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FUS3

Gene
FUS3
Protein
Mitogen-activated protein kinase FUS3
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
353 amino acids
Function
Together with closely related KSS1, FUS3 is the final kinase in the signal transduction cascade regulating activation/repression of the mating and filamentation pathways, induced by pheromone and nitrogen/carbon limitation, respectively. Phosphorylated FUS3 activates the mating but suppresses the filamentation pathway, whereas activated KSS1 activates both pathways. Pheromone-activated FUS3 functions by inhibiting the binding of the transcriptional activator STE12 to filamentation specific genes while inducing its binding to and activity at mating specific genes. Non-activated FUS3 has a repressive effect on STE12 transcriptional activity. KSS1 can partially compensate for the lack of FUS3 but mating efficiency is reduced and the filamentation program is partially activated upon pheromone signaling. FUS3 phosphorylates STE7, STE5, FAR1, DIG1, DIG2 and STE12.
Similarity
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
Mass
40.772 kDa
Sequence
MPKRIVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQMLSDDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRITAKEALEHPYLQTYHDPNDEPEGEPIPPSFFEFDHYKEALTTKDLKKLIWNEIFS

Gene
FUS3
Protein
B3 domain-containing transcription factor FUS3
Organism
Arabidopsis thaliana
Length
313 amino acids
Function
Transcription regulator involved in gene regulation during late embryogenesis. Its expression to the epidermis is sufficient to control foliar organ identity by regulating positively the synthesis abscisic acid (ABA) and negatively gibberellin production. Negatively regulates TTG1 in the embryo. Positively regulates the abundance of the ABI3 protein in the seed. Cooperates with KIN10 to regulate developmental phase transitions and lateral organ development and act both as positive regulators of abscisic acid (ABA) signaling during germination (PubMed:22026387, PubMed:22902692).
Mass
35.616 kDa
Sequence
MMVDENVETKASTLVASVDHGFGSGSGHDHHGLSASVPLLGVNWKKRRMPRQRRSSSSFNLLSFPPPMPPISHVPTPLPARKIDPRKLRFLFQKELKNSDVSSLRRMILPKKAAEAHLPALECKEGIPIRMEDLDGFHVWTFKYRYWPNNNSRMYVLENTGDFVNAHGLQLGDFIMVYQDLYSNNYVIQARKASEEEEVDVINLEEDDVYTNLTRIENTVVNDLLLQDFNHHNNNNNNNSNSNSNKCSYYYPVIDDVTTNTESFVYDTTALTSNDTPLDFLGGHTTTTNNYYSKFGTFDGLGSVENISLDDFY

Gene
FUS3
Protein
Glutathione S-transferase-like protein FUS3
Organism
Gibberella moniliformis (strain M3125 / FGSC 7600)
Length
220 amino acids
Function
Glutathione S-transferase-like protein; part of the gene cluster that mediates the biosynthesis of the mycotoxin fusarin C (PubMed:22652150). Within the cluster, FUS1, FUS2, FUS8 and FUS9 are sufficient for fusarin production (By similarity). The other FUS cluster members are not essential for fusarin C biosynthesis (By similarity).
Similarity
Belongs to the GST superfamily.
Mass
24.372 kDa
Sequence
MTSFGTLYTYMPNARVFKILAAAKLNNLIIEIPAYQHGVTNKSAEFLSKFPAGKVPAFEGPDGFCLVESDAIAQYVAQSGPQASQLLGQDAMSSAKIRQWISFFAEEIYPTVLDLVMWRVGLGAFDETTEIKALAQLAYGLSVLEKHLNPGILLTGDELTLADLTGASTLLWAFMHIIDEPMRQQYPNVVAWYLKVVQNEEVKEVFGKPNLIEKRRIGAK

Gene
FUS3
Protein
Glutathione S-transferase-like protein FUS3
Organism
Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)
Length
210 amino acids
Function
Glutathione S-transferase-like protein; part of the gene cluster that mediates the biosynthesis of the mycotoxin fusarin C (PubMed:23932525). Within the cluster, FUS1, FUS2, FUS8 and FUS9 are sufficient for fusarin production (PubMed:23932525). The other FUS cluster members are not essential for fusarin C biosynthesis (PubMed:23932525).
Similarity
Belongs to the GST superfamily.
Mass
23.16 kDa
Sequence
MPNARVFKILAAAKLNNIALEIPAYQHGVTNKSAEFLLKFPAGKVPAFEGPDGFCLVESDAIAQYVAQSGPQASQLLGQDAMSSAKIRQWISFFAEEIYPTVLDLVMWRVGLGAFDETTETKALTQLVYGLSVLEKHLGTGALLVGDKLTLADLTGASTLLWAFMHIVDEPMRQQYPNVVAWYLKVVQNEEVEEVFGKPNFIEKRRLGAK