GONST1

GDP-mannose transporter GONST1

333 amino acids

Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen (PubMed:11595802, PubMed:20576760, PubMed:27381418). Required for the luminal synthesis of a variety of plant cell surface components (PubMed:11595802). Is required for the correct mannosylation of the glycosylinositol phosphoceramides (GIPC). Can indifferently transport GDP-mannose, GDP-Glucose, GDP-Fucose or GDP-Galactose in vitro (PubMed:23695979, PubMed:27381418).

Belongs to the nucleotide-sugar transporter family. GDP-Mannose:GMP antiporter (GMA) (TC 2.A.7.13) subfamily.

36.84 kDa

MKLYEHDGVDLEDGKTVKSGGDKPIPRKIHNRALLSGLAYCISSCSMILVNKFVLSSYNFNAGIFLMLYQNFVSVIIVVGLSLMGLITTEPLTLRLMKVWFPVNVIFVGMLITSMFSLKYINVAMVTVLKNVTNVITAVGEMYLFNKQHDNRVWAALFLMIISAVSGGITDLSFNAVGYAWQIANCFLTASYSLTLRKTMDTAKQVTQSGNLNEFSMVLLNNTLSLPLGLLLSYFFNEMDYLYQTPLLRLPSFWMVMTLSGLLGLAISFTSMWFLHQTGATTYSLVGSLNKIPLSIAGIVLFNVPTSLQNSASILFGLVAGVVFARAKMREKS