ku70

ATP-dependent DNA helicase ku70

909 amino acids

Involved in non-homologous end joining (NHEJ) DNA double strand break repair.

102.003 kDa

MSGTNSWLNNNNNNSNTTLTNTNTIGGTNFGINQFDGDDWDNIFDGNNGDGDGDLDGDSYKSYQNPYSYRDCIIFLIDASKAMFEPNENNEIPFHNAVKCLIQTITDKIITSDSDLIGVCFYNTNKKKNINDFENIYVLSDLDIPDPKIILTLEEMLENSNFTTNGLGNCQGEMPFCDALWTCSTMFSNIKQSGSSSGENSNNNNFKRIFLFTNEDNPNAYNDSIRNSSIQRSKDLSDLNIQIELFSMNKSVNDKFDFSLFYQHILIFADEENYLDPTQFDASSKFSDLRFKLKRKEFKKRSLGKLPLYIGNLNNNNNNSNSLDSQVIISTQLYNLFSHAHKSSPTLLDPKTNLPVKQLIKNVCANTQATLLPSQIKLCYHYGGEPVIFTKDEMQTIKSIDRIGFTLLGFKPLENIKPYHSIKHSQFIFPDDQSIKGSVLAFNALVEQMLKSGKAAICRFTPRSSSSPRMVALIPQEEILQSESEFNNQQLLNSLSSQQQQQQSSQQSSSSQQQQQQQQQQQQQQQQQQQQQLPSSSQQSNNNRKIQIRPRGMHVIYLPFADDIRYPNNIGVKSDGLEIKQENIDKAKNIIKMMKIKFDEKKFVNPGLQKHYASLQAIALERDKVEETVDNIQPDRKLIEKVIDTTQDFSDGIFPVGYASTVSSATSSTSSSSAKRLRDGKDLSTMDWPDMVKSGEIIKLTVDDLKSFLSNQNIKPSSKAKKADLIDLISNLISGGNFKPDKLHLLKKDSPPLSDNTITTNGGDDDDNNRPSKKVKSTSTSTTASKNTSSSSPPLVSAATMNKKAPPKKSFSVKDKNSSNNSSGGSSKANVNDEFDIDFKNSDQDDDTDNESDVNNKATTSTTTITTTTAAPKKNNFVNNGMFDTRELCKYGKNCYRTNKQHLDEYRHQ

ku70

ATP-dependent DNA helicase II subunit 1

655 amino acids

Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. ku70, of the ku70/ku80 heterodimer, binds to the stem loop of tlc1, the RNA component of telomerase. Involved in telomere maintenance. Interacts with telomeric repeats and subtelomeric sequences thereby controlling telomere length and protecting against subtelomeric rearrangement. Maintains telomeric chromatin, which is involved in silencing the expression of genes located at the telomere. Required for mating-type switching (By similarity).

Belongs to the ku70 family.

73.617 kDa

MADEDQYRGDDQIDEEEEETDESGYKTVKDAVLFAIEVSDSMLTPRPSSDSKKPAEESPTTAALKCAYYLMQQRIISNPRDMIGVLLYGTQASKFYDEDENSRGDLSYPHCYLFTDLDVPSAQEVKNLRALAQDGDESKDVLKASGERVSMANVLFCANQIFTSKAPNFLSRRLFIVTDNDDPHGDNKSLRSASTVRAKDLYDLGVTIELFPISRPGHEFDTARFYDDIIYKASPSDPDAPAYLQTDSKASPATGDGISLLNTLLSNINSRSVPRRAQFSNIPLELGPNLKISVSGYLLFKRQAPARNSFIWLGGEQPQIVKGVTTQIADDTARTIEKWEIKKAYKFGGDQVAFTPEEMKSLRNFGDPVIRIIGFKPLSALPFWANIKHPSFIYPSEEDFVGSTRVFSALHQTLLRDKKAALVWFIARKNASPVLGAMVAGEEKLDESGVQKFPPGMWIIPLPFADDVRQNPETTLHVAPEPLIDQMRYIVQQLQLPKASYDPFKYPNPSLQWHYRILQALALDEDLPEKPEDKTLPRYRQIDKRTGDYVLSWADELEKQYAKISAHGPKSTLVKRSAKDRTSEVEDAAQKPYKKVKVETDEQGVEDVVRAHYQKGSLSKLTVPVLKDFLNAHGRSAAGKKADLVERVEEYLEQK

ku70

ATP-dependent DNA helicase II subunit 1

655 amino acids

Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. ku70, of the ku70/ku80 heterodimer, binds to the stem loop of tlc1, the RNA component of telomerase. Involved in telomere maintenance. Interacts with telomeric repeats and subtelomeric sequences thereby controlling telomere length and protecting against subtelomeric rearrangement. Maintains telomeric chromatin, which is involved in silencing the expression of genes located at the telomere. Required for mating-type switching (By similarity).

Belongs to the ku70 family.

73.64 kDa

MADEDQYRGDDQIDEEEEEIDESGYKTVKDAVLFAIEVSDSMLTPRPSSDSKKPAEESPTTAALKCAYHLMQQRIISNPRDMIGVLLYGTQASKFYDEDENSRGDLSYPHCYLFTDLDVPSAQEVKNLRALAQDGDESEDVLKASGERVSMANVLFCANQIFTSKAPNFLSRRLFIVTDNDDPHGDNKSLRSAATVRAKDLYDLGVTIELFPISRPDHEFDTARFYDDIIYKASPSDPDAPAYLQTDSKASPATGDGISLLSTLLSSINSRSVPRRAQFSNIPLELGPNFKISVSGYLLFKRQAPARNSFIWLGGEQPQIVKGVTTQIADDTARTIEKWEIKKAYKFGGDQVAFTPEEMKSLRNFGDPVIRIIGFKPLSALPFWANIKHPSFIYPSEEDFVGSTRVFSALHQTLLRDKKAALVWFIARKNASPVLGAMVAGEEKLDESGVQKFPPGMWIIPLPFADDVRQNPETTLHVAPEPLIDQMRYIVQQLQLPKASYDPFKYPNPSLQWHYRILQALALDEDLPEKPEDKTLPRYRQIDKRTGDYVLSWADELEKQYAKISAHGPKSTLVERSAKDRTSEVEDAAPKPYKKVKVETDEQGVEDVVRAPYQKGSLSKLTVPVLKNFLKAHGRSAAGKKKELVERVEEYLEQK

KU70

ATP-dependent DNA helicase II subunit 1

652 amino acids

Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. KU70, of the KU70/KU80 heterodimer, binds to the stem loop of TLC1, the RNA component of telomerase. Involved in telomere maintenance. Interacts with telomeric repeats and subtelomeric sequences thereby controlling telomere length and protecting against subtelomeric rearrangement. Maintains telomeric chromatin, which is involved in silencing the expression of genes located at the telomere. Required for mating-type switching (By similarity).

Belongs to the ku70 family.

72.705 kDa

MADTQDNRPGEEEDDDEEIDESAYKTMKDAVLFAIDVSPSMLERPPKTEDKKADRDSPTSAALKCAYQLMQQRIISNPNDMMGILLFGTEKTDLKDGDSTFQHCYLLADLDVPSAQDVKRLRDLVEDEEEAEQILKPAKDGASIATVLFCANQIFTTKAPNFSSRRLFLVTDNDYPVNVKADKDTAVTRARDLYDLGCTIDLFPISQPDQTFDRSRFYDDLVYPTSPSDPDAPIAVATTTKVAKSGEGITLLKQLISSINSKATPRRALFSLPLELGPDLRIGVKGYILIKRQEHAKSCYVWVGGDKPQIVSSSTSHMADDTARVVEKTELRKAYKFGGDAITFTPDEIIKIRQAFGDPIIRIIGFKPISCLPIWTNTNKATFIYPSEADFIGSTRVFSALQQKLLKSKKMGLVWFIARRNAAPILSALIPAEEQTNEDGEQAMPPGLWLVPLPWADDIRQFPSPAADVLKTTDALTDKMRIIIEQLQLPKGVYDPAKYPNPDLQWFYRILQAMALEEELPEKPDDKTMPKFRQIDKRCGEYITEYGAEFEAAFAQLAVSTFPHRGKRASADPGDDKPAPKRVKKEPKVKEEGEDDEGLTDEQMATVNNKGQISKQTVAVLKAWLSQRGESTSGKKADLVERVQGYLEGKGL

KU70

ATP-dependent DNA helicase II subunit 1

647 amino acids

Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. KU70, of the KU70/KU80 heterodimer, binds to the stem loop of TLC1, the RNA component of telomerase. Involved in telomere maintenance. Interacts with telomeric repeats and subtelomeric sequences thereby controlling telomere length and protecting against subtelomeric rearrangement. Maintains telomeric chromatin, which is involved in silencing the expression of genes located at the telomere. Required for mating-type switching (By similarity).

Belongs to the ku70 family.

72.554 kDa

MAESEYNREDDSFEEEEEVDDSGYKSVKDAVLFAIEVSESMLTAAPNPTSKKARPESPATAALKCAYHLMQQRIISNPKDMIGVLLYGTESSKFYDDDEDGRGSLPYPHCYLFTDLDVPAASDVKELHALVEDEDRAAEILVPSKEPVSMANVLFCANQIFTTKAPNFSSRRLFIVTDNDNPHSKDKVLKSAATVRAKDLYDLGVVIELFPISTPDHDFDTSKFYDDMIYRASPTDPEAPNYSCTSTKTSGADGISILNSLLSSINSKSVPRRALFSNLPLELGPEFRISVSGFLIFKRQAPARSCYVWLGGEQPQIVKGVTTLVADDSAREVEKWEIRKAYKFGGEHVAFTQEEQSALRNFGDPVIRIIGFKPMSSLPIWASTKHSTFIYPSEAGFVGSTRVFSALQQTLLKQKKFALVWFVARKNAAPVMAALIPGEEKLDDNDAQVIPPGMWIQPLPFADDIRQNPETHNIVAPEPLIDKMREIIQVLQLPKGRYDPQRYPNPSLQWHYRILQALALDEDLPDQAEDKTIPKYKQIDKRAGEHVLEWGEELETQNRLLENSKPITSTLAKRPAPSRKAEGDERATKRVRAESTGDAEVKMHYEKGSLNKLTVTILKDFLLSHNLSGTGKKADLIDRVEEFFDRK

ku70

ATP-dependent DNA helicase II subunit 1

629 amino acids

Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. ku70, of the ku70/ku80 heterodimer, binds to the stem loop of tlc1, the RNA component of telomerase. Involved in telomere maintenance. Interacts with telomeric repeats and subtelomeric sequences thereby controlling telomere length and protecting against subtelomeric rearrangement. Maintains telomeric chromatin, which is involved in silencing the expression of genes located at the telomere. Required for mating-type switching (By similarity).

Belongs to the ku70 family.

71.058 kDa

MADDYREDDVVEEEEELDEAPRPSADPKRQSYESPATAALKCAYHLMQQRIISNPRDMIGVLLYGTKQSKFYDEDENSRGDLTYPNCYLFTDLNIPSAHEVLELRSLVQDEENAKKILEPSNEPVSMANLLFCVNQIFTLKAPNFLSRRLFIVTDNDNPHGDNKSFRSAATVRAKDLYDLGVTIELFPISQIEHEFDTSKFYDDIIYKASPNDPDAPAYLKPDAKMNDAQDGISLLNGLLSSINSRSVPRRAQFSNMSLELGPNFKISVSGYILFKRQESARSCYVWLGGEKPQIAKGVTTQIADDSARTIEKWEIKKAYKFGGDQVCFTPEEQKSLKDFGEPVIRIIGFKPLSTLPFWANIKHPLFIYPTEEDYVGSTRVFSALYQKLLRDQKVALVWYIARKAASPVLGAMMAGEEKVDENGIQKIPPGMWIIPLPFADDVRQNPETALQVAPEPLIDQMRTVIQQLQLPKGVYDPQKYPNPSLQWHYRILQALALDEDVPEKPDDKTIPKYRQIDKRAGGYVLDWADELEKQYAKITADQPKSTTLAKRPAKADNPDKAAPPAKKVKAEAGSGNIQDEVQKHFEQHTLSKLTVATLRDFLASQGRATAGKKAELLERVEELLETKF

KU70

ATP-dependent DNA helicase 2 subunit KU70

624 amino acids

Single-stranded DNA-dependent ATP-dependent helicase. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair. When associated with KU70, binds to double-stranded telomeric and non-telomeric DNA sequences, but not to single-stranded DNA (By similarity). Required for the maintenance of chromosome stability and normal developmental growth. Plays a role in maintaining telomere length. Acts as a negative regulator in telomere homeostasis.

Belongs to the ku70 family.

70.056 kDa

MDLDPEGLFRDDSDEDDDNVQEREANKEMVVYLIDASPKMFTPATKADEKEETHFHTIVNCITHALKTQIIGRSYDEVAICFFNTKEKKNLQELAGVYVYNVTEREPLDRPDARLIKEFSCIEDSFMSNIGSRYGITSGSRENTLYNALWVAQALLRKGSVKTVSKRIVIFTNEDDPFGGLTGAVKTDMIRTTIQRARDAQDLGLSIELLPLSRPDEEFNMSLFYADLIGLEGDEIVDYLPSSGEKLEDMTNQLKKRMMKKRKVKTLAFAITNDVCIEVNTYALIRSTTPGAITWLDSISNLPLKAERSFICNDTGALIQDPQKRFQVYNDKIVKFSTRELSDVKRVSSHHLRLLGFKPLDYLKDYHNLRPSTFIYPSDEQIFGSTRVFVALHSSMRRLGRFALAFYGNPTRPQLVALIAQEEVTSAGGQIEPPGIHMIYLPYSDDVRYPEEVHLTSDDAPRATDEQIKKASNLLRRIDLKNFSVCQFSNPALQRHYGILEALALGEDEMPDVKDETLPDEEGLARPVVVKAVEEFKASVYGENYDQEEAEAAAAKAGASKKRKALTDAAAEKSAAHNWAELADTGKLKDMTVVDLKSYLSAHGLPVSGKKEALVSRILTHLGK

KU70

ATP-dependent DNA helicase II subunit 1

622 amino acids

Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. KU70, of the KU70/KU80 heterodimer, binds to the stem loop of TLC1, the RNA component of telomerase. Involved in telomere maintenance. Interacts with telomeric repeats and subtelomeric sequences thereby controlling telomere length and protecting against subtelomeric rearrangement. Maintains telomeric chromatin, which is involved in silencing the expression of genes located at the telomere. Required for mating-type switching (By similarity).

Belongs to the ku70 family.

68.878 kDa

MAWGGDDDRRPDADEGEEELDETDYKTQKDAVLFAIDVSSSMLQQPPATDKKRADKDSAIAAALKCAYQFMQQRIIAQPKDMMGILLFGTEKSRFRDEVGGRSSGYPHCYLFTDLDVPAAEDVKSLKALVEEGEDPDEVLVPAKEPASMANVLFCANQVFTTNAANFGSRRLFIITDNDAPHGKDKAAKSAAAVRAKDLYDLGVVIELFPVSHEGKAFDVSKFYDDIIYRDPATEAISDEVKTSKSGDGLSLLNSLISNINSKQTPKRAYFSNLHFELAPNVTISVKGYMPLHRQQPARTCYVWLGGEQAQLAQSETIKVDSATRTVDKSEVKKAYKFGGEYIHFKPEEAASLKNLGGKVLRVIGFKPRSLLPTWASVKKSIFIFPSEEHFVGSTPRENANPIMVAIIPSRAMDDETSETPYLPAGLWLYPLPFADDVRNVDLAAPPRPADELTDKMREIVQNLQLPKAMYNPLKYPNPSLQWHYKVLQAMALDEDVPEALDDATIPKYRQIDKRVGGYLAEWKEALTEKAGGLMKSRAMKREAEDEDVSRPLAKRTKPAAPKEAAGGHMSNAQLKAALEQDTLKKMTVAELKDVLASKGVSAVGKKAELVDKLEQWIEENV

KU70

ATP-dependent DNA helicase 2 subunit KU70

621 amino acids

Single-stranded DNA-dependent ATP-dependent helicase. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair. When associated with KU80, binds to double-stranded telomeric and non-telomeric DNA sequences, but not to single-stranded DNA. Plays a role in maintaining telomere length. Acts as a negative regulator of telomerase. Required for maintenance of the telomeric C-rich strand.

Belongs to the ku70 family.

70.291 kDa

MELDPDDVFRDEDEDPENDFFQEKEASKEFVVYLIDASPKMFCSTCPSEEEDKQESHFHIAVSCIAQSLKAHIINRSNDEIAICFFNTREKKNLQDLNGVYVFNVPERDSIDRPTARLIKEFDLIEESFDKEIGSQTGIVSDSRENSLYSALWVAQALLRKGSLKTADKRMFLFTNEDDPFGSMRISVKEDMTRTTLQRAKDAQDLGISIELLPLSQPDKQFNITLFYKDLIGLNSDELTEFMPSVGQKLEDMKDQLKKRVLAKRIAKRITFVICDGLSIELNGYALLRPAIPGSITWLDSTTNLPVKVERSYICTDTGAIMQDPIQRIQPYKNQNIMFTVEELSQVKRISTGHLRLLGFKPLSCLKDYHNLKPSTFLYPSDKEVIGSTRAFIALHRSMIQLERFAVAFYGGTTPPRLVALVAQDEIESDGGQVEPPGINMIYLPYANDIRDIDELHSKPGVAAPRASDDQLKKASALMRRLELKDFSVCQFANPALQRHYAILQAIALDENELRETRDETLPDEEGMNRPAVVKAIEQFKQSIYGDDPDEESDSGAKEKSKKRKAGDADDGKYDYIELAKTGKLKDLTVVELKTYLTANNLLVSGKKEVLINRILTHIGK

ku70

ATP-dependent DNA helicase 2 subunit 1

600 amino acids

Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. KU70, of the KU70/KU80 heterodimer, binds to the stem loop of TLC1, the RNA component of telomerase. Involved in telomere maintenance. Interacts with telomeric repeats and subtelomeric sequences thereby controlling telomere length and protecting against subtelomeric rearrangement. Maintains telomeric chromatin, which is involved in silencing the expression of genes located at the telomere. Required for mating-type switching (By similarity).

Belongs to the ku70 family.

67.405 kDa

MDQPWMRQDDDESDDESSTVDFGQAVDGILFLIDATEGMFEEVDGDTAFMQCIKAAKSTMLNKITSSPKDLVGIILFGTDKDNNPNRFKNVYVLQDLESPGAESVLKLEKLIADGPKKFKQEYGHGNVNMADVLWTCALMFSKSRAGQRRVLVLTNQDDPHKGSGDLDDKAVVKAKDLLQSGIELDLVHLKPPGDKKFRPQILYKNLVTDKENYEDGFPEASDKMEELLLRVRMKDHKKRRLMSLPFWLGPEVKMSVSLYNLVRPTGKPATTRLARDNNEELLSRRITYAMDSAEALMPGDISKTQEYGGRKAYFDICEVKQIKSMAPPGLQLLGFKPLSYLEKQPHVRPSHFVYPDEGSVRGSTRLFAALLQSCLRHRVAPICFWISRAAQAPKLVYLLAQEEERDPHGLQMVPPGFHVVQLPFSDDRRRLQALQEGTTKATPGLVALAREMAEKLRFTYHPDKFENPELQGFWSCLEALALDRDDAEHPKDYTRPDHEKMKAKAGEEMDAFLEAAFPDGCSATTAGSRKRTQAGEGGQAKKARSENQGSNVDVREEAKRGKLASLTVSVLRDFCKQEGLRCPSKKAEIVDCIKKHLKL

KU70

ATP-dependent DNA helicase II subunit 1

592 amino acids

Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. KU70, of the KU70/KU80 heterodimer, binds to the stem loop of TLC1, the RNA component of telomerase. Involved in telomere maintenance. Interacts with telomeric repeats and subtelomeric sequences thereby controlling telomere length and protecting against subtelomeric rearrangement. Maintains telomeric chromatin, which is involved in silencing the expression of genes located at the telomere. Required for mating-type switching (By similarity).

Belongs to the ku70 family.

68.666 kDa

MSFEQPDFLKSQLTQTRDDDKESDHKKWRRYEAHDGIVFCIQLTPTMYLSNPDLGGKIQLLEILDSLNDLMSQLVVVMPSTAVGCYIYNCSHPNAEDNVYELIPLRDVNYKNMKRVSDLLEDIEQDRILLKDEIPIADPNNPIELSPVLIKVRETFLQPIEGQKQLTNKKIFFFTDDDKPAEFLNVDSRSRLRKVVDDLYDYYINFVTFFIGSEDKPFDDSMYADILKWGSKINEAQSWLSSHGPSTNPINASYIKSKVKRTKEIKRIKFRCPLMLDERADLVVSVNGYTIVSHEIPGSKYKLVYANGSVRREAYSHREYLDAETGEAVDNSQLSKVYTFGDEIIELTEDENLKIQSGYSEHESFLKLIGFRSTEQCLHYYDNIDVPAFVVPNEEDYAGSIKTLASLYRTMLFKKKSAMVWGKLRPNSPPSMFVLTPSSKKDYNQGFYLYKVPFMEEVRKLPDFLNHSALIESDDYKVMSKVTETLINFFNLKNGYRPSDFHNPALQKHFKILREYLLQIEVDKSKPEDEGDETLQKVKQIYARIASSAKSDDVKQQRLVKYLKLWNSFYNRLSNLEVDTKPTKNKKAKLNL

KU70

ATP-dependent DNA helicase II subunit 1

585 amino acids

Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. KU70, of the KU70/KU80 heterodimer, binds to the stem loop of TLC1, the RNA component of telomerase. Involved in telomere maintenance. Interacts with telomeric repeats and subtelomeric sequences thereby controlling telomere length and protecting against subtelomeric rearrangement. Maintains telomeric chromatin, which is involved in silencing the expression of genes located at the telomere. Required for mating-type switching (By similarity).

Belongs to the ku70 family.

66.611 kDa

MEWISHLENDDDVLEIEDYKVRKDALLIAIQVTQNAINNGTLHKALEAAFDAVTDRIVISPQDYTGVMLFGASMQSEDDGDEFDDESDTHFILKLGLPTAAQIKRLKRLAEDPDLGERFKVQEEPHLMDVFFDMNRHFINMAPNFASRRIIYITDDDTPTTNEDDINKTRVRIEDLSHLKVKVEPLLINPSEDKTFDSSKFYALVFNEDTSVEPVEAIDLKQFINKRNVLNRSLFNVKMEIGEGLVVGVRGYLLYAEQKATSTTRKAWVYTGGEKPEIAKLESQAVTIESGRSVDKADLRKTFKFGNDYVPFTEEQLTQIRYFGEPIIRILGFHNSSDFSELFIHSVRSSMFLYPTDEKLVGSIRAFSALYQSLKNKDKMALAWVIVRKGAKPILALLIPSTKEIEGLHMVFLPFTDDIRQEPKTELVSAAPELVDATKNIFTRLRMPGGFESQRYPNPRLQWHYRVVRAMALQEEVPKVPEDKTTPKYRSIDTRVGDAIEEWNKVLQSSSKRPAEDICKAEKKVKSSDAGPPSNEQMQNMVENDIVGKLTVAELRAWGAANNVEPNGSKLKKDWVEVVKKYYGK

KU70

ATP-dependent DNA helicase II subunit 1

560 amino acids

Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. KU70, of the KU70/KU80 heterodimer, binds to the stem loop of TLC1, the RNA component of telomerase. Involved in telomere maintenance. Interacts with telomeric repeats and subtelomeric sequences thereby controlling telomere length and protecting against subtelomeric rearrangement. Maintains telomeric chromatin, which is involved in silencing the expression of genes located at the telomere. Required for mating-type switching (By similarity).

Belongs to the ku70 family.

63.992 kDa

MSSYYNKGDAPSWEALDQDGLDDVIDTSEPSAVAEDPGNYQPGNYVFQTLRTINAEEMKRLVKLMQTAKEQYEAQDDDETVETTEPEILRKTFPPIEESHEMNIANVIQTCNFLFRDGGTQLRGNKRVFWITDNDMPPGMNNRQPARTSYGDLTTYGVTAETFFIDRPDHRFNPNIFWNDILDREAIDYNDDQPDPEGLSSLADLMKDLVIKTSPKRTHFHVPLKLGKDGEIVIGVSGCSMVSEQGKGASRYVKMRGQVVEEVQSKTEYTSAKSLNSGQWGSNPIKVLGFQAASQLRFQDNLKHPFFIYPNEEEYTGSTRTFAALLNSCLKYNRHALALCRLRSNHVPEFCVLIPQEEKTSSNGQEYPPGFHLIILPYKDSIRPPPKKVAEFLQSPPIATDEQINAMKAVIKRTRFKAAAYRPEIYPNPSLAYHYDQLQALAFEEDWDPEDPAKQALDKTMPLYGGMHSRAGEFMEEFNKEIENDERAVEKLAAPTKRGKAEKETTVNEWDLRNIPDMWKKGTLSQLSILARLRLRRRPFTGQNQKGGYHRRRIRTSFHK

KU70

ATP-dependent DNA helicase II subunit 1

560 amino acids

Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. KU70, of the KU70/KU80 heterodimer, binds to the stem loop of TLC1, the RNA component of telomerase. Involved in telomere maintenance. Interacts with telomeric repeats and subtelomeric sequences thereby controlling telomere length and protecting against subtelomeric rearrangement. Maintains telomeric chromatin, which is involved in silencing the expression of genes located at the telomere. Required for mating-type switching (By similarity).

Belongs to the ku70 family.

63.992 kDa

MSSYYNKGDAPSWEALDQDGLDDVIDTSEPSAVAEDPGNYQPGNYVFQTLRTINAEEMKRLVKLMQTAKEQYEAQDDDETVETTEPEILRKTFPPIEESHEMNIANVIQTCNFLFRDGGTQLRGNKRVFWITDNDMPPGMNNRQPARTSYGDLTTYGVTAETFFIDRPDHRFNPNIFWNDILDREAIDYNDDQPDPEGLSSLADLMKDLVIKTSPKRTHFHVPLKLGKDGEIVIGVSGCSMVSEQGKGASRYVKMRGQVVEEVQSKTEYTSAKSLNSGQWGSNPIKVLGFQAASQLRFQDNLKHPFFIYPNEEEYTGSTRTFAALLNSCLKYNRHALALCRLRSNHVPEFCVLIPQEEKTSSNGQEYPPGFHLIILPYKDSIRPPPKKVAEFLQSPPIATDEQINAMKAVIKRTRFKAAAYRPEIYPNPSLAYHYDQLQALAFEEDWDPEDPAKQALDKTMPLYGGMHSRAGEFMEEFNKEIENDERAVEKLAAPTKRGKAEKETTVNEWDLRNIPDMWKKGTLSQLSILARLRLRRRPFTGQNQKGGYHRRRIRTSFHK