Protein
Serrate RNA effector molecule homolog
Organism
Drosophila pseudoobscura pseudoobscura
Function
Acts as a mediator between the cap-binding complex (CBC) and RNA-mediated gene silencing (RNAi). Involved in innate immunity via the short interfering RNAs (siRNAs) processing machinery by restricting the viral RNA production. Also involved microRNA (miRNA)-mediated silencing by contributing to the stability and delivery of primary miRNA transcripts to the primary miRNA processing complex containing drosha and pasha (By similarity).
Similarity
Belongs to the ARS2 family.
Sequence
MADSDDEYDRKRRDKFRGERESYRTERRDERRPIGGAGGGRDEWSERNPFRGGGAGGGGAPRHRPDYSDYRGPGPRARYGSPVRDMPPPKRMRSDWGDGDGRPGPRYGGYDPYLMQAWTDHYQSMHSAYHHASHPPPVRELPIIGGDTLTQPAMLNLKQFLDTQDENISDSEVMRKYTEYKTDFKRQQLNEFFVAHKDEEWFKNKYHPEDSVNRSEEQRGFLRRRTDVFVELLENGTIGSVKVDSSHGDALIRVLDTCVIKLEGGTDEDLKVLDEKPKEALVFDRKPESVDPTTVVENTPKSPKKEKEEDELPLIVSPQRIALKPVNSDDENWDDAEVEDAPPKKPEEEEPKESEPIPEIKQKQKKEKKKKIKKRKRNSSSDEESSSSESESSSSSSEEEEEDDEKLKAKYDVEDGLRAEQKAEAEKDQAEAAKAKLGSVSPKEEISPEKSAADPEVEGEAKEDGKQAEKSPKCDDEKKQENGDAAKVESAAEPATGDAQGEVKPVTIDLDKVNPPRAMHRTSSIFLRNLAPSITKAEIEALCSRFSGYLRTAIADPLVERRWYRRGWITFTRDVNIKEICWSLNNQRLRDCEMGAIVNRDLSRRVRPANGITAHKQVVRSDIKLCARIVMNLDEKFKLWSEGPLSKPSPASDSEATAANGSGSSYGFNSKNPVLQNITDYLIEEASAEEEELLGLSGDRKDGEGEPIERDEQLLSVLDRLVLYLRIVHSVDYYNHCEYPYEDEMPNRCGIIHARGPAPSRVTSNELNEYIKSYEGKLLQFLTKTALLSEDQIKDLGAKNADTEVEKFVQANTQELAKDKWLCPLSGKKFKGPEFIRKHIFNKHEEKVDEVRKEVQYFNNYLRDPKRPQLPEHPGSVKRPETESVRGPGGYRPPMYTPMSGMPYSFGGHMMGGGRGGRHFPPARRELPLEHHRRLVGYHDLDAPSNSDIFD