E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. Ubiquitination leads to vcp/p97 recruitment for extraction and degradation of the incomplete translation product.

Belongs to the LTN1 family.

1696 amino acids

MQEFGFMCKEREMETVRGVLPYWPRIYCKISLDLDRRVREATQQAFEQLILKVKKYLAPHLKSLMGFWLIAQCDTYSPAASSARVAFEAAFPAHKQPEALAFCKEEIMNVLLDHLLKETPDTLSDTQAVPIEDRESKYFRVVTCSLLALKRLLCMLPRSENSSLQERLAHLLSQSKFWKYSKHSTSSIRSAFFELMSALCQCSPDVLRAEASRLCPAVLLSIDDSDAVVCPALWEAVLYTITTIEDCWEHVNAQKGVLPKLWSVLREGGRGLATVIFPNLLPFISRVPTNIIKTPTDFYSNFFNSLGQGLSSERAVASPAECSAIISAYMECLRFAMQENAGEEEENKKVQQILISDQLMPLIDSSLKDPKLQNSPLFSQVEETLYSWEKKAESQGLDDKLSRIHATLLREFWENLAHICVSHVDVIEAGEKNLAGVSGLLQVLQNPNCLLKVNKKKKAKIRFKGEGDDESDAVSHVSESQPMSKFIMETCSSSGRDPGIAQLRQERLEDLVCKLAELSMVYISEQRSQQHLMFLAALLSTFPSIRVFQVLLQQSSEEDPKNLNSPDHDVTPRHKNPAVQFLYAKLIFWFNDKSLEESDFLVDILYSVLFCCTDSSERKHLLDDMTKMNFKWSVFLYIIQKACTDPEKYSLASDWLKGEVLGERLICLANDLCTSGLMDKATPSEAYCSKKWALLSLVLSEHVHNEYLIADAYVEKIINKLHSALMKARNLSKAGHLEQSVSFICDVGSNFFSSIKGCLQMPSAEDLLLTIFQLCAQASDTSHMSESLLLKLKNTWLAGLHSLVCQYKNMPQGSNFLKQSAQWVKDQIQTSHLNVKSLQSLICTVDDLYSTILDSSLSGFSLLAEHTASMMPSAETWQKMRHALSSQWLSKPLLEGRLSMNTETSGTDLKSFPKTWLPSHLCTASLLSKMALRLLEKEKSLKEEEIGVKINITVAEMLYSLQWCEELEKPPTLIGECCEMLCSLGVSHEKVMDLSVHLPGLLELLYNRSKEDGSLWSLTANRFIHKRGAGPSELLPLTEDTEKYFPVTLGSLHTIQSLSAFLCPELKEELVIQCTARLMTCSASAVSCTDGGFGYLAIINSCLGSDSDLCQEILPGVLKVMLSWKDDQEDIFLFSSNVQDSSQSLIGLNVEMIRFLSILLKYLASSVSSLVDVDWDFIMCSMLAWLESACESSAAYHIPLVRLFACASCDLATEISHYFESVATSTTMSLPANLMSEWKEFFSEGIYSLMLPMLVRIAEEYKASETSHMSHVLKSLGRTLGYISKEQLLNHKLPAKFVAGQKTNLTDSLQSLLNTLAPLLLYRERSVQITVYHLLDKIMADLPGFDDEDLKSYGDEDEEPALSPPAALMSVLAIQEDLVESILKEIPVGEFAVIEPLKEEFCFVLGYLLTWKLILTFFKAASSQLRALYSQYLRKTKSLNKLLYNLFKLMPHNPVLPGQASDMPSKEPKTFFTEELQLAVKGTATVQQEVPHLACCVYHMTLKDLPAMVRLWWNGCEKRIFNVVDRFTTKYVSSVLSSQEISSVQLSTQVFDGMTVKARSTTREVIATYSVDDICIELIIQLPQNYPLGSITVESGRRVGVAVQQWRNWMLQLNTYLTHQNGSIMEGLALWKNNVDKRFEGVEDCMICFSVIHGSNYSLPKKACRTCKKKFHSECLYKWFTSSNKSTCPLCRETFF

191.1 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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