Protein
Probable inosine/xanthosine triphosphatase
Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)
Function
Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.
Similarity
Belongs to the YjjX NTPase family.
Sequence
MARHKLRIVAVGSTNPVKIEAVKEGFEKVLGAVEVIGVDVISGVSSHPIGLEETYLGALNRAKNAFEKVQCTYAVGIEAGLIKVGEHYIDIHICVVFDGVNETVGLSQGFEYPKIVAEKVLEGIEGGKIAEEISGIKDIGKNIGLIGYLTDNNITRKDLCRESVIMALIPRMIKNAHLY