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CSN8

Gene
CSN8
Protein
COP9 signalosome complex subunit 8
Organism
Arabidopsis thaliana
Length
197 amino acids
Function
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes such as photomorphogenesis and auxin and jasmonate responses. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. It is involved in repression of photomorphogenesis in darkness by regulating the activity of COP1-containing Ubl ligase complexes. The complex is also required for degradation of IAA6 by regulating the activity of the Ubl ligase SCF-TIR complex.
Similarity
Belongs to the CSN8 family.
Mass
22.547 kDa
Sequence
MDLSPVKEALAAKSFDKIADICDTLMLQVASEGIEYHDDWPYAIHLLGYFYVDDCDSARFLWKRIPTAIKERKPEVVAAWGIGQKLWTHDYAGVYEAIRGYDWSQEAKDMVAAFSDLYTKRMFQLLLSAYSTITIHDLALFLGMTEDDATTYVVENGWTVDAASQMASVKKQAVKREQKVDSSKLQRLTEYVFHLEH

Gene
csn8
Protein
COP9 signalosome complex subunit 8
Organism
Dictyostelium discoideum
Length
196 amino acids
Function
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of E3 ligase complexes, leading to modify the Ubl ligase activity.
Similarity
Belongs to the CSN8 family.
Mass
22.508 kDa
Sequence
MAFTEIANLISSKNFKAILDYCQRQEIESKNIDLIKSYYGVYLLSYLINNDLINAKHLWKRIPNDFKQSNQQLKNIYTIIKSISQTNPTITYTSLSINIGDDYTPFITTLKENFQQRTFELISNAYSSITVNDCSSYLGISPEDTIKFTTSKCWEHDKASNTLKPVPIQKQSSELPTGNQQIRSLTSYVLFLEKST

Gene
csn8
Protein
COP9 signalosome complex subunit 8
Organism
Xenopus laevis
Length
195 amino acids
Function
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of E3 ligase complexes, leading to modify the Ubl ligase activity (By similarity).
Similarity
Belongs to the CSN8 family.
Mass
21.756 kDa
Sequence
MKLSESVMAQNSVSFQKLQEQCEEQELEAPGGIASPQVYNQLLALYLLHNDLNNARYLWKRIPSAIKSSHSELGGIWEVGQKIWQRDFPGIYTSISAYQWSENIQQIMEAVRDATQQRAFGLVSQAYTSISADDFAAFVGLPVEEAVKGVLEQGWQADSATGMVMPKKPDSAPLSLIPNEQQLARLTDYVAFLEN

Gene
csn8
Protein
COP9 signalosome complex subunit 8
Organism
Xenopus tropicalis
Length
193 amino acids
Function
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of E3 ligase complexes, leading to modify the Ubl ligase activity (By similarity).
Similarity
Belongs to the CSN8 family.
Mass
21.552 kDa
Sequence
MPVAVMAQNPVSFQRLQEQCEEQELEAPGGIANPQVYSQLLALYLLHNDMNNARYLWKRIPPAIKSAHSELGGIWEVGQKIWQRDFPGIYTSISACQWSEAIQPVMEAVRDATRRRAFGLVSQAYTSISADDFAAFVGLSVEEAVKGVIEQGWQADLATRMVMPKKPDSAPLSLIPNEQQLARLTDYVAFLEN

Gene
CSN8
Protein
COP9 signalosome complex subunit 8
Organism
Drosophila melanogaster
Length
182 amino acids
Function
Probable component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. The CSN complex plays an essential role in oogenesis and embryogenesis and is required for proper photoreceptor R cell differentiation and promote lamina glial cell migration or axon targeting. It also promotes Ubl-dependent degradation of cyclin E (CycE) during early oogenesis.
Similarity
Belongs to the CSN8 family.
Mass
21.431 kDa
Sequence
MHLNKYSEVVERLENEEFEQVELGAEVYQQLLAIYLYQNKLADAKLLWMRVPANLRDDKELIQLNLLNIALQNNNYADFFKHIKYEWSERVKSPVEDLLNKQREELFKLMGSAYMSIYQHNLLELSLMSEDELKHACAALNWTEELDGDRVILKPKVQEAPPARGNDDQLLKLTEFVTFLEN

Gene
CSN8
Protein
COP9 signalosome complex subunit 8
Organism
Brassica oleracea
Length
23 amino acids
Function
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes such as photomorphogenesis and auxin and jasmonate responses. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. It is involved in repression of photomorphogenesis in darkness by regulating the activity of COP1-containing Ubl ligase complexes (By similarity).
Similarity
Belongs to the CSN8 family.
Mass
2.748 kDa
Fragment
single
Sequence
LWTRDYAGVYEAIRGFDWSQDAK