Involved in monoterpene indole alkaloids (MIAs) biosynthesis (PubMed:29942076). Converts by cyclization the strictosidine-derived geissoschizine to the sarpagan alkaloid polyneuridine aldehyde (PubMed:29942076). Converts by aromatization the tetrahydro-beta-carboline alkaloids tetrahydroalstonine and ajmalicine to the corresponding beta-carboline alkaloids alstonine and serpentine, respectively (PubMed:29942076).

Belongs to the cytochrome P450 family.

501 amino acids

MEVMQLSFSYPALFLFVFFLFMLVKQLRRPKNLPPGPNKLPIIGNLHQLATELPHHTLKQLADKYGPIMHLQFGEVSAIIVSSAKLAKVFLGNHGLAVADRPKTMVATIMLYNSSGVTFAPYGDYWKHLRQVYAVELLSPKSVRSFSMIMDEEISLMLKRIQSNAAGQPLKVHDEMMTYLFATLCRTSIGSVCKGRDLLIDTAKDISAISAAIRIEELFPSLKILPYITGLHRQLGKLSKRLDGILEDIIAQREKMQESSTGDNDERDILGVLLKLKRSNSNDTKVRIRNDDIKAIVFELILAGTLSTAATVEWCLSELKKNPGAMKKAQDEVRQVMKGETICTNDVQKLEYIRMVIKETFRMHPPAPLLFPRECREPIQVEGYTIPEKSWLIVNYWAVGRDPELWNDPEKFEPERFRNSPVDMSGNHYELIPFGAGRRICPGISFAATNAELLLASLIYHFDWKLPAGVKELDMDELFGAGCVRKNPLHLIPKTVVPCQD

56.6 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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