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HAP2

Gene
HAP2
Protein
Hapless 2
Organism
Chlamydomonas reinhardtii
Length
1139 amino acids
Function
During fertilization, required on male (minus) gametes for their fusion with female (plus) gametes (PubMed:18367645, PubMed:20335357, PubMed:25655701, PubMed:28235200). Required for membrane fusion, but not for the initial adhesion between gametes (PubMed:18367645, PubMed:25655701, PubMed:28235200). Inserts (via its extracellular domain) into lipid membranes (in vitro) (PubMed:28235200). Probably initiates the fusion of gamete cell membranes by inserting its extracellular domain into the cell membrane of a female gamete (PubMed:28235200).
Similarity
Belongs to the HAP2/GCS1 family.
Mass
115.204 kDa
Sequence
MCRAIAVALIVYLAQHYILAHAEVIASGRLEKCVVDGVTEELDCQEKVVVTLTVGNGQSLQTEALEFSLSCLNSPDGRCPCSCSAADPTCACRDLAAPLRVSLTKSPLWASYPLQYLSSFNWKPLEVILRPSNKVCKDGDWEDSPTCGWFSQGGVRVADSQGFCCECSSSQVWDDTFGSSKERTRANLDCDFWSDPLDILIGRKPVSAHCLTFDPQWYSGYELGAASLQFEIAITVEVPTAPSPTTATTSATPRTNNSSSANSTNSTNSPAPQFLSPPAPSTREVLHLGPSVPLASSASRLLSAKLLGDLAMYTQLPAISNQVLMVPQPPAAAAATGSPLDATLATNRSAWMLLDKTMLSMDGLACDKVGTGFSAFRYQPSGCGRAPQACLSGQLKDLWEADLARIADGRVPLYMITRFTGGSDTTLQSFSGGPLSFALPVTSHSQSLVTLSVAADGVRLVTNRSPGKITGAAVCRFAGTSCGGFEAVAARGYIYVNITNTGRLDSDYTLTVSNCSSNVRPIEARTLAVRAGSAASLDPPMELYVEDQAAAAARTCTVSLYDSVGAVTDSLTLSFYTNATQLVVKPSGGYNGTGDGAGVKRNGTDCSTACTNPIDVLCFVTKKCWSKFGRLLGIIGGALVGLGLLAVALKFGWLASLAASCCGGGGGAAAGGAGGGMGLGTGGGGGCFGGGQQQQQLPPAASHAMSPPQQQQRSHAEVAAGAAVAGAGAAGAAAAVLGAKHGGGGGGARGKQQHADTRHLQDRDSRAIDGGASIGSSSAGGSSSLSSYSQPREAGGRLLQPPAAAVFVPEGGGGGAAGDEGARAQSSDWDARGRSPRVADEHGSPRQRYDGVRQSPYMVSANPYDGWYDGGSGGGGGGGGGGYGREAPPPQGPPPHPVGAPPPPPRRRSLWERMWLQRPGGGGGGGGGGGGGGGGGSGGGVDQHGGRSCADAARRGGGGPGGMRGVEGLMSNGGRPNGPHPHAPPPPPPPQQQQQQQRQRRSFLESLTAMMTLPWGGGREEEAGGDRRGGGRGGAAAAHGGRGAGGGRGHPPSIGSPPPGPLQPPEYGPQGGQARRWGAGGGRGGVGGDGGGGGVGAAAYVQLSTGGRGGGGGGGRGRGGGREGPTWHNPVYDWQAPPK

Gene
HAP2
Protein
Hapless 2
Organism
Nematostella vectensis
Length
853 amino acids
Function
During fertilization, required on male gametes for their fusion with female gametes (PubMed:25111819). Probably initiates the fusion of gamete cell membranes by inserting part of its extracellular domain into the cell membrane of a female gamete (PubMed:20080406).
Similarity
Belongs to the HAP2/GCS1 family.
Mass
96.468 kDa
Sequence
MGRGQIIMILVGLLCLANESYSDVIAKSSLQMCENTGNSDDPYNVVDQKACEKKLIVTLSVRSGQNGTEFLKAVTNVSKVYDQTEKEMARLYNPFIITLAKTPVKLTYPYYYLAMVNNKPTERVVISDSKWHASGSYHACSDAWDDEDALCGFYTDAEGKPIWDSQGFCCRCTEQEKWRGSFNDKNPYSRAGINCKLFGTQAAAHCMTFDDLWYTVNEVGLWQMDFSIHVKAYDLVVEKVGNKTQSKWVDGGEIVIGPTIRSGVGVHGRLHATFIGEFQSHKQFPVLTTKYLLIPYVSEKVDPKTHPQFRNGPHDYMLIDKHEVNYKSSGPHECDKIGVSFSAFRAQAPMGCSQKQGDCLHNQPKDYFEEDTKRRASGKTPYYFPQKFGKLLGVNQRKDNNHFVLTYEVDEVMTSMVTLQISADDVILIYNRAEGKILRAYAQDFEALSRDGNLYVIVQNIGLVTADFYVVIKECSVGIGKLLEKAASINPQQTHSFTFSVKAQQWKGGDNFCIVQLYDARRKMVDSSNVTFRTTEPCVCASSCGCSCFKNGFKCTKREDRDFTKTKPKDSGLDLGFFPKLWNKIKNVWDTVTSVFNFMESGWALLGTALGLLSLGGLKAFLGFRKTGSRIARFGFGGANKGRVRRRDGSGRMVTMEFNETGDRIDPETKEVIEPRNKKKELLLNLFFFFILPFLLIYHLVGWIRWRMRKPGSEDEEQAGTGDEQGGASPLHNIEARAAVDQFLQPDTIVYHSYSQDDYVAQFLINPGKRFCMAGRMTSLSGPSADQFRFDLLQAIQIYEVIDNKRRRLESVNSLNAHYFSRLLNAEAMIDCLSLKPAFPCLNVNRKRKPKQK

Gene
HAP2
Protein
Hapless 2
Organism
Plasmodium berghei (strain Anka)
Length
812 amino acids
Function
During fertilization, required on male gametes for their fusion with female gametes, and for subsequent ookinete formation in the host (PubMed:18403203, PubMed:18367645, PubMed:21209845). Thereby, required for mosquito-mediated transmission to other animals (PubMed:18403203, PubMed:18367645). Probably initiates the fusion of gamete cell membranes by inserting part of its extracellular domain into the cell membrane of a female gamete (PubMed:20080406).
Similarity
Belongs to the HAP2/GCS1 family.
Mass
93.887 kDa
Sequence
MIIIIFFCIILKYYKWCDFKNKVFFIQLVYSFAKKSVCTSSLDDSTCHTVTFGELDVSNNSVVRLKVMRKGGKGYFLTIRRDYVTVSYYLKYVKDIPLEFREIIDIFNNHKFEQYTQEQINKYTYTCNVRKIEDIDKYDEKNPTKFHEYTRGEACRCQTYNYFKDDEFIKRAKLKCIYYNMLFTESATVYRHCPIIDLMHFAVYDIEYPPIFNTIVNITIEEYYYNDVSSVLNNKSDLVTKEKKYQLNDTITEIRDDYFDLWLFLKGETHGKRTLVNLSNDYIVIPSSPINNRDVIASDITRNCGLSQNSPLLKGCNYSSICNIMHPCLRKAMMLPKYMFDLSGKTCGKLGVSLNTWRKSEGNFCGSEAGYCISNNLKKYYDIHNSASIKDGISLSKYKIKNIYNSEPQTKIYESYKLPDYLKDKIKNNNHAEMDENDLDNKIFYKPNVAAHSQFIDYKYNGNHSVEIKFETDAIEVYEIRPVSIATITHVTIPNDCASNNSNSNECVLIIHVWNNSKFVGSNFSCSIACTNKETDQLASHINPIAPVRAFIGPNKNYAFYFIIKFLINKEITTLCKAIVKDSNGKECSIEEFELQSKESVHIVESEVDETTDQVVVEHHTQSPDIKNPDEYVCKCTINLLCYVINFKTCSNYYINTVKTLIGKFAIIAILIILAPALIPLLPFFLNFFFLFISTILKLYQSIISTIGQIRIRNNDKPIIYKKKIHDMKTNYLSVSSYSSLSDSSSIYSTDSVSSMRKNKKKFNKNNISSNIKHKKGGKKVKQKEPNRNSNHTSHEYADTSPSGKSKIPPLR

Gene
HAP2
Protein
Hapless 2
Organism
Tetrahymena thermophila
Length
742 amino acids
Function
During fertilization, required for the formation of intercellular membrane pores and subsequent exchange of gametic pronuclei between cells. Probably initiates the formation of intercellular membrane pores by inserting part of its extracellular domain into the cell membrane of the adjoining cell in the mating pair. Mating requires the presence of HAP2 on at least one of the two cells. Mating efficiency is high when HAP2 is present on both cells, and is strongly reduced when HAP2 is present on only one of the two cells.
Similarity
Belongs to the HAP2/GCS1 family.
Mass
82.663 kDa
Sequence
MKFLAFGLIYFHFCILNRCEYITSSTIQKCYNSSNEPNNCSQKAVIVLSLENGQIANTEQVVATLNQLSDSGVNKQLQNSFIFEVTKSPVTALFPLIYLQDFNSQPLEQVIATTLFSCKDGFYDSSPTCKFQYDSKGQKILDSQGYCCYCSLSDILGMGNDLSRGKVCYALNLGAGSATAHCLKFSPLWYSAFKIQQYQLYFEVNINIYTVDSQNQKNLKQTLKLSTSNPTMKSSDNSTISKIIGTFTPTQPPADLSSYYLVKPSFPATDPRVLQGISSWMFVDKTMFTLDGTQCNKIGVSYSGFRQQSSSCSQPVGSCLQNQLENLYQSDLILLSQNKQPKYLLESQGNFNQVQFQGQTILQQGLSGSASTLITIEIDAAQIKFVTNLGIGCISQCSINNFESHSGNGKLVALVQNQGNYSAEFVLGFNCSSNVQPIQGQKLFLTANQLYNFNCSVSVNSDISAINNNCTINLYDAIGNQLDSKNILFNTTSTNHTSNQGNNTGQQQSSQEYKSSQSCSDKCSSFWSFWCYFSAGCIKEAFKSIASIAGVASALALVIFLAKNGYLVPIIRFLCCCCCKSKKKENEKNKDKTDKKSIQESCSYDRSCCSHSISQSYQVENKNKYKRSKIQRSFSSESCQDKSKKIINELSNLEETFEANKLYANIDKNSSIFEYFGFKKSFTFILYERNDILFLPQNSTILDMIGALQPQKGSYLAQKFLEIVNKNALKVVSTSPLYLLIE

Gene
HAP2
Protein
Protein HAPLESS 2
Organism
Arabidopsis thaliana
Length
705 amino acids
Function
Required for male fertility (PubMed:17079265, PubMed:20333238). Plays a role in pollen tube guidance and successful gamete attachment (PubMed:17079265). Essential for the fusion of gametes during double fertilization, where one male gamete fuses with the egg to produce a zygote, and another male gamete fuses with the central cell to produce the endosperm (PubMed:17079265, PubMed:20333238, PubMed:21209845). Mediates the fusion of cell membranes (PubMed:28137780). Not required for pollen tube outgrowth (PubMed:17079265, PubMed:20333238).
Similarity
Belongs to the HAP2/GCS1 family.
Mass
80.505 kDa
Sequence
MVNAILMACILAGIFVGMFNEVDGIQILSKSKLEKCEKTSDSGNLNCSTKIVLNLAVPSGSSGGEASIVAEIVEVEDNSSSNMQTVRIPPVITVNKSAAYALYDLTYIRDVPYKPQEYHVTTRKCEHDAGPDIVQICERLRDEKGNVLEQTQPICCPCGPQRRMPSSCGDIFDKMIKGKANTAHCLRFPGDWFHVFGIGQRSLGFSVRVELKTGTRVSEVIIGPENRTATANDNFLKVNLIGDFGGYTSIPSFEDFYLVIPREAAEAGQPGSLGANYSMWMLLERVRFTLDGLECNKIGVGYEAFNTQPNFCSSPYWSCLHNQLWNFRESDINRIDRHQLPLYGLEGRFERINQHPNAGPHSFSIGVTETLNTNLMIELRADDIEYVFQRSPGKIINIAIPTFEALTQFGVAAVIIKNTGEVEASYSLTFDCSKGVAFVEEQFFIIKPKAVTTRSFKLYPTKDQAAKYICTAILKDSQFSEVDRAECQFSTTATVLDNGTQVTNPFQIPETQPKGFFDSIRILWTKIINGLVDFITGDTCRNKCSSFFDFSCHIQYVCLSWMVMFGLLLALFPITCLLLWLLHQKGLFDPCYDWWEDHFDLDHHRRLLPSRADVVNRHHHHHKHRHHHNHHRRTHQRHKHHHGQDDDVLQKMMLERDHSDSHYYHQLHRVHKDSKQKQRRRAKHGIVLPRDVHVERQRKQRLRES

Gene
hap2
Protein
Transcriptional activator hap2
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Length
334 amino acids
Function
Global regulator of respiratory functions in yeast cells. It belongs to a complex that binds to the sequence CCAAT located upstream of genes involved in mitochondrial electron transport.
Similarity
Belongs to the NFYA/HAP2 subunit family.
Mass
34.893 kDa
Sequence
MNPYEPVEGLYVNAKQYHRILKRREARAKLEERLRGVQTTKKPYLHESRHKHAMRRPRGPGGRFLTADKVSKLRAQEAAEAAANGGSTGDDVNATNANDATVPATVSSEVTHTSEGYADSNDSRPSSISNSSESPAPINSATASMSPANNTSGNNITSPNVRGELDMSGNIAMSGGPTNTASTSGPVPHDMTVLPQTDSNTSNLMSSGSQLGSFATASTNGNNSTTTTTSSAAHPGSFHKGTNDYSSTLAGNEHSAFPGLDVYHDDSVSAGAAFIPHNPMDSIDHLDVNDPTATGLPVLPASDIDPLNLTGNTQDSMIIGQQTYPSHGSSGTMK

Gene
HAP2
Protein
Transcriptional activator HAP2
Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
Length
300 amino acids
Function
Binds to the upstream activation site (UAS) of the CYC1 gene and other genes involved in mitochondrial electron transport and activates their expression. Recognizes the sequence CCAAT.
Similarity
Belongs to the NFYA/HAP2 subunit family.
Mass
34.499 kDa
Sequence
MPTELITYEQNFSSGVDAENDYPPLDSGMGSFQVSELERQGDSHKRSNDEISELRDETLNGREKKLRQSESISRNSTGNAQVEAIPHHSINVDQSDNLLSEQENPTKVYLYDDPHLENDPQQRQEESDANGIMEKLTDDNSMKQVSNAKTSLETAQFLETSNSMELQRTKPHDMNIISPSEPLEQPFYVNAKQYYRILKRRYARAKLEENLKISRERRPYLHESRHKHAMRRPRGQGGRFLTAAEMAEMKRKEEEGTDNDSFLQEHVPKMNVLPQQLPGPVKDNNNEKSDEKPVAKEASN

Gene
HAP2
Protein
Transcriptional activator HAP2
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
265 amino acids
Function
Acts a component of the CCAT-binding factor, which is a transcriptional activator and binds to the upstream activation site (UAS2) of the CYC1 gene and other genes involved in mitochondrial electron transport and activates their expression. Recognizes the sequence 5'-CCAAT-3'. HAP2 has primarily a structural role in the HAP complexes I and II.
Similarity
Belongs to the NFYA/HAP2 subunit family.
Mass
29.867 kDa
Sequence
MSADETDAKFHPLETDLQSDTAAATSTAAASRSPSLQEKPIEMPLDMGKAPSPRGEDQRVTNEEDLFLFNRLRASQNRVMDSLEPQQQSQYTSSSVSTMEPSADFTSFSAVTTLPPPPHQQQQQQQQQQQQQQLVVQAQYTQNQPNLQSDVLGTAIAEQPFYVNAKQYYRILKRRYARAKLEEKLRISRERKPYLHESRHKHAMRRPRGEGGRFLTAAEIKAMKSKKSGASDDPDDSHEDKKITTKIIQEQPHATSTAAAADKKT