Protein
NAD(P)H-hydrate epimerase
Organism
Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)
Function
Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.
Similarity
Belongs to the NnrE/AIBP family.
Sequence
MPIRYISQKLAQQIDVELMSASGAFSLDQLMELAGLSCAQALAKSFPPTKHKHVMVACGPGNQGGDGLVAARHLHHFSYTPTVYLPKPSSKDFLQRLVKQCENLNIPILKDVDAFQTELAKSDVILDAIFGFSFQPPLRKPFDQVLKAIKGVSKKIPIVSVDIPSGWSVTDGPQPLWTEEDDKGGKEMIETFEPEVLVSLTAPKEGVKAFKGQHWLGGRFVPDELGKKHELNIPPYEGIDQVVELPRNH