Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair. MSH3 provides substrate-binding and substrate specificity to the complex. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions (By similarity).

Belongs to the DNA mismatch repair MutS family. MSH3 subfamily.

1125 amino acids

MSQSSSLKRKQQPTISSFFGKTTSSSGESTNKKASLNGLGRAKQRIREEESNLSPSPEDKGEYLDDEDEDIVPPSRKRVKSSRISTDGANAAAKGNDDDLSQSPHRNVPASSRTERFRFQSSPVSSLDAEGSQVEGREAIDTERERKRKENLHQKFVRRLGGPGCLPSLEHGSNANTAMTEGGEDEDEALDEEDVAPPPSTKARGARKAASTKLTPLEKQVIDIKNKHKDAILVVEVGYKFRFFGEDARIAAKELSIVCIPGKLRFDEHPSEAHLNRFASASIPVHRLHVHVKRLVRAGHKVGVVRQLETAALKAAGDNRNAPFERKLTHLYTKGTYIDDTEELEGLNAVGANSAAPATGYLLCMTESNAKGWGNDEKVQVGILAVQPATGNIIHDSFEDGFMRTEIETRLLHIAPCEFLLIGDVSRATDKLVQHLSGSKMNVFGDKVRVERVSKSKTAAAESHSHVSSFYAGRMKATSTTQDERARDLLDKVLNLPEDVTICLSAMIKHLKEYNLENVFDLTKYFQPFSARSHMLLNGNTLINLEIYQNQTEQTSKGSLFWTLDRTKTRFGQRLLRKWVGRPLLDKQELEDRVAAVTELKDSDATPRVGRLKTLLSKVKTDLEKNLLRIYYGKCTRPELLTVLQTLQLIATEFSHVKSPADAGFDSPVINEAISQLPVVLDDVVSYLNKINLHSAKADDKFSFFQESEETDEITEQKLGIGSVEHDLEEYRNTAAEILCKKKVCYVTNAGIEYLIEVENSSLQMKKIPASWRKISGTKKVSRFHPPEVVNLMRERDQHKEALAAACDKAFLGLLADISTKYQPFRDCIQALATLDCFMSLAAVAAQPGYVRPTYADEARISVRGGRHPMVEQLLLDTYVPNDTELGTDGTRALLVTGPNMGGKSSYVRQVALISIMGQIGSYVPAESATLGMLDAVYTRMGAFDNMLAGESTFMVELSETSDILKQATPRSLVILDELGRGTSTHDGVAIAQAVLDYMVRDIRSLTLFITHYQHLSNLARTFPNGELRNVHMKFTESGKDGQDITFLYEVGEGVAHRSYGLNVARLANIPSSVLDVAYTKSAELEEKIKRKNLEGIAKGLSRVLENGENEGELMERLLSEVEQL

124.6 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

Upon ordering, we will perform rigorous biosecurity and export control screening to ensure that order fulfillment is consistent with all legal and regulatory guidance.

Make MSH3 using our protein expression services starting at $99 + $.30/amino acid in as fast as two weeks (includes the cost of DNA synthesis)

Order Here