During fertilization, required on male gametes for their fusion with female gametes, and for subsequent ookinete formation in the host (PubMed:18403203, PubMed:18367645, PubMed:21209845). Thereby, required for mosquito-mediated transmission to other animals (PubMed:18403203, PubMed:18367645). Probably initiates the fusion of gamete cell membranes by inserting part of its extracellular domain into the cell membrane of a female gamete (PubMed:20080406).

Belongs to the HAP2/GCS1 family.

812 amino acids

MIIIIFFCIILKYYKWCDFKNKVFFIQLVYSFAKKSVCTSSLDDSTCHTVTFGELDVSNNSVVRLKVMRKGGKGYFLTIRRDYVTVSYYLKYVKDIPLEFREIIDIFNNHKFEQYTQEQINKYTYTCNVRKIEDIDKYDEKNPTKFHEYTRGEACRCQTYNYFKDDEFIKRAKLKCIYYNMLFTESATVYRHCPIIDLMHFAVYDIEYPPIFNTIVNITIEEYYYNDVSSVLNNKSDLVTKEKKYQLNDTITEIRDDYFDLWLFLKGETHGKRTLVNLSNDYIVIPSSPINNRDVIASDITRNCGLSQNSPLLKGCNYSSICNIMHPCLRKAMMLPKYMFDLSGKTCGKLGVSLNTWRKSEGNFCGSEAGYCISNNLKKYYDIHNSASIKDGISLSKYKIKNIYNSEPQTKIYESYKLPDYLKDKIKNNNHAEMDENDLDNKIFYKPNVAAHSQFIDYKYNGNHSVEIKFETDAIEVYEIRPVSIATITHVTIPNDCASNNSNSNECVLIIHVWNNSKFVGSNFSCSIACTNKETDQLASHINPIAPVRAFIGPNKNYAFYFIIKFLINKEITTLCKAIVKDSNGKECSIEEFELQSKESVHIVESEVDETTDQVVVEHHTQSPDIKNPDEYVCKCTINLLCYVINFKTCSNYYINTVKTLIGKFAIIAILIILAPALIPLLPFFLNFFFLFISTILKLYQSIISTIGQIRIRNNDKPIIYKKKIHDMKTNYLSVSSYSSLSDSSSIYSTDSVSSMRKNKKKFNKNNISSNIKHKKGGKKVKQKEPNRNSNHTSHEYADTSPSGKSKIPPLR

93.9 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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