Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with CCDC65/DRC2 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules.

Belongs to the DRC1 family.

670 amino acids

MHQTEAFAAGEEAEELRPSVESDKKEERILARRLRLAARKEAQTKQRLGEDDLGKEDVKEETRKSQKEVEHRERRMAKLKSDGLELVTNIQVAADARESDRRTELEEGHRLRREKLENEAKSSQEKFEEINRKWTDAKMKQTPLDLRDALSSQQQLCEQIIADKNKLISELQQELKASDDRYVKDLKRQAKDIDLLVERMEEQISTLKKSYREDLHQIENSLDEERRTLLTKHKKKWEHERKDRNEKELKNMMQSLSVMEEYADLLQKLRVQTAEEYNIDKIRMDTEVQKLRMKVQQTKFNCHMNEEKLDYKYEVLKKKEEENAIIKSQLKRKIIRMQDVLNNLKSKLTKQEKQSKAGNQSLSNDYTRISQQYKDMQKKARHFAALDAERLEKLWLMCEDEAKALTHRALETDRVIHEQQLGLEWASPPLPFMERSGAVQQKTFRTATQAAADTLKGEPEGGLDEDTAAGLNKRTVKSILELLCDEMGFLVESKLLMLLSPLEKNEQSLIKLDAIFSAIGIESEKDVYKMAEFFMNYRQHESKYTKDETANGQGESAEELSNLIHTEDLLAALKDFTAQFCRQDVHASHKSSILGLDMRDDSEDAAYWESIANVMPESKLKLWDALDTALNKYHAVLTERTELLMETQNIQQQNSELRQLLHLYTTSKAQ

78.2 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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