Required for maintenance of chromosomal stability. Promotes accurate and efficient pairing of homologs during meiosis. Involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing. May participate in S phase and G2 phase checkpoint activation upon DNA damage. Plays a role in preventing breakage and loss of missegregating chromatin at the end of cell division, particularly after replication stress (By similarity). Promotes BRCA2/FANCD1 loading onto damaged chromatin. May also be involved in B-cell immunoglobulin isotype switching (By similarity).

1451 amino acids

MVSKRSRLDFEDKETLAEDASKIMKQPLSKLAKKSCGSHEVEENGSVFVRLLKASGLTLKTGDNQNQLGVDQIIFQRKLFQALRKHPSYPKVIEEFVNGLESYTEDIDSLRNCLLSCERLQDEEASMGTFYSKSLIKLLLGIDILQPAIIKMLFEKVPQFLFESESRDGISMPRLIISQLKWLDRIVDSKDLTTQMMQLISVAPVNLQHDFITSLPEILGDSQHANVGKELSELLVQNTSLTVPILDVFSSLRLDPNFLSEIRQLVMGKLSSVRLEDLPVIVKFILHSVTDSTSLEVIAELREKLNVQHFTLPSRIQASQSKLKSKGLASSSGNQENSDKDCIVLLFDVIKSAIRYEKTISEAWIKAIERIQSAAEHKALDVAMLLIIYGTSTQTKKGVERLLRNKIQSDCIQEQLLDSTFSTHCLVLKDICPSILLLAQTLFHSQDQRIILFGSLLCKYAFKFFDTYCQQEVVGALVTHVCSGNEAEVDAALDVLLELIVLNASAMRLNAAFIKGILDYLENMSPQQIRKIFCILSTLAFSQQPGTSNHIQDDMHLVIRKQLSSTVFKYKLIGIIGAVTMAGIMAEDRTMPSNSTQRSASVSSEQHTQVTSLLQLVHSCTEHSPWASSLYYDEFANLIQERKLAPKTLEWVAQTIFNDFQDAFVVDFCAVPEGDFPFPVKALYGLEECNTQDGIVINLLPLFFQEFAKDVSQVTSQESSQKSMSPLCLASHFRLLRLCVARQHNGNLDEIDALLDCPLFLPDLEPGEKLESMSAKDRSLMCSLTFLTFNWFREVVNAFCQQTSPEMKGKVLSRLKDLVELQEILEKYLAVIPDYVPPFTSVDLDTLDVIPRSNSAVAAKSRHKGKTGGKKQKADSSTASCTDTLLTEDTSECDVAPSGKSQVDKESTGKEGKTFVSLQNYRAFFRELDIEVFSILHSGLVTKFILDTEMHTEATEVVQLGPAELLFLLEDLSQKLENRLTPSFTKRVCFFKNKGSRNIGFSHLHQRSVQDIVHCVVQLLTPMCNHLENIHNFFQCLGAENLSVNDKARVTAQEHYTMSSCYQKLLQVFHALLAWKGFTHQSNHRLLRSALEVLASRLKQTEEGQPLEELLSQSFSYLQNLQHSIPSFQCGLYLLRLLMALLEKSAVPTQKKEKLASLAKQLLCRAWPHGDKEKNPTFNDHLHDLLCIYLEHTDNVLKAIEEITGVGVPELVNAPKDASSSTFPTLTRHTFVIFFRVMMAELEKTVKGLQAGTATDSQQVHEEKLLYWNMAVRDFSILINLMKVFDSYPVLHVCLKYGRRFVEAFLKQCMPLLDFSFRKHRDDVLSLLQTLQLNTRLLHHLCGHSKIHQDTRLTKHVPLLKKSLELLVCRVKAMLVLNNCREAFWLGTLKNRDLQGEEIISQHPSSPENTSEDSEDGMTSYVSRNRAIEDGEDEANDGQDRDSDESDDSSS

163.6 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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