About Products Protein Database Contact

LCD1

Gene
LCD1
Protein
DNA damage checkpoint protein LCD1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
747 amino acids
Function
Forms a complex with the serine/threonine kinase MEC1 which activates checkpoint signaling upon genotoxic stresses. The MEC1-LCD1 complex is recruited by the single-strand-binding protein complex RPA to DNA lesions in order to initiate the DNA repair by homologous recombination, after the MRX-complex and TEL1 are displaced. Required for the recruitment of MEC1 to DNA lesions, the activation of CHK1 and RAD53 kinases and phosphorylation of RAD9 in response to DNA damage. Required for cell growth and meiotic recombination.
Mass
86.425 kDa
Sequence
MRRETVGEFSSDDDDDILLELGTRPPRFTQIPPSSAALQTQIPTTLEVTTTTLNNKQSKNDNQLVNQLNKAQGEASMLRDKINFLNIEREKEKNIQAVKVNELQVKHLQELAKLKQELQKLEDEKKFLQMEARGKSKREVITNVKPPSTTLSTNTNTITPDSSSVAIEAKPQSPQSKKRKISDNLLKKNMVPLNPNRIIPDETSLFLESILLHQIIGADLSTIEILNRLKLDYITEFKFKNFVIAKGAPIGKSIVSLLLRCKKTLTLDRFIDTLLEDIAVLIKEISVHPNESKLAVPFLVALMYQIVQFRPSATHNLALKDCFLFICDLIRIYHHVLKVPIHESNMNLHVEPQIFQYELIDYLIISYSFDLLEGILRVLQSHPKQTYMEFFDENILKSFEFVYKLALTISYKPMVNVIFSAVEVVNIITSIILNMDNSSDLKSLISGSWWRDCITRLYALLEKEIKSGDVYNENVDTTTLHMSKYHDFFGLIRNIGDNELGGLISKLIYTDRLQSVPRVISKEDIGMDSDKFTAPIIGYKMEKWLLKLKDEVLNIFENLLMIYGDDATIVNGEMLIHSSKFLSREQALMIERYVGQDSPNLDLRCHLIEHTLTIIYRLWKDHFKQLREEQIKQVESQLIMSLWRFLVCQTETVTANEREMRDHRHLVDSLHDLTIKDQASYYEDAFEDLPEYIEEELKMQLNKRTGRIMQVKYDEKFQEMARTILESKSFDLTTLEEADSLYISMGL

Gene
LCD1
Protein
DNA damage checkpoint protein LCD1
Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
Length
694 amino acids
Function
Forms a complex with the serine/threonine kinase MEC1 which activates checkpoint signaling upon genotoxic stresses. The MEC1-LCD1 complex is recruited to DNA lesions in order to initiates the DNA repair by homologous recombination. Required for cell growth and meiotic recombination (By similarity).
Mass
79.452 kDa
Sequence
MSSQWDEDSDADILELANKPPRGTQLTQIESHAETETCGNDESGTGARTHEDLDKLQMDLMTARGESGMLRDRLMMLQQEKDRERERLLGREQELQGRHLQELQKLQEELQRLEDEKQFLVLEKRQLVKGHIAAGLPAQDIQDDSTEVSAKRRKTEDSLVQTYVTLNHTRVVTGDSSLFLDHMVLFKLHGSDMTVLDMLDHISLESPASCSMLVIPSGEPLGKPIHMMLLRLKSMHPLDKMIDIVLENLAMLIKKIMQGKDCRFAVPFLVAYMHQALSFRPSAVHVHALKDLFQFSSDLAIKFQPLLKSPLHASPLELGVEPNIFQYELLDTLSLFYCFDVMELCVKYLLQCSPESQKSFFDEIIWKNITKVMQLSLTISYKSILNVVFSMVEILRALSELITPEELSTVQWWDSAISKLFQLWNRQVSNANLHDNDNLHVLPKHNFPGLNRCLGDSTNVHLIEELIDTKAVQAIPEVIYRDFPPFSRECKIRIEGWGLQLHKATVNILQQLLLRYGKQLAHAELLHQTAKFLCREQELLLVVRLTADSHNSDMRITLAEELIRLLYHAWQEHEEPSKAITEVQNELIACLWRVVFGHMSNRDPQTQPELDALLLDSFHGLSLKEQHDLYDDVFDQPAAQAFLARELAAENVLRCETQFSGCHAYTCREMAKSVLESIISLEDTDSLFLAMVSE

Gene
LCD1
Protein
DNA damage checkpoint protein LCD1
Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)
Length
667 amino acids
Function
Forms a complex with the serine/threonine kinase MEC1 which activates checkpoint signaling upon genotoxic stresses. The MEC1-LCD1 complex is recruited to DNA lesions in order to initiates the DNA repair by homologous recombination. Required for cell growth and meiotic recombination (By similarity).
Mass
77.821 kDa
Sequence
MLRDKLKLLQAQIEQERSKSNYRVNEVKEEFDKEIQKLRQQLQSLEDEKKFLVLESRGINAVNQRIKTSPPEAFSRVSSQHRALNTPDSSHIQEHIPKKRKTEISTQPSIVLNPNRVIKDEVSAFFDCLYVHRIVGVELSTIEILNCIKFEHIDEFNYKLLKINKDTSIGSGIVDFLQSCKKNMKLNELVDSVLEHLATLIKAIIINDQELNFSVPFLVALMVQTILFRPSAVSVNSLKDLFIFTCDLIRKFQIVLKKPLHKSPLEVDLGPQIFQYELIDNLILVYSFDLLESTTKVIRIQQLSETLYMEFFDESLMKSLEAVYKLTLTISFKPVINVIYSMVAVFVTITNIMNNDNLSKPFGSSKWWSDLLTRLYQLLGKRILNFHVFDDTNTNNMHIDRFFDFYSLLRNMGTNSVSPLLAQLVTRGEIKGIPNIVLKDDIIDKYESKKEKGVLSDNLELEKWFVYLKDDILSIIENLMGYFKKDSKITNGEILINLTKLISVEQSQFMDHLIDQDTDVFAVRMNLVEHALSIIYRMWKYYEENITQESIKEVESELVMSLWRIIVCKHASKKICKDDLMEHRILINQMENLHLQDTIDLYEDAFEDMPEYIKEELECSINNGTQQKMQVQYDDIYIEMARYILESKLTNFISVENTDSLYLSMGF

Gene
LCD1
Protein
DNA damage checkpoint protein LCD1
Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
Length
664 amino acids
Function
Forms a complex with the serine/threonine kinase MEC1 which activates checkpoint signaling upon genotoxic stresses. The MEC1-LCD1 complex is recruited to DNA lesions in order to initiates the DNA repair by homologous recombination. Required for cell growth and meiotic recombination (By similarity).
Mass
76.86 kDa
Sequence
MADLWDDNDDDDDILELVNRPPMSQMAVPIKPPESQAEQLMKAKGEVGVLRQKLSMLEKTLREHDDNQKKLESSLKSSHEEEVTKLKIELERLEDERKFMLLEQKHLFTPRNSSKSETTHETETAEPSPIENKRRRMEPVKEYVTLTQNFKVDDGSLFYDHLLNFKLLGSEHTVLEMLDHICTYKTDLILSPEHKIIKARLPLGPPIRSLIFKWKSIYTLDQLVDKTLEILAIAIKSVSVLPENKLAIPFLISLMHCTINFRHSATSVSSLKDVFQFITDFIISDPKFLKQPLHESPLDLDVSPDVFQYSMLDQLCMTYSFDVLETCIVILLNCNTRAQEIVLNDATIAENLIKCCNFTLSISYKPIMPIIVNVTEILLGIVELDGAENVWKGKWAVLFSKLIQNWERSLTFDSVSLNFAGLNRCCGDNSNHSMIDNIISLEEVRYLPMIIENEFEPLTFTALDNLEYWSIQIQINITLIMHKLLHRYRSTLCSLEFLQKTFSLFSSHQELLLTVFLDRDHISDIKRQELLSVLLKLIYFCWVSISDEYKRALRLDELTICLWRIVYGWPESTDELSTEWAALINPLKALALEEEKKYFDDAYDEDNLPAFMHSEELDIKRESAVSKFNNNSSWPLRDMAKYILESITTMDEADSLYVAMVSET