KATNA1

Katanin p60 ATPase-containing subunit A1

516 amino acids

Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. In mitotic spindles this could allow depolymerization of the microtubule end proximal to the centrosome, and subsequent poleward microtubule flux.

Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily.

57.593 kDa

MSVDEICENTKMGREYALLGNYETSLVYYQGVLQQIQKLLTSVHEPQRKHQWQTIRQELSQEYEHVKNITKTLNGFKSEPAAPEPAPNHRAAPFSHHQHAAKPAAAEPARDPDVWPPPTPVDHRPSPPYQRAARKDPPRRSEPSKPANRAPGNDRGGRGPSDRRGDARSGGGGRGGARGSDKDKNRGGKSDKDKKAPSGEEGDEKKFDPAGYDKDLVENLERDIVQRNPNVHWADIAGLTEAKRLLEEAVVLPLWMPDYFKGIRRPWKGVLMVGPPGTGKTMLAKAVATECGTTFFNVSSASLTSKYHGESEKLVRLLFEMARFYAPSTIFIDEIDSICSKRGTGSEHEASRRVKSELLIQMDGVSGPSAGEESSKMVMVLAATNFPWDIDEALRRRLEKRIYIPLPEIDGREQLLRINLKEVPLADDIDLKSIAEKMDGYSGADITNVCRDASMMAMRRRIQGLRPEEIRHIPKEELNQPSTPADFLLALQKVSKSVGKEDLVKYMAWMEEFGSV

KATNA1

Katanin p60 ATPase-containing subunit A1

492 amino acids

Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation.

Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily.

56.039 kDa

MSLVMISENVKLAREYALLGNYDSAMVYYQGVLDQMNKYLYSLRDTYLQQKWQQVWQEISVEAKHVKDIMKMLESFKIDSTPPKASQQELPAHDAEVWSLPVPAERRPSPGPRKRQSAQYSDCRGHNNRISAAVRGPHRPSSRNPNDKGKAVRGREKKDQQNKGKEEKSKSTSEISESEPKKFDSTGYDKDLVEALERDIISQNPNIRWDDIADLVEAKKLLKEAVVLPMWMPEFFKGIRRPWKGVLMVGPPGTGKTLLAKAVATECKTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFIDEIDSICSRRGTSEEHEASRRVKAELLVQMDGVGGATENDDPSKMVMVLAATNFPWDIDEALRRRLEKRIYIPLPSAKGREELLRINLRELELADDVDLANIAEKMEGYSGADITNVCRDASLMAMRRRIEGLTPEEIRNLSRDEMHMPTTMEDFEIALKKVSKSVSAADIEKYEKWIVEFGSC

KATNA1

Katanin p60 ATPase-containing subunit A1

492 amino acids

Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation.

Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily.

56.039 kDa

MSLVMISENVKLAREYALLGNYDSAMVYYQGVLDQMNKYLYSLRDTYLQQKWQQVWQEISVEAKHVKDIMKMLESFKIDSTPPKASQQELPAHDAEVWSLPVPAERRPSPGPRKRQSAQYSDCRGHNNRISAAVRGPHRPSSRNPNDKGKAVRGREKKDQQNKGKEEKSKSTSEISESEPKKFDSTGYDKDLVEALERDIISQNPNIRWDDIADLVEAKKLLKEAVVLPMWMPEFFKGIRRPWKGVLMVGPPGTGKTLLAKAVATECKTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFIDEIDSICSRRGTSEEHEASRRVKAELLVQMDGVGGATENDDPSKMVMVLAATNFPWDIDEALRRRLEKRIYIPLPSAKGREELLRINLRELELADDVDLANIAEKMEGYSGADITNVCRDASLMAMRRRIEGLTPEEIRNLSRDEMHMPTTMEDFEIALKKVSKSVSAADIEKYEKWIVEFGSC

katna1

Katanin p60 ATPase-containing subunit A1

492 amino acids

Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation.

Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily.

56.162 kDa

MSLLMISENVKLAREYALLGNYDSAMVYYQGVLDQMNKYLYSVKDTFLQQKWQQVWQEINMEAKHVKDIMSTLEGFKLDNSPVKTTQHEFPAHDGEVWSLPVPVERRPSPGPRKRQSVQCNDNKSHNNRFGAGKGPNLPSSKNTNNVKMKPVRAREKKDTFLKVKDEKNKSSVDVSETEVKKFDGTGYDKDLIEALERDIISQNPNIRWDDIADLEEAKKLLKEAVVLPMWMPEFFKGIRRPWKGVLMVGPPGTGKTLLAKAVATECKTTFFNISSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFIDEIDSICSRRGTSEEHEASRRVKAELLVQMDGVGGASENEDPSKMVMVLAATNFPWDIDEALRRRLEKRIYIPLPSAKGREELLRINLKELELADDVNIECIAENMDGYSGADITNVCRDASLMAMRRRIEGLTPEEIRNLSRDDMHMPTTMEDFEMALKKVSKSVSASDIEKYEKWIEEFGSC

KATNA1

Katanin p60 ATPase-containing subunit A1

491 amino acids

Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.

Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily.

55.965 kDa

MSLLMISENVKLAREYALLGNYDSAMVYYQGVLDQMNKYLYSVKDTYLQQKWQQVWQEINVEAKHVKDIMKTLESFKLDSTPLKAAQHDLPASEGEVWSMPVPVERRPSPGPRKRQSSQYSDPKSHGNRPSTTVRVHRSSAQNVHNDRGKAVRCREKKEQNKGREEKNKSPAAVTEPETNKFDSTGYDKDLVEALERDIISQNPNVRWDDIADLVEAKKLLKEAVVLPMWMPEFFKGIRRPWKGVLMVGPPGTGKTLLAKAVATECKTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYSPATIFIDEIDSICSRRGTSEEHEASRRVKAELLVQMDGVGGTSENDDPSKMVMVLAATNFPWDIDEALRRRLEKRIYIPLPSAKGREELLRISLRELELADDVDLASIAENMEGYSGADITNVCRDASLMAMRRRIEGLTPEEIRNLSKEEMHMPTTMEDFEMALKKVSKSVSAADIERYEKWIFEFGSC

KATNA1

Katanin p60 ATPase-containing subunit A1

491 amino acids

Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.

Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily.

55.909 kDa

MSLLMISENVKLAREYALLGNYDSAMVYYQGVLDQMNKYLYSVKDTYLQQKWQQVWQEINVEAKHVKDIMKTLESFKLDSTPLKAAQHDLPASEGEVWSMPVPVERRPSPGPRKRQSSQYSDSKSHGNRPGTTVRVHRSSAQNLHNDRGKAVRCREKKEQNKGREEKNKSPAAVTEPETNKFDSTGYDKDLVEALERDIISQNPNVRWDDIADLVEAKKLLKEAVVLPMWMPEFFKGIRRPWKGVLMVGPPGTGKTLLAKAVATECKTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYSPATIFIDEIDSICSRRGTSEEHEASRRVKAELLVQMDGVGGASENDDPSKMVMVLAATNFPWDIDEALRRRLEKRIYIPLPSAKGREELLRISLRELELADDVDLASIAENMEGYSGADITNVCRDASLMAMRRRIEGLTPEEIRNLSKEEMHMPTTMEDFEMALKKVSKSVSAADIERYEKWIFEFGSC

Katna1

Katanin p60 ATPase-containing subunit A1

491 amino acids

Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. The function in regulating microtubule dynamics at spindle poles seems to depend on the association of the katanin KATNA1:KATNB1 complex with ASPM which recruits it to microtubules. Reversely KATNA1:KATNB1 can enhance ASPM blocking activity on microtubule minus-end growth. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.

Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily.

55.949 kDa

MSLQMIVENVKLAREYALLGNYDSAMVYYQGVLDQMNKYLYSVKDTHLRQKWQQVWQEINVEAKQVKDIMKTLESFKLDITSLQAAQHELPAAEGEVWSLPVPVERRPLPGPRKRQSSQHSDPKPHSNRPSTVVRAHRPSPQNLHNDRGKAVRSREKKEQSKGREEKNKLPAAVTEPEANKFDGTGYDKDLVEALERDIISQNPNVRWYDIADLVEAKKLLQEAVVLPMWMPEFFKGIRRPWKGVLMVGPPGTGKTLLAKAVATECKTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYSPATIFIDEIDSICSRRGTSEEHEASRRMKAELLVQMDGVGGASENDDPSKMVMVLAATNFPWDIDEALRRRLEKRIYIPLPSAKGREELLRISLRELELADDVNLASIAENMEGYSGADITNVCRDASLMAMRRRIEGLTPEEIRNLSREAMHMPTTMEDFEMALKKISKSVSAADIERYEKWIVEFGSC

Katna1

Katanin p60 ATPase-containing subunit A1

491 amino acids

Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.

Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily.

55.844 kDa

MSLLMITENVKLAREYALLGNYDSAMVYYQGVLDQINKYLYSVKDTHLHQKWQQVWQEINVEAKHVKEIMKTLESFKLDSTSLKAAQHELPSSEGEVWSLPVPVERRPLPGPRKRQSTQHSDPKPHSNRPGAVVRAHRPSAQSLHSDRGKAVRSREKKEQSKGREEKNKLPAAVTEPEANKFDSTGYDKDLVEALERDIISQNPNVRWYDIADLVEAKKLLQEAVVLPMWMPEFFKGIRRPWKGVLMVGPPGTGKTLLAKAVATECKTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYSPATIFIDEIDSICSRRGTSEEHEASRRVKAELLVQMDGVGGASENDDPSKMVMVLAATNFPWDIDEALRRRLEKRIYIPLPSAKGREELLRISLRELELADDVNLASIAENMEGYSGADITNVCRDASLMAMRRRIEGLTPEEIRNLSREEMHMPTTMEDFEMALKKVSKSVSAADIERYEKWIVEFGSC

katna1

Katanin p60 ATPase-containing subunit A1

486 amino acids

Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation.

Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily.

55.462 kDa

MSLHEINENVKLAREYALLGNYSSAIVCYRGVLEQIKKYLFTVRDSSFQQKWQQVWQEINEENNQVQEIMRTLESFQLETTPSKPPSNQDGINDIWPVQVERRSSPLPVRRPPVPYKDSKPHNNRLSVAGVRAQHRQSPRGANGDRAKPLKGKEKKEAKPKDDKNKAEVSEKEVKRFDGQGYDKDLIEALERDIISQNPNVKWDDIADLEEAKKLLKEAVVLPMWMPEFFKGIRRPWKGVLMVGPPGTGKTLLAKAVATECRTTFFNVSSSTLTSKYRGESEKLVRILFEMARFYAPTTIFIDEIDSMCSRRGTSEEHEASRRVKAELLVQMDGVGGASDNEDPSKMVMVLAATNFPWDIDEALRRRLEKRIYIPLPSAKGRVELLRINLKELELANDVDMAKIAEQSEGYSGADITNVCRDASLMAMRRRIEGLTPEEIRNISRAEMHMPTTMEDFESSLKKVSKSVSASDLEKYEKWIEEFGSC

katna1

Katanin p60 ATPase-containing subunit A1

486 amino acids

Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. In mitotic spindles this could allow depolymerization of the microtubule end proximal to the centrosome, and subsequent poleward microtubule flux.

Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily.

55.43 kDa

single

MSLLMISENVKLAREYALLGNYDSAMVYYQGVLDQMNKYLYSVKDTFLQQKWQQVWQEINMECKHVKDIMSTLEGFKLDSSPVKTTQHEFPSHDGEVWSLPVPVERRPSPGPRKRQSVQCNDNKSHNNRFSAAAKGPNLPSARNANNVKMKPVRAREKKDALIKNKSSADVSETEVKRFDGSGYDKDLIEALERDIISQNPNIRWDDIADLEEAKKLLKEAVVLPMWMPEFFKGIRRPWKGVLMVGPPGTGKTLLAKAVATECKTTFFNISSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFIDEIDSICSRRGTSEEHEASRRVKAELLVQMDGVGGASENEDPSKMVMVLAATNFPWDIDEALRRRLEKRIYIPLPSAKGREELLRINLKELELADDVNIECIAENMDGYSGADITNVCRDASLMAMRRRIEGLTPEEIRNLSRDDMHMPTTMEDFEMALKKVSKSVSASDIEKYEKWIFEFG

katna1

Katanin p60 ATPase-containing subunit A1

485 amino acids

Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation.

Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily.

54.882 kDa

MSLGEINENVKLAREYALLGNYSSAVVCYQGVLEQIKKYLYSVRDSSLQQKWQQVWQEINEETKQVREIMTTLESFQMESTPSKPSSFAQDNDIMPVHVEHRSSPCVVRKSSVPYKDSKGHGNRLSVGPRGQARPSPRVANGDKGKPQKSKEKKENPSKPKEDKNKAEAVETEVKRFDRGGEDKDLIDALERDIISQNPNVTWDDIADLEEAKKLLKEAVVLPMWMPEFFKGIRRPWKGVLMVGPPGTGKTLLAKAVATECRTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFIDEIDSICSRRGTSEEHEASRRVKAELLVQMDGVGGTSENDPSKMVMVLAATNFPWDIDEALRRRLEKRIYIPLPSAKGRVDLLKINLKELDLANDVNMDKIAEQMEGYSGADITNVCRDASLMAMRRRIEGLTPEEIRNLPKDEMHMPTTMEDFETALKKVSKSVSAADLEKYEKWIAEFGSC

katna1

Katanin p60 ATPase-containing subunit A1

485 amino acids

Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation.

Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily.

54.882 kDa

MSLGEINENVKLAREYALLGNYSSAVVCYQGVLEQIKKYLYSVRDSSLQQKWQQVWQEINEETKQVREIMTTLESFQMESTPSKPSSFAQDNDIMPVHVEHRSSPCVVRKSSVPYKDSKGHGNRLSVGPRGQARPSPRVANGDKGKPQKSKEKKENPSKPKEDKNKAEAVETEVKRFDRGGEDKDLIDALERDIISQNPNVTWDDIADLEEAKKLLKEAVVLPMWMPEFFKGIRRPWKGVLMVGPPGTGKTLLAKAVATECRTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFIDEIDSICSRRGTSEEHEASRRVKAELLVQMDGVGGTSENDPSKMVMVLAATNFPWDIDEALRRRLEKRIYIPLPSAKGRVDLLKINLKELDLANDVNMDKIAEQMEGYSGADITNVCRDASLMAMRRRIEGLTPEEIRNLPKDEMHMPTTMEDFETALKKVSKSVSAADLEKYEKWIAEFGSC