FIGL1

ATPase family AAA domain-containing protein FIGL1

680 amino acids

Involved in DNA double-strand break (DBS) repair via homologous recombination (HR). Limits class II meiotic crossover (CO) formation by regulating the invasion step of meiotic HR. May counteract DMC1 and RAD51-mediated inter-homolog strand invasion to limit CO formation. Functions independently of FANCM.

Belongs to the AAA ATPase family.

75.348 kDa

MCGSVVSDSEREFEFHFWGFGHLGKEEERIMAGKRSSPFSSPLLRPPPEFLNVKEEGETETPCWRKEVDENLKRLQSLLFGADKFLEKSDFSSAQILGLRLLGFLDSRSVTDADRDFIGPIRREVASKIDLALEGLVSDSDRKAFELANTAPGAIFGSKGGFDVEKIKQSKYFGFHVSQSNGKGVKEMEERHDTDKLIPKAPKSMMQAKLTSLYGNSIGKPDNQRKTSVNNQDRASDECVIVERSHGFGFGTKRPHAETSSLANDGEVKEDGAPNGFVSAKIKLEMDVRQKRGSTESPSSCLSPQSDKNALGRGYGSRSGGLRRGYRSNFVPPVKTNGNNVGNLTSRIGGKTDDALDDSTRTCLEMLCGPDGELPEKLRNLEPRLIEHVSNEIMDRDPNVRWDDIAGLEHAKKCVTEMVIWPLLRPDIFKGCRSPGKGLLLFGPPGTGKTMIGKAIAGEAKATFFYISASSLTSKWIGEGEKLVRALFGVASCRQPAVIFVDEIDSLLSQRKSDGEHESSRRLKTQFLIEMEGFDSGSEQILLIGATNRPQELDEAARRRLTKRLYIPLPSSEARAWIIQNLLKKDGLFTLSDDDMNIICNLTEGYSGSDMKNLVKDATMGPLREALKRGIDITNLTKDDMRLVTLQDFKDALQEVRPSVSQNELGIYENWNNQFGSLSL