One of the multiple factors required for polyadenylation and 3'-end cleavage of pre-mRNAs (By similarity). Required for the targeted 3' processing of antisense transcripts that triggers transcriptional silencing of the corresponding sense gene (PubMed:19965720).

734 amino acids

MADKYIVEEAEALAKRALHSPIAQATPIYEQLLSLYPTSARFWKQYVEAQMAVNNDDATKQIFSRCLLTCLQVPLWQCYIRFIRKVYDKKGAEGQEETTKAFEFMLNYIGTDIASGPIWTEYIAFLKSLPALNLNEDLHRKTALRKVYHRAILTPTHHVEQLWKDYENFENTVNRQLAKGLVNEYQPKFNSARAVYRERKKYIEEIDWNMLAVPPTGTSKEETQWVAWKKFLSFEKGNPQRIDTASSTKRIIYAYEQCLMCLYHYPDVWYDYAEWHVKSGSTDAAIKVFQRALKAIPDSEMLKYAFAEMEESRGAIQSAKKLYENILGASTNSLAHIQYLRFLRRAEGVEAARKYFLDARKSPSCTYHVYIAFATMAFCIDKEPKVAHNIFEEGLKLYMSEPVYILKYADFLTRLNDDRNIRALFERALSTLPVEDSAEVWKRFIQFEQTYGDLASILKVEQRMKEALSGKGEEGSSPPESSLQDVVSRYSYMDLWPCTSNDLDHLARQELLVKNLNKKAGKTNLPHVPAAIGSVASSSKVVYPDTSQMVVQDPTKKSEFASSANPVAASASNTFPSTVTATATHGSASTFDEIPKTTPPALVAFLANLPIVDGPTPNVDVVLSICLQSDFPTGQTVKQSFAAKGNPPSQNDPSGPTRGVSQRLPRDRRATKRKDSDRQEEDDTATVQSQPLPTDVFRLRQMRKARGIATSSQTPTGSTSYGSAFSGELSGSTG

82.7 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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