Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. One of the in vivo functions of this enzyme is the addition of nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of B- and T-cells.

Belongs to the DNA polymerase type-X family.

507 amino acids

MNPLSQSALVPLRKKAKMAPISQSFCQHNVKFKEIVLFLVERKMGSSRRTFLMELARKRGFQTEIELSDSVTHIVAENNSGAEVLEWLQSKKLGFTVKTHILDISWFTECMEAGRPVEIQNRHLLPVQQDCSANFNPPLSSSCVQVSQYACQRCTTLQDTNRIFTDAFDILAEHFEFCENKGRTVAFLRASSLIKSLPFPITAMKELEGLPWLGDQMKGIIEEILEEGKSYKVLEVMNEERYKSFKQFTSVFGVGLKTSDKWFRMGFRTLEEIKNEKELKLTKMQKCGLLYYEDITSYVSRAEAETTEQLIKSIVWKFVPDAIVTLTGGFRRGKKKGHDVDILITCARKGKEKNILHNTMSVLKNRGLLLFYNIIESTFDETKLPSRHVDALDHFQKCFTILKLPKRQMDIGNIIDPHECERKNWKAVRLDLVITPYEQYPYALLGWTGSRQFERDLRRYATHEKRMMLDNHGLYDKTKNNFLKANNEEDIFKQLGLDYLEPWERNA

58.8 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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