Ccdc65

Dynein regulatory complex subunit 2

502 amino acids

Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with DRC1 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules.

Belongs to the DRC2 family.

59.004 kDa

MPKKGKKPKLPLTDEEQLILFQQKLLADEEAAKKKERLLTQFLKDKLAKEEHNSSLNLNKINTQWRTVLREVKTRELHKDIEILSQIFERVVDCKDSVIKSLARDLTEAEEQYAHALRGHLHNVDQLLTLQRRRLSLLEENYNMELEVLTKEFETERKAILDHHDKEIHYLHDVFMAMEQNYVDSEYESKLEFQSMWDDLKNKNLEEKHFLRLQLENVVEDLWRRFQDALKNYTDATEDRKIAFETLKVKDEKSSKEIEVQMKKIQRLQEAISALKGKIVAHSREGEWQNQCIRNDKELVHVQLRKLKIQRTQARTESQENLVKLTLESNATLKALKKVVEKGEKILKLAEICRKFETEEEKVLPFYSSALTPEEQEEVEIQSQEEITEDLAKIMMDYLGMENFWKRYNKVKLEVLSLQHRRLQLLDISSKLREMLKQYLDGISVSDEVLSRLNPLFIVNHKSNLPQLPPSAAQPGGDRGPGGDRRLTYNVIEAAHIASHIL

CCDC65

Dynein regulatory complex subunit 2

498 amino acids

Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with DRC1 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules.

Belongs to the DRC2 family.

58.814 kDa

MSKKGKKAKVPLSDEEQLLLFQQKLLAEEEMAKKKERLLNQFLKDKLAKEEHNSALNLNKINTQWRTVLREIKTRELHKDIEILSQTFERVVDCKDSVIKSLAKDLSEAEEQHAHALRSHLHSIDQLLALQRCRLNLLEENYNMELEALTKEFETERKTIIDQHEKEIHYLQDVFMAMEQNYIDSEYESKLEFQSMWDDLKNKNLEEKHFLRLQLENIVEDLWRRFQDALKNYTDATEDRKIAFETLKVKDEKSSREIEAQMKKIQKLQDSIIIFKGKILVHSRESEEQNQDIREDKELVLVQLRKLKAQRTQARGIAQENLVKLTLESSATLKALREIVDKGEKILKLAEICRKFETEEEKVLPFYSSVLTPKEQEEIETMDLEEFNEELGKVIMDYKGMENFWKRYNKVKLEQLSLRHRRAQLLEINEKLREMLRQYLDGISVSDEVLSQLNPLFIVNHRSNLPQLLPMPTAQPGDKKPPATYNIIEAAHVVSHTL

Ccdc65

Dynein regulatory complex subunit 2

493 amino acids

Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with DRC1 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules.

Belongs to the DRC2 family.

58.17 kDa

MSKKGKKPKLPKAPLSEEDQLLIFQQKMLADEEAAKKKERLLTQFLKDKLAKEEHNSALNLNKINTQWRTILREVKTRELHQDIEILSQTFERVVDCKDSVIKSLAKDLTEAEEQYAHALRSHLHNIDQLLTLQRRRLGLLEENYNMELEVLTKEFETERKLIIDHHEKEMHYLQDVFMAMEQNYIDSEYESKLEFQSMWDDLKNKNLEEKHFLRLQLENIVEDLWRRFQDALKNYTDATEDRKIAFEYLKVKDEKSSKEIETQMKKIQKLQETIGILKGKIVAHSREGEWQNQCIRNNKELVHVQLRKLKVQRTQARTLSQENLVKLTLESNATLKALKKVVEKGEKILKLAEICRKFETEEEKVLPFYSSVLTPEEQEEAKLQNPEDITEDLAKIMMDYAGMENFWKRYNKVKLEVLSLQHRRLQLLDISSKLREMLKQYLDGISVSDEVLSHLNPLFVVNHRSNLPQLPPPSAQPVYNVIEAAHIASHIL

ccdc65

Dynein regulatory complex subunit 2

492 amino acids

Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes (By similarity). Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with DRC1 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules.

Belongs to the DRC2 family.

57.703 kDa

MPKKAGKKAGGKLAGLTEEERLLYMQQKAQAEEEIAKRKEDMLTHFLKDKLQKEEKNTVLNLHKLRQQWRAVLTQTKIAELRNDMSVLSQTFERVLDYKDNIIRSLQVDLSERELQSELKRSSHLHNVDCLLEIHKSRLAQLEFNFKSSLVELSSEYNTEREQILSQHQQECVDLDNVMFSMEKHYSDLDGEAKRDYQSTRNQIKKRNFDDKQAVKEQMDGVVEKLWQDQQQVLNHYNESTRDKIITTDDLMNKDVQSAKEIDSLKKHIQKLQDSISTFRGQLSSGQTDKTAEQLRSERDELAQEVQHFRVQLNAAQAIRKKHITKLTVQSNDATKKLQEIVARGERLLRQCEMCCKLETEHEKVLPFYKSSLSEEEQKQEKAKAMESSNEKLTQLMHDYSPLAKFWQRYNKVELDCLCVKREKLLLLQENERLRLFLKQYLDEVSVSDESFRQQKLLVVSSPALQDTAATDRHQQKRHVVQEAACIVQKQL

CCDC65

Dynein regulatory complex subunit 2

484 amino acids

Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes (By similarity). Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with DRC1 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules (PubMed:24094744).

Belongs to the DRC2 family.

57.297 kDa

MPKKEKMAKTPLSDEKQLLLFQQKLLAEEEMAKKKERLLSQFLKDKLAKEEHNSALNLNKINTQWRTVLREVKTRELHKDIEILSQTFERVVDCKDNVIKSLAKDLSEAEEQYAHALRSHLHNVDQLLALQRHRLSLLEESYNMELEALTKEFETERKTIIDQHEKEIHYLQDIFMAMEQNYIDSEYESKLEFQSMWNDLKNMNLEEKHFLRLHLENRVEDLWRKFQDVLKNYTDATEDRKAAFETLQVKDEKSSKEIEVQMKKIQKLQDAITISKGKIMIHSRESEDENRYIRNDKELVLVQLRKLKAQRTQARAASQKNLVRLTLESNATLKALRKIVDKGEKILKLAEICRKFETEEEKVLPFYSSVLTPKEQEGIQKNNLEELTEELTKVMVDYIGMENFWKRYNKVKLEQLSLQHRRAQLLDINGKLREMLKQYLDGISVSDEVLSQLNPLFIVNYQSNLLQPLSIRIAHPGDKQHPTT

CCDC65

Dynein regulatory complex subunit 2

484 amino acids

Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with DRC1 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules.

Belongs to the DRC2 family.

57.131 kDa

MPKKEKKAKTPLSDEEQLLLFQQKLLTEEEMAKKKERLLSQFLKDKLAKEEHNSALNLNKINTQWRTVLREVKTRELHKDIEILSQTFERVVDCKDNVIKSLAKDLSEAEEQYARALRSHLHSVDQLLALQRHRLSLLEESYNMELEALTKEFETERKTIIDQHEKEIHYLQDIFMAMEQNYIDSEYESKLEFQSMWNDLKNMNLEEKHFLRLHLENIVEDLWRKFQDVLKNYTDATEDRKAAFETLQVKDEKSSKEIEVQMKKIQKLQDAITISKGKIMIHSRESEDENRYIRNDKELVLVQLRKLKAQRTQARAASQKNLVKLTLESNATLKALRKIVDKGEKILKLAEICRKFETEEEKVLPFYSSVLTPKEQEGIEENNLEELTEELAKVMVDYTGMENFWKRYNKVKLEQLSLQHRRAQLLDINGKLREMLKQYLDGISVSDEVLSQLNPLFIVNYQSNLPQPLSIPIAHPGDKQHPTT