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FMO3

Gene
Fmo3
Protein
Dimethylaniline monooxygenase [N-oxide-forming] 3
Organism
Mus musculus
Length
534 amino acids
Function
Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds. Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite. TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thrombus formation.
Similarity
Belongs to the FMO family.
Mass
60.516 kDa
Sequence
MKKKVAIIGAGVSGLAAIRSCLEEGLEPTCFERSDDVGGLWKFSDHIEEGRASIYQSVFTNSSKEMMCFPDFPYPDDFPNFMHHSKLQEYITSFAKEKNLLKYIQFETPVTSINKCPNFSTTGKWEVTTEKHGKKETAVFDATMICSGHHIFPHVPKDSFPGLNRFKGKCFHSRDYKEPGIWKGKRVLVIGLGNSGCDIAAELSHVAQKVTISSRSGSWVMSRVWDDGYPWDMVVLTRFQTFLKNNLPTAISDWWYTRQMNARFKHENYGLVPLNRTLRKEPVFNDELPARILCGMVTIKPNVKEFTETSAVFEDGTMFEAIDCVIFATGYGYAYPFLDDSIIKSRNNEVTLYKGVFPPQLEKPTMAVIGLVQSLGATIPITDLQARWAAQVIKGTCTLPSVNDMMDDIDEKMGEKFKWYGNSTTIQTDYIVYMDELASFIGAKPNLLWLFLKDPRLAVEVFFGPCSPYQFRLVGPGKWSGARNAILTQWDRSLKPMKTRVVSKVQKSCSHFYSRLLRLLAVPVLLIALFLVLI
Protein
Dimethylaniline monooxygenase [N-oxide-forming] 3: Fmo3

Gene
FMO3
Protein
Dimethylaniline monooxygenase [N-oxide-forming] 3
Organism
Bos taurus
Length
532 amino acids
Function
Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds. Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite. TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thrombus formation.
Similarity
Belongs to the FMO family.
Mass
60.093 kDa
Sequence
MVKKVAIIGAGISGLASIRNCLEEGLEPTCFEKGEDIGGLWKFSDHVEEGRASIYRSVFTNSSKEMTCFPDFPFPDDFPNFMHNSKLQEYITMFAKEKNLLKYIQFKTIVSSVNKRPDFQTTGQWDVITEKDGKKESAVFDAVMICSGHHVYPNIPKESFPGIKLFKGKCFHSRDYKEPGIFKGKRVLVIGLGNSGCDIASELSHIAEKVIISSRSGSWVMSRVWDEGYPWDMLFITRFETFLKNTLPTVISNWWYMKQMNARFKHENYGLMPLNSTLRKEPVFNDELPACILCGIVTIKPNVKEFTEDSAIFEDGTVFKAIDYVIFATGYSYAYPFLDDSIIKSRDNEVTLFKGIFPPPLEKPTLAVIGLVQSLGAAIPTTDLQSRWAVQVIKGTCPLPSVKDMMNDIDEKMGKKLKLFGKSDTIQTDYVVYMDELASFIGAKPNIPWLFLTDPKLALEVYFGPCTPYQFRLVGPGKWPGARNAILTQWDRLLKPMTTRVVGSPLKPCLFCNWFRPVLISVVSIAALIVLF
Protein
Dimethylaniline monooxygenase [N-oxide-forming] 3: FMO3

Gene
FMO3
Protein
Dimethylaniline monooxygenase [N-oxide-forming] 3
Organism
Canis lupus familiaris
Length
532 amino acids
Function
Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds. Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite. TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thrombus formation.
Similarity
Belongs to the FMO family.
Mass
60.07 kDa
Sequence
MGKRVAIIGAGVSGLASIRSCLEEGLEPTCFERSEDIGGLWKFSEHAEEGRASIYQSVFTNSSKEMMCFPDFPYPDDFPNFMHNSKLQEYITVFSKEKNLLKYIQFKTLVCSVNKRPDFSVSGQWDITTERDGKRESATFDAVLICSGHHVYPNLPEESFPGLKLFKGKCFHSREYKEPGIFKGKRVLVIGLGNSGCDIATELSHTAEQVIISSRSGSWVMSRVWDDGYPWDMMFITRFETFLKNSLPTIISDWWYMKQMNARFKHENYGLMPLNGTLRKEPVFNDELPACILCGTVSIKPNVKAFTETSAIFEDGTVFEAIDCVIFATGYNYAYPFLDESIIKSKNNEITLFKGIFPPKLEKPTMAVIGFVQSLGATIPTTDLQARWAVQVIKGTCTLPSVTDMMNDIDKKREGKLKWFGTSETVQTDYISYMDELASFIGAKPNIPWLFLTDPKLAVEVFFGPCSPYQFRLVGPGKWPGARNAILTQWDRTLKPMKTRAVGNPQKPCMLCHLVKLFVLPVLFIAVFLALI
Protein
Dimethylaniline monooxygenase [N-oxide-forming] 3: FMO3

Gene
FMO3
Protein
Dimethylaniline monooxygenase [N-oxide-forming] 3
Organism
Homo sapiens
Length
532 amino acids
Function
Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds (PubMed:10759686, PubMed:30381441). Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite (PubMed:9776311). TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thrombus formation (PubMed:29981269).
Similarity
Belongs to the FMO family.
Mass
60.033 kDa
Sequence
MGKKVAIIGAGVSGLASIRSCLEEGLEPTCFEKSNDIGGLWKFSDHAEEGRASIYKSVFSNSSKEMMCFPDFPFPDDFPNFMHNSKIQEYIIAFAKEKNLLKYIQFKTFVSSVNKHPDFATTGQWDVTTERDGKKESAVFDAVMVCSGHHVYPNLPKESFPGLNHFKGKCFHSRDYKEPGVFNGKRVLVVGLGNSGCDIATELSRTAEQVMISSRSGSWVMSRVWDNGYPWDMLLVTRFGTFLKNNLPTAISDWLYVKQMNARFKHENYGLMPLNGVLRKEPVFNDELPASILCGIVSVKPNVKEFTETSAIFEDGTIFEGIDCVIFATGYSFAYPFLDESIIKSRNNEIILFKGVFPPLLEKSTIAVIGFVQSLGAAIPTVDLQSRWAAQVIKGTCTLPSMEDMMNDINEKMEKKRKWFGKSETIQTDYIVYMDELSSFIGAKPNIPWLFLTDPKLAMEVYFGPCSPYQFRLVGPGQWPGARNAILTQWDRSLKPMQTRVVGRLQKPCFFFHWLKLFAIPILLIAVFLVLT
Protein
Dimethylaniline monooxygenase [N-oxide-forming] 3: FMO3

Gene
FMO3
Protein
Dimethylaniline monooxygenase [N-oxide-forming] 3
Organism
Macaca mulatta
Length
532 amino acids
Function
Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds. Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite. TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thrombus formation.
Similarity
Belongs to the FMO family.
Mass
60.152 kDa
Sequence
MGKKVAIIGAGVSGLASIRSCLEEGLEPTCFEKSNDIGGLWKFSDHAEEGRASIYKSVFTNSSKEMMCFPDFPYPDDFPNFMHNSKIQEYLTAFAKEKSLLKYIQFKTFVSSVNKRPDFATTGQWDVTTERDGKRESAVFDAVMVCSGHHVYPNLPKESFPGLNHFKGKCFHSRDYKEPGVFKGKRVLVVGLGNSGCDIATELSHTAEQVVISSRSGSWVMSRVWDNGYPWDMVLITRFGTFLKNNLPTAISDWLYMKQMNARFKHENYGLMPLNGVLRKEPVFNDELPACILCGIVSVKPNVKKFTETSAIFEDGTTFEGIDCVIFATGYSYTYTFLDESIIKNRNNEIILFKGVFPPLLEKSTIAVIGFVQSLGAAIPTVDLQSRWAARVIKGTCTLPSMEDMMNDINEKMERKHKWYGKSETLQTDYIVYMDELSSFIGVKPNIPWLFLTDPKLAMEVYFGPCSPYQFRLVGPGKWPGARNAILTQWDRSLKPLQTRVVGRLQKPCFFFHWLKPFAIPILLIAVFLGLT
Protein
Dimethylaniline monooxygenase [N-oxide-forming] 3: FMO3

Gene
FMO3
Protein
Dimethylaniline monooxygenase [N-oxide-forming] 3
Organism
Pan troglodytes
Length
532 amino acids
Function
Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds. Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite. TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thrombus formation.
Similarity
Belongs to the FMO family.
Mass
60.052 kDa
Sequence
MGKKVAIIGAGVSGLASIRSCLEEGLEPTCFEKSNDIGGLWKFSDHAEEGRASIYKSVFSNSSKEMMCFPDFPFPDDFPNFMHNSKIQEYIIAFAKEKNLLKYIQFKTFVSSVNKRPDFATTGQWDVTTERDGKKESAVFDAVMVCSGHHVYPNLPKESFPGLNHFKGKCFHSRDYKEPGVFNGKRVLVVGLGNSGCDIATELSRTAEQVMISSRSGSWVMSRVWDNGYPWDMLLVTRFGTFLKNNLPTAISDWLYVKQMNARFKHENYGLMPLNGVLRKEPVFNDELPASILCGIVSVKPNVKEFTETSAIFEDGTIFEGIDCVIFATGYSFAYPFLDESIIKSRNNEIILFKGVFPPLLEKSTIAVIGFVQSLGAAIPTVDLQSRWAAQVIKGTCTLPSMEDMMNDINEKMEKKRKWFGKSETIQTDYIVYMDELSSFIGAKPNIPWLFLTDPKLAMEVYFGPCSPYQFRLVGPGQWPGARNAILTQWDRSLKPMQTRVVGRLQKPCFFFHWLKLFAIPILLIAVFLVLT
Protein
Dimethylaniline monooxygenase [N-oxide-forming] 3: FMO3

Gene
FMO3
Protein
Dimethylaniline monooxygenase [N-oxide-forming] 3
Organism
Oryctolagus cuniculus
Length
531 amino acids
Function
Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds. Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite. TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thrombus formation.
Similarity
Belongs to the FMO family.
Mass
59.815 kDa
Sequence
MGKKVAIIGAGISGLASIRSCLEEGLEPTCFEMSDDIGGLWKFSDHAEEGRASIYQSVFTNSSKEMMCFPDFPFPDDFPNFMHNSKLQEYITTFAREKNLLKYIQFKTLVSSIKKHPDFSVTGQWYVSTERNGKKETAVFDAVMICSGHHVYPNLPKDSFPGLKHFKGKSFHSREYKEPGIFKGKRVLVIGLGNSGCDIATELSHTAEQVVISSRSGSWVMSRVWDDGYPWDMLYVTRFQTFLKNNLPTAISDWWYVKQMNAKFKHENYSLMPLNGTLRKEPVFNDDLPARILCGTVSIKPNVKEFTETSAIFEDGTVFEAIDSVIFATGYGYAYPFLDDSIIKSENNKVTLFKGIFPPQLEKPTMAVIGLVQSLGAAIPTTDLQARWAAQVIKGTCTLPPVKDMMNDIHEKMGTKLKWFGKSETIQTDYINYMDELASFIGVKLNIPWLFLTDPRLALEVFFGPCSPYQFRLVGPGKWPGARQAILTQWDRSLKPMKTRAVGHLQKPALFSPWLKLLAIAVLLIAAVLVF
Protein
Dimethylaniline monooxygenase [N-oxide-forming] 3: FMO3

Gene
Fmo3
Protein
Dimethylaniline monooxygenase [N-oxide-forming] 3
Organism
Rattus norvegicus
Length
531 amino acids
Function
Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds. Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite. TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thrombus formation.
Similarity
Belongs to the FMO family.
Mass
59.96 kDa
Sequence
MKRKVAVIGAGVSGLAAIRSCLEEGLEPTCFERSDDVGGLWKFSDHTEEGRASIYQSVFTNSSKEMMCFPDFPYPDDFPNFMHNSKLQEYITSFATEKNLLKYIQFETLVTRINKCPDFSTTGKWEVTTEKNSKKETAVFDAVMICSGHHVYPHLPKDSFPGLNRFKGKCFHSRDYKEPGTWKGKRVLVIGLGNSGCDIAAELSHVAQQVIISSRSGSWVMSRVWNDGYPWDMVVITRFQTFLKNNLPTAISDWWYMKQMNARFKHENYGLMPLNGTLRKEPVFNDELPARILCGTVSIKPNVKEFTETSAVFEDGTVFEGIDCVIFATGYGYAYPFLDDSIIKSRNNEVTLYKGIFPPQLEKPTMAVIGLVQSLGAAIPTTDLQARWAAQVIRGTCILPSVNDMMDDIDEKMGKKLKWFGNSTTIQTDYIVYMDELASFIGAKPNILWLFLKDPRLAIEVFFGPCSPYQFRLVGPGKWSGARNAILTQWDRSLKPMKTRVVGGIQKPCLYSHFLRLLAVPVLIALFLVLI
Protein
Dimethylaniline monooxygenase [N-oxide-forming] 3: Fmo3