGRVLVITGPNMGGKSSYIRQIALMVIMAQIGSYVPAESLKLSVFDNVLTRIGSQDNILQGQSTFKVELSETVEIINSCTSKTLLLLDEVGRGTSTRDGNAIAWALIKYFVEEEQCPFILFTTHFTIVTTVKSPLLKSYHMNYVQHKNENENWTTVVFLYQLKAGVTDSSYGLNVAKLAGIDTHIINRAHDVAISYKNDTEFDTNMILFQKVRNILANRTTARETLKVLLELDV

MSH3

DNA mismatch repair protein MSH3

1025 amino acids

Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair. MSH3 provides substrate-binding and substrate specificity to the complex. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions (By similarity).

Belongs to the DNA mismatch repair MutS family. MSH3 subfamily.

117.247 kDa

MSYRSKQASISRFFKSTKSNNSAKNEPAVQHIPKKTGVMLKFSYNNKENVVEGGKDTEGPHIVGSHVELPGQSVNSVVNSDSIVVNSNLEIDPKISSVLKRKPDIDIQLKTTKKRSKTLTPLEKQIRELRESHKDKVLVIQIGYKYKMFGDDAKLGSKILDIMYIRGGDDGTRDEFSYCSFPDFKLHINLKRLLTHGLKIGVVKQLESAIVKTVEKSSKSSDLMKREITGVYTRGTYMGDEYVQSSGNSADTESPYYIICINEINQKELSMVAVQPKTGDIVQDTFKDGLNRDELETRLMYLNPSEVIVLSSEQPSVETLKTIRLVASDVQLLPRKRKGEDEVFNGLIEFFDSIDNGKYKHLGDYFSVNFSKHIQSCFYELINYLSEFKLSNVFTIPDNISNFTNSRKYMVLPNNTLYALEIFQNYTNPASQKGTLIWLLNHTRTRFGNRLLNKWVSKPLIEKEKIEERLLAIEDLTGDFNNVVDALKIQLDKMGKSLDLEELLMKTHYAATYNLDKINRRDIYNMLDCFQSVLESMNRFEKGITEFSKTKKSPLLTNILLELSEMSKTTVVSNLLNKINRSYVMNESKDPEEQVTQFFNLDNHNWEDIRSEFSELDKIEKLFEEELLNIRRVLKRPQLQYITNNKEPYLIEVRNGKQVDELPTDFHRINGTTTVSRFRSERTAQLYIKKQYHKEKLLVNCNVAFNDFLKEIDEQYEFFSKIVKNLSVFDCLLSLTAASLASKNTRPILVDQQLIEVQKGRNPIIESLHNRNDYVPNDIDICYDNKVLIITGPNMGGKSSYVKQVALLVIMSQIGCYIPCDRATLGVFDSIFIRMGASDNILKGNSTFMNEMLECSNIIHGISNKSLVILDEIGRGTGTSDGIALAYSILRYLIESPLRPLVLFITHYPSLHVLEDSFPTVVTNYHMGFQQIHKDDNDFPEIIFLYNLVKGVINNSYGLNVAKLAGLPVSVISGAHRVSESLKYKVEIQQKEQFTMKFGSILQMLKKDEINSNNILELENLFSYI

MSH3

DNA mismatch repair protein MSH3

1023 amino acids

Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair. MSH3 provides substrate-binding and substrate specificity to the complex. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions (By similarity).

Belongs to the DNA mismatch repair MutS family. MSH3 subfamily.

117.059 kDa

MSKQPVISRFFKPIARKEVTSEKGVEKEKPVDLDEEKHNEPATTSRLMPKGFDAAAETVTDEVIEIEVEIEHESEPKIEIKNGTVTAENKSMDFAEKLNRIWNDKKRVISNNDNDDSDGENDTIVKKSKNNSNKLTPLDQQVKDLKLLHMDKILVIRVGYKYKCFAQDAEIVSKILHIMLIPGKLTIDESNPQDSNYRQFAYCSFPDIRLKVHLETLVHNNLKVAVVEQSETSAIKKNSNASSKNSVFERKISGVYTKATFGINSAFSSNRKNVLGQYNSIWIINFSEIDKINSSFFMISVNLNSGEIIYDTFECSTTSIENLETRIKYLNPIEVLTVSALPEKVKLRLHGSNSTILLKEKEDIDKEIMEEINKSTKGLNLSAELFELVPVLYKYLTEYNNEELLLISENYKPFASKKHMVLNAAAIESLGIFGEEGGKGSLFWLLDHTRTSFGSRKLREWILHPLLDKKEIEDRLDAVDCIIHEVSNIFFESLNKMLTNVPDLLRTINRIAYGTTSRKEIYYFLKQMKSFSDHFQLHSNYLNSQVVSNDGRIHKSSALLTNLLTEITSGLKEINIENILSMINVSSVMEKDTYKQVSEFFNLNYYDHAEEIIKIQGNINEVKNELAEELSSIRKILKRPHLNYKDEMDYLIEVRNTQTKGLPSDWIVVNRTKMISRYHTPTSRKLIEKLQYQKDILYQETQKEYFQFVKRIKNDYFALNKIINHIATYDCILALASTSQNMNYVRPVLTDESQFIDAKNARNPIIESLDINYVPNDVNLSHSAGKFLIITGPNMGGKSSYIRQVALLVILAQVGSYVPADFMKTSIFDKILTRIGAYDNLLKGQSTFKVELLEIQNIIKNKTENSLLLLDEVGRGTSTEDGKAISYSIVDYFINLPVCPLVLFTTHYPFLGSINSKILKSYYMDFVEQKKEGEDWPSIVFLYKLRSGITDSSFGLNVARLAQIDKDIINHAFSISEKIRQETETANTMNLPILLKHILSSNDLKPQQKIIEILNLQNDSQEL

MSH3

DNA mismatch repair protein MSH3

1018 amino acids

Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair. MSH3 provides substrate-binding and substrate specificity to the complex. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication. After mismatch binding, forms a ternary complex with either the MutL alpha or MutL beta heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. MutS beta also has a role in regulation of heteroduplex formation during mitotic and meiotic recombination. MutS beta binds to DNA flap structures predicted to form during recombination, and is required for 3' non-homologous tail removal (NHTR). MutS beta-binding alters the DNA conformation of its substrate at the ds/ssDNA junction and may facilitate its recognition and/or cleavage by the downstream nucleotide excision repair (NER) RAD1-RAD10 endonuclease. ATP binding and hydrolysis play a pivotal role in MMR and NHTR (By similarity).

Belongs to the DNA mismatch repair MutS family. MSH3 subfamily.

116.534 kDa

MAGQPTISRFFKKAVKSELTHKQEQEVAVGNGAGSESICLDTDEEDNLSSVASTTVTNDSFPLKGSVSSKNSKNSEKTSGTSTTFNDIDFAKKLDRIMKRRSDENVEAEDDEEEGEEDFVKKKARKSPTAKLTPLDKQVKDLKMHHRDKVLVIRVGYKYKCFAEDAVTVSRILHIKLVPGKLTIDESNPQDCNHRQFAYCSFPDVRLNVHLERLVHHNLKVAVVEQAETSAIKKHDPGASKSSVFERKISNVFTKATFGVNSTFVLRGKRILGDTNSIWALSRDVHQGKVAKYSLISVNLNNGEVVYDEFEEPNLADEKLQIRIKYLQPIEVLVNTDDLPLHVAKFFKDISCPLIHKQEYDLEDHVVQAIKVMNEKIQLSPSLIRLVSKLYSHMVEYNNEQVMLIPSIYSPFASKIHMLLDPNSLQSLDIFTHDGGKGSLFWLLDHTRTSFGLRMLREWILKPLVDVHQIEERLDAIECITSEINNSIFFESLNQMLNHTPDLLRTLNRIMYGTTSRKEVYFYLKQITSFVDHFKMHQSYLSEHFKSSDGRIGKQSPLLFRLFSELNELLSTTQLPHFLTMINVSAVMEKNSDKQVMDFFNLNNYDCSEGIIKIQRESESVRSQLKEELAEIRKYLKRPYLNFRDEVDYLIEVKNSQIKDLPDDWIKVNNTKMVSRFTTPRTQKLTQKLEYYKDLLIRESELQYKEFLNKITAEYTELRKITLNLAQYDCILSLAATSCNVNYVRPTFVNGQQAIIAKNARNPIIESLDVHYVPNDIMMSPENGKINIITGPNMGGKSSYIRQVALLTIMAQIGSFVPAEEIRLSIFENVLTRIGAHDDIINGDSTFKVEMLDILHILKNCNKRSLLLLDEVGRGTGTHDGIAISYALIKYFSELSDCPLILFTTHFPMLGEIKSPLIRNYHMDYVEEQKTGEDWMSVIFLYKLKKGLTYNSYGMNVAKLARLDKDIINRAFSISEELRKESINEDALKLFSSLKRILKSDNITATDKLAKLLSLDIH

MSH3

DNA mismatch repair protein MSH3

1018 amino acids

Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair. MSH3 provides substrate-binding and substrate specificity to the complex. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication. After mismatch binding, forms a ternary complex with either the MutL alpha or MutL beta heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. MutS beta also has a role in regulation of heteroduplex formation during mitotic and meiotic recombination. MutS beta binds to DNA flap structures predicted to form during recombination, and is required for 3' non-homologous tail removal (NHTR). MutS beta-binding alters the DNA conformation of its substrate at the ds/ssDNA junction and may facilitate its recognition and/or cleavage by the downstream nucleotide excision repair (NER) RAD1-RAD10 endonuclease. ATP binding and hydrolysis play a pivotal role in MMR and NHTR.

Belongs to the DNA mismatch repair MutS family. MSH3 subfamily.

116.534 kDa

MAGQPTISRFFKKAVKSELTHKQEQEVAVGNGAGSESICLDTDEEDNLSSVASTTVTNDSFPLKGSVSSKNSKNSEKTSGTSTTFNDIDFAKKLDRIMKRRSDENVEAEDDEEEGEEDFVKKKARKSPTAKLTPLDKQVKDLKMHHRDKVLVIRVGYKYKCFAEDAVTVSRILHIKLVPGKLTIDESNPQDCNHRQFAYCSFPDVRLNVHLERLVHHNLKVAVVEQAETSAIKKHDPGASKSSVFERKISNVFTKATFGVNSTFVLRGKRILGDTNSIWALSRDVHQGKVAKYSLISVNLNNGEVVYDEFEEPNLADEKLQIRIKYLQPIEVLVNTDDLPLHVAKFFKDISCPLIHKQEYDLEDHVVQAIKVMNEKIQLSPSLIRLVSKLYSHMVEYNNEQVMLIPSIYSPFASKIHMLLDPNSLQSLDIFTHDGGKGSLFWLLDHTRTSFGLRMLREWILKPLVDVHQIEERLDAIECITSEINNSIFFESLNQMLNHTPDLLRTLNRIMYGTTSRKEVYFYLKQITSFVDHFKMHQSYLSEHFKSSDGRIGKQSPLLFRLFSELNELLSTTQLPHFLTMINVSAVMEKNSDKQVMDFFNLNNYDCSEGIIKIQRESESVRSQLKEELAEIRKYLKRPYLNFRDEVDYLIEVKNSQIKDLPDDWIKVNNTKMVSRFTTPRTQKLTQKLEYYKDLLIRESELQYKEFLNKITAEYTELRKITLNLAQYDCILSLAATSCNVNYVRPTFVNGQQAIIAKNARNPIIESLDVHYVPNDIMMSPENGKINIITGPNMGGKSSYIRQVALLTIMAQIGSFVPAEEIRLSIFENVLTRIGAHDDIINGDSTFKVEMLDILHILKNCNKRSLLLLDEVGRGTGTHDGIAISYALIKYFSELSDCPLILFTTHFPMLGEIKSPLIRNYHMDYVEEQKTGEDWMSVIFLYKLKKGLTYNSYGMNVAKLARLDKDIINRAFSISEELRKESINEDALKLFSSLKRILKSDNITATDKLAKLLSLDIH

MSH3

DNA mismatch repair protein MSH3

993 amino acids

Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair. MSH3 provides substrate-binding and substrate specificity to the complex. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions (By similarity).

Belongs to the DNA mismatch repair MutS family. MSH3 subfamily.

112.039 kDa

MASKKQSTISLFFSSQTRKSPGRDAKKNDISSSPFNAASSTNNSIGSTPRVSPIAKFQYNKSTSTLHENTNPRVKRVSTLNVDVEKEHKKIKRARSTKLTPLESQILQLLSEHPDKILLIQVGYKYKVYGEDARHVARCLNIMFISSSTDPTFSYCSFPENRLHINLQRILNTGVKVGVVKQMESAIIKEVDKIGKSGDLMKRELTGVYTRGTYMNDEFIDSGVNSPEQEELGYIVCVNEISRYQFAIVAIQPLTGEIIYDDFTDDVSHDELETRLLYLRPSEVLLLGCGGNESNNNNNNNSNNSSNNNDNGTDADAQNQTSTLQCFQKLVNHNIKIERKPKGLNNLKAVLNAAALNFYRELLEPVQVCVSELVKYLEEFNLSNIFTVIENVSKFDSKKTMILPASTMLSLEIFQNSENSTTKGTLFSLLNHTKTPFGMRLLESWVSHPLIDKDKIEERYQAVEDLSTGSHFNDCLSRLLQKIGKNLDLESIAIKIHYSTTTRSLATKINRKDIFMMLLMYQSALQFVSQFEKTIKASNLSPLLKRVLDNLLQLANTDTVDRFMDMINPSYLLGEQQNLHQSSRSTREQKVKFFNLNNGFEEINRELAEIMNVKMLLEEELVKVKKLLQRPQLNYVTSNGEPYLIEVRNGKAVESLPIDFIKINGTTTVSRFRSKEIAHLYKMKQYHEEVLNNRCDEAFNTFLNELDSHYGFFQGITKNLAVLDCLLSLAAVSNSNSNTHVKPNLSDELIIDVKNARHPIIEHLRDGYVANDIDIRYDSNRVLVITGPNMGGKSSYVKMVALLIIMTQIGCYIPCEAATIGIFDSILIRMGASDNLLKGRSTFMTEMLECSNIIQKLTPRSLVILDEIGRGTGSIDGYSLAYAILRYLVESKLKPIVLCITHYTGLLSETEDEKFDKDAKDENLDTGDDVVKSYYMGYEEITQPGQVFPEIVFLYNLCPGVSNSYGLQVAKMAGLPKKVLLEAYLMSSVTDFD

msh3

DNA mismatch repair protein msh3

993 amino acids

Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with msh2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair. Msh3 provides substrate-binding and substrate specificity to the complex. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions (By similarity). Involved in termination of copy-synthesis during mating-type switching.

Belongs to the DNA mismatch repair MutS family. MSH3 subfamily.

113.362 kDa

MRGMSYNITHECDAINILSDNLHEGAISEDMVALSGPAIELLENNVGSSKNSYQEDEGSSSIDENAPLISIKRKRRIRTVKSTSNKELVQRKASKPTKQKSVFTPLEQQYLELKKNYQETILAIEVGYKFRFFGKDAKIASEVLGISCYFEHNFLNASVPSYRIDYHLERLINFGLKVAVVRQTETAALKSTSSSRNTLFDRRVARVLTKGTTLDDSFFRFEQTQHGTLQASQFILCVADNVDKSKAKSGRVQVGLIAIQLSSGTTVYDHFQDDFLRSELQTRLSHFQPCELIYSNKLSSESVALLNHYVSTEKTCGRVVRVQHAVQQDVKLALENLQDFFSSKCIMSGSKIIELHMEKVKSLHSLSIICLDMAISYLMEFSLEDLFVASNFYQPFDSISSMVLSKQALEGLELFVNQTDHTPVGSLFWVLDRTYTRFGQRMLQRWLQKPLVDKENIIERLDAVEELAFNSNSQVQAIRKMLYRLPDLEKGLSRIYYQRGFYKAASAFSKNSYSCFKSALLRRLIQQLPSISSIIDHFLGMFDQKEAENNNKVDMFKDIDNFDLSEEPNDVDYELAQEIRELKMSILMVRTEMDFHLQELRDYLEYPNLEFSIWGNVKFCIEVSKGCKKIPPDWIKLSSTRSLFRFHTPKIQSLLIELSSHEENLTISSEKIYRSFLSRISEHYNELRNVTTVLGTLDCLISFARISSQSGYTRPEFSDKELLIHESRHPMIELLSDKSFVPNHIHLSSDGVRCLLITGPNMGGKSSFVKQLALSAIMAQSGCFVPAKSALLPIFDSILIRMGSSDNLSVNMSTFMVEMLETKEVLSKATEKSMVIIDELGRGTSTIDGEAISYAVLHYLNQYIKSYLLFVTHFPSLGILERRFEGQLRCFHMGYLKSKEDFETSVSQSISFLYKLVPGVASKSYGLNVARMAGIPFSILSRATEISENYEKKHRNARKNVFIRKVAKLLMILNAEEIDFKRLFYDLTAFEEI

MSH3

DNA mismatch repair protein MSH3

990 amino acids

Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair. MSH3 provides substrate-binding and substrate specificity to the complex. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions (By similarity).

Belongs to the DNA mismatch repair MutS family. MSH3 subfamily.

110.54 kDa

MKRSKQATLSRFFKKPKTGADAVHTEAVIGKKPTDSGSPAEQKDAKSPQQVTDEPPLEPVTVTTDVVAMDTQPDLSIGSEINSKSRPKSLASFKSGKSINTDHNPELKQKFRAKLELVRNKNDEDLPVITKKTKLNATEFQWYEIKKQHRDTLLFVQVGYKYHIYGDDAEIAHAQTRLFLSPGITNLKDIGNDGVVQQGSKYIKLAYSSFPVHRIDFYTKQLVEKGFKVGHVQQMEVAALKNVENKKGPMIRELTNTFTKGTYIESGNGGSVNDVQYSSYLVALHESKGDKPTVTLLATEVSTGDVIWDSFNDDYVKSELEIRLLTLAPCEILNCGVSSSTLKMCQKYMHRNKGRLAEMNVLEEEVEDPDAQVALFFEGKANAGTCSTVLELPAMVKTLILATSRYLTHCKLDSLFLLTNNFTRYTGSYMRLSANTVASLELFANTTDHTAKGSLFWVLNRCLTVFGSRELKKWVSRPLTDRTAILQRLSAVEAIIKSIYGAESDELTTLINKLVKLLKPIPDLSKMLMRLHYGQLNRKEVYLLLRELLFVAQEFKPGSGDKYIDTNPVLGEIFNSLGIHVSDIEKLLEEINPDAARQDEALTFFVTDPPSLVDRKKDLKKVEAELQIELLALRAELNRPKLQYSSVAGIDYLIEVANKDTKKLPLEWTKISGTKSVSRFRTPTLNSLVKRHEYCVEKLKAACDIEFNMFRSRCATHYEFFRSMVVAMSQFDCLFALAKVSGQSGWVKADYVDEGGIDLKDSRHVITEKLMTNYISNDIKIRCPTVVTGPNMGGKSSLVRQIALSVLLAHIGCYVPASKAQIPITDSILCRMGAQDNIMSGQSTFMVELCECAEILRNATSKSLVLLDEIGRGTTTTDGIAIAHSVLKHFIELEALTLFITHYPLGQLLDSEDSNKCDLVHMDITNTNPPIFTYKMKPGSATDSYGLNVAGLAGIPQAIINRAEEMGKDMKHDVMYQEGVRMLTDIKKVM

MSH3

DNA mismatch repair protein MSH3

960 amino acids

Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair. MSH3 provides substrate-binding and substrate specificity to the complex. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions (By similarity).

Belongs to the DNA mismatch repair MutS family. MSH3 subfamily.

107.853 kDa

MKRGIDIVQALKNSKRSKSSDDSVESKLSKASPDLSQYAAVQISKEDVTVNPEVKSTIDNHKKEPPSIASSIKKSPKTVIGKHANSTKKPKKRTPLDQQFIDLKNEYPDCVLAIQVGYKYKFFGVDAVPVSRILNIMFIPGNLTERDATHDKFAYCSVPDNRLHIHLQRLLTNGLKVAVVSQTESAVLREAESSKGLFLREVTAIYTKATYIEEGSGDFISCITWNGTSAGAVTVQPCTGEIIVEDFSEKEPEALSELQTYLHHLRPSEIIVTDNEATKENDKLSRLLKSFGGARISYKPFDEVSPIEELLPASIANYYVTNHSTTTTQCISQLITYLKDFSLDQIFTVPSNVSKFSTKMYMNLPGNTLKALEIFQNSSGTEKGTLFWHLDHTHTKMGRRMLQKWVSKPLIDNASIQERLDAIESLMNYNYAVEVFEGIIKKIGRDESDWEKSMIKIHYTANGSQNRVTRKEVVQLLLQFRSVIDTVYKFKSSFKDSSISKLLQSMFSELAELASTPIVNDLLSRVKIEAVYREEVEDQKKEFFDLDSHPHEGIKSELNAISELEQALQDELVEIKKIIKKPVDYMTVSREPYLIALRGDSGPQDWLKISATKTVTRYRPPKVSKLYKELLYHQEKLIQQCDEAFATFLKDIDSHYTYFSRLIKIVAEIDCLLSLKATSSSNSGYSKPILSDKQMIKAKRSRNPVIENLTSTSQYVANDIEISYDENRVLIITGPNMGGKSSYVKQVALIALMTQIGCYLPCESAIVGIFDTILVRMGAEDNILKGESTFMVEMSECSTIIKSLTNKSLVILDEIGRGTGTEDGIAIAYSIISYLIEEPRLPLTLFITHYPSLKVLEDTHPKNVANYHMGFMEVAKADQEWPDVTFLYTLKRGVVSNSYGLNVARLAGIPSEIITKAFKVAEALKQDIEDSELSSMGQILKSEQSSASKLVEIDRIVSYI