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FABP5

Gene
FABP5
Protein
Fatty acid-binding protein 5
Organism
Bos taurus
Length
135 amino acids
Function
Intracellular carrier for long-chain fatty acids and related active lipids, such as the endocannabinoid, that regulates the metabolism and actions of the ligands they bind. In addition to the cytosolic transport, selectively delivers specific fatty acids from the cytosol to the nucleus, wherein they activate nuclear receptors (By similarity). Delivers retinoic acid to the nuclear receptor peroxisome proliferator-activated receptor delta; which promotes proliferation and survival. May also serve as a synaptic carrier of endocannabinoid at central synapses and thus controls retrograde endocannabinoid signaling. Modulates inflammation by regulating PTGES induction via NF-kappa-B activation, and prostaglandin E2 (PGE2) biosynthesis during inflammation (By similarity).
Similarity
Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
Mass
15.074 kDa
Sequence
MATVQQLVGRWRLVESKGFDEYMKEVGVGMALRKVGAMAKPDCIITSDGKNLSIKTESTLKTTQFSCKLGEKFEETTADGRKTQTVCNFTDGALVQHQEWDGKESTITRKLEDGKLVVVCVMNNVTCTRVYEKVE

Gene
FABP5
Protein
Fatty acid-binding protein 5
Organism
Homo sapiens
Length
135 amino acids
Function
Intracellular carrier for long-chain fatty acids and related active lipids, such as the endocannabinoid, that regulates the metabolism and actions of the ligands they bind. In addition to the cytosolic transport, selectively delivers specific fatty acids from the cytosol to the nucleus, wherein they activate nuclear receptors (PubMed:22170058). Delivers retinoic acid to the nuclear receptor peroxisome proliferator-activated receptor delta; which promotes proliferation and survival. May also serve as a synaptic carrier of endocannabinoid at central synapses and thus controls retrograde endocannabinoid signaling. Modulates inflammation by regulating PTGES induction via NF-kappa-B activation, and prostaglandin E2 (PGE2) biosynthesis during inflammation (By similarity). May be involved in keratinocyte differentiation (PubMed:8092987).
Similarity
Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
Mass
15.164 kDa
Sequence
MATVQQLEGRWRLVDSKGFDEYMKELGVGIALRKMGAMAKPDCIITCDGKNLTIKTESTLKTTQFSCTLGEKFEETTADGRKTQTVCNFTDGALVQHQEWDGKESTITRKLKDGKLVVECVMNNVTCTRIYEKVE

Gene
Fabp5
Protein
Fatty acid-binding protein 5
Organism
Mus musculus
Length
135 amino acids
Function
Intracellular carrier for long-chain fatty acids and related active lipids, such as the endocannabinoid, that regulates the metabolism and actions of the ligands they bind (PubMed:8608126, PubMed:12540600). In addition to the cytosolic transport, selectively delivers specific fatty acids from the cytosol to the nucleus, wherein they activate nuclear receptors (By similarity). Delivers retinoic acid to the nuclear receptor peroxisome proliferator-activated receptor delta; which promotes proliferation and survival (PubMed:17512406). May also serve as a synaptic carrier of endocannabinoid at central synapses and thus controls retrograde endocannabinoid signaling (PubMed:29531087). Modulates inflammation by regulating PTGES induction via NF-kappa-B activation, and prostaglandin E2 (PGE2) biosynthesis during inflammation (PubMed:29440395). May be involved in keratinocyte differentiation (By similarity).
Similarity
Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
Mass
15.137 kDa
Sequence
MASLKDLEGKWRLMESHGFEEYMKELGVGLALRKMAAMAKPDCIITCDGNNITVKTESTVKTTVFSCNLGEKFDETTADGRKTETVCTFQDGALVQHQQWDGKESTITRKLKDGKMIVECVMNNATCTRVYEKVQ

Gene
Fabp5
Protein
Fatty acid-binding protein 5
Organism
Rattus norvegicus
Length
135 amino acids
Function
Intracellular carrier for long-chain fatty acids and related active lipids, such as the endocannabinoid, that regulates the metabolism and actions of the ligands they bind. In addition to the cytosolic transport, selectively delivers specific fatty acids from the cytosol to the nucleus, wherein they activate nuclear receptors (By similarity). Delivers retinoic acid to the nuclear receptor peroxisome proliferator-activated receptor delta; which promotes proliferation and survival. May also serve as a synaptic carrier of endocannabinoid at central synapses and thus controls retrograde endocannabinoid signaling. Modulates inflammation by regulating PTGES induction via NF-kappa-B activation, and prostaglandin E2 (PGE2) biosynthesis during inflammation (By similarity).
Similarity
Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
Mass
15.059 kDa
Sequence
MASLKDLEGKWRLVESHGFEDYMKELGVGLALRKMGAMAKPDCIITLDGNNLTVKTESTVKTTVFSCTLGEKFDETTADGRKTETVCTFTDGALVQHQKWEGKESTITRKLKDGKMVVECVMNNAICTRVYEKVQ

Gene
FABP5
Protein
Fatty acid-binding protein 5
Organism
Pygoscelis papua
Length
134 amino acids
Function
Intracellular carrier for long-chain fatty acids and related active lipids, such as the endocannabinoid, that regulates the metabolism and actions of the ligands they bind. In addition to the cytosolic transport, selectively delivers specific fatty acids from the cytosol to the nucleus, wherein they activate nuclear receptors (By similarity). Delivers retinoic acid to the nuclear receptor peroxisome proliferator-activated receptor delta; which promotes proliferation and survival. May also serve as a synaptic carrier of endocannabinoid at central synapses and thus controls retrograde endocannabinoid signaling. Modulates inflammation by regulating PTGES induction via NF-kappa-B activation, and prostaglandin E2 (PGE2) biosynthesis during inflammation (By similarity). Has the highest binding affinity for docosahexaenoic acid (DHA) and decreasing relative affinity for eicosapentaenoic acid (EPA), alpha-linolenic acid (ALA), oleic acid, palmitic acid, linoleic acid and stearic acid, respectively (PubMed:26206084).
Similarity
Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
Mass
15.107 kDa
Sequence
MAIDAFLGKWCLISSEGFDEYMKELGVGMAMRKMGSMAKPDVYIIKDGDTITVKTESTFKTSQFSFKLGEKFEENTLDGRKTQTLVSLKDDGSLIQEQEWDGKKTIITRKLVDGQLVVECDMNGIKCVRVYQKA