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FRZB

Gene
FRZB
Protein
Secreted frizzled-related protein 3
Organism
Bos taurus
Length
325 amino acids
Function
Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development.
Similarity
Belongs to the secreted frizzled-related protein (sFRP) family.
Mass
36.234 kDa
Sequence
MVCGSRGGMLLLPAGLLALAALCLLRVPGARAAACEPVRIPLCKSLPWNMTKMPNHLHHSTQANAILAIEQFEGLLGTHCSPDLLFFLCAMYAPICTIDFQHEPIKPCKSVCERARQGCEPILIKYRHSWPESLACEELPVYDRGVCISPEAIVTADGADFPMDSSNGNCRGASSERCKCKPVRATQKTYFRNNYNYVIRAKVKEIKTKCHDVTAVVEVKEILKASLVNIPRETVNLYTSSGCLCPPLNVNEEYLIMGYEDEERSRLLLVEGSIAEKWKDRLGKKVKRWDMKLRHLGLNTSDSSHSDSTQSQKPGRNSNSRQARN
Protein
Secreted frizzled-related protein 3: FRZB

Gene
FRZB
Protein
Secreted frizzled-related protein 3
Organism
Homo sapiens
Length
325 amino acids
Function
Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development.
Similarity
Belongs to the secreted frizzled-related protein (sFRP) family.
Mass
36.254 kDa
Sequence
MVCGSPGGMLLLRAGLLALAALCLLRVPGARAAACEPVRIPLCKSLPWNMTKMPNHLHHSTQANAILAIEQFEGLLGTHCSPDLLFFLCAMYAPICTIDFQHEPIKPCKSVCERARQGCEPILIKYRHSWPENLACEELPVYDRGVCISPEAIVTADGADFPMDSSNGNCRGASSERCKCKPIRATQKTYFRNNYNYVIRAKVKEIKTKCHDVTAVVEVKEILKSSLVNIPRDTVNLYTSSGCLCPPLNVNEEYIIMGYEDEERSRLLLVEGSIAEKWKDRLGKKVKRWDMKLRHLGLSKSDSSNSDSTQSQKSGRNSNPRQARN
Protein
Secreted frizzled-related protein 3: FRZB

Gene
FRZB
Protein
Secreted frizzled-related protein 3
Organism
Pongo abelii
Length
325 amino acids
Function
Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development (By similarity).
Similarity
Belongs to the secreted frizzled-related protein (sFRP) family.
Mass
36.254 kDa
Sequence
MVCGSPGGMLLLRAGLLALAALCLLRVPGARAAACEPVRIPLCKSLPWNMTKMPNHLHHSTQANAILAIEQFEGLLGTHCSPDLLFFLCAMYAPICTIDFQHEPIKPCKSVCERARQGCEPILIKYRHSWPENLACEELPVYDRGVCISPEAIVTADGADFPMDSSNGNCRGASSERCKCKPIRATQKTYFRNNYNYVIRAKVKEIKTKCHDVTAVVEVKEILKSSLVNIPRDTVNLYTSSGCLCPPLNVNEEYIIMGYEDEERSRLLLVEGSIAEKWKDRLGKKVKRWDMKLRHLGLSKSDSSNSDSTQSQKSGRNSNPRQARN
Protein
Secreted frizzled-related protein 3: FRZB

Gene
Frzb
Protein
Secreted frizzled-related protein 3
Organism
Mus musculus
Length
323 amino acids
Function
Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development (By similarity).
Similarity
Belongs to the secreted frizzled-related protein (sFRP) family.
Mass
36.011 kDa
Sequence
MVCCGPGRMLLGWAGLLVLAALCLLQVPGAQAAACEPVRIPLCKSLPWNMTKMPNHLHHSTQANAILAMEQFEGLLGTHCSPDLLFFLCAMYAPICTIDFQHEPIKPCKSVCERARQGCEPILIKYRHSWPESLACDELPVYDRGVCISPEAIVTADGADFPMDSSTGHCRGASSERCKCKPVRATQKTYFRNNYNYVIRAKVKEVKMKCHDVTAVVEVKEILKASLVNIPRDTVNLYTTSGCLCPPLTVNEEYVIMGYEDEERSRLLLVEGSIAEKWKDRLGKKVKRWDMKLRHLGLGKTDASDSTQNQKSGRNSNPRPARS
Protein
Secreted frizzled-related protein 3: Frzb

Gene
FRZB
Protein
Secreted frizzled-related protein 3
Organism
Gallus gallus
Length
315 amino acids
Function
Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development.
Similarity
Belongs to the secreted frizzled-related protein (sFRP) family.
Mass
35.004 kDa
Sequence
MWRGLPALALAALLLLGRAPAGRAAACEPVRIPLCKPLPWNMTKMPNHLHHSTQANAVLAMEQFEGLLGTNCSPDLLFFLCAMYAPICTIDFQHEPIKPCKSVCERARAGCEPVLIRYRHAWPESLACDELPLYDRGVCISPEAIVTAEGADFPMDSNNGNCRGTGIERCKCKPIKATQKTYLRNNYNYVIRAKVKEVKTKCHDVTAVVEVKEILKSSLVNIPKDTVNLYTNSGCLCPPLSANEEYIIMGYEDEERSRLLLVEGSIAEKWKDRLGKKVKRWDQKLRHLGKGKGEPGQSDSALKTGKPGNARQTRS
Protein
Secreted frizzled-related protein 3: FRZB

Gene
frzB
Protein
Frizzy aggregation protein FrzB
Organism
Myxococcus xanthus
Length
112 amino acids
Function
Necessary for proper aggregation of cells to form fruiting bodies. FRZ genes define a system of signal transduction analogous to the enterobacterial chemotaxis systems.
Mass
12.115 kDa
Sequence
MDLLFFDIGATLYGTDASQVLRIDRALPEDLTLAELGLPHRGNRAIVFDTPEGEAHLKVDAVHGVRSIPVNSLRRMPPTAGAAAYAVGVCLEEARTVLLIDLVETARTQGRH
Protein
Frizzy aggregation protein FrzB: frzB