DNTT

DNA nucleotidylexotransferase

518 amino acids

Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. One of the in vivo functions of this enzyme is the addition of nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of B- and T-cells.

Belongs to the DNA polymerase type-X family.

60.01 kDa

MHRIRTIDSDFGKKRQKKMDNHISSMIYEIKFHEFVLFILEKKMGATRRTFLTDLARKKGFRVENELSNSVTHIVAENNSGSDVLAWLKTHKMEKTTQFELLDISWLIECMKVGKPVDTKGKYQLMESRVDSANPDPTAGTLNILPPTTKTISQYACQRRTTINNHNQRFTDAFEILAKNYEFKENDDTCLTFMRAISVLKCLPFEVVSLKDTEGLPWIGDEVKGIMEEIIEDGESLEVQAVLNDERYQSFKLFTSVFGVGLKTADKWYRMGFRTLNKIRSDKTLKLTKMQKAGLCYYEDLIDCVSKAEADAVSLLVQDAVWTFLPDALVTITGGFRRGKEFGHDVDFLITSPGAEKEQEDQLLQKVTNLWKKQGLLLYCDLIESTFEDLKLPSRKIDALDHFQKCFLILKLYHHKEDKRKWEMPTGSNESEAKSWKAIRVDLVVCPYDRYAFALLGWSGSRQFERDLRRYATHEKKMMLDNHALYDKTKKIFLKAKSEEEIFAHLGLEYIQPSERNA

DNTT

DNA nucleotidylexotransferase

511 amino acids

Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. One of the in vivo functions of this enzyme is the addition of nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of B- and T-cells.

Belongs to the DNA polymerase type-X family.

58.585 kDa

MDPLQTAHAGPRKKRPRQTGASMASTPQDVRFQDLVLFILEKKMGSTRRTFLTELARRKGFRVENEFSDSVTHIVAENNSGSDVLEWLQVQKIKASSQLEVLDVSWLIECMRTGKPVETTGKHQLVARSDCSASPNPGPQKTPPLAVQKISQYACQRRTTLNNCNHVFTDAFEILAENYEFKENEGCAVTFLRAASVLKSLPFTIITMRDTEGIPCLEDKVKCIIEEIIEDGESSEVKAVLNDERYQSFKLFTSVFGVGLKTSEKWFRMGFRTLSKIRSDKSLTFTRMQRAGFHYYEDLVSCVTRAEAEAVSVLVKEAVWAFLPDAFVTMTGGFRRGKKIGHDVDFLITSPGSTEEEEEQLLHKVMNLWEKKGLLLYCDLVESTFEKLKLPSRKVDALDHFQKCFLILKLHHQRVVDSQKSSQQDGKTWKAIRVDLVMCPYERRAFALLGWTGSRQFERDLRRYATHERRMMLDNHGLWDKTKRIFLKAESEEEIFAHLGLDYIEPSERNA

DNTT

DNA nucleotidylexotransferase

510 amino acids

Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. One of the in vivo functions of this enzyme is the addition of nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of B- and T-cells.

Belongs to the DNA polymerase type-X family.

58.244 kDa

MYAFPTTRIAPRRKQPKCIKPPKCTSKYDIKFKDIAIYILERKMGASRRYFLMELARKKGFRVEPDLSEYVTHVVSEKNSGAEVLEWLQAKKAGSIPNVAILDISWFTDCMGAGQPVEIERKHRLTLQKICVCKSPSPVVPSRVGVSQYACQRKTTLDNKNTLFTDAFEILAENYEFRENERSCLSFRQAASVLKSLTFTIAGMADVDGLPGFGDHIRAVIEDLIEDGESSKVSEVLNDEVYRSLKLFTTIFGVGLRTAEKWHRLGIRTLEEIKSNENLKFSKMQIAGLQHYEDILGGVRKAEADAVAMVVRDAVWTFLPDAVVTLTGGFRRGNKTGHDVDMLITSPIQGKEKELLHKVINLWKKQDLLLCHTIHESTMDEDNLPSKSVNLLDHFQKCFAILKSNQHRGEISSCDGPHDSRERGKRIWKAIRVDLVFCPFEQYAFALLGWTGSRQFERDLRRYASHEKKMMIDNHALYDKTKRVFVKCESEEEIFGHLGLEYIDPVERNA

Dntt

DNA nucleotidylexotransferase

510 amino acids

Isoform TDT-L: 3'-to-5' DNA exonuclease. Involved in the generation of diversity in the antigen-binding region of immunoglobulin heavy and light chains and T-cell receptors during B-and T-cell development. Acts on single-stranded and double-stranded DNA with 3' or 5' extensions, but not on double-stranded DNA with blunt ends. Attenuates not only isoform TDT-S-catalyzed N addition, but also P (palindromic) addition in coding joins (PubMed:11938351). Lacks terminal transferase activity (PubMed:11136823, PubMed:7556063).

Belongs to the DNA polymerase type-X family.

58.266 kDa

MDPLQAVHLGPRKKRPRQLGTPVASTPYDIRFRDLVLFILEKKMGTTRRAFLMELARRKGFRVENELSDSVTHIVAENNSGSDVLEWLQLQNIKASSELELLDISWLIECMGAGKPVEMMGRHQLVVNRNSSPSPVPGSQNVPAPAVKKISQYACQRRTTLNNYNQLFTDALDILAENDELRENEGSCLAFMRASSVLKSLPFPITSMKDTEGIPCLGDKVKSIIEGIIEDGESSEAKAVLNDERYKSFKLFTSVFGVGLKTAEKWFRMGFRTLSKIQSDKSLRFTQMQKAGFLYYEDLVSCVNRPEAEAVSMLVKEAVVTFLPDALVTMTGGFRRGKMTGHDVDFLITSPEATEDEEQQLLHKVTDFWKQQGLLLYCDILESTFEKFKQPSRKVDALDHFQKCFLILKLDHGRVHSEKSGQQEGKGWKAIRVDLVMCPYDRRAFALLGWTGSRQFERDLRRYATHERKMMLDNHALYDRTKRVFLEAESEEEIFAHLGLDYIEPWERNA

DNTT

DNA nucleotidylexotransferase

509 amino acids

Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator (PubMed:3755527). One of the in vivo functions of this enzyme is the addition of nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of B- and T-cells.

Belongs to the DNA polymerase type-X family.

58.296 kDa

MDPLCTASSGPRKKRPRQVGASMASPPHDIKFQNLVLFILEKKMGTTRRNFLMELARRKGFRVENELSDSVTHIVAENNSGSEVLEWLQVQNIRASSQLELLDVSWLIESMGAGKPVEITGKHQLVVRTDYSATPNPGFQKTPPLAVKKISQYACQRKTTLNNYNHIFTDAFEILAENSEFKENEVSYVTFMRAASVLKSLPFTIISMKDTEGIPCLGDKVKCIIEEIIEDGESSEVKAVLNDERYQSFKLFTSVFGVGLKTSEKWFRMGFRSLSKIMSDKTLKFTKMQKAGFLYYEDLVSCVTRAEAEAVGVLVKEAVWAFLPDAFVTMTGGFRRGKKIGHDVDFLITSPGSAEDEEQLLPKVINLWEKKGLLLYYDLVESTFEKFKLPSRQVDTLDHFQKCFLILKLHHQRVDSSKSNQQEGKTWKAIRVDLVMCPYENRAFALLGWTGSRQFERDIRRYATHERKMMLDNHALYDKTKRVFLKAESEEEIFAHLGLDYIEPWERNA

DNTT

DNA nucleotidylexotransferase

509 amino acids

Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. One of the in vivo functions of this enzyme is the addition of nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of B- and T-cells.

Belongs to the DNA polymerase type-X family.

58.536 kDa

MDPPRASHLSPRKKRPRQTGALMASSPQDIKFQDLVVFILEKKMGTTRRAFLMELARRKGFRVENELSDSVTHIVAENNSGSDVLEWLQAQKVQVSSQPELLDVSWLIECIRAGKPVEMTGKHQLVVRRDYSDSTNPGPPKTPPIAVQKISQYACQRRTTLNNCNQIFTDAFDILAENCEFRENEDSCVTFMRAASVLKSLPFTIISMKDTEGIPCLGSKVKGIIEEIIEDGESSEVKAVLNDERYQSFKLFTSVFGVGLKTSEKWFRMGFRTLSKVRSDKSLKFTRMQKAGFLYYEDLVSCVTRAEAEAVSVLVKEAVWAFLPDAFVTMTGGFRRGKKMGHDVDFLITSPGSTEDEEQLLQKVMNLWEKKGLLLYYDLVESTFEKLRLPSRKVDALDHFQKCFLIFKLPRQRVDSDQSSWQEGKTWKAIRVDLVLCPYERRAFALLGWTGSRQFERDLRRYATHERKMILDNHALYDKTKRIFLKAESEEEIFAHLGLDYIEPWERNA

dntt

DNA nucleotidylexotransferase

507 amino acids

Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. One of the in vivo functions of this enzyme is the addition of nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of B- and T-cells.

Belongs to the DNA polymerase type-X family.

58.846 kDa

MNPLSQSALVPLRKKAKMAPISQSFCQHNVKFKEIVLFLVERKMGSSRRTFLMELARKRGFQTEIELSDSVTHIVAENNSGAEVLEWLQSKKLGFTVKTHILDISWFTECMEAGRPVEIQNRHLLPVQQDCSANFNPPLSSSCVQVSQYACQRCTTLQDTNRIFTDAFDILAEHFEFCENKGRTVAFLRASSLIKSLPFPITAMKELEGLPWLGDQMKGIIEEILEEGKSYKVLEVMNEERYKSFKQFTSVFGVGLKTSDKWFRMGFRTLEEIKNEKELKLTKMQKCGLLYYEDITSYVSRAEAETTEQLIKSIVWKFVPDAIVTLTGGFRRGKKKGHDVDILITCARKGKEKNILHNTMSVLKNRGLLLFYNIIESTFDETKLPSRHVDALDHFQKCFTILKLPKRQMDIGNIIDPHECERKNWKAVRLDLVITPYEQYPYALLGWTGSRQFERDLRRYATHEKRMMLDNHGLYDKTKNNFLKANNEEDIFKQLGLDYLEPWERNA

DNTT

DNA nucleotidylexotransferase

506 amino acids

Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. One of the in vivo functions of this enzyme is the addition of nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of B- and T-cells.

Belongs to the DNA polymerase type-X family.

58.447 kDa

MERIRPPTVVSQRKRQKGMYSPKLSCGYEIKFNKLVIFIMQRKMGMTRRTFLMELARSKGFRVESELSDSVTHIVAENNSYPEVLDWLKGQAVGDSSRFEILDISWLTACMEMGRPVDLEKKYHLVEQAGQYPTLKTPESEVSSFTASKVSQYSCQRKTTLNNCNKKFTDAFEIMAENYEFKENEIFCLEFLRAASVLKSLPFPVTRMKDIQGLPCMGDRVRDVIEEIIEEGESSRAKDVLNDERYKSFKEFTSVFGVGVKTSEKWFRMGLRTVEEVKADKTLKLSKMQRAGFLYYEDLVSCVSKAEADAVSSIVKNTVCTFLPDALVTITGGFRRGKKIGHDIDFLITSPGQREDDELLHKGLLLYCDIIESTFVKEQIPSRHVDAMDHFQKCFAILKLYQPRVDNSSYNMSKKCDMAEVKDWKAIRVDLVITPFEQYAYALLGWTGSRQFGRDLRRYATHERKMMLDNHALYDKRKRVFLKAGSEEEIFAHLGLDYVEPWERNA

dntt

DNA nucleotidylexotransferase

501 amino acids

Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. One of the in vivo functions of this enzyme is the addition of nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of B- and T-cells.

Belongs to the DNA polymerase type-X family.

56.859 kDa

MNHAGMLALVKKRKRPVEAGAQGQVEVKFKEVTLELVERKMGSSRRNFLTRLARSKGFRVEDVLSDDVTHVVAEDNQAEVLWAWLMGHGLRDVSRLALLDISWFTDSMREGRPVRVETRHSIQNTPTGTDCSPPTAVANVSQYACQRRTTTENHNNKIFTDVMEELAESSEFNESKGPCLAFRQAASVLKSLPSAVHCLKAIQGLPCLGEHTKAVMEEILTFGRSFKVEEIRCDERYQALKLFTSVFGVGPKTAEKWYRRGLRSLQEILTEPNIQLNRMQRAGFLYYSDISKAVSKAEAKAVGCIIEDTFHWIAPDAILALTGGFRRGKEYGHDVDFLLTMPEIGKDEGLLLHVIDRLKDQGILLYCDYQGSTFDVSKLPSCRFEDMDCFQKCFLILRLEQGQVEGERGLQRDPGDSRGWRAVRVDLVAPPVDRYAFALLGWTGSRFGRDLRTFAQKERQMLLDNHALYDKTKKLCLLATTEEDIFTHLGLEYVEPWQRNA