Protein
Sarpagan bridge enzyme
Organism
Gelsemium sempervirens
Function
Involved in monoterpene indole alkaloids (MIAs) biosynthesis (PubMed:29942076). Converts by cyclization the strictosidine-derived geissoschizine to the sarpagan alkaloid polyneuridine aldehyde (PubMed:29942076). Converts by aromatization the tetrahydro-beta-carboline alkaloids tetrahydroalstonine and ajmalicine to the corresponding beta-carboline alkaloids alstonine and serpentine, respectively (PubMed:29942076).
Similarity
Belongs to the cytochrome P450 family.
Sequence
MEVMQLSFSYPALFLFVFFLFMLVKQLRRPKNLPPGPNKLPIIGNLHQLATELPHHTLKQLADKYGPIMHLQFGEVSAIIVSSAKLAKVFLGNHGLAVADRPKTMVATIMLYNSSGVTFAPYGDYWKHLRQVYAVELLSPKSVRSFSMIMDEEISLMLKRIQSNAAGQPLKVHDEMMTYLFATLCRTSIGSVCKGRDLLIDTAKDISAISAAIRIEELFPSLKILPYITGLHRQLGKLSKRLDGILEDIIAQREKMQESSTGDNDERDILGVLLKLKRSNSNDTKVRIRNDDIKAIVFELILAGTLSTAATVEWCLSELKKNPGAMKKAQDEVRQVMKGETICTNDVQKLEYIRMVIKETFRMHPPAPLLFPRECREPIQVEGYTIPEKSWLIVNYWAVGRDPELWNDPEKFEPERFRNSPVDMSGNHYELIPFGAGRRICPGISFAATNAELLLASLIYHFDWKLPAGVKELDMDELFGAGCVRKNPLHLIPKTVVPCQD