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DRAP1

Gene
drap1
Protein
Dr1-associated corepressor homolog
Organism
Dictyostelium discoideum
Length
550 amino acids
Function
Involved in transcriptional regulation. Component of the NC2 complex which represses RNA polymerase II transcription through binding to tbp and thereby inhibiting the assembly of the preinitiation complex (By similarity).
Similarity
Belongs to the NC2 alpha/DRAP1 family.
Mass
60.893 kDa
Sequence
MKKKYKTKFPMARIKKIMQKDEEVGKIASATPILISQCLELFMADLVMKTCKITQAKKGKVISVNHLKECIKQESTFDFLTEIVDRIPDDKNEKRGRPKKTEGEDGGEEEEEEEEEMDMGEEEEEEEDEDDDDSDEEEEEAPKKGGKGSRGGKGSRGGRGGARGGASTRKVKSETSPVLKNTTITTTTATTTPTPTPTPNFANSPKDIQSTSLKKPSARKSNTTSPKSSPFLSSSAGSIQSPPLNNNNNNNNNNNNNNNNNGNFNNNNNFNNNNNNFNNNNNFNNNNFNNNNNNNNFNNNSNNNNNNFNNNNFNNNNYNSNEDENNNNNNNNNNKNNNNNNNSNNSNNNNRGQQFLSSSTASTITLPSNQYQPLAPISLPVLNNSNNNNSSNNNNNNNNNNNNNNNNNNEHILGNLNNNNSNRKINTNFDEEDSNHNINKSNINSIMNSSNNSIDNKDNGFNSFTFSNNNSNFNDNNNYNPNNPNNNNDNNGNGIVLPSLSSTNSSSTLPSFSSVPPILNTNNSNSNNSISHILNNLNSKKPNVEDEDFD

Gene
DRAP1
Protein
Dr1-associated corepressor
Organism
Bos taurus
Length
205 amino acids
Function
The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own (By similarity).
Similarity
Belongs to the NC2 alpha/DRAP1 family.
Mass
22.324 kDa
Sequence
MPSKKKKYNARFPPARIKKIMQTDEEIGKVAAAVPVIISRALELFLESLLKKACQVTQSRNAKTMTTSHLKQCIELEQQFDFLKDLVASVPDMQGDGEDNHMDGDKGPRRGRKSGSSGRKNGGMGSKGKDKKLSGTDSEQEDESEDTDSDGEEETPQVPPQASHPPAHFQSPPTPFMPFTSTLPVPPAPPGASAPDAEEEEDYDS

Gene
DRAP1
Protein
Dr1-associated corepressor
Organism
Homo sapiens
Length
205 amino acids
Function
The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own.
Similarity
Belongs to the NC2 alpha/DRAP1 family.
Mass
22.35 kDa
Sequence
MPSKKKKYNARFPPARIKKIMQTDEEIGKVAAAVPVIISRALELFLESLLKKACQVTQSRNAKTMTTSHLKQCIELEQQFDFLKDLVASVPDMQGDGEDNHMDGDKGARRGRKPGSGGRKNGGMGTKSKDKKLSGTDSEQEDESEDTDTDGEEETSQPPPQASHPSAHFQSPPTPFLPFASTLPLPPAPPGPSAPDEEDEEDYDS

Gene
Drap1
Protein
Dr1-associated corepressor
Organism
Mus musculus
Length
205 amino acids
Function
The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own (By similarity).
Similarity
Belongs to the NC2 alpha/DRAP1 family.
Mass
22.278 kDa
Sequence
MPSKKKKYNARFPPARIKKIMQTDEEIGKVAAAVPVIISRALELFLESLLKKACQVTQSRNAKTMTTSHLKQCIELEQQFDFLKDLVASVPDMQGDGEDNHVDGDKGPRRGRKPGSSGRKNGGTGSKGKDKKLSGTDSEQEDESEDTDTDGEEETPQLPPQASHPPAHFQSPPTPFIPFTSPLPLPPAPPGPSAADAEDEEDYDS

Gene
Drap1
Protein
Dr1-associated corepressor
Organism
Rattus norvegicus
Length
205 amino acids
Function
The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own (By similarity).
Similarity
Belongs to the NC2 alpha/DRAP1 family.
Mass
22.326 kDa
Sequence
MPSKKKKYNARFPPARIKKIMQTDEEIGKVAAAVPVIISRALELFLESLLKKACQVTQSRNAKTMTTSHLKQCIELEQQFDFLKDLVASVPDMQGDGEDNHTDGDKGPRRGRKPGSSGRKNGGTGSKSKDKKLSGTDSEQEDESEDTDTDGEEETPQAPPQASHPPAHFQSPPTPFMPFTSPLPLPPAPPGPSAPEAEDEEDYDS