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DHRS9

Gene
DHRS9
Protein
Dehydrogenase/reductase SDR family member 9
Organism
Bos taurus
Length
319 amino acids
Function
3-alpha-hydroxysteroid dehydrogenase that converts 3-alpha-tetrahydroprogesterone (allopregnanolone) to dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesterone. Plays also a role in the biosynthesis of retinoic acid from retinaldehyde. Can utilize both NADH and NADPH.
Similarity
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Mass
35.388 kDa
Sequence
MLFWLLVLLILCGFLWNYKRQLKIANITDKYIFITGCDTGFGNLAARTFDKKGFHVIAACLTESGSTALKAETSERLHTVLLDVTDPENVKRAAQWVKNQVGEKGLWGLINNAGILGVLAPNDWLTVEDYREPVEVNLFGLISVTLNMLPLVKKARGRIINVSSIGGRLAFGGGGYSPSKYAVEGFNDSLRRDMKAFGVHVACIEPGLFKTNLSDPEKTAEKKLAIWKHLSPDIKQQYGESYIEKSLEQLKGTASFVNVDLSLVVECMDHALTSLFPKTRYAAGKDAKTFWIPLSHMPAVLQDFLLLKQKVELANPRAV
Protein
Dehydrogenase/reductase SDR family member 9: DHRS9

Gene
DHRS9
Protein
Dehydrogenase/reductase SDR family member 9
Organism
Homo sapiens
Length
319 amino acids
Function
3-alpha-hydroxysteroid dehydrogenase that converts 3-alpha-tetrahydroprogesterone (allopregnanolone) to dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesterone (PubMed:11294878, PubMed:29541409). Plays also a role in the biosynthesis of retinoic acid from retinaldehyde (PubMed:11304534, PubMed:12618084). Can utilize both NADH and NADPH.
Similarity
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Mass
35.227 kDa
Sequence
MLFWVLGLLILCGFLWTRKGKLKIEDITDKYIFITGCDSGFGNLAARTFDKKGFHVIAACLTESGSTALKAETSERLRTVLLDVTDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLAPTDWLTLEDYREPIEVNLFGLISVTLNMLPLVKKAQGRVINVSSVGGRLAIVGGGYTPSKYAVEGFNDSLRRDMKAFGVHVSCIEPGLFKTNLADPVKVIEKKLAIWEQLSPDIKQQYGEGYIEKSLDKLKGNKSYVNMDLSPVVECMDHALTSLFPKTHYAAGKDAKIFWIPLSHMPAALQDFLLLKQKAELANPKAV
Protein
Dehydrogenase/reductase SDR family member 9: DHRS9

Gene
Dhrs9
Protein
Dehydrogenase/reductase SDR family member 9
Organism
Mus musculus
Length
319 amino acids
Function
3-alpha-hydroxysteroid dehydrogenase that converts 3-alpha-tetrahydroprogesterone (allopregnanolone) to dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesterone. Plays also a role in the biosynthesis of retinoic acid. Can utilize both NADH and NADPH.
Similarity
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Mass
35.242 kDa
Sequence
MLFWLLALLFLCAFLWNYKGQLKIADIADKYVFITGCDTGFGNLAARTFDKKGFRVIAACLTESGSAALKAKTSERLHTVLLDVTDPENVKKTAQWVKSHVGEKGLWGLINNAGVLGVLAPTDWLTVDDYREPIEVNLFGLINVTLNMLPLVKKARGRVINVSSIGGRLAFGGGGYTPSKYAVEGFNDSLRRDMKAFGVHVSCIEPGLFKTELADPIKTTEKKLAIWKHLSPDIKQQYGEGYIEKSLHRLKSNTSSVNLDLSLVVGCMDHALTSLFPKTRYIAGKDAKTFWIPLSHMPAVLQDFLLLKQKVELANPKAV
Protein
Dehydrogenase/reductase SDR family member 9: Dhrs9

Gene
Dhrs9
Protein
Dehydrogenase/reductase SDR family member 9
Organism
Rattus norvegicus
Length
319 amino acids
Function
3-alpha-hydroxysteroid dehydrogenase that converts 3-alpha-tetrahydroprogesterone (allopregnanolone) to dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesterone (By similarity). Plays also role in the biosynthesis of retinoic acid from retinaldehyde (PubMed:12390888). Can utilize both NADH and NADPH (By similarity).
Similarity
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Mass
35.214 kDa
Sequence
MLLWVLALLFLCAFLWNYKGQLKIADIADKYIFITGCDSGFGNLAARTFDRKGFRVIAACLTESGSEALKAKTSERLHTVLLDVTNPENVKETAQWVKSHVGEKGLWGLINNAGVLGVLAPTDWLTVDDYREPIEVNLFGLINVTLNMLPLVKKARGRVINVSSIGGRLAFGGGGYTPSKYAVEGFNDSLRRDMKAFGVHVSCIEPGLFKTGLADPIKTTEKKLAIWKHLSPDIKQQYGEGYIEKSLHRLKSSTSSVNLDLSLVVECMDHALTSLFPKTRYTAGKDAKTFWIPLSHMPAALQDFLLLKEKVELANPQAV
Protein
Dehydrogenase/reductase SDR family member 9: Dhrs9