JMJD4

Gene

JMJD4

Protein

2-oxoglutarate and iron-dependent oxygenase JMJD4

Organism

Homo sapiens

Length

463 amino acids

Function

Catalyzes the 2-oxoglutarate and iron-dependent C4-lysyl hydroxylation of ETF1 at 'Lys-63' thereby promoting the translational termination efficiency of ETF1.

Mass

52.493 kDa

Sequence

MRAGPEPQALAGQKRGALRLLVPRLVLTVSAPAEVRRRVLRPVLSWMDRETRALADSHFRGLGVDVPGVGQAPGRVAFVSEPGAFSYADFVRGFLLPNLPCVFSSAFTQGWGSRRRWVTPAGRPDFDHLLRTYGDVVVPVANCGVQEYNSNPKEHMTLRDYITYWKEYIQAGYSSPRGCLYLKDWHLCRDFPVEDVFTLPVYFSSDWLNEFWDALDVDDYRFVYAGPAGSWSPFHADIFRSFSWSVNVCGRKKWLLFPPGQEEALRDRHGNLPYDVTSPALCDTHLHPRNQLAGPPLEITQEAGEMVFVPSGWHHQVHNLDDTISINHNWVNGFNLANMWRFLQQELCAVQEEVSEWRDSMPDWHHHCQVIMRSCSGINFEEFYHFLKVIAEKRLLVLREAAAEDGAGLGFEQAAFDVGRITEVLASLVAHPDFQRVDTSAFSPQPKELLQQLREAVDAAAAP

Protein

2-oxoglutarate and iron-dependent oxygenase JMJD4: JMJD4

Gene

Jmjd4

Protein

2-oxoglutarate and iron-dependent oxygenase JMJD4

Organism

Mus musculus

Length

427 amino acids

Function

Catalyzes the 2-oxoglutarate and iron-dependent C4-lysyl hydroxylation of ETF1 at 'Lys-63' thereby promoting the translational termination efficiency of ETF1 (By similarity). Not essential for embryonic stem cell (ESC) maintenance and the embryonic and postnatal development (PubMed:27147518).

Mass

49.152 kDa

Sequence

MDRETRTFAERYYRDLRDPVPSGGGGPTPSGVTFIQTPNAFSYADFVKGFLLPNLPCVFSSAFTEGWGSRRRWVTSEGKPDFEYLQQKYGDAVVPVANCGVREYNSNPKEHMSFRDYISYWKDYIQGSYSSSRGCLYLKDWHLCRDSLVNDLEDIFTLPVYFSSDWLNEFWDVLNVDDYRFVYAGPRGTWSPFHADIFRSFSWSVNICGKKKWLFFPPGEEEALRDCHGNLPYDVTSTELLDTHLYPKIQHHSLPIEVIQEPGEMVFVPSGWHHQVYNLDDTISINHNWVNGCNLPNMWHFLQQELQAVQHEVEEWKDSMPDWHHHCQVIMKSCTGINFEEFYHFLKVIAEKRLLVLEQGLKGDSGDSRSLDLGLQQAAFDIGRLADVLASVVVNPDFQRVDTSAFSPQPEELLQQLEDAVAAAEAL

Protein

2-oxoglutarate and iron-dependent oxygenase JMJD4: Jmjd4

Gene

JMJD4

Protein

2-oxoglutarate and iron-dependent oxygenase JMJD4

Organism

Gallus gallus

Length

425 amino acids

Function

Catalyzes the 2-oxoglutarate and iron-dependent C4-lysyl hydroxylation of ETF1 at 'Lys-63' thereby promoting the translational termination efficiency of ETF1.

Mass

49.121 kDa

Sequence

MDRATFACSTAFFHDYSSSAQGTFSTGHVDFIDKIESFTYSDFFRDYLIPNQPCVFSEKFTDGWGSRRNWVTWGGKPDFDHLLQEFGEAIVPVANCDVKEYNSNPKEQLPFKEYISYWKEYIKNGYRSSRGCLYLKDWHLSRAFPEQDVYTTPVYFSSDWLNEYWDAIAVDDYRFVYMGPKGSWTPFHADVFRSYSWSANICGRKKWLLYPPGQEDYLKDCHGNLPFDVTAPGLQDRSVYPRYNQSQPPVEIVQEAGEIVFIPSGWHHQVYNLEDTISINHNWVNGCNVAIMWCFLQDELAAVQREINEWKDPMDDWHLQCQLIMKSCTGIDYKEFYNFLKVIAENRISILENGLDDEASAKNTPKAAISTLGMLHAVFDLKRTVKVLTSLSANEDFKKLDLTSLSPPQEALLHHLKAAIDTALL

Protein

2-oxoglutarate and iron-dependent oxygenase JMJD4: JMJD4

Gene

jmjd4

Protein

2-oxoglutarate and iron-dependent oxygenase JMJD4

Organism

Danio rerio

Length

422 amino acids

Function

Catalyzes the 2-oxoglutarate and iron-dependent C4-lysyl hydroxylation of ETF1 at 'Lys-63' thereby promoting the translational termination efficiency of ETF1.

Mass

49.892 kDa

Sequence

MDRETFHSCSSLVKLPRQIHQQHCSSHFIEYIEREIPYSKFFKNYLIPNQPCMFSKKFTEEWNCRKKWVTAEGKPNLQRLLHEFDETPVPVANCSVKEYNANPKQIMPFKEFIQYWRESIQNGHSSPKGCLYLKDWHMQRNFPEHNIYKTPIYFSSDWLNEYWDTIEVDDYRFVYMGPKGSWTPFHADVFRSYSWSANICGRKKWLLYPPGQEDFLRDCHGNLAYDVTAPILQDKGLYAQFEEACQPLEIIQEAGEIIFVPSGWHHQVYNLEDTISINHNWLNGCNLDIMWQFLQDELSSVQREIEEWRDTMDTWHQHCQVIMKSCTGIDYAEFASFLKTIANNRISFLNSSPRNADSCQDLLAESLCALGPHHAAFDLQRVLHIFEIMLNNEDFKRLDPATLSFKPEDLLQEIREAIRTIV

Protein

2-oxoglutarate and iron-dependent oxygenase JMJD4: jmjd4