Ltn1

E3 ubiquitin-protein ligase listerin

1767 amino acids

E3 ubiquitin-protein ligase (PubMed:19196968). Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation (By similarity). Ubiquitination leads to Vcp/p97 recruitment for extraction and degradation of the incomplete translation product (By similarity).

Belongs to the LTN1 family.

198.921 kDa

MGGKNKQRTKGNLRPSNSGRAAELLAKEQGTVPGFIGFGTSHSDLGYVPAVQGAEDIDSLVDSDFRMVLRKLSKKDVTTKLKAMQEFGIMCTERDTEAVKGVLPYWPRIFCKISLDHDRRVREATQQAFEKLILKVKKHLAPYLKSVMGYWLMAQCDTYPPAALAAKDAFEAAFPPSKQPEAIAFCKEEITTVLQDHLLKETPDTLSDPQTVPEEEREAKFHRVVTCSLLALKRLLCFLPNNELDSLEEKFKSLLSQNKFWKYGKHSVPQVRSAYFELVSALCQHVPQVMKEEAAKVSPSVLLSIDDSDPVVCPALWEAVLYTLTTIEDCWFHVNAKKSVFPKLMAMIREGGRGLAAVMYPYLLPFISKLPQSITEPKLDFFKNFLTSLVTGLSTERTKSSSSECSAVISAFFECLRFIMQQNLGEEEMVQMLINEQLIPFIDTVLKDSGLHHGPMFDHLADTLSSWEAKADAERDPGAVYNLENVLLSFWGRLSEICTEKIRQPEADVKSVLCVSSLVGVLQRPRSSLKLHRKKTAQVRFAINIPEAHKGDEKSMSSEGENSEGSDGGAQSPLSNTSSDLVSPLRKKPLEDLVCKLAEVSISFVNERKSEQHLQFLSTLLDSFSSVQVFNILLSDKQKNVVKAKPLEITKLAEKNPAVKFLYHKLIGWLNDSQKEDGGFLVDILYSALRCCDSGVERKEVLDDLTKEDLKWSSLLQVIEKACSSSDKHALVTPWLKGSILGEKLVALADCLCDKDLEATTSESHSSEQWSLLRLALSQHVKNDYLIGEVYVGRIIVKLHETLSKTKDLSEAANSDSSVSFVCDVVHSFFSSAGGGLLMPPSEDLLLTLFQLCAQSKERTHLPDFLICKLKNTLLSGVNLLVHQTASTYEQSTFLRLSVLWLKDQVQSSALDNTSLQVLLSAAGDLLGTLVESEDTSLLGVYIGSVMPSDSEWEKMRQALPVQWLHRPLLEGRLSLNYECFKTDFKEQDTKTLPNHLCTSSLLSKMILVAQKKKLVLEDNVLEKIIAELLYSLQWCEELDNAPSFLSGFCGILQKMNITYSNLSVLSETSSLLQLLFDRSRKNGTLWSLIIAKLILSRSISSDEVKPYYKRKESFFPLTEGSLHTIQSLCPFLSKEEKKEFSAQCIPAFLGWTKEDLCSINGAFGHLAIFNSCLQTRSIDDKQLLHGILKIITSWRKQHEDIFLFSCNLSEASPEVLGLNIEIMRFLSLFLKHCAYPLPLADSEWDFIMCSMLAWLETTSENQALYSVPLVQLFACVSFDLACDLCAFFDSITPDIVDNLPVNLISEWKEFFSKGIHSLLLPLLVNAIGENKDLSETSFQNAMLKPMCETLTYISKDQLLSHKLPARLVASQKTNLPEHLQTLLNTLTPLLLFRARPVQIAAYHMLCKLMPELPQHDQDNLRSYGDEEEEPALSPPAALMSLLSSQEELLENVLGCVPVGQIVTVKPLSEDFCYVLGYLLTWKLILTFFKAASSQLRALYSMYLRKTKSLNKLLYHLFRLMPENPTYGETAIEVSSKDPKTFFTEEVQLSIRETATLPYHIPHLACSVYHMTLKDLPAMVRLWWNSSEKRVFNIVDRFTSKYVSNVLSFQEISSVQTSTQLFNGMTVKARATTREVMATYTIEDIVIELIIQLPSNYPLGSITVESGKRIGVAVQQWRNWMLQLSTYLTHQNGSIMEGLALWKNNVDKRFEGVEDCMICFSVIHGFNYSLPKKACRTCKKKFHSACLYKWFTSSNKSTCPLCRETFF

LTN1

E3 ubiquitin-protein ligase listerin

1766 amino acids

E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. Ubiquitination leads to VCP/p97 recruitment for extraction and degradation of the incomplete translation product.

Belongs to the LTN1 family.

199.446 kDa

MGGKNKQRTKGNVRPSSSGRAAELLAKERGTVPGFIGFGTSQSDLGYVPAVQGAEEIDSLVDADFRMVLRKLSKRDIITKLKAMQEFGTMCKEREAEVVKGVLPYWPRIYCKISLDHDRRVREATQQSFEQLILKVKKHLAPYLKSIMGYWLIAQCDTYSPAASAAKEAFEKAFPSSKQPEALAFCKDEILNVLQDHLLKETPDTLSDPQTVPEEEREAKFFRILTCSLLALKKLLSMLPKKEMHSLEEKLMSLLSQNKFWKYGKHSTPQVRSAFFELASAFCQFLPELVKAEAPRVCPAVLLSIDDSDAVVCPALWEAVLHAIATIEDCWSHVNARKGVLPKLWTVLREGGRGLATVIYPNILPFISKVPPGITEPKLEYFRTFFSSIIQGLSNERALASPSESSAIITTFMECLRFAILQKIDEDEQRQIHQMLIYDQLIPLTDAVLQEPRLQNGPLFYQIAETLSSWEAKAEVSSDDNTNEVFQKLLSNFWDRLLKMCILHVDKLEADEKTLFAISDMLEVLQNPKTATKPNNRKSLKVKFSDEDESERNTENGKITEVRSNSDSEIQADLQHSSILRKEPLENLVCNLAELSIVYVNEQKSEQHLKFLSALLNFFSSNRVFQVLLEQGSNAGCPPAESQEDMKVHNENPSVQFLYMNLITWLKEDWRKDMHFLVDILYSVLNCCNSDDERKVILDDLTKMDLKWIVFLQIIQKACSSTTKLSLISEWLKGDMLGERLVMLADDLCHLGLKPIATSPESSSSEKWTVLSLVLSQHIKNESLIGETYVERIIDKLQAALSKAKDLSEAGNTEPSVSFICDVASSFFSSVKGCLLMPSSEDLLLTIFQLCAQRQDATHLTVDLLVCKLKHTWISGVNSLVRHLRSMQNQSTFLHKSALWIKNQIQSSSLDVKSLQVLISAVSDLLSTLLEADRQSGCLVGAYVEHVMPNRTEWETLRESLSAEWMHKPLLEGRLSMNCEHLGSCVKLCGTTKLPGHLCTSALLSKMVLLVLENDMVKGNEDAEILVAELLYSLQWIEELENPPYLLLEYLHMLEEMHITYEKFSALSNTTNLQQTIFDRSEEHGRLWSLTMAKVIRGENAVSREMTKLFKTSEGFLPLTEGRLHTLQCLSPFLIEEEKRELVFHCVAKLMTCTQTELSSTDGAFGCLAILNSSLNDKSFGCDHLLPGVLKIIISWKNDNEDSFLFSCNLKETSAQLLGFNIEMIRYLPLLLKYSTAPLADNEWDFIMCSMLAWLETTSENYSLYHVPLVQIFACVSCDLASALSAYFEPAAPKTTENLPVNLVSEWKEFFSEGIHNLLLPLFVKVTGETKTAAEGSFQNSVLTSLGEALTYISKDQLLNHKLPAKFVAGQKTNLPDNLQTLLNTLSPLLLFWARSVQVSVYHMLSKLMPELPKFDDEDLKSYGDEEEELALSPPAALMSVLATQELLLENILECIPVGEFAVIQPLSDEFCLVLGYLLTWKLTLTFFKAASSQLRVLYSQYLRRTKSLNKLLYHLFRLMPENPVFSGLTSEVPNKDTKTFFTEELHLDVKGTGALSSQIPHLACSVYHITLKDLPAMVRLWWNSCEKRVFNVVDKFTSKYVSSVLSSQEISSVQTSTQLFNGMTVKARSAAREVIATYSVDDIFIELIIQLPSNYPLGSITVESGKRVGVAVQQWRNWMLQLSTYLTHQNGSIMEGLSLWKNNVDKRFEGIEDCMICFSVIHGSNYSLPKKACRTCKKKFHSACLYKWFTSSNKSTCPLCRETFF

LTN1

E3 ubiquitin-protein ligase listerin

1766 amino acids

E3 ubiquitin-protein ligase component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation (PubMed:23685075, PubMed:25132172, PubMed:25578875). Ubiquitination leads to VCP/p97 recruitment for extraction and degradation of the incomplete translation product (By similarity).

Belongs to the LTN1 family.

200.552 kDa

MGGKNKQRTKGNLRPSNSGRAAELLAKEQGTVPGFIGFGTSQSDLGYVPAIQGAEEIDSLVDSDFRMVLRKLSKKDVTTKLKAMQEFGTMCTERDTETVKGVLPYWPRIFCKISLDHDRRVREATQQAFEKLILKVKKQLAPYLKSLMGYWLMAQCDTYTPAAFAAKDAFEAAFPPSKQPEAIAFCKDEITSVLQDHLIKETPDTLSDPQTVPEEEREAKFYRVVTCSLLALKRLLCLLPDNELDSLEEKFKSLLSQNKFWKYGKHSVPQIRSAYFELVSALCQRIPQLMKEEASKVSPSVLLSIDDSDPIVCPALWEAVLYTLTTIEDCWLHVNAKKSVFPKLSTVIREGGRGLATVIYPYLLPFISKLPQSITNPKLDFFKNFLTSLVAGLSTERTKTSSLESSAVISAFFECLRFIMQQNLGEEEIEQMLVNDQLIPFIDAVLKDPGLQHGQLFNHLAETLSSWEAKADTEKDEKTAHNLENVLIHFWERLSEICVAKISEPEADVESVLGVSNLLQVLQKPKSSLKSSKKKNGKVRFADEILESNKENEKCVSSEGEKIEGWELTTEPSLTHNSSGLLSPLRKKPLEDLVCKLADISINYVNERKSEQHLRFLSTLLDSFSSSRVFKMLLGDEKQSIVQAKPLEIAKLVQKNPAVQFLYQKLIGWLNEDQRKDFGFLVDILYSALRCCDNDMERKKVLDDLTKVDLKWNSLLKIIEKACPSSDKHALVTPWLKGDILGEKLVNLADCLCNEDLESRVSSESHFSERWTLLSLVLSQHVKNDYLIGDVYVERIIVRLHETLFKTKKLSEAESSDSSVSFICDVAYNYFSSAKGCLLMPSSEDLLLTLFQLCAQSKEKTHLPDFLICKLKNTWLSGVNLLVHQTDSSYKESTFLHLSALWLKNQVQASSLDINSLQVLLSAVDDLLNTLLESEDSYLMGVYIGSVMPNDSEWEKMRQSLPMQWLHRPLLEGRLSLNYECFKTDFKEQDIKTLPSHLCTSALLSKMVLIALRKETVLENNELEKIIAELLYSLQWCEELDNPPIFLIGFCEILQKMNITYDNLRVLGNTSGLLQLLFNRSREHGTLWSLIIAKLILSRSISSDEVKPHYKRKESFFPLTEGNLHTIQSLCPFLSKEEKKEFSAQCIPALLGWTKKDLCSTNGGFGHLAIFNSCLQTKSIDDGELLHGILKIIISWKKEHEDIFLFSCNLSEASPEVLGVNIEIIRFLSLFLKYCSSPLAESEWDFIMCSMLAWLETTSENQALYSIPLVQLFACVSCDLACDLSAFFDSTTLDTIGNLPVNLISEWKEFFSQGIHSLLLPILVTVTGENKDVSETSFQNAMLKPMCETLTYISKEQLLSHKLPARLVADQKTNLPEYLQTLLNTLAPLLLFRARPVQIAVYHMLYKLMPELPQYDQDNLKSYGDEEEEPALSPPAALMSLLSIQEDLLENVLGCIPVGQIVTIKPLSEDFCYVLGYLLTWKLILTFFKAASSQLRALYSMYLRKTKSLNKLLYHLFRLMPENPTYAETAVEVPNKDPKTFFTEELQLSIRETTMLPYHIPHLACSVYHMTLKDLPAMVRLWWNSSEKRVFNIVDRFTSKYVSSVLSFQEISSVQTSTQLFNGMTVKARATTREVMATYTIEDIVIELIIQLPSNYPLGSIIVESGKRVGVAVQQWRNWMLQLSTYLTHQNGSIMEGLALWKNNVDKRFEGVEDCMICFSVIHGFNYSLPKKACRTCKKKFHSACLYKWFTSSNKSTCPLCRETFF

Ltn1

E3 ubiquitin-protein ligase listerin

1747 amino acids

E3 ubiquitin-protein ligase component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation (PubMed:25128630). Ubiquitination leads to TER94/VCP recruitment for extraction and degradation of the incomplete translation product (By similarity).

Belongs to the LTN1 family.

198.64 kDa

MGGKTKQAPRTKNNAKPSSSSRTAELLGSSTPIFVGFSAQTDGGGLVPFAPGFASAEQMPDSFDAAISPQTQIILRKLSKKDPMTKKKALQELHELIEQSDVEVLKNILPLWPKYYLNLASDPEHTVREQTQTVLQLLMAKCKKAMAPYLKLLVPVWLGSRFDTYAPAASIASQSFRDTFAGNANRSREVCMHCQVEILEYATRNLTFHTAATLSIGKSLTPEDAEQKYQRVIISSLKLLSFFMGQTAQTEELSQVKEGFGTLVAHQKFWSFAKHKVPAIKAAWFECIYHILQSVALLDVITPQKTQLTNLCFQFIDDADPVVAPHIWGCVLLLQSNYVDWFVPLNIRKTLLPKLSSLLQNGFNRNAQAICPNLLPFLSKVTQASLQDLDIYDFYQRFFDDMKLAVTKKFDPPLSKSDCIVIHNAYFECLRFLMQQINNNKQREQKEEEFSFSLLDNNVLEPIAWLLKSDSTHVKIFFQHSSALVAFWDRQINNRLDNGDLYAKLLNKFWIRIFELVTQDLSAEEVNEQLLGHVLLLVQDLHMANPSLESPSVKFVEGPNEKIEKSEPTTPVKKAQEAAAFIQKELKQLVIKLVRICLDKANKGSGSGTSSSRYIEQIRTLTKMFNDAAFYKSLTDDGDLASALNKFVSLLGQLSCQACESVVEIVFEILPLLETGKRFEYIENTLMKLPQHGVQNLLLHRLLSYPLCAEAAVRQMLSGPETCEMIARIAEEVVVDNDREKLNLLHKCFFQTDTGDILINAKTVDKILLSMCGPLEQPVVDDAVEVCGSFIAQIMPVICSNNNSSLHVRQHIFLKLFKFSLEHRPEDYLSEDTLWEITTCWQDGLSSKDIEIDDDMLKCCAGIVEELANSAELKADTLDGMAEAMAKFVICSTENIEDEYKRLERIDETLTALLETPLKTTDKVQQFENHCVLLEALHGSVTAGVPFENACLSRNEILPLLQRSTLNFSTIYKLVYQFPPPQDTNDPEDELTEDYCDPNADVLKKWNEPLIAELLQCIRVAGTAECWLEMSVLQSSTEELVLILSEKVQSFMGNSSDLVAIVKERLQQAAVQQSSVIDCRLLSYLRFCPQYAAFEESASILLHEDLSENLVTQGALKTYVIALQFLLPKLSQKAITLSSAIMGTEPPEIWVKAAVFHALLLNNFEGDVNEQTDRNIIVSAVQFMTSIGERQASQKDLLHYNVEIQRQPYESVINTVEFIKLLTEVLKRFPYELSIKNWDAIRIGLSSWVLSVSKSIAQYQDPKTSLFIVAVYELFAALIDFIRSEKQKSSTELLKNMIDEWDSLFAKEVNLVLFKSYYLLTHEVSVDPGFQACYEALLEQITPVIERLDYSFVYSFCKSNSNITLDHLCNFLFKQLYSVQHSVRLSAVHSLRQLTPHFVADDIELNEKQSESLDASTTICKWHFLNRFEDYLTRYDALITKYLEEFTFKLSELDDLEPIDRHNALSYLFLWDCIINACAKSPVALRAVYTNWLNDNKYEENFLHFLFRAMPVDILKNHGAKVHSNGVYKELTWSQQKDRHLPLERYACHLYTEVLRKLPAVVRRWWNATQSRQKNFIDNLTTNYVSSLICSEELKAIANRKEKHENMQVTVHSSTREVLAVYAIDEARMELVITLAPNYPLGAVKVECGKQIGGRASSRNVGMQLTIFLTHQNGTIYDGLTMWKNNLDKKFEGVEECYVCYTVIHQETCQLPKLTCKTCKKKFHGPCLYKWFTTSSKSTCPICRNVF

ltn1

E3 ubiquitin-protein ligase listerin

1696 amino acids

E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. Ubiquitination leads to vcp/p97 recruitment for extraction and degradation of the incomplete translation product.

Belongs to the LTN1 family.

191.061 kDa

MQEFGFMCKEREMETVRGVLPYWPRIYCKISLDLDRRVREATQQAFEQLILKVKKYLAPHLKSLMGFWLIAQCDTYSPAASSARVAFEAAFPAHKQPEALAFCKEEIMNVLLDHLLKETPDTLSDTQAVPIEDRESKYFRVVTCSLLALKRLLCMLPRSENSSLQERLAHLLSQSKFWKYSKHSTSSIRSAFFELMSALCQCSPDVLRAEASRLCPAVLLSIDDSDAVVCPALWEAVLYTITTIEDCWEHVNAQKGVLPKLWSVLREGGRGLATVIFPNLLPFISRVPTNIIKTPTDFYSNFFNSLGQGLSSERAVASPAECSAIISAYMECLRFAMQENAGEEEENKKVQQILISDQLMPLIDSSLKDPKLQNSPLFSQVEETLYSWEKKAESQGLDDKLSRIHATLLREFWENLAHICVSHVDVIEAGEKNLAGVSGLLQVLQNPNCLLKVNKKKKAKIRFKGEGDDESDAVSHVSESQPMSKFIMETCSSSGRDPGIAQLRQERLEDLVCKLAELSMVYISEQRSQQHLMFLAALLSTFPSIRVFQVLLQQSSEEDPKNLNSPDHDVTPRHKNPAVQFLYAKLIFWFNDKSLEESDFLVDILYSVLFCCTDSSERKHLLDDMTKMNFKWSVFLYIIQKACTDPEKYSLASDWLKGEVLGERLICLANDLCTSGLMDKATPSEAYCSKKWALLSLVLSEHVHNEYLIADAYVEKIINKLHSALMKARNLSKAGHLEQSVSFICDVGSNFFSSIKGCLQMPSAEDLLLTIFQLCAQASDTSHMSESLLLKLKNTWLAGLHSLVCQYKNMPQGSNFLKQSAQWVKDQIQTSHLNVKSLQSLICTVDDLYSTILDSSLSGFSLLAEHTASMMPSAETWQKMRHALSSQWLSKPLLEGRLSMNTETSGTDLKSFPKTWLPSHLCTASLLSKMALRLLEKEKSLKEEEIGVKINITVAEMLYSLQWCEELEKPPTLIGECCEMLCSLGVSHEKVMDLSVHLPGLLELLYNRSKEDGSLWSLTANRFIHKRGAGPSELLPLTEDTEKYFPVTLGSLHTIQSLSAFLCPELKEELVIQCTARLMTCSASAVSCTDGGFGYLAIINSCLGSDSDLCQEILPGVLKVMLSWKDDQEDIFLFSSNVQDSSQSLIGLNVEMIRFLSILLKYLASSVSSLVDVDWDFIMCSMLAWLESACESSAAYHIPLVRLFACASCDLATEISHYFESVATSTTMSLPANLMSEWKEFFSEGIYSLMLPMLVRIAEEYKASETSHMSHVLKSLGRTLGYISKEQLLNHKLPAKFVAGQKTNLTDSLQSLLNTLAPLLLYRERSVQITVYHLLDKIMADLPGFDDEDLKSYGDEDEEPALSPPAALMSVLAIQEDLVESILKEIPVGEFAVIEPLKEEFCFVLGYLLTWKLILTFFKAASSQLRALYSQYLRKTKSLNKLLYNLFKLMPHNPVLPGQASDMPSKEPKTFFTEELQLAVKGTATVQQEVPHLACCVYHMTLKDLPAMVRLWWNGCEKRIFNVVDRFTTKYVSSVLSSQEISSVQLSTQVFDGMTVKARSTTREVIATYSVDDICIELIIQLPQNYPLGSITVESGRRVGVAVQQWRNWMLQLNTYLTHQNGSIMEGLALWKNNVDKRFEGVEDCMICFSVIHGSNYSLPKKACRTCKKKFHSECLYKWFTSSNKSTCPLCRETFF