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CSKMT

Gene
cskmt
Protein
Citrate synthase-lysine N-methyltransferase CSKMT, mitochondrial
Organism
Danio rerio
Length
254 amino acids
Function
Protein-lysine methyltransferase that selectively trimethylates citrate synthase (CS) in mitochondria. Seems to conduct trimethylation in a highly distributive manner rather than in a processive manner, and thus introduces a single methly group per binding event.
Similarity
Belongs to the methyltransferase superfamily.
Mass
28.331 kDa
Sequence
MLLNRFLVPLRSLQKLTQARRWHQTSLINDLVVNMDKKAMWDRFYTENGSKGQFKNFEWFFGFPSVKDLVLPALQAMSCSHSGPLHILDMGCGTSALGPCIYSTSPCAVRVTCADISPVAVKLMEEHTKSTSTQPCNPSSALVFLELDCTQMTGHFKSRSLDLILDKGTTDALVRSKEGQVKAGQILRQSLQVLRPSGSFLQFSDEDPDARLIWLEREVQGAEVTADVGVQEIGELRGVSYFCYQISPRSRPHS

Gene
CSKMT
Protein
Citrate synthase-lysine N-methyltransferase CSKMT, mitochondrial
Organism
Homo sapiens
Length
240 amino acids
Function
Protein-lysine methyltransferase that selectively trimethylates citrate synthase (CS) in mitochondria (PubMed:28391595, PubMed:28887308). Seems to conduct trimethylation in a highly distributive manner rather than in a processive manner, and thus introduces a single methly group per binding event (PubMed:28887308).
Similarity
Belongs to the methyltransferase superfamily.
Mass
25.91 kDa
Sequence
MAALRRMLHLPSLMMGTCRPFAGSLADSCLADRCLWDRLHAQPRLGTVPTFDWFFGYDEVQGLLLPLLQEAQAASPLRVLDVGCGTSSLCTGLYTKSPHPVDVLGVDFSPVAVAHMNSLLEGGPGQTPLCPGHPASSLHFMHADAQNLGAVASSGSFQLLLDKGTWDAVARGGLPRAYQLLSECLRVLNPQGTLIQFSDEDPDVRLPCLEQGSYGWTVTVQELGPFRGITYFAYLIQGSH

Gene
CSKMT
Protein
Citrate synthase-lysine N-methyltransferase CSKMT, mitochondrial
Organism
Pongo abelii
Length
240 amino acids
Function
Protein-lysine methyltransferase that selectively trimethylates citrate synthase (CS) in mitochondria. Seems to conduct trimethylation in a highly distributive manner rather than in a processive manner, and thus introduces a single methly group per binding event.
Similarity
Belongs to the methyltransferase superfamily.
Mass
25.956 kDa
Sequence
MAALRRMLHLPRLTMGTCRPFAGSLADSCLADRCLWDRLHAQPRLGTVPTFDWFFGYEEVQGLLLPLLQEAQAASPLRVLDVGCGTSSLCTGLYTKSPHPVDVLGVDFSPVAVAHMNSLLEGGPGQTPLCPGHPASSLHFMHADARNLGAVASSGSFQLLLDKGTWDAVAQGGLPRAYQLLSECLRVLNPQGTLIQFSDEDPDVRLPCLEQGSRGWTVTVQELGPFRGITYFAYLIQGSH