Involved in DNA double-strand break (DBS) repair via homologous recombination (HR). Limits class II meiotic crossover (CO) formation by regulating the invasion step of meiotic HR. May counteract DMC1 and RAD51-mediated inter-homolog strand invasion to limit CO formation. Functions independently of FANCM.

Belongs to the AAA ATPase family.

680 amino acids

MCGSVVSDSEREFEFHFWGFGHLGKEEERIMAGKRSSPFSSPLLRPPPEFLNVKEEGETETPCWRKEVDENLKRLQSLLFGADKFLEKSDFSSAQILGLRLLGFLDSRSVTDADRDFIGPIRREVASKIDLALEGLVSDSDRKAFELANTAPGAIFGSKGGFDVEKIKQSKYFGFHVSQSNGKGVKEMEERHDTDKLIPKAPKSMMQAKLTSLYGNSIGKPDNQRKTSVNNQDRASDECVIVERSHGFGFGTKRPHAETSSLANDGEVKEDGAPNGFVSAKIKLEMDVRQKRGSTESPSSCLSPQSDKNALGRGYGSRSGGLRRGYRSNFVPPVKTNGNNVGNLTSRIGGKTDDALDDSTRTCLEMLCGPDGELPEKLRNLEPRLIEHVSNEIMDRDPNVRWDDIAGLEHAKKCVTEMVIWPLLRPDIFKGCRSPGKGLLLFGPPGTGKTMIGKAIAGEAKATFFYISASSLTSKWIGEGEKLVRALFGVASCRQPAVIFVDEIDSLLSQRKSDGEHESSRRLKTQFLIEMEGFDSGSEQILLIGATNRPQELDEAARRRLTKRLYIPLPSSEARAWIIQNLLKKDGLFTLSDDDMNIICNLTEGYSGSDMKNLVKDATMGPLREALKRGIDITNLTKDDMRLVTLQDFKDALQEVRPSVSQNELGIYENWNNQFGSLSL

75.3 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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