Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes (By similarity). Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with DRC1 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules.

Belongs to the DRC2 family.

492 amino acids

MPKKAGKKAGGKLAGLTEEERLLYMQQKAQAEEEIAKRKEDMLTHFLKDKLQKEEKNTVLNLHKLRQQWRAVLTQTKIAELRNDMSVLSQTFERVLDYKDNIIRSLQVDLSERELQSELKRSSHLHNVDCLLEIHKSRLAQLEFNFKSSLVELSSEYNTEREQILSQHQQECVDLDNVMFSMEKHYSDLDGEAKRDYQSTRNQIKKRNFDDKQAVKEQMDGVVEKLWQDQQQVLNHYNESTRDKIITTDDLMNKDVQSAKEIDSLKKHIQKLQDSISTFRGQLSSGQTDKTAEQLRSERDELAQEVQHFRVQLNAAQAIRKKHITKLTVQSNDATKKLQEIVARGERLLRQCEMCCKLETEHEKVLPFYKSSLSEEEQKQEKAKAMESSNEKLTQLMHDYSPLAKFWQRYNKVELDCLCVKREKLLLLQENERLRLFLKQYLDEVSVSDESFRQQKLLVVSSPALQDTAATDRHQQKRHVVQEAACIVQKQL

57.7 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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