IntS13

Integrator complex subunit 13

732 amino acids

Crucial regulator of the mitotic cell cycle and development. At prophase, required for dynein anchoring to the nuclear envelope important for proper centrosome-nucleus coupling. At G2/M phase, may be required for proper spindle formation and execution of cytokinesis. Probable component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing.

Belongs to the asunder family.

82.78 kDa

MKIFSESHKTVFVVDHCPYMAESCRQHVEFDMLVKNRTQGIIPLAPISKSLWTCSVESSMEYCRIMYDIFPFKKLVNFIVSDSGAHVLNSWTQEDQNLQELMAALATVGPPNPRADPECCSILHGLVAAVETLCKITEYQHEARTLLMENAERVGNRGRIICITNAKSDSHVRMLEDCVQETIHEHNKLAANSDHLMQIQKCELVLIHTYPVGEDSLVSDRPKKELSPVLTSEVHSVRAGRHLATKLNVLVQQHFDLASTTITNIPMKEEQHANTSANYDVELLHHKDAHVDFLRSGDSHSGSSSREGPFKETVTLKWCTPRTNSIELHYCTGAYRISPVDVNSRPSSCLTNFLLNGRSVLLEQPRKSGSKVISHMLSSHGGEIFLHVLSSSRSILEDPPSISEGCGGRVTDYRITDFGEFMRENRLTPFLDPRYKIDASLEIPLERAKDQLEKHTRYWPMIISQTTIFNMQAVVPLAGVIVKESLTEEDVLNCQKTIYNLVDMERKNDPLPVSTVGTRGKGPKRDEQYRIMWNELETLVRAHISNSEKHQRVLECLMACRSKPPEEEERKKRGRKREDREDKSEQAGKEHGTEKARPDADRLKGILERGKEELAEAEVIKDSPDSPEPPNKKPLVETDETPHMEKSKGPVSLLSLWSNRINTANSRKHQEFAGRLNSVNNRAELYQHLKEENGEEVGLTGGPRTAIPFLKCPRSPVVNRMETTENGKASRQ

ints13

Integrator complex subunit 13

715 amino acids

Crucial regulator of the mitotic cell cycle and development. At prophase, required for dynein anchoring to the nuclear envelope important for proper centrosome-nucleus coupling (By similarity). At G2/M phase, may be required for proper spindle formation and execution of cytokinesis (By similarity). Probable component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing (By similarity). Plays a role in gastrulation and early embryogenesis (PubMed:15737938).

Belongs to the asunder family.

80.967 kDa

MKTFSESHKTVFVVDHCPYMSESCRQHVEFDMLTKNRTQGIIPLAPISKSLWTCAVEASMEYCRIMYDIFPFRKLVNFIVSDSRSRTLNSWNREDQNLQELMAALAVIGPPNPRADPECCSILHGLVEAVESLCKITDFQHESRTALMGNADWVANRGRIICITNAKSDSHVQMLEDCVNETIHEHNKMAAGSDHLMQIQKCHLVLLHTYPVGEDSLVSDRPKKELSNVLVSEVHSVKAGRHLSTKLNQLVQLHFDLASTTITNIPMKPTLSVCDQEEQHANTSANYDVELLHHKEAHVDFIKSGEGYTGSSSIRENSLKETVTLKWCTPRTNSVELHYCTGAFRISPVDVNSRPSSCLTNFLLNGRSVLLEQPRKSGSKVISHMLSSHGGEIFLHVLSSSRSILEDPPSISEGCGGRVTDYRITDFGEFMRENRLMPFPEQSYQMDGGPEVPLERAKEQLERHTRYWPMIISQTTIFNMQAVVPLASVIVKESLSEEDLLNCQKTIYNLVDMERKNDPLPISTAGTRGKGPKRDEQYRIMWNELETLVRAHVSGSERHQRVMECLMACRSKPPEEEERKKRGRKREDKEEKGEKLNKDHEHDKKGQESERIKSVLDQEKEDLAEAEVIKDSPDSPEPPNKKPHIVIEDTGPAEKSKGPMSLLSLWSSRINTANSRKHQEFVGRLNSVNNKAELYQHLKEENGGEGVENGKASRQ

ints13

Integrator complex subunit 13

707 amino acids

Crucial regulator of the mitotic cell cycle and development. At prophase, required for dynein anchoring to the nuclear envelope important for proper centrosome-nucleus coupling. At G2/M phase, may be required for proper spindle formation and execution of cytokinesis. Probable component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing (By similarity). Plays a role in gastrulation and early embryogenesis (By similarity).

Belongs to the asunder family.

80.285 kDa

MKTFSESHKTVFVVDHCPYMSESCRQHVEFDMLTKNRTQGIIPLAPISKSLWTCAIEASMEYCRIMYDIFPFRKLVNFIVSDSGSRTLNSWNQEDQNLQELMAALAVIGPPNPRADPECCSILHGLVEAVESLCKITDYQHESRTELMENADRVANRGRIICITNAKSDSHVQMLEDCVNETIHEHNKLAAGSDHLMQIQKCHLVLIHTYPVGEDSLVSDRPKKELSNVLISEVHSVKAGRHLSTKLNQLVQLHFDLASTTITNIPMKEEQHANTSANYDVELLHHKEAHVEFNKSAGEGYNGSSSRENCLKETVTLKWCTPRTNSVELHYCTGAFRISPVDVNSRPSSCLTNFLLNGRSVLLEQPRKSGSKVISHMLSSHGGEIFLHVLSSSRSILEDPPSISEGCGGRVTDYRITDFGEFMRENRLMPFAEPRYCMDGGPEVPLERAKEQLERHTRYWPMIISQTTIFNMQAVVPLASVIVKESLSEEDVLNCQKTIYNLVDMERKNDPLPISTAGTRGKGPKRDEQYRIMWNELETLVRAHVRGSDRHQRVMDCLMACRSKPPEEEERKKRGRKREDKEEKAEKPPKENEHEKKWQESERVKSVLDREKEDLAEAEVIKDSPDSPEPPNKKPHIMVEDTGPAEKSKGPMSLLSLWSSRINTANSRKHQEFVGRLNSVNNKAELYQHLKEENGAEGVENGKGSRQ

INTS13

Integrator complex subunit 13

706 amino acids

Crucial regulator of the mitotic cell cycle and development. At prophase, required for dynein anchoring to the nuclear envelope important for proper centrosome-nucleus coupling. At G2/M phase, may be required for proper spindle formation and execution of cytokinesis. Probable component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing (PubMed:23904267).

Belongs to the asunder family.

80.225 kDa

MKIFSESHKTVFVVDHCPYMAESCRQHVEFDMLVKNRTQGIIPLAPISKSLWTCSVESSMEYCRIMYDIFPFKKLVNFIVSDSGAHVLNSWTQEDQNLQELMAALAAVGPPNPRADPECCSILHGLVAAVETLCKITEYQHEARTLLMENAERVGNRGRIICITNAKSDSHVRMLEDCVQETIHEHNKLAANSDHLMQIQKCELVLIHTYPVGEDSLVSDRSKKELSPVLTSEVHSVRAGRHLATKLNILVQQHFDLASTTITNIPMKEEQHANTSANYDVELLHHKDAHVDFLKSGDSHLGGGSREGSFKETITLKWCTPRTNNIELHYCTGAYRISPVDVNSRPSSCLTNFLLNGRSVLLEQPRKSGSKVISHMLSSHGGEIFLHVLSSSRSILEDPPSISEGCGGRVTDYRITDFGEFMRENRLTPFLDPRYKIDGSLEVPLERAKDQLEKHTRYWPMIISQTTIFNMQAVVPLASVIVKESLTEEDVLNCQKTIYNLVDMERKNDPLPISTVGTRGKGPKRDEQYRIMWNELETLVRAHINNSEKHQRVLECLMACRSKPPEEEERKKRGRKREDKEDKSEKAVKDYEQEKSWQDSERLKGILERGKEELAEAEIIKDSPDSPEPPNKKPLVEMDETPQVEKSKGPVSLLSLWSNRINTANSRKHQEFAGRLNSVNNRAELYQHLKEENGMETTENGKASRQ