CSTF77

Cleavage stimulation factor subunit 77

734 amino acids

One of the multiple factors required for polyadenylation and 3'-end cleavage of pre-mRNAs (By similarity). Required for the targeted 3' processing of antisense transcripts that triggers transcriptional silencing of the corresponding sense gene (PubMed:19965720).

82.65 kDa

MADKYIVEEAEALAKRALHSPIAQATPIYEQLLSLYPTSARFWKQYVEAQMAVNNDDATKQIFSRCLLTCLQVPLWQCYIRFIRKVYDKKGAEGQEETTKAFEFMLNYIGTDIASGPIWTEYIAFLKSLPALNLNEDLHRKTALRKVYHRAILTPTHHVEQLWKDYENFENTVNRQLAKGLVNEYQPKFNSARAVYRERKKYIEEIDWNMLAVPPTGTSKEETQWVAWKKFLSFEKGNPQRIDTASSTKRIIYAYEQCLMCLYHYPDVWYDYAEWHVKSGSTDAAIKVFQRALKAIPDSEMLKYAFAEMEESRGAIQSAKKLYENILGASTNSLAHIQYLRFLRRAEGVEAARKYFLDARKSPSCTYHVYIAFATMAFCIDKEPKVAHNIFEEGLKLYMSEPVYILKYADFLTRLNDDRNIRALFERALSTLPVEDSAEVWKRFIQFEQTYGDLASILKVEQRMKEALSGKGEEGSSPPESSLQDVVSRYSYMDLWPCTSNDLDHLARQELLVKNLNKKAGKTNLPHVPAAIGSVASSSKVVYPDTSQMVVQDPTKKSEFASSANPVAASASNTFPSTVTATATHGSASTFDEIPKTTPPALVAFLANLPIVDGPTPNVDVVLSICLQSDFPTGQTVKQSFAAKGNPPSQNDPSGPTRGVSQRLPRDRRATKRKDSDRQEEDDTATVQSQPLPTDVFRLRQMRKARGIATSSQTPTGSTSYGSAFSGELSGSTG