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Dhc1

Gene
DHC1
Protein
Dynein-1-alpha heavy chain, flagellar inner arm I1 complex
Organism
Chlamydomonas reinhardtii
Length
4625 amino acids
Function
Force generating protein of eukaryotic cilia and flagella. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required for assembly of the I1 inner arm complex and its targeting to the appropriate axoneme location. Also required for phototaxis.
Similarity
Belongs to the dynein heavy chain family.
Mass
522.843 kDa
Sequence
MDRRLEWVKEKACLGLGVEPNLFEAAIANPESRARVTAFLDGTVTSSALLFALEEATIYVEEYQEVLAEEQAPEAEDGEGEEHDGQEPGEAGGEGAEGSTAPGDSGDGQPEDAPAAAAEANGANPEDEAAAPADGAADGAAGEGGEEGDGAEGDEPPAPPAPKYVRRVISVPKVVSKLNVALGSLPEELSVFPVFYFILNRSGHVAAEELDSAVEFGLLSEGPSLRILEQMLSSVFVPILVQMSGGDVASGGVLMQSMTDNSHRELLGNMQKFHSQVTQALQQLTGDVTLQLPDFPLEDMDRAAADTDLVMQLEQYMAEWSQVLASVLQRESQKHPTGKGPLAEIEFWRERNAVLSSLYEQLNLPQVKRMILVVEKGSDDRNLMAGFKSQLGELTKLATEARDNVKFLTTLERHFKNIATGPLGGILDTLPPMMNALRMVWIISRHYSDDQRMGSLFQRIAREIGDRVEAAVDLRHIFRMTSADAVELLKVCKSVLEHWLQTYMAMREKIELSGRDARWEFPKQLLFARTNYMAEICTDLIEMVEIVDDFFRFLGPELKTVTGDTAGIDRVVHRVVAMYEPIESISFNVFDYGNQHEWKAAKQQFYADNEDIKEATRELIDTSFRKLRSAEGACELLQSFKSIKSKGAIQKQVMNKFNDILEQFAREIEQTADIFERNKDAPPVTKNQPPVAGAIKWVRSLLERLKRTMAKLLSTEEEIIRTTELGQAVESKFKSFARSVMLTEKKWFSSWSDSINGVAMQHLKQTIFRRSAATNRVEVNFHPDLVRLIRETRYLDRMGFPIPEIALNVALQEDKFLQWLEGLNSMLFKYYESIDQLTPVERELMERKLEELESCLQPGFTILNWNSLGITEFIGTCDKAIATFQQLVKQVQKNSGIIEQVVYAIAGAQLVTEPEEGAEVMDLQEFYEDIERQRLAALESLVKKYRTISPLLGKIEEVVAGTNSGKSPALSSYYSFWERAIFNALNTMVLCAMTKLQDMIEQRSKHAEGGRKPPLFKVTVSLQSVDVVVQPPMTEVNKALGRLVRSLVESTKAFVRWMDGTCVETPEQRGATDDDEPIVFTFYWDVAANPQVIKTMLNLNQSIQRAITSVNKYAESWRRHQALWKTDKNSVLDKFKARDPSAAQFEDKLSKYAKMATEISAQAKDFDQDFIRVSCHALASSVCDEAQAWVRAIAQTMRELDAVTESQLRDKIAKYQTALHRPPDTLEELKQVLNTVNTIRGESMVMELRYADLEERYRTRLLYATNPEEESQCAHELASASQVRALWTELLNEAEAVDWSLEETKKKFSETTRSQVSDFAAITAELWEKFRTTGPGLPTVELASGLDELHKYESNLADALRQREQLVLAEKLFGMEITAYPELAQLESEIRKLAQVYGVYAEHAEAVRQYGGQLWSELDVGKMMAGTEAILTKLRKLKSLKLLPVYELVEKEIQGFYNSLPLMKELKSEALRKRHWTRLMEVTGQEFDMDPKTFTLGNMFAMQLHKYAEEIGKITNAAVKELTIESEIRKLADVWREQRFELGKYMKGPEDRGWVLRSTEDILVLLEDMGLNLQSMMASPFVRPFLTEVRAWEQKLSLIGECIEVWMHVQRKWMYLESIFVGSDDIRHQLPAEAKRFDNIDRQWQKIMNDTAKNTVVLDACMADGRLDLLKSLSEQLEVCQKSLSEYLDTKRCAFPRFYFISDDELLSILGTSDPTSVQEHMLKLFDNCAALVFGRGNKTITGMVSSEKEGFEFRNVVPIEGAVELWMTNVEAEMRKTLYQITKEGIFFYAKTPRTKWISENLGMVTLVGSQIWWTWETEDVFRRVRDGNKHSMKEFAAKLTGQLSELTSMVRSDLSNEVRKKVNTLIIIDVHARDIIDTYVRDSIVDAREFAWESQLRFYWDRQQDDILIRQCTGLFKYGYEYMGLNGRLVITALTDRCYMTLTTALTYRLGGAPAGPAGTGKTETTKDLAKSMALLCVVFNCGEGLDYKAMGSIFSGLVQCGAWGCFDEFNRIEAEVLSVVSSQIKNIQEALKNDLTRFQFEGKEISIDPRTGIFITMNPGYAGRTELPDNLKALFRPVTMVVPDLEQICEIMLFSEGFDSAKVLAKKMTVLYKLSREQLSKQHHYDFGLRALKSVLVMAGSLKRGAPDMSEQLVLMRALRDMNLPKFIFDDVPLFLGLINDLFPGMDCPRVRYPQFNDVVEADLADQGFKVLTEPSEQVDKVVQLYEVMMTRHTTMVVGQTGGGKTVILNTLARAQTKLGKKTHLYTINPKAISVAELYGVLDKDTRDWTDGLLSNIFREMNKPLPAERDEARYLVFDGDVDAVWVENMNSVMDDNKLLTLPNGERIRLQNHCKLLFEVFDLQYASPATISRCGMVYVDSRNLGYKPYIYTWLNSRAKQAEVDILRGLFEKYAVPSVDWILEGIDGEELVRRPKQAVPVTNLNMITQLCNLLNATITDHPRMSDPQILEAIFIFCTIWSLGAAIVQRPESPDRDRFDAFVKHIASMGLVDGERVAATQLPARSLYEYCFDTNEGVWKSWRSYLQPYEPPADGAFAKILVPTVDVVRSTWLLNTVVAAGKPCLFVGESGTAKSVTIANYLAHLDSTINIVLNVNFSSRTSSLDVQRAIEDSTEKRTKDTYGPPMGKRLLMFIDDLNMPRVDTYGTQQPIALLKLFIERKGLYDRGKELSWKNMKDVQVVGAMGPPGGARNPVDPRFISLFSVFEIQFPSNENLRTIYQAILSRHLAKLPTDEIRDQLGERLTDVTLELYNFIIDKLPPTPSRFHYIFNLRDLSRIYEGLLLTVGDVFKTPEQFLRLWRNECLRVLHDRLISTDDKRVMTERLEALVQQKFPNLAAHTLASPVLFGDFKNVINELQGEGEVAPRMYDDLGDYNSIKPLFEDVMTNFYNRKRKPMNLVFFEDALEHLTRIHRTLRLPQGNCLLVGVGGSGKQSLSKLAAFTAGCEVFEITLTRGYDELAFREDLKRLYAMLGSDNKRVMFLFTDAHVADEGFLELINNMLTSGMVPALYDGAEKDGLIGSVRAEVEKKGLLATKESCWSYYVDKCRNNLHVVLAMSPVGETLRSRCRNFPGMVNNTVIDWFEPWPEQALTSVASVFLAEEALPEALRPQIVEHMVTVHQSVRTFSTRFLEELRRYNYVTPKNYLDFINNYKRALATNRRTIEDTVTRLSGGLEKLIQAAVEVDAMQKELSQAQVVVAQATKECNELLEVISTNTVDVETKAKAAAIKEAQLKVDSEQIAIEKAEAEAALEEAIPALEEAAAALQDLSKDHITEIRSYAKPPEQVQKVCECVVILRNIKDVSWLGAKSMMADGNFLRSLVEFDKDSLTDKQVKKVKEYFKDPKAPLTYDSLRAISTAGAGLLKWVLAMVNYNNVARTVEPKRKKVAESEKNLRIAQKDLASTKLELQSLNDQLGKLRTQFEEKTAEQQDLKAKADLMERRLIAASKLIAGLGSERERWTRDIADLESRRDRLIGDCLLTSSFLSYTGAFTATYRHAMVYEMWQDDVKARGVPVTQPFRLEALLTSDVETTGWASEGLPSDELSIQNGILTVRANRWPLCIDPQMQAVNWIKSREGKMLEGKVKTFNDSDFLKQLELSIQYGFPFLFENLDEYIDPVIDPVLEKNLVPGDGKFVIKLGDKEVEWDSNFRLYMTSKLSNPHYGPEISGKTMIINYGVTQQGLTEQLLNVTLRHERSDLEEAREALIKQMSENKATLQALEDTLLRELSNAQGNILDNSELIATLESAKLKAVEIAEKLEASKVTAAEIEETRVRYSPAAKRGAILFFVIAGLSAITNMYEYSLASFLVVFNGSLHSSRRDASIEGRLRNIIDTLTYDVYAYTCLGLFERHKLMFSFQMTCKILEGDTPLDPQLLDFFLKGNLSLEKAARRKPFDWFPDAGWQDLMRLVELGQKKIGADGRMHALGSLANDVESDEAAWRTWYDLEAPEEAELPCGYQSFLSDFEKLCLMRCLRMDRVTVGITRFVIGVMGEKYVQPPVLEYRSIYKQSTETTPIVFVLSPGADPAFDVFKLGEEMGFRPGAKLKYMALGQGMGPKAQELIETGATRGLWIMLQNCHLLPTWLKTLEKILEKITKPHADFRLWLTTELTDRFPLGVLQRSLKVVTEPPNGLKLNMRQSYSKITEEVLADCPHQAFRPLVYVLGFFHAVVQERRKYGKLGWNVPYDFNETDFRISMALISTYLTKAWDAQDDLIPWGTLRYLIGEAMYGGRVSDSYDRRILTTYLDEYLGDFLFDTFQPFRFYACKDYEIAIPQTGSRDTYLKAVEALPLVQSPEAFGLNANADISYYTSATKAIWTDLVDLQPRTGGGGGGVAREEFIGGVARDIAAKIPEPFDLPQLRKELGTPSPTQVVLLQELERWNSVLGVMVSSLRDLQRALSGEIGFSSRLEELASSLYNGKLPAMWARLNPATEKALGAWMLWFGRRYRQYKDWTEHGEPKVIWLSGLHIPETYIAALVQAACRDKGWPLDKSTLYTKVTKFTDPYQVSERPKYGCYMSGLYLEGAAWDLEASQLRKQDPKVLVNELPILQVIPIEANKLKLANTFRAPVYVTQARRNAMGVGLVFDADLASAEHSSHWVLQGVALVLNIDQ

Gene
DHC1
Protein
Dynein heavy chain, cytoplasmic
Organism
Fusarium solani subsp. pisi
Length
4349 amino acids
Function
Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP.
Similarity
Belongs to the dynein heavy chain family.
Mass
493.463 kDa
Sequence
MEVTSAAAPSTGSSANGVTAAAPFPTIEPERVVEHLAAVCEIALGATRDELEQLGSLLHKARYGETVSRCTRFASDSQNVLYIQKDIANPSAVEAGADPAAPVTYNYTLSTEISSSSTTVSSLVLIKSPQPIDPTRPLTSQIFITNLPGPASLNAGVGEQGTALSPWEVLHSQVHHALVPYFDANTKSQQLANGSRGRADVDAKTGIPVTKKRLNDLELSLLHLQQNVDIPEISLTFHSIVQNVLDDAESRHTRPSLDAIPQIFSQDSTFLNRLQANVNTWIKSIQGITKLTKDPSSNANQEFNTASQEVNFWLSMESALEGIEGQLRSEGVLLTLEILKHAKRFQATVSFTADTGLKEAMDKVQKYNQLMRDFPLDELLSATSLSKAQEAIAQIFGHLNKKLRICPYPIRRALPLVEAISADLDEVLHRLLPGTELVNLDYQQFQTIMQTCDDIFRTWEENVKEFTNVAREVTRRRNEKFIPIKINKKHSELESRIKYVSTFRDNHEQLQRTIINVLGPQATIPGVTETTGSNGIVMEEMGDVDAVEEVKQAWEALHNVDLLDVTDQGKERWVRAENLYNERTTRVENSIIARLRDRLATAKTANEMFRVFSKFNALFVRPKIRGAIQEYQNQLMDHVKQAINGLHERFKQQYGHSETHAMAQLRDLPPVSGAIIWARQIEFQLDGYMRKVEAVLGPDWTMHTEGHKLQEESELFKQKLDTARIYEAWIADVGRRKISISGQLFEIARVRSAGGILELTVNFDPQVITLFKETRNLTWQSYSVPHAVTTVSKDAKRVYPYAVSLMESVRTLSQTLRQISVMGEESVLLFGYRNDVYKLISEGVPLRWESFINSHELFYSDNRQTRPLLPGGTDFGLAKNTESKHGMFIRGFAAAVSVLQQKAVSLNFIHATVEQALKELNTCPYEEAAFHSRLDTIQAAVDQLNLEQYVNLDFWVRGLNSKVQSILLTRLQSAVHAWIEAFEDDTPDDEMRRKVNNNNEEAKPDGPTMKRLVLELAMRNQVIYLDLLLEFARASWFLHLHEWLGIVCNLRKIKATRYQMSLTTTANDEPRFTDLPSECAGLLQRVYVSVEKKLHEVSAYVDKWLQFQSLWDLQSEQVYDALGEQLPRWLQLLQEIRKTRSTFDTQEVSRAFGHLTIDYDQVQTKVNAKYDQWQHEILMKFASRLGNRMREINAEIEKARKHLESQSSDASSTAQAVQFITVVQSCKRNVKTWAPEIDMFRQGQSTLVRQRYQFPNDWLHIEQIDSQWEALKEILEKKSRIVQDQTDALQAKIVAEDKLINERIAEIAAQWNEEKPVSGTIQPDVASATLSSFESRISKLQDDAQMVAKAKEALDIPASPDTSLEATLEEVRDFQSVWSNLSTIWASLNETRDVLWTAVQPRKIRSKVDDLIKSTKEMPSRMRQYAAFEHVQGILRGFLKVNSILSDLKSDAIRERHWHKIYKQIKPQKRFSPSSMTLGDVWDLNLVATEVIVKDIIAQAQGEMVLEEFLKQVRETWQNYALEMVNYQNKIGLIRGWDDLFAKCSENLNSLQAMKHSPYYKEFEEEAVAWEDKLNRVHVLFDVWIDVQRQWVYLEGVFTGNADIKHLLPIESGRFQNINSEFLAVMKKANKSPYVLEVLNIPNVQKSLERLAEMLNKIQKALGEYLEKERVSFPRFYFVGDEDLLEMIGNSNDTLRIAKHFKKMFAGLSGLVMDDETVISGFTSKEGEVVRLKKEISLAKTPKINDWLALLEGGMKSTLAELLAEAVDQYTPIFESETIDREALNGFMDAYPSQIVVLATQVVWTTAVHKSLTTGGETLKAIFDREVRVLRVLADTVLGELEVILRKKCEQQITECVHQRDTIEKLINAKANSTNHYLWQLQMRYVYEPQGEYLDRLYIKMANAKLNYGFEYLGVPERLVRTPLTDRCFLTLTQALCQRLGGSPYGPAGTGKTESVKALGVQLGRFTLVFCCDDTFDFQAMGRIFLGICQVGAWGCFDEFNRLEERILSAVSQEIQNIQLGLKQGVEDDQSQIELVGRHLHVNENTGIFITMNPGYAGRSNLPDNLKKLFRSVAMSKPDKELIAEVMLYSQGFNQAKQLSKQTVPFFDQCSGRLSKQAHYDFGLRALKSVLVSSGGLKRARLGEGSLGAEEVVEPEIIVQSIRETIAPKLIKSDVDIMATIETDCFPGVQYVPANLEALENAIRELAAERHLVVNELWMTKVLQLYQIQKIHHGVMMVGNSGSGKSAAWRLLLDALQKVEGVEGVSHVIDSKVMSKEALYGNLDSTTREWTDGLFTSILRKIVDNLRGEDSKRHWIVFDGDVDPEWVENLNSVLDDNKLLTLPNGERLNLPANVRIMFEVETLKYATLATVSRCGMVWFSEDTVSPTMMVQNYLSTLRSVPFEDLDEDSVATGHTPAKTLAVQSEFASLLHVYLTDENFILPALQRAEGYNHIMEFTTARVLTTLFSLLNKAVRDAIEYNGQHSDFPLESEQIESFISKKLLLALVWALTGDCPLTDRKSFGDDICALANFGSPPLDGNSSLIDFDVTLPKAEWAPWQNQVPSVEVNTHSITQTDVVIPTLDTVRHENVLYSWLAEHKPLLLCGPPGSGKTMTLFSALRKLPNMEVVGLNFSSATTPDLLIKTFEQYCEYKKTLNGVMLSPTQIGRWLVIFCDEINLPAPDKYGTQRAISFLRQLVEHNGFWRTSDKSWVTLDRIQFVGACNPPTDAGRTPMGARFLRHAPLIMVDYPGELSLNQIYGTFNSAVLKIIPSLRGYAEPLTHAMVRFYLESQQRFTPKIQPHYVYSPRELTRWVRGVYEAIRPLEALTIEGLIRIWAHEALRLFQDRLVAEEERQWTDESVRRIALEFFPNIDEEKALGGPILFSNWLSKNYVPVDREQLRDFVKARLKTFCEEEVDVPLILFNDVLEHVLRIDRVFRQPQGHLILIGVSGSGKTTLSRFVAWMNGLKVFQIKVHGKYSAEDFDDDLRDVLRRCGCKGEKICFIMDESNVLDSGFLERMNTLLANAEVPGLFEGDEYAALMTACKEGAQRQNLRLDSPEEMYKWFTQQIVKNLHVVFTMNPPEDGLSSKAATSPALFNRCVLNWFGDWSDQALFQVGHELTQSIDLDRSNFECPDTIPVAYRGLQLPPSHRERVVNSMVHIHYSLQRYNEKLLKQQGKVTFLRPRHFLDFVTQYIKLYNEKREDLEEQQRHLNVGLEKLRDTVDKVRDLRVSLAEKKKQLEQKDAEANEKLQRMVADQREAEQRKNTSLEIQANLEKQEAEVASRKKVVLEDLAKAEPAVEEAKASVSNIKRQHLTEVRSMGNPPQGVRLAMDAVCTLLGHRINDWKAVQGILRKDDFIASILMFDNAKQMTKGLRNKMRNDFLSNPEFTFEKVNRASKACGPLVQWVAAQVNYFDILDRVGPLKIEVEQLEDQALETKAQAKSVQNNIADLEASINTYKTEYAALISETQAIKAEMSRVQFKVDRSVRLLDSLSSERVRWEAGSKSFEIQISTLVGDVLVAAAFLAYSGLYDQTFRKSMMDDWFHQLHLSGIQYKSPNPVTEYLSTADERLGWQENALPVDDLCTENAIILKRFNRYPLIIDPSGRVTEFLQKECKDRRLTVTSFLDDTFTKQLESSLRFGNPILIQDAEHLDPILNHVLNKECQRTGGRVLIQLGKQEIDFSPAFKLYLSTRDPSATFAPDICSRTTFVNFTVTQSSLQTQSLNDVLKSERPDVDERRSNLIKLQGEFKIHLRQLEKRLLQALNESRGNILDDDNVIETLETLKTEAAEISAKMSNTEGVMAEVEEITQQYSIIARSCSAVFAVLEQLHYLNHFYQFSLQYFLDIFQSVLHGNKNLANETDHNARRDVIVHDLFVNTFKRTALGLLQKDRITLGMLLAQASPYKMDKSVIDMILDNRVEGKDLSSHPDDRENAFAQAKKLSAIKDKIDAISTEDWDKFFTEELAENAVPHIWDEKTEAIDQALLSLLLVKLFRMDRFVPAAERFVAQVFGSDIFDIVEDLKQTVTQVSATLPISLVSSPGFDASYKVDNLVERMRVKCTNIAMGSNEGLASADKAISNAAQTGSWVLVKNVHLAPTWLQSLEKRMESLNPHSDFRLFLSMESSPKIPVNLLRASRVLMYEQPAGVRANMKDSMSSLSTRATKSPVERTRLYLLLSFLHAVVQERLRYAPNLGWKGFWEFNDSDYECSAYIVDTWIDGVAGNRTNLAPQNIPWEMLRYLVTETYGGKIDDEGDFKLLSQLVTSFLTPAAYEVDHKLVDGPEGGLVVPSGTSFQDFNAWIHRLPEREPPTYLGLPANAEKLLLGGLGRSLIGNLRKVTELLDEGEQLVTEV

Gene
dhc1
Protein
Dynein heavy chain, cytoplasmic
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Length
4196 amino acids
Function
Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required for nuclear movement during meiotic prophase.
Similarity
Belongs to the dynein heavy chain family.
Mass
484.318 kDa
Sequence
MDKNDNSQCQLSTVSDEILIFLKKLLSLSVSDNLDDICETIALQSTFVDTFRSFINDEYYTVIYLYGSPCLTSSPTSPDSCTFGNMTFQWTSLLQDVFSGTSAFAIFKRFPLTDTPLTLQNMLYINQLPILKGGHKSNEIPERPINAIFLYTKYVMSCYFTAYLAMESVDDRSTIDLNSPSKGKELELTCQKFADFERSFTFFCREYQNSDTILQHHPLILSTIKHAEENNLDLSVRLLPSKVLSDSEFYKSLSNLVNVWLKTTRSLIKLFHDQISKTALEEFNFWQFYYRSLSRLNDQLHSRPVLFVLDILAFGKRFHTIASFNSETNIQCFVDKVGKIDALFKEISLDIFLSSSTLESLQLSAALLYSTFSKKWRNTGYPETRVLDFINFITEDLLKLISRLLPALGALSLSNVDFSHRTAVSSDILSLCYIRLKDFLRISGSLKEEQSYYGLKNSIKQIKAFENKLKYIQSFHEKHQQLIGALSEVYGLTHLTELEILEHLNKKEHVFNILTVFKDLQSLNVLDISLKGVNAWNSLETSYYNCMTVLEDEVIAQLKSLLQYSKTSSQMFTTLMRFQPLFFRTRVRTSISDCLHLLVNRIKQELDLLKTRFTEDVSDTELIAMNELRNLPMASSAIIWATQLKNRLHEYTKNINIIFGEDWNNFPDGFELKVECITLQKRLDTNLIFTNWINDVSSRNLNFDFDSKIFYLTQSESAESPLRLSVSIDFDPCSFCKEIRTLAHLGYNIPSQLMELASCLQRIQLIAMCLIDSVQSFNDVSFEISKTEEERFLLQEYELAVRQHIVTGLFISWNDFIVGNLSTPPKCAIGKRNFLKNIHPNVENYAYQFSSLTSLLMNKRNAISHTYMQIQEQLFQLDICEYSGDIFLTIQRKLQDLIDLLYVNGYSNLPPFVRALNLRFQDLLISRCRKFLSFFKTTILTSGNENNDLKSKFSSDMYEKLRGFLKPTNLTIQRNIIEFDPPVYRKKEDSIYLLDMCLQSVVNIPLLSIKTTAQRNCTLIGFFPVINRLESEILGIFESLLFHFDSILGYQNYWKKVEPFLNLNSLNLLLKSELFQLDQCYSLSLYLIHLKSEVDEIGKVTDFKIFSVNNTEFKSQVYLYLREWINALFDRFTFLLGKESEHLLNELDDTHSSLSTVDFTVNNTESLINSLKIFKKAGCYKLNVEHKIITYQNYEMTFNDCDAFSEFNFSLLKDITSKWKDLLESFECRRLKLENNKDEILRNFSEFAKRVNTETLSLISEWCASSLSLIKANYDEFSSTVDDFLFRFSKATEQCLMVKYIKKDLEIEIEESCDFSIQTEEIHLYKKFKDVISSNLEFIVEIKNTRWKLFDTATLSVQTTHQINALESVHTSFQHFKLFTNTKQSLNQLKDCTLLLQKLKSCPLKPVHWISLFEITKSTEQLDFEKLLVSDILGIDLQAHESFITTLLNSAVVEANLENQFNEVHSFWKNSYFSFKSFKGRNYIVVGCQELIDAVEKNMDSLNLIKTSRHFKDGDMNITDLQSKMKIIVKFLNIWKEIQQIWTHLSAIFYESTYIQQLLPELAASFFNSSKTYMHLVTLLKERSYLYKVSNIPSLLESAAKLSTTLEDSKKSLLKYFELQRHKISRLYFLGDDDLMELISNPCDPFVINKQIIKLYPGIRSLIVDTENTNINGCTTNEGNELLFDNPICLLDNTQPLHWISSLEPFLKATLFQLFSTSFQQIRDFYYNKSRNVFCKEWFLRYPSQITLLSLRCTLCHEIETGIADCCLDAVFNFINDGISSLVLLADENELSIKKKVTLMFNELLHFKETVGLLCKNSFNNYFWSREVKAFYREDHDDEAVVIKMFSLEFIYAFEYSELDDPIVYTDLTRNCFSVLLHSIASNLGGSPIGPAGTGKTETVKAVSAYLGKNVFVFNCDNAFNYKTIQRILSGLAQIGTYICFDEFNRLDSGTLSAISYDIQRIQSLVSHSDGLCQSPILLDAPTIFVTMNPGYLGRFKLPSNLKKLFRPIWMGSPDNKKICEILFLSFGFKESSLLSQVLDSFFLCCSGSLSNCLHYDFGLRAMKVVIKAAKRIKGFLKKKNTICQELEILWYAIREVLYPSLIYQDIPLFFKAEESYFNFPAVKANAFIDPDNFEVNIEQTLSKNFFGNNQYLKLKIMQLYQMSEAYNGIILLGKTGSGKSQIFRILQSALLNIGIDCIVYVISPKALTKESLFGSMNMDTREWTDGVFTKLLRKTRDSCYYKRYMFVFDDELSPEWVEAMNSLLDDNKTLTLSNGERIALQPYVKIFFEADSVASLTRATISRCGLICISNIDDNILSSTDKMLSFTSGATNYPLGSSNDEFSTVFSKVLTDEVMMNLISSCYKFSVDLQHIMNFTKQRFFTTFYSLLDQTKLFTRSSNITESLSFKELCNYLKKKICYILAWCCTGDTDAKSRERFTHWLMQNASVDLPEIKDFEHVSILDFDVSLETQSWYPIAGKTLKSSALKYAGNTVIPTLDTVRYAEFLNFSLTKNRCVIFCGPPGSGKSMLMLGTLRSRQDVEVIALNFSISTSSKSVVSFLEQSTVYYRSTGMTIMCPKNHEKVLVLFCDEINLPRSRNCLAEDVICFLRHMLEHQGFWHPLHKEWVTIKNIFVCGACNPSTDIGRNDFPERFLRRTVLIFVDYPESYSLVTIYNALLEKSALINQYKTIILNIVKASVKFYQVLRENFKSSTQGYVYTPRDLTRWLISFKNYAESYAETNNLSLIKVWYHEACRVLLDRLVSQKECSWGMTELQKVIVTDFGEFEVSVIFEKQIIFTDILKNGLEFLDFASLRPKLESLYKKFYSSHPNNTLVFVDETITHILRFHRILNNSGMHALLQGSVGLGQKAVVEFVCWLNSFSLFELQKNQTYSIEDFEDNLKSILILAGTTNCKACLAINESIAGVPGFLDLLNNLLTNSEVSNFFDQNDWAEIKKNLNKLNEFQPLKFDSEESVTEIFMNNVFQNLCVVFYVYTSADVDFQTNSLSPALLNRCTIDYYHSWDYHSMLQIANEVLQETISLNALDHDNPNLKNIKGSSIYDAVAQAVVNTHTSIVWEFKHLGKTSYFSCLHFIRFLNTFCLIFGRDANKLSKEKSRIENGFKKIKETSQGIDKFKEALSDQQNVLFSKTKTANDRLQCIIQTKQAVEAKKVYSLQAEASLQKKSFLLNEKKNSVMKEVSYAKPAVIEARKSVSDIKKAHLIELRSLSRPPMAIRITMEVVCKLLGFSATDWKNVQQLLKRDDFIPKILNYNLEKELSINLRRKIEQDYFSNPIFTFDSVNRASKACGPLLLWIKSICNYSKVLEKLEPLNSEVDRLKLEQKNAEECIQETIAACKDLDEKLLQLQEEYASMISEIHSMELQMDEVKCKMQRSIEVITDLSIERNEWSGFLNLYPKRMWNLVGESLMEASFVVYAGNLDPSMRIFLRNKCEPIISSFGFPISKSAVRTNIERCVQTSIESKYYKNLTDYSLENIYIIQENKSPLLIIDPSSQILDILPSLYKGKASDLISFSNKSFQNQIKLALLSGSAIIIKDAELWDVSIEPLLKPEFFTGSGEVQTTFAKDTITITLPLNIIFFSEVQSNELENKASKFMNVVNFTLSISLLETQMLKSVISVQEPGVFKQKDNCFTLKLSIERQIRSLQEQLLKTLCSSNENIVGTDEIVVLLKNLKEKHETIRLAYSESQSINRKVDELIRRYKLSIKSFLSVVVVFQHFISLKKSYSFSFNFIWSTFHQMLNVVLENRNQDFKSLIMDALRDLIRRCFLYIFPEDRVLFLFLLMFFFFPKETESLRKLLIVNGKTLELEQSYLNFFETCSDSNERGGLESLFFKTHASNIQNFCTEVLANTHCEEDCLKLLYDLWSSAFKVEFSNIKYDFLKIINDESESRMPTIVYLMENCEIDSLLQNAKIPQNIKKLTVSLGSAENESLADSYLKLASTEPLWLFINNIHLSTPWAEKLPSKMSNHLHKNSRIVCLSEIHNQLPHQLLCISRSIVFNKQTSFKNNLLNLLELLPTMTHTLPHNRFRLFFFLSWLHATLAEIYCFTCSSWKEPCYFDDSDFYFGTKILCNILYRNVHLEEFSWGTFKDLLLNVVYGPKVSASSDFIALDKILKRLIAQFKTQISSNILLTDNFKFILPYEITFSSAKEVIGQLPDEIPPGWLDIPENSKRKRTDIYFSMCI

Gene
Dhc1
Protein
Polyketide synthase-related protein Dhc1
Organism
Alternaria cinerariae
Length
477 amino acids
Function
Polyketide synthase-related protein; part of the gene cluster that mediates the biosynthesis of 10,11-dehydrocurvularin, a prevalent fungal phytotoxin with heat shock response and immune-modulatory activities (PubMed:26493380). The highly reducing polyketide synthase Dhc3 is responsible for biosynthesis up to the tetraketide stage (PubMed:26493380). The non-reducing polyketide synthase Dhc5 then conducts four additional chain extension cycles, producing the unreduced part of the nascent octaketide from C-1 to C-8 in 10,11-dehydrocurvularin (PubMed:26493380). The role of Dhc1 in 10,11-dehydrocurvularin biosynthesis has not been identidied yet (PubMed:26493380).
Mass
51.984 kDa
Sequence
MPKTPNGKLDRKSIAALLLRNAKRDMNGVVNDVEKMTVREGELRLLWERVLPTLGDLRLGPSSDFFMCGGNSMLLMKLQKAIKETTGIRVSTKDLYESSTLRAMTHCVFDRANRADDDAAPIDWAVETSLPASLQTQIQDLATSSPPEAGGHGTNGTEVLLTGATSFLGSHLLRSLLSSPRVKKVHCVAVPADEQATLFSHDTRIVCYSGTLLSPTLGVTPQERRTLEQSVHVIVHAGAHGHCLNRFDSLRAPNLQSLHFLATLALPRCVTILFLSSSRVVLLSGDTAPAPASMRSYPPAVDGKDGYTASKWAGEVFLENLVAHVENVASSASSPSVFWRSSLNVEVHRACTLVSESAPNSDAMNAILRHSLDMRCAPRLERAEGYLDFAPMESIVAKITVHAVEMATAVQQQQQQQQRQSQPPRDDAADGSPTERARGLRIAITLAVSSRPWATLGRIWRGRMVGDPKNWIYKSGL