Function
Polyketide synthase-related protein; part of the gene cluster that mediates the biosynthesis of 10,11-dehydrocurvularin, a prevalent fungal phytotoxin with heat shock response and immune-modulatory activities (PubMed:26493380). The highly reducing polyketide synthase Dhc3 is responsible for biosynthesis up to the tetraketide stage (PubMed:26493380). The non-reducing polyketide synthase Dhc5 then conducts four additional chain extension cycles, producing the unreduced part of the nascent octaketide from C-1 to C-8 in 10,11-dehydrocurvularin (PubMed:26493380). The role of Dhc1 in 10,11-dehydrocurvularin biosynthesis has not been identidied yet (PubMed:26493380).
Sequence
MPKTPNGKLDRKSIAALLLRNAKRDMNGVVNDVEKMTVREGELRLLWERVLPTLGDLRLGPSSDFFMCGGNSMLLMKLQKAIKETTGIRVSTKDLYESSTLRAMTHCVFDRANRADDDAAPIDWAVETSLPASLQTQIQDLATSSPPEAGGHGTNGTEVLLTGATSFLGSHLLRSLLSSPRVKKVHCVAVPADEQATLFSHDTRIVCYSGTLLSPTLGVTPQERRTLEQSVHVIVHAGAHGHCLNRFDSLRAPNLQSLHFLATLALPRCVTILFLSSSRVVLLSGDTAPAPASMRSYPPAVDGKDGYTASKWAGEVFLENLVAHVENVASSASSPSVFWRSSLNVEVHRACTLVSESAPNSDAMNAILRHSLDMRCAPRLERAEGYLDFAPMESIVAKITVHAVEMATAVQQQQQQQQRQSQPPRDDAADGSPTERARGLRIAITLAVSSRPWATLGRIWRGRMVGDPKNWIYKSGL