Fancd2

Fanconi anemia group D2 protein homolog

1451 amino acids

Required for maintenance of chromosomal stability. Promotes accurate and efficient pairing of homologs during meiosis. Involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing. May participate in S phase and G2 phase checkpoint activation upon DNA damage. Plays a role in preventing breakage and loss of missegregating chromatin at the end of cell division, particularly after replication stress (By similarity). Promotes BRCA2/FANCD1 loading onto damaged chromatin. May also be involved in B-cell immunoglobulin isotype switching (By similarity).

163.621 kDa

MVSKRSRLDFEDKETLAEDASKIMKQPLSKLAKKSCGSHEVEENGSVFVRLLKASGLTLKTGDNQNQLGVDQIIFQRKLFQALRKHPSYPKVIEEFVNGLESYTEDIDSLRNCLLSCERLQDEEASMGTFYSKSLIKLLLGIDILQPAIIKMLFEKVPQFLFESESRDGISMPRLIISQLKWLDRIVDSKDLTTQMMQLISVAPVNLQHDFITSLPEILGDSQHANVGKELSELLVQNTSLTVPILDVFSSLRLDPNFLSEIRQLVMGKLSSVRLEDLPVIVKFILHSVTDSTSLEVIAELREKLNVQHFTLPSRIQASQSKLKSKGLASSSGNQENSDKDCIVLLFDVIKSAIRYEKTISEAWIKAIERIQSAAEHKALDVAMLLIIYGTSTQTKKGVERLLRNKIQSDCIQEQLLDSTFSTHCLVLKDICPSILLLAQTLFHSQDQRIILFGSLLCKYAFKFFDTYCQQEVVGALVTHVCSGNEAEVDAALDVLLELIVLNASAMRLNAAFIKGILDYLENMSPQQIRKIFCILSTLAFSQQPGTSNHIQDDMHLVIRKQLSSTVFKYKLIGIIGAVTMAGIMAEDRTMPSNSTQRSASVSSEQHTQVTSLLQLVHSCTEHSPWASSLYYDEFANLIQERKLAPKTLEWVAQTIFNDFQDAFVVDFCAVPEGDFPFPVKALYGLEECNTQDGIVINLLPLFFQEFAKDVSQVTSQESSQKSMSPLCLASHFRLLRLCVARQHNGNLDEIDALLDCPLFLPDLEPGEKLESMSAKDRSLMCSLTFLTFNWFREVVNAFCQQTSPEMKGKVLSRLKDLVELQEILEKYLAVIPDYVPPFTSVDLDTLDVIPRSNSAVAAKSRHKGKTGGKKQKADSSTASCTDTLLTEDTSECDVAPSGKSQVDKESTGKEGKTFVSLQNYRAFFRELDIEVFSILHSGLVTKFILDTEMHTEATEVVQLGPAELLFLLEDLSQKLENRLTPSFTKRVCFFKNKGSRNIGFSHLHQRSVQDIVHCVVQLLTPMCNHLENIHNFFQCLGAENLSVNDKARVTAQEHYTMSSCYQKLLQVFHALLAWKGFTHQSNHRLLRSALEVLASRLKQTEEGQPLEELLSQSFSYLQNLQHSIPSFQCGLYLLRLLMALLEKSAVPTQKKEKLASLAKQLLCRAWPHGDKEKNPTFNDHLHDLLCIYLEHTDNVLKAIEEITGVGVPELVNAPKDASSSTFPTLTRHTFVIFFRVMMAELEKTVKGLQAGTATDSQQVHEEKLLYWNMAVRDFSILINLMKVFDSYPVLHVCLKYGRRFVEAFLKQCMPLLDFSFRKHRDDVLSLLQTLQLNTRLLHHLCGHSKIHQDTRLTKHVPLLKKSLELLVCRVKAMLVLNNCREAFWLGTLKNRDLQGEEIISQHPSSPENTSEDSEDGMTSYVSRNRAIEDGEDEANDGQDRDSDESDDSSS

Fancd2

Fanconi anemia group D2 protein homolog

1450 amino acids

Required for maintenance of chromosomal stability. Promotes accurate and efficient pairing of homologs during meiosis. Involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing. May participate in S phase and G2 phase checkpoint activation upon DNA damage. Plays a role in preventing breakage and loss of missegregating chromatin at the end of cell division, particularly after replication stress (By similarity). Promotes BRCA2/FANCD1 loading onto damaged chromatin. May also be involved in B-cell immunoglobulin isotype switching.

163.618 kDa

MISKRRRLDSEDKENLTEDASKTMPLSKLAKKSHNSHEVEENGSVFVKLLKASGLTLKTGENQNQLGVDQVIFQRKLFQALRKHPAYPKVIEEFVNGLESYTEDSESLRNCLLSCERLQDEEASMGTFYSKSLIKLLLGIDILQPAIIKMLFEKVPQFLFESENRDGINMARLIINQLKWLDRIVDGKDLTAQMMQLISVAPVNLQHDFITSLPEILGDSQHANVGKELGELLVQNTSLTVPILDVFSSLRLDPNFLSKIRQLVMGKLSSVRLEDFPVIVKFLLHSVTDTTSLEVIAELRENLNVQQFILPSRIQASQSKLKSKGLASSSGNQENSDKDCIVLVFDVIKSAIRYEKTISEAWFKAIERIESAAEHKALDVVMLLIIYSTSTQTKKGVEKLLRNKIQSDCIQEQLLDSAFSTHYLVLKDICPSILLLAQTLFHSQDQRIILFGSLLYKYAFKFFDTYCQQEVVGALVTHVCSGTEAEVDTALDVLLELIVLNASAMRLNAAFVKGILDYLENMSPQQIRKIFCILSTLAFSQQPGTSNHIQDDMHLVIRKQLSSTVFKYKLIGIIGAVTMAGIMAEDRSVPSNSSQRSANVSSEQRTQVTSLLQLVHSCTEHSPWASSLYYDEFANLIQERKLAPKTLEWVGQTIFNDFQDAFVVDFCAAPEGDFPFPVKALYGLEEYSTQDGIVINLLPLFYQECAKDASRATSQESSQRSMSSLCLASHFRLLRLCVARQHDGNLDEIDGLLDCPLFLPDLEPGEKLESMSAKDRSLMCSLTFLTFNWFREVVNAFCQQTSPEMKGKVLSRLKDLVELQGILEKYLAVIPDYVPPFASVDLDTLDMMPRSSSAVAAKNRNKGKTGGKKQKADSNKASCSDTLLTEDTSECDMAPSGRSHVDKESTGKEGKTFVSLQNYRAFFRELDIEVFSILHSGLVTKFILDTEMHTEATEVVQLGPAELLFLLEDLSQKLENMLTAPFAKRICCFKNKGRQNIGFSHLHQRSVQDIVHCVVQLLTPMCNHLENIHNFFQCLGAEHLSADDKARATAQEQHTMACCYQKLLQVLHALFAWKGFTHQSKHRLLHSALEVLSNRLKQMEQDQPLEELVSQSFSYLQNFHHSVPSFQCGLYLLRLLMALLEKSAVPNQKKEKLASLAKQLLCRAWPHGEKEKNPTFNDHLHDVLYIYLEHTDNVLKAIEEITGVGVPELVSAPKDAASSTFPTLTRHTFVIFFRVMMAELEKTVKGLQAGTAADSQQVHEEKLLYWNMAVRDFSILLNLMKVFDSYPVLHVCLKYGRRFVEAFLKQCMPLLDFSFRKHREDVLSLLQTLQLNTRLLHHLCGHSKIRQDTRLTKHVPLLKKSLELLVCRVKAMLVLNNCREAFWLGTLKNRDLQGEEIISQDPSSSESNAEDSEDGVTSHVSRNRATEDGEDEASDEQKDQDSDESDDSSS