Drc1

Dynein regulatory complex protein 1

754 amino acids

Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with CCDC65/DRC2 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules.

Belongs to the DRC1 family.

88.31 kDa

MNPSGSIGVLEQNGEEHLAAPILGPSVNSDNPQERIQARRLRIAARQEARRREALGEYLDGKKESEEEQSKSYKQKEESRLKLTKLLLCGTELVTNIQVAADIREIHRRVEEEETKRQRLEKLENEVKTSQDKFDEITSKWEEGRQKRIPQELWEMLNNQQVHCAGLVEDKNKLISELQQELKIKDDQYVKDLKKQSEDITVLLERMEEQVKSVMKNFRQELNYIEKAFESERQELLTTNKKKWERALQAHNAKELEYLINRMKRVEDYEKQLNRQRVWDCEEYNSIKIKLEQDVQILEQQLQQMKATYQLNQEKLEYNFQVLKKRDEESTVIKSQQKRKLNRLHDILNNLRTKYSKQIKQFQEDNQSLTSDYKRLVTQFKDLQKAIRHFIIIDQDKFREIWLMNEAEAKELAQRAFDVDKIIHSQHLGLPWKIPNFWFLNNVGPISLQQQQKSVTQILEELLLQSEDEGTETAMSEDESYMDLPNQVSAKTTKKILVLLCDESGFLIESKLLSLLLPLEKSECYLLRLDAIFSALGIESEDDLYKMVNFFLRFKAHHLSSAQVSISTHSNAERTSLVSALQHMSLMSQTDRRSSASKSDGDPTELEDQQGSDNGSLMGRELVEQEDLSSPMFIHPNDVLKILDAFVTGLKKPKDARPVQRLKKDTRNNLKDTEYWESLAMVIPFSKQNLWDALFKALEKYYLVLTQRAKLLMENDSLEQQNAEMQSLLQQYLQAKVNLELQVPPTQGFRMPSK

Drc1

Dynein regulatory complex protein 1

753 amino acids

Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with CCDC65/DRC2 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules.

Belongs to the DRC1 family.

88.507 kDa

MNPSGTIGVLEQNGEEHLATPILGPSVHSDNPQERIQARRLRIAARQEARRREALGEYLDGKKESEEEQSKSYKQKEESRLKLTKLLLCGTELVTNIQVAADVREIHRRVEEEETKRQRLEKLENEVKTSQDKFDEITAKWEEGRRKRIPQELWEMLNSQQVHCAELIEDKNKLANELQQELKIKDDQYVKDLKKQSEDITLILERMEEQVKNVMKNFRQELIHIEKAFESERQELLSSNKKKWERALQAHNAKELEYLTNRMKKVEDYEKQLNKQRVWDCEEYNTIKIKLEQDVQILEQQLQQMKATYQLNQEKLEYNFQVLKKRDEESTVIKSQQKRKLNRLHDVVNNLRTKYTKQIRQFQDDNQSLTSDYKRLVTQFKDLQKALRHFIIIDEEKFREIWLMNEAEAKELAQRAFDVDRIIHSQHLGLPWNMPDLWFLNNVGPISLQQQKSVTQILEELLLQTEDEATEAAMSEDEDYMDLPNQISAKTTTKVLMLLCDESGFLIESKLLSLLHPLEKSECYLLRLDAIFSALAIEDEDDLYKLVNFFLRYRAHRLSSAQASSSIHSNVERTSLMSALERLSLMSQTDKGSMVSKSDQEPTEQEDEQEGDNASLSSRELEEQEDLSSPRFIHPNDVLKILEAFVTGLKKPKDAQPVLKLKKETRDNSKDTEYWESLAAVIPFFKQNLWDALYKALEKYYLVLTERAKLLMENESLEQQNAEMQSLLQQYLQAKVNTELQIPPTQGFRMPSK

DRC1

Dynein regulatory complex protein 1

740 amino acids

Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes (By similarity). Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with CCDC65/DRC2 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules (PubMed:23354437).

Belongs to the DRC1 family.

87.134 kDa

MNPPGSLEALDPNVDEHLSTQILAPSVHSDNSQERIQARRLRIAARLEARRREALGEYLDGKKESEEDQSKSYKQKEESRLKLAKLLLCGTELVTNIQVAIDIREIHRRVEEEEIKRQRIEKLENEVKTSQDKFDEITSKWEEGKQKRIPQELWEMLNTQQLHCAGLLEDKNKLISELQQELKTKDDQYVKDLKKQSDDICLLLERMEEQVKNVMKTFREELYNIEKAFEVERQELLASNKKKWEQALQAHNAKELEYLNNRMKKVEDYEKQLNRQRIWDCEEYNMIKIKLEQDVQILEQQLQQRKAIYQLNQEKLEYNLQVLKKRDEESTVIKSQQKRKINRLHDILNNLRSKYAKQIKQFQEENQSLTSDYKRLVMQFKELQKAMRHFALIDDEKFWEIWLMNEEEAKDLIARAFDVDRIIHTHHLGLPWAAPDFWFLNNVGPISQQPQKSATQIVEEMLMRSEEEEAEEAAAEPESYLDLPKQISEKTTKRILMLLCDESGFLIESKLLSLLLPLEQNECYLLRLDAIFSALGIESEDDLYKLVNFFLKYRAHRLSSSLQIKPCSQASMEKASMEETSTRSELELAEQTEMEGEKEESLVEGEKEEEEETPPSPWVIHPNDVLKILEAFVMGLKKPRDSRAPLRVQKNVRDNSKDSEYWQALTTVIPSSKQNLWDALYTALEKYHLVLTQRAKLLLENSSLEQQNTELQALLQQYLNSKINSELQVPPTQVLRVPTK

DRC1

Dynein regulatory complex protein 1

740 amino acids

Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with CCDC65/DRC2 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules.

Belongs to the DRC1 family.

87.01 kDa

MNPPGSLAGLDPNLDEHLSTQILAPSVHSDNPQERIQARRLRIAARLEPRRREALGEYLDGKKESEEDQSKSYKQKEESRLKLAKLLLCGTELVTNIQVAIDIREIHRRVEEEEIKRQRIEKLENEVKTSQDKFDEITSKWEEGKQKRIPQELWEMLNTQQLHCAGLLEDKNKLISELQQELKTKDDQYVKDLKKQSDDICLLLERMEEQVKNVMKTFREELYNIEKAFEVERQELLASNKKKWERALQAHNAKELEYLTNRMKKVEDYEKQLNRQRIWDCEEYNTIKIKLEQDVQILEQQLQQRKAIYQLNQEKLEYNLQVLKKRDEESTVIKSQQKRKINRLHDILNNLRSKYAKQIKQFQEENQSLTLDYKRLVLQFKELQKAMRHFALIDDEKFREIWLMNEEEAKDLIARAFDVDRIIHTHHLGLPWTAPDFWFLKNVGPISQQPQKSATQIVEEMLMHTEEEEAEEAASEPESYLDLPKQVSEKTTKKILMLLCDESGFLIESKLLSLLLPLEQNECYLLRLDAIFSALGIESEDDLYKLVNFFLKYRAHRLSSSLQIKSCSQASMEKASMEETSMGSELELAEQTEMEGAKEESLVEGEKEEEEETPPSPWDIHPNDVLKILEAFVMGLKKPRDSRAPPRVQKNMRNNSKDSEYWQALTTVIPSSKQNLWDALYTALEKYHIVLTQRAKLLLENSSLEQRNTELQALLQQYLNSKINSELQVPPTQVLRVPTK

DRC1

Dynein regulatory complex protein 1

712 amino acids

Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with CCDC65/DRC2 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules.

Belongs to the DRC1 family.

84.07 kDa

MNPPGSLGVLEEKEEEHLAPPILGPSIHSDNPQERIQARRLRIAARLEARRREALGEYLDGKKESEEDQSKSYKQKEESRLKLAKLLLCGTELVTNIQVAADIREIHRRVEEEEIKRQRLEKLENEVKTSQDKFDEITVKWEEGKQRRIPQELWEMLNAQQVHCAGLIEDKNKLISELQQELKMKDDQYVKDLKKQSDDICLLLERMEEQVKNVMKTFRQELQNIEKAFEVERQELLTSNKKKWERALQAHNAKELEYLMNRIKKVEDYEKQLNKQRIWDCEEYNTIKIKLEQDVQILEQQLQQMKATYQLNQEKLEYNFQVLKKRDEESTVIKSQQKRKINRLHDVLNNLRSKYNKQVKQFQEENQSLTSDYKRLVLQFKELQKAMRHFALIDDKRFREIWLMNEEEAKDLINRAFDVDRIISTHHLGLPWMAPDFWFLKNVGPISQQQQKSATQILEEVLMEAEKEGADEDSSESETYLDLPKQVSARTTRKILMLLCDESGFLIESKLLSLLLPLEKNECYLLRLDAVFSALGIENEDDLYKLVNFFLKYQTHHSPSSQEPLDLRAEKERSLVDGKSQEKEPPPSPKLIHPNDVLKILEAFVMSLRKPRDFWVPVKLLKAVRDDSKDSEYWEALTTVIPATTLNLWDALYTALEKYHLVLTQRAELLIENSSLERQNTELQQLLQQYLDTKINSELQVPPTQVFRVPTK

DRC1

Dynein regulatory complex protein 1

698 amino acids

Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with DRC2 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules (PubMed:23427265, PubMed:25411337, PubMed:29167384, PubMed:23354437).

Belongs to the DRC1 family.

79.331 kDa

MDELQSQTEREARILARRKRIQERLAALREGDHGGGKEGENKEEIGKGKQQIIESKRRLMRVKYRTDQDVSSVRVAGDDRENQHRIQEEQTRQDLRAKLLAEAEQSARQNAAVAMRWADLFSIEVPQDLYNEIESQRQACERIIASKDKLIGEIKGELKKKDDEFVKTLKRQAEDIDTLLQYMSRQFVEVQNAYKEELDEIENAFLQERSDLLESNRREMQELFDKRSRLEQDFMDRYLAAVEAYQSQLEGHRQMDAEEYHILKIRLETDIQNLEQHLEAMRATYQLNTEKLEYNYRVLKEREKENTQTIESQKKKLSRQRDILSSLKQRYAETDRRYRDDNMKLTDEYKRITEQFKDLQSKFRHFELVDTKKYKEVWGMKEADVAALVRQLLQADKVLHEQQLGWDWRPPDDAVFAPVHGDAGSGGGAAAAATGGAAGGAAAAGGVGPNGEEESEEDAAARVREAELAERLRDGRNWGALGLLCDEAGFLIDIKARNMIERLPKDEQGQVKAEAILRSLGIADGSAFDALLEALSADSNIELRAKGMVAPQGRGMAEEKSDRGGTAVLVHPDEAVRRLKAFVEVYGTGPSRGPGGGGGGGGGMSGPMRVQGAMRRAAEREQEFWSRMTHVISDKHTRVWGALEKQLEKYLALLQERAGSLRDVESLQHQNNELRALLNQYLSSRINDELQIPPTQII

drc1

Dynein regulatory complex protein 1

690 amino acids

Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with CCDC65/DRC2 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules.

Belongs to the DRC1 family.

81.076 kDa

MSLYERESEESAVAGPSLDSEDQQQRIEARRLRIVTRIEAKRREALGEDLKILKKKTEEPRKSHKQTEDSRQRLGKLVNDGSQLVTNIQIATDARETQRRGEEEELKRLRREKLDNEAKSSLEKFEEITKRWTLDKAKQVPQKMWEILNTQQQQCAQLIEDKNNLISDLQKELRRKDDQYVKDLKKQAEDIDLLVERMEEQIKNLIKTYRQELLQIEKVFELERRELLTANRNTWEQGMQGRRDKELESLMSRMKKVEEYENQLKQLRVQDGEEYNMIKIKLETDVQILQQQLQQMKATYQLNQEKLEYNYQVLKKRDEENTITKSQQKRKITRLQDVLNNLRLKQAKQVKQYKEENQSLMDDYKRIVEQYKELQKKMRHFSAVDAKMFQDIWLMNEEEMKQLVQKALEADQVIQEQQLGMCWEPPDLCFMDNVGPLLGKLKDQKSAMSLAQEVMSSHAPGDQSSASEGETDGRQCREVSAETVKHILELLCDESGFLIENKLTRLLSPLERDERSLIKLDSIFGALGVTVEEDVYKLVEFLCRYKREPEEEGDAGGSLEPGSKAHGLIHSNDVLRAVKAFVMDFQKPRGKVSRLRLMEERDSREDTEYWAAAAKAIPESRFRVWDALESALEKYYDVLGSRGQLITETVSLRQQNTELRTLLHQYLNSKINVELEIPPTQMMQGEYPHT

drc1

Dynein regulatory complex protein 1

670 amino acids

Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with CCDC65/DRC2 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules.

Belongs to the DRC1 family.

78.176 kDa

MHQTEAFAAGEEAEELRPSVESDKKEERILARRLRLAARKEAQTKQRLGEDDLGKEDVKEETRKSQKEVEHRERRMAKLKSDGLELVTNIQVAADARESDRRTELEEGHRLRREKLENEAKSSQEKFEEINRKWTDAKMKQTPLDLRDALSSQQQLCEQIIADKNKLISELQQELKASDDRYVKDLKRQAKDIDLLVERMEEQISTLKKSYREDLHQIENSLDEERRTLLTKHKKKWEHERKDRNEKELKNMMQSLSVMEEYADLLQKLRVQTAEEYNIDKIRMDTEVQKLRMKVQQTKFNCHMNEEKLDYKYEVLKKKEEENAIIKSQLKRKIIRMQDVLNNLKSKLTKQEKQSKAGNQSLSNDYTRISQQYKDMQKKARHFAALDAERLEKLWLMCEDEAKALTHRALETDRVIHEQQLGLEWASPPLPFMERSGAVQQKTFRTATQAAADTLKGEPEGGLDEDTAAGLNKRTVKSILELLCDEMGFLVESKLLMLLSPLEKNEQSLIKLDAIFSAIGIESEKDVYKMAEFFMNYRQHESKYTKDETANGQGESAEELSNLIHTEDLLAALKDFTAQFCRQDVHASHKSSILGLDMRDDSEDAAYWESIANVMPESKLKLWDALDTALNKYHAVLTERTELLMETQNIQQQNSELRQLLHLYTTSKAQ

drc1

DNA replication regulator sld2

337 amino acids

Has a role in the initiation of DNA replication. Required at S-phase checkpoint.

Belongs to the SLD2 family.

38.685 kDa

MHDESRTKQISSIKALLKKWEHEYVHTNNCKPSKEDVKKQPEIALLYKQYYELKRESSITPKKAKTKVDFKFQTPTKQRAETEANESPKAPRNDYLQVTPKTVDKSLLGPTPQLSRRVLNLLEDMSPIADSHVDQISDIKHNTSEISSTMIPTTPSKNPEPVAQHTPTVLETPSSYRLQVYTSPNLLRVNAPCRKSLSEMLRELKDIEDDYGSNEEKILQEFESFSSSSSESLVDRDISQPMKKKIKRQNRLVKLPPSMNLSKSHLEGLPEIDEDAENGIDDNEDTTASKDSSPFLDLQSERQNKKIMRNGLVIGKQVSQNYSSYKLKKRKFRRHRS