MIP

Lens fiber major intrinsic protein

263 amino acids

Water channel. Channel activity is down-regulated by CALM when cytoplasmic Ca(2+) levels are increased. May be responsible for regulating the osmolarity of the lens. Interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core.

Belongs to the MIP/aquaporin (TC 1.A.8) family.

28.369 kDa

MWELRSASFWRAIFAEFFATLFYVFFGLGASLRWAPGPLHVLQVALAFGLALAXLVQTVGHISGAHVNPAVTFXFLVGSQMSLLRAFCYMAAQLLGAVAGAAVLYSVTPPAVRGNLALNTLHAGVSVXQATTVEIFLTLQFVLCIFATYDERRNGRLGSVALAVGFSLTLGHLFGMYYTGAGMNPARSFAPAILTRNFTNHWVYWVGPIIGGGLGSLLYDFLLFPRLKSVSERLSILKGTRPSDNNGQPEGTGEPVELKTQAL

MIP

Lens fiber major intrinsic protein

263 amino acids

Water channel (PubMed:24120416). Channel activity is down-regulated by CALM when cytoplasmic Ca(2+) levels are increased. May be responsible for regulating the osmolarity of the lens. Interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core (By similarity). Plays a role in cell-to-cell adhesion and facilitates gap junction coupling (PubMed:24120416).

Belongs to the MIP/aquaporin (TC 1.A.8) family.

28.122 kDa

MWELRSASFWRAIFAEFFATLFYVFFGLGSSLRWAPGPLHVLQVAMAFGLALATLVQSVGHISGAHVNPAVTFAFLVGSQMSLLRAFCYMAAQLLGAVAGAAVLYSVTPPAVRGNLALNTLHPAVSVGQATTVEIFLTLQFVLCIFATYDERRNGQLGSVALAVGFSLALGHLFGMYYTGAGMNPARSFAPAILTGNFTNHWVYWVGPIIGGGLGSLLYDFLLFPRLKSISERLSVLKGAKPDVSNGQPEVTGEPVELNTQAL

Mip

Lens fiber major intrinsic protein

263 amino acids

Water channel. Channel activity is down-regulated by CALM when cytoplasmic Ca(2+) levels are increased. May be responsible for regulating the osmolarity of the lens. Interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core.

Belongs to the MIP/aquaporin (TC 1.A.8) family.

28.193 kDa

MWELRSASFWRAIFAEFFATLFYVFFGLGASLRWAPGPLHVLQVALAFGLALATLVQTVGHISGAHVNPAVTFAFLVGSQMSLLRAFCYIAAQLLGAVAGAAVLYSVTPPAVRGNLALNTLHAGVSVGQATTVEIFLTLQFVLCIFATYDERRNGRMGSVALAVGFSLTLGHLFGMYYTGAGMNPARSFAPAILTRNFSNHWVYWVGPIIGGGLGSLLYDFLLFPRLKSVSERLSILKGARPSDSNGQPEGTGEPVELKTQAL

MIP

Lens fiber major intrinsic protein

263 amino acids

Water channel. Channel activity is down-regulated by CALM when cytoplasmic Ca(2+) levels are increased. May be responsible for regulating the osmolarity of the lens. Interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core.

Belongs to the MIP/aquaporin (TC 1.A.8) family.

28.171 kDa

MWELRSASFWRAIFAEFFATLFYVFFGLGASLRWAPGPLHVLQVALAFGLALATLVQAVGHISGAHVNPAVTFAFLVGSQMSLLRAICYMAAQLLGAVAGAAVLYSVTPAAVRGNLALNTLHPGVSLGQATTVEIFLTLQFVLCIFATYDERRNGRLGSVALAVGFSLTLGHLFGMYYTGAGMNPARSFAPAILTRNFTNHWVYWVGPIIGGGLASLLYDFLLFPRLKSVSERLSILKGARPSDSNGQPEGTGEPVELKTQAL

MIP

Lens fiber major intrinsic protein

263 amino acids

Water channel. Channel activity is down-regulated by CALM when cytoplasmic Ca(2+) levels are increased. May be responsible for regulating the osmolarity of the lens. Interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core.

Belongs to the MIP/aquaporin (TC 1.A.8) family.

28.263 kDa

MWELRSASFWRAIFAEFFATLFYVFFGLGASLRWAPGPLHVLQVALAFGLALATLVQAVGHISGAHVNPAVTFAFLVGSQMSLLRAICYVVAQLLGAVAGAAVLYSVTPPAVRGNLALNTLHPGVSVGQATIVEIFLTLQFVLCIFATYDERRNGRLGSVALAVGFSLTLGHLFGMYYTGAGMNPARSFAPAILTRNFTNHWVYWVGPVIGAGLGSLLYDFLLFPRLKSVSERLSILKGTRPSESNGQPEVTGEPVELKTQAL

MIP

Lens fiber major intrinsic protein

263 amino acids

Water channel (PubMed:23893133). Channel activity is down-regulated by CALM when cytoplasmic Ca(2+) levels are increased. May be responsible for regulating the osmolarity of the lens. Interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core (By similarity).

Belongs to the MIP/aquaporin (TC 1.A.8) family.

28.223 kDa

MWELRSASFWRAICAEFFASLFYVFFGLGASLRWAPGPLHVLQVALAFGLALATLVQAVGHISGAHVNPAVTFAFLVGSQMSLLRAICYMVAQLLGAVAGAAVLYSVTPPAVRGNLALNTLHPGVSVGQATIVEIFLTLQFVLCIFATYDERRNGRLGSVALAVGFSLTLGHLFGMYYTGAGMNPARSFAPAILTRNFTNHWVYWVGPVIGAGLGSLLYDFLLFPRLKSVSERLSILKGSRPSESNGQPEVTGEPVELKTQAL

MIP

Lens fiber major intrinsic protein

263 amino acids

Water channel. Channel activity is down-regulated by CALM when cytoplasmic Ca(2+) levels are increased. May be responsible for regulating the osmolarity of the lens. Interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core.

Belongs to the MIP/aquaporin (TC 1.A.8) family.

28.233 kDa

MWELRSASFWRAIFAEFFATLFYVFFGLGASLRWTPGPLHVLQVALAFGLALATLVQAVGHISGAHVNPAVTFAFLVGSQMSLLRAFCYMAAQLLGAVAGAAVLYSVTPPAVRGNLALNTLHPGVSVGQATTVEIFLTLQFVLCIFATYDERRNGRLGSVALAVGFSLTLGHLFGMYYTGAGMNPARSFAPAILTRNFTNHWVYWVGPIIGGGLGSLLYDFLLFPRLKSVSERLSILKGARPSDSNGQPEGTGEPVELKTQAL

MIP

Lens fiber major intrinsic protein

262 amino acids

Water channel. May be responsible for regulating the osmolarity of the lens. Interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core.

Belongs to the MIP/aquaporin (TC 1.A.8) family.

27.072 kDa

MRELRSSSFWRAILAEFLGSLLYTLLGLGASLRWAPGPHGVLGSALAFGLAQATLVQALGHVSGGHINPAITLAFLLASQLSLPRALGYLLAQLLGALAGAGVLYGVTPAAVRGTLGLSALHPSVGPGQGTVVELLLTAQFILCVFASFDDRHDGRPGSAALPVGFSLALGHLFGIPFTGAGMNPARSFAPAVITRNFTNHWVFWAGPLLGAALAALLYELALCPRARSMAERLAVLRGEPPAAAPPPEPPAEPLELKTQGL

Mip

Lens fiber major intrinsic protein

261 amino acids

Water channel. Channel activity is down-regulated by CALM when cytoplasmic Ca(2+) levels are increased. May be responsible for regulating the osmolarity of the lens. Interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core.

Belongs to the MIP/aquaporin (TC 1.A.8) family.

27.891 kDa

single

ELRSASFWRAIFAEFFATLFYVFFGLGSSLRWAPGPLHVLQVALAFGLALATLVQTVGHISGAHVNPAVTFAFLVGSQMSLLRAFCYIAAQLLGAVAGAAVLYSVTPPAVRGNLALNTLHAGVSVGQATTVEIFLTLQFVLCIFATYDERRNGRMGSVALAVGFSLTLGHLFGMYYTGAGMNPARSFAPAILTRNFSNHWVYWVGPIIGGGLGSLLYDFLLFPRLKSVSERLSILKGARPSDSNGQPEGTGEPVELKTQAL

mip

Peptidyl-prolyl cis-trans isomerase Mip

258 amino acids

PPIases accelerate the folding of proteins.

Belongs to the FKBP-type PPIase family.

28.33 kDa

MNRRWNLVLATVALALSVASCDVRSKDKDKDQGSLVEYKDNKDTNDIELSDNQKLSRTFGHLLARQLRKSEDMFFDIAEVAKGLQAELVCKSAPLTETEYEEKMAEVQKLVFEKKSKENLSLAEKFLKENSKNAGVVEVQPSKLQYKIIKEGAGKAISGKPSALLHYKGSFINGQVFSSSEGNNEPILLPLGQTIPGFALGMQGMKEGETRVLYIHPDLAYGTAGQLPPNSLLIFEINLIQASADEVAAVPQEGNQGE

mip

Peptidyl-prolyl cis-trans isomerase Mip

243 amino acids

PPIases accelerate the folding of proteins.

Belongs to the FKBP-type PPIase family.

26.782 kDa

MKNILSWMLMFAVALPILGCDNNGGSQTSAMGKDMVEDSVLTDNQKLSRTFGHLLARQLSSTEDFTLDLTEVIKGMQSEIEGKSAPLTDSEYETQMALVQKASFEKKCSENLASAEKFLKENKDKEGVIELEPNKLQYRIVKEGTGRVLTGKPNALLHYTGSFINGKVFDTSEKNKDPILLPLTKVISGFSQGMQGMREGEVRVLYIHPDLAYGTSGQLPPNSLLIFEVKLIEANDDNVSVAE

mip

Peptidyl-prolyl cis-trans isomerase Mip

243 amino acids

PPIases accelerate the folding of proteins.

Belongs to the FKBP-type PPIase family.

26.663 kDa

MKNILSWMLMFAVALPIVGCDNGGGSQTSATEKSMVEDSALTDNQKLSRTFGHLLSRQLSRTEDFSLDLVEVIKGMQSEIDGQSAPLTDTEYEKQMAEVQKASFEAKCSENLASAEKFLKENKEKAGVIELEPNKLQYRVVKEGTGRVLSGKPTALLHYTGSFIDGKVFDSSEKNKEPILLPLTKVIPGFSQGMQGMKEGEVRVLYIHPDLAYGTAGQLPPNSLLIFEVKLIEANDDNVSVTE

mip

Outer membrane protein MIP

243 amino acids

Essential virulence factor associated with macrophage infectivity. Exhibits PPIase activity.

Belongs to the FKBP-type PPIase family.

25.93 kDa

MKMRLVAAAAMGLAMSTTIAATATTDATTSAPGTSLTTDTEKLSYSIGADLGKNFKKQGIEISPAAMAKGLQDGMSGGQLLLTDDQMKDVLNKFQKDLMMKRSAEFNKKAEENKSKGEAFLNENKSKEGVVSLPSGLQYNILERGDGAKPTKDDVVTVEYTGKLIDGQVFDSTEKTGKPATFKVSQVIPGWTEALQLMPAGSTWEVYIPSNLAYGPRSVGGPIGPNETLIFKIHLISVKKSDA

mip

Outer membrane protein MIP

233 amino acids

Essential virulence factor associated with macrophage infectivity. Exhibits PPIase activity.

Belongs to the FKBP-type PPIase family.

24.662 kDa

MKMKLVTAAIMGLAMSTAMAATDATSLTTDKDKLSYSIGADLGKNFKNQGIDINPDVLAKGMQDGMSGAQLILTEEQMKDVLSKFQKDLMAKRSAEFNKKAEENKAKGDAFLSANKSKPGIVVLPSGLQYKIIDAGTGAKPGKSDTVTVEYTGTLIDGTVFDSTEKAGKPATFQVSQVIPGWTEALQLMPAGSTWEVFVPADLAYGPRSVGGPIGPNETLIFKIHLISVKKAA

mip

Outer membrane protein MIP

233 amino acids

Essential virulence factor associated with macrophage infectivity. Exhibits PPIase activity.

Belongs to the FKBP-type PPIase family.

24.865 kDa

MKMKLVTAAVMGLAMSTAMAATDATSLATDKDKLSYSIGADLGKNFKNQGIDVNPEAMAKGMQDAMSGAQLALTEQQMKDVLNKFQKDLMAKRTAEFNKKADENKVKGEAFLTENKNKPGVVVLPSGLQYKVINAGNGVKPGKSDTVTVEYTGRLIDGTVFDSTEKTGKPATFQVSQVIPGWTEALQLMPAGSTWEIYVPSGLAYGPRSVGGPIGPNETLIFKIHLISVKKSS

mip

Outer membrane protein MIP

233 amino acids

Essential virulence factor associated with macrophage infectivity. Exhibits PPIase activity.

Belongs to the FKBP-type PPIase family.

24.881 kDa

MKMKLVTAAVMGLAMSTAMAATDATSLATDKDKLSYSIGADLGKNFKNQGIDVNPEAMAKGMQDAMSGAQLALTEQQMKDVLNKFQKDLMAKRTAEFNKKADENKVKGEAFLTENKNKPGVVVLPSGLQYKVINSGNGVKPGKSDTVTVEYTGRLIDGTVFDSTEKTGKPATFQVSQVIPGWTEALQLMPAGSTWEIYVPSGLAYGPRSVGGPIGPNETLIFKIHLISVKKSS

mip

Outer membrane protein MIP

233 amino acids

Essential virulence factor associated with macrophage infectivity. Exhibits PPIase activity.

Belongs to the FKBP-type PPIase family.

24.865 kDa

MKMKLVTAAVMGLAMSTAMAATDATSLATDKDKLSYSIGADLGKNFKNQGIDVNPEAMAKGMQDAMSGAQLALTEQQMKDVLNKFQKDLMAKRTAEFNKKADENKVKGEAFLTENKNKPGVVVLPSGLQYKVINAGNGVKPGKSDTVTVEYTGRLIDGTVFDSTEKTGKPATFQVSQVIPGWTEALQLMPAGSTWEIYVPSGLAYGPRSVGGPIGPNETLIFKIHLISVKKSS

mip

Peptidyl-prolyl cis-trans isomerase Mip

230 amino acids

May be an essential virulence factor associated with macrophage infectivity. Exhibits PPIase activity.

Belongs to the FKBP-type PPIase family.

25.518 kDa

MKRLILPFLSVGLLLGTTAHAATPLKTEQDKLSYSMGVMTGKAFRKHDIKIDPQTFSMGLSDAYLGKETQMTEAEMRQTLQQFEKQSLQKMQHKMKQTAQQNAEKSRAFLTANKNKPGVKTLANGLQYKVLQAGQGQSPTLNDEVTVNYEGRLINGTVFDSSYKRGQPATFPLKSVIKGWQEALTRMKPGAIWEIYVPPQLAYGEQGAPGVIGPNEALIFKVNLISVKKK

Mip

Allatostatins MIP

211 amino acids

Ligand for the sex peptide receptor (SPR) (PubMed:20308537, PubMed:20458515, PubMed:25333796). Stabilizes sleep and maintains sleep homeostasis to inhibit the activity of wake-promoting circuits, such as those that involve the pigment dispersing factor (pdf) neurons. Regulated by the circadian clock network and pathways associated with a sleep homeostat (PubMed:25333796). May also have a regulatory role in gut motility (PubMed:11181081).

23.412 kDa

MAHTKTRRTYGFLMVLLILGSACGNLVASGSAGSPPSNEPGGGGLSEQVVLDQLSESDLYGNNKRAWQSLQSSWGKRSSSGDVSDPDIYMTGHFVPLVITDGTNTIDWDTFERLASGQSAQQQQQQPLQQQSQSGEDFDDLAGEPDVEKRAWKSMNVAWGKRRQAQGWNKFRGAWGKREPTWNNLKGMWGKRDQWQKLHGGWGKRSQLPSN

MIP

Macrophage infectivity potentiator

196 amino acids

Essential virulence factor associated with macrophage infectivity. Exhibits PPIase activity.

Belongs to the FKBP-type PPIase family.

22.136 kDa

MHRENYFSKIAFCLLGVLFLSCITSVQTVSGDAASHEERMNNYRKRVGRLFMEQKAAQPDAVKLPSGLVFQRIARGSGKRAPAIDDKCEVHYTGRLRDGTVFDSSRERGKPTTFRPNEVIKGWTEALQLMREGDRWRLFIPYDLAYGVTGGGGMIPPYSPLEFDVELISIKDGGKGRTAEEVDEILRKAEEDREDM