Crucial regulator of the mitotic cell cycle and development. At prophase, required for dynein anchoring to the nuclear envelope important for proper centrosome-nucleus coupling (By similarity). At G2/M phase, may be required for proper spindle formation and execution of cytokinesis (By similarity). Probable component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing (By similarity). Plays a role in gastrulation and early embryogenesis (PubMed:15737938).

Belongs to the asunder family.

715 amino acids

MKTFSESHKTVFVVDHCPYMSESCRQHVEFDMLTKNRTQGIIPLAPISKSLWTCAVEASMEYCRIMYDIFPFRKLVNFIVSDSRSRTLNSWNREDQNLQELMAALAVIGPPNPRADPECCSILHGLVEAVESLCKITDFQHESRTALMGNADWVANRGRIICITNAKSDSHVQMLEDCVNETIHEHNKMAAGSDHLMQIQKCHLVLLHTYPVGEDSLVSDRPKKELSNVLVSEVHSVKAGRHLSTKLNQLVQLHFDLASTTITNIPMKPTLSVCDQEEQHANTSANYDVELLHHKEAHVDFIKSGEGYTGSSSIRENSLKETVTLKWCTPRTNSVELHYCTGAFRISPVDVNSRPSSCLTNFLLNGRSVLLEQPRKSGSKVISHMLSSHGGEIFLHVLSSSRSILEDPPSISEGCGGRVTDYRITDFGEFMRENRLMPFPEQSYQMDGGPEVPLERAKEQLERHTRYWPMIISQTTIFNMQAVVPLASVIVKESLSEEDLLNCQKTIYNLVDMERKNDPLPISTAGTRGKGPKRDEQYRIMWNELETLVRAHVSGSERHQRVMECLMACRSKPPEEEERKKRGRKREDKEEKGEKLNKDHEHDKKGQESERIKSVLDQEKEDLAEAEVIKDSPDSPEPPNKKPHIVIEDTGPAEKSKGPMSLLSLWSSRINTANSRKHQEFVGRLNSVNNKAELYQHLKEENGGEGVENGKASRQ

81 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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