Acts as a mediator between the cap-binding complex (CBC) and RNA-mediated gene silencing (RNAi). Involved in innate immunity via the short interfering RNAs (siRNAs) processing machinery by restricting the viral RNA production. Also involved microRNA (miRNA)-mediated silencing by contributing to the stability and delivery of primary miRNA transcripts to the primary miRNA processing complex containing drosha and pasha (By similarity).

Belongs to the ARS2 family.

951 amino acids

MADSDDEYDRKRRDKFRGERESYRTERRDERRPIGGAGGGRDEWSERNPFRGGGAGGGGAPRHRPDYSDYRGPGPRARYGSPVRDMPPPKRMRSDWGDGDGRPGPRYGGYDPYLMQAWTDHYQSMHSAYHHASHPPPVRELPIIGGDTLTQPAMLNLKQFLDTQDENISDSEVMRKYTEYKTDFKRQQLNEFFVAHKDEEWFKNKYHPEDSVNRSEEQRGFLRRRTDVFVELLENGTIGSVKVDSSHGDALIRVLDTCVIKLEGGTDEDLKVLDEKPKEALVFDRKPESVDPTTVVENTPKSPKKEKEEDELPLIVSPQRIALKPVNSDDENWDDAEVEDAPPKKPEEEEPKESEPIPEIKQKQKKEKKKKIKKRKRNSSSDEESSSSESESSSSSSEEEEEDDEKLKAKYDVEDGLRAEQKAEAEKDQAEAAKAKLGSVSPKEEISPEKSAADPEVEGEAKEDGKQAEKSPKCDDEKKQENGDAAKVESAAEPATGDAQGEVKPVTIDLDKVNPPRAMHRTSSIFLRNLAPSITKAEIEALCSRFSGYLRTAIADPLVERRWYRRGWITFTRDVNIKEICWSLNNQRLRDCEMGAIVNRDLSRRVRPANGITAHKQVVRSDIKLCARIVMNLDEKFKLWSEGPLSKPSPASDSEATAANGSGSSYGFNSKNPVLQNITDYLIEEASAEEEELLGLSGDRKDGEGEPIERDEQLLSVLDRLVLYLRIVHSVDYYNHCEYPYEDEMPNRCGIIHARGPAPSRVTSNELNEYIKSYEGKLLQFLTKTALLSEDQIKDLGAKNADTEVEKFVQANTQELAKDKWLCPLSGKKFKGPEFIRKHIFNKHEEKVDEVRKEVQYFNNYLRDPKRPQLPEHPGSVKRPETESVRGPGGYRPPMYTPMSGMPYSFGGHMMGGGRGGRHFPPARRELPLEHHRRLVGYHDLDAPSNSDIFD

107.8 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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