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GATA2

Gene
GATA2
Protein
Endothelial transcription factor GATA-2
Organism
Homo sapiens
Length
480 amino acids
Function
Transcriptional activator which regulates endothelin-1 gene expression in endothelial cells. Binds to the consensus sequence 5'-AGATAG-3'.
Mass
50.5 kDa
Sequence
MEVAPEQPRWMAHPAVLNAQHPDSHHPGLAHNYMEPAQLLPPDEVDVFFNHLDSQGNPYYANPAHARARVSYSPAHARLTGGQMCRPHLLHSPGLPWLDGGKAALSAAAAHHHNPWTVSPFSKTPLHPSAAGGPGGPLSVYPGAGGGSGGGSGSSVASLTPTAAHSGSHLFGFPPTPPKEVSPDPSTTGAASPASSSAGGSAARGEDKDGVKYQVSLTESMKMESGSPLRPGLATMGTQPATHHPIPTYPSYVPAAAHDYSSGLFHPGGFLGGPASSFTPKQRSKARSCSEGRECVNCGATATPLWRRDGTGHYLCNACGLYHKMNGQNRPLIKPKRRLSAARRAGTCCANCQTTTTTLWRRNANGDPVCNACGLYYKLHNVNRPLTMKKEGIQTRNRKMSNKSKKSKKGAECFEELSKCMQEKSSPFSAAALAGHMAPVGHLPPFSHSGHILPTPTPIHPSSSLSFGHPHPSSMVTAMG

Gene
Gata2
Protein
Endothelial transcription factor GATA-2
Organism
Mus musculus
Length
480 amino acids
Function
Transcriptional activator which regulates endothelin-1 gene expression in endothelial cells. Binds to the consensus sequence 5'-AGATAG-3'.
Mass
50.468 kDa
Sequence
MEVAPEQPRWMAHPAVLNAQHPDSHHPGLAHNYMEPAQLLPPDEVDVFFNHLDSQGNPYYANPAHARARVSYSPAHARLTGGQMCRPHLLHSPGLPWLDGGKAALSAAAAHHHSPWTVSPFSKTPLHPSAAGAPGGPLSVYPGAAGGSGGGSGSSVASLTPTAAHSGSHLFGFPPTPPKEVSPDPSTTGAASPASSSAGGSVARGEDKDGVKYQVSLSESMKMEGGSPLRPGLATMGTQPATHHPIPTYPSYVPAAAHDYGSSLFHPGGFLGGPASSFTPKQRSKARSCSEGRECVNCGATATPLWRRDGTGHYLCNACGLYHKMNGQNRPLIKPKRRLSAARRAGTCCANCQTTTTTLWRRNANGDPVCNACGLYYKLHNVNRPLTMKKEGIQTRNRKMSSKSKKSKKGAECFEELSKCMQEKSPPFSAAALAGHMAPVGHLPPFSHSGHILPTPTPIHPSSSLSFGHPHPSSMVTAMG

Gene
Gata2
Protein
Endothelial transcription factor GATA-2
Organism
Rattus norvegicus
Length
480 amino acids
Function
Transcriptional activator which regulates endothelin-1 gene expression in endothelial cells. Binds to the consensus sequence 5'-AGATAG-3' (By similarity). Plays an important role in the regulation of phagocytosis in alveolar macrophages, particularly during P.carinii infection.
Mass
50.464 kDa
Sequence
MEVAPEQPRWMAHPAVLNAQHPDSHHPGLAHNYMEPAQLLPPDEVDVFFNHLDSQGNPYYANPAHARARVSYSPAHARLTGGQMCRPHLLHSPGLPWLDGGKAALSAAAAHHHSPWTVSPFSKTPLHPSAAGAPGGPLSVYPGAAGGSGGGSGSSVASLTPTAAHSGSHLFGFPPTPPKEVSPDPSTTGAASPASPSAGGSVARGEDKDGVKYQVSLSESMKMEGGSPLRPGLAPMGTQPATHHPIPTYPSYVPASAHEYGSGLFHPGGFLGGPASSFTPKQRSKARSCSEGRECVNCGATATPLWRRDGTGHYLCNACGLYHKMNGQNRPLIKPKRRLSAARRAGTCCANCQTTTTTLWRRNANGDPVCNACGLYYKLHNVNRPLTMKKEGIQTRNRKMSSKSKKSKKGAECFEELSKCMQEKSSPFSAAALAGHMAPVGHLPPFSHSGHILPTPTPIHPSSSLSFGHPHPSSMVTAMG

Gene
gatA2
Protein
Glutamyl-tRNA(Gln) amidotransferase subunit A 2
Organism
Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)
Length
478 amino acids
Function
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity).
Similarity
Belongs to the amidase family. GatA subfamily.
Mass
52.481 kDa
Sequence
MEILDMTVEQLRNAILDKHLKSEDIVKAYFDNIKRNEPEINAYITLCEDYALKEAKDVDKKIANGDKVGRLAGIPIAIKDNICTDGIKTTCASKMLYDFVPPYDATVIKKLKAEDAIIIGKVNMDEFAMGSSTENSAFKITKNPRDITRVPGGSSGGSAAVVAAKMAPISLGSDTGGSIRQPAAFCGVVGLKPTYGLVSRFGLIAFASSLDQIGPLGKTVKDCAELLEVISGEDELDNTSSKKHEKEDYLEGIDDGIKGMKIGMPKEFLNDGLDPEIRKCIDDTIEKLKSLGAEVCEMSLPITEEGLSAYYIISSAEASSNLARFDGIRYGYRPDDFEDVYDLMETSRSEAFGDEVKRRIMLGTYALSSGYYDAYYKRALKLKKKIKNEFKEAFENYDLILSPVSPVLPFKIGEKKADPLQMYLADIYTVNINLAGIPAISLPCSVSKEGLPIGLQLLGPHFGEKKIFRAARALEKER

Gene
GATA2
Protein
GATA-binding factor 2
Organism
Gallus gallus
Length
466 amino acids
Function
Transcriptional activator which probably serves as a general switch factor for cell-specific development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of genes.
Mass
50.15 kDa
Sequence
MEVATDQPRWMTHHAVLNGQHPESHHPGLAHNYMEPAQLLPPDEVDVFFNHLDSQGNPYYANSAHARARVSYSQAHARLTGSQMCRPHLIHSPGIPWLDSSKAALSAHHHNPWTVNPFTKTPLHPSAAGAPGAISVYPGSSTSSTASVSSLTPASHSGSHLFGFPPTPPKEVSPDPNSTSAASPSSSAGARQEDKDSIKYQVSLSEGMKMESASPLRSSLTSMGAQPSTHHPIPTYPSYVPAAHDYSSSLFHPGSFLGGPASSFTPKPRSKARSCSEGRECVNCGATATPLWRRDGTGHYLCNACGLYHKMNGQNRPLIKPKRRLSAARRAGTCCANCQTTTTTLWRRNANGDPVCNACGLYYKLHNVNRPLTMKKEGIQTRNRKMSNKSKKSKKGSECFEELSKCMQEKSSPFSAAALASHMAPMGHLPPFSHSGHILPTPTPIHPSSSISFGHPHPSSMVTAMG

Gene
gata2
Protein
GATA-binding factor 2
Organism
Xenopus laevis
Length
452 amino acids
Mass
48.94 kDa
Sequence
MEVATDQPRWMAHHAVLNGQHPDSHHPGLAHNYMEPTQLLPPDEVDVFFNHLDSQGNPYYANSAHARARVSYSQAHARLTGSQMCRPHLLHSPGLPWLESGKTALSAAHHHNPWTVSPFGKAPLHPAARGGSLYPGTGSSACPSSSHSSPHLFGFPPTPPKDVSPDPGPASPPSSSRLEDKDSIKYQMSLSEGMKMEGGSPLRSSLAPMGTQCSTHHPIPTYPSYVPAAHDYSSGLFHPGSLLGGPASSFTPKQRSKSRSCSEGRECVNCGATATPLWRRDGTGHYLCNACGLYHKMNGQNRPLIKPKRRLSAARRAGTCCANCQTSTTTLWRRNANGDPVCNACGLYYKLHNVNRPLTMKKEGIQTRNRKMSNKSKKNKKGSECFEELSRCMQEKSSPFSAAALASHMAPMGHLAPFSHSGHILQTPTPIHPSSSLSFGHPHHSSMVTAMG

Gene
GATA2
Protein
GATA transcription factor 2
Organism
Arabidopsis thaliana
Length
264 amino acids
Function
Transcriptional activator that specifically binds 5'-GATA-3' or 5'-GAT-3' motifs within gene promoters. May be involved in the regulation of some light-responsive genes.
Similarity
Belongs to the type IV zinc-finger family. Class A subfamily.
Mass
28.864 kDa
Sequence
MDVYGLSSPDLLRIDDLLDFSNEDIFSASSSGGSTAATSSSSFPPPQNPSFHHHHLPSSADHHSFLHDICVPSDDAAHLEWLSQFVDDSFADFPANPLGGTMTSVKTETSFPGKPRSKRSRAPAPFAGTWSPMPLESEHQQLHSAAKFKPKKEQSGGGGGGGGRHQSSSSETTEGGGMRRCTHCASEKTPQWRTGPLGPKTLCNACGVRFKSGRLVPEYRPASSPTFVLTQHSNSHRKVMELRRQKEVMRQPQQVQLHHHHHPF