Protein
D-galactonate dehydratase family member Achl_0790
Organism
Pseudarthrobacter chlorophenolicus (strain ATCC 700700 / DSM 12829 / CIP 107037 / JCM 12360 / KCTC 9906 / NCIMB 13794 / A6)
Function
Has no detectable activity with D-mannonate and with a panel of 70 other acid sugars (in vitro), in spite of the conservation of the residues that are expected to be important for catalytic activity and cofactor binding. May have evolved a divergent function.
Similarity
Belongs to the mandelate racemase/muconate lactonizing enzyme family. GalD subfamily.
Sequence
MKIIAADVFVTSPSRNFVTLRITTEDGVTGIGDATLNGRELAVAAYLKEHVAQLLIGKDPHRIEDTWQFLYRSSYWRRGPVTMAAIAAVDMALWDIKGKVAGMPVYQLLGGASRNGLRAYGHASGADIPSLFDSVREHLELGYKSIRIQTAVPGIKAVYGVAAQAQASGERYDYEPAGRGAFPVEEDWDTRAYLRHLPSVFEAVRNEFGPEIPLLHDGHHRMTPIQAAKLGKALEPYDLFWLEDCTPAENQEALRLVRQHTTTPLAIGEIFNTVYDYQTIIKEQLIDYVRAASTHFGGISPLKKVMDFAAQYQIKSGFHGPTDISPVGFAAQLHVGLAIHNYGIQEYMQHSDKTNEVFHQSMTFKDGYLHPGDEPGIGVEFNEEAAAAFPYQQAYLPYNRLVDGTVHDW