ATG18

Autophagy-related protein 18

568 amino acids

The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Necessary for proper vacuole morphology. Plays an important role in osmotically-induced vacuole fragmentation. Required for cytoplasm to vacuole transport (Cvt) vesicle formation, pexophagy and starvation-induced autophagy. Involved in correct ATG9 trafficking to the pre-autophagosomal structure. Might also be involved in premeiotic DNA replication (By similarity).

Belongs to the WD repeat SVP1 family.

60.933 kDa

MLKSQIAPIPSYESQPVHKPSSSVNFITFNQDGSCIAVGNNKGYSIFTTNPFTKCYDSPPGEAIGIVEMLYSTSLVVVVALGEETGSSPRKLKIINTKRGSTICDLVFPSTILKVKLTRSRMIVLLEEQIYLYDISTMKLLHTIETSPNMAGICAISADQGSTDTSNSADNSGSIGSGPASGSGAGSGSASMTSTDSTPDAQSHSYLAYPSPPKTAMHDSLLVAGINTNGGSHSKQNNIQSVSNAPNRVGDVIIFDTDSLQPLCVIEAHKSALAAISLSSDGRLLATASDKGTIVRVFSVSTGAKLYQFRRGTYPTKVYSVAFSPDNRYVVTTSASGTVHIFRLGEDESLESKHKRKRASRQHETIAEETSATQDLDDEIEDDGDDSDVDDVESLEVVPSKQRKLSQGSSNSYTSMNSGISGMSEDGKEPKIDPIVDHARLSVARMIRRSSQTLGRKAAQKMGDFLPSKFASILEPTRHFASLKIASASKDVKSIAVLDSQVVHDMVPQMFLHSKDAAPASALDTQSMTEMALLHIFVVTSDGYLYVYGLDPERGGDCILLQQHSFDI

ATG18

Autophagy-related protein 18

563 amino acids

The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Necessary for proper vacuole morphology. Plays an important role in osmotically-induced vacuole fragmentation. Required for cytoplasm to vacuole transport (Cvt) vesicle formation, pexophagy and starvation-induced autophagy. Involved in correct ATG9 trafficking to the pre-autophagosomal structure. Might also be involved in premeiotic DNA replication (By similarity).

Belongs to the WD repeat SVP1 family.

61.538 kDa

MLKAQSAAAGSLHQTLSQYSASIATDGSSSVTGSFKTDDSVNFITFNQDASCIAVGLNNGYKIFNCKPKFGKCYQIRKEESVGIIEMLYCTSLLAIVALGEEPGSSPRKLKIVNTKRQTTICDLIFPSTILQVKLTKSRLIVLLEEQIYIYDITTMKLLHTIETSPNSIGLCALSTTPDNDGNNYLAYPSPPKTITHDSLLASGINTNGGTNSVVNNISSVSNSPNRVGDVIMFNLNTLQPMSVIEAHKSALAAITLSSDGSLLATASDKGTIVRVFSVATGVKLFQFRRGTYSTKIYSLSFSSDNNYVVATSSSETVHIFRLGESEALENKHKKKKASTPKPTQPETIEEEDATLLQERPSQESTQDDDEFADDGDDSDEAVEGDDNDDESLEVISNKQRKLSQGSSNSFASFNSGTDDSSQAAKNEPLIDQNRLSVARLIRRSSQTLGRKAAQRMGDFLPSRFSSILEPTRHFASLKINAIGKDVKSIAVMNNELQEDLVPQAFLMRKDSDSYLSKEMLSLNLLHIYVVTSEGFFYTYGLDPERGGDCILLHQYSLIDESN

ATG18

Autophagy-related protein 18

562 amino acids

The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Necessary for proper vacuole morphology. Plays an important role in osmotically-induced vacuole fragmentation. Required for cytoplasm to vacuole transport (Cvt) vesicle formation, pexophagy and starvation-induced autophagy. Involved in correct ATG9 trafficking to the pre-autophagosomal structure. Might also be involved in premeiotic DNA replication (By similarity).

Belongs to the WD repeat SVP1 family.

62.45 kDa

MLKNQSNSVHVDGSHNNSSNYNDEVSSIAKSIRNADESVNFITFNQDASCIALGLKNGYKIFNCKPNFGKCYQFKKNESIGKIEMLYCTSLIAIVGLGEEVGSSPRKLKIINTRRQSTICELIFPSTILQVKLSKSRMIILLEEQIYIYDVTTMKLLHTIETSPNGNGLCTLSADNCDGKNNSYLAYPSPPKTITHDSLLVNGINTNGGMNSIQNNIQSVSNSPNRIGDVIIFNTTTLQPLSVIEAHKSALAAITLSTDGTLLATASDKGTIVRVFSVATGLKLYQFRRGTYPTKIFTLSFSFDNKYVLATSSSGTVHIFRLGEEESLENKHKRKRNSKKLKLNPEYETITEENENEIQKDDAEDDDIIQDDGDDSDADDDDDESLEVIPSKHRKLSQDSNNSFTSFNSAFSNDDNKDNKSEPLIDQTRLSVARLIRRSSQTLGRKAAQKMGDFLPTRFSSILEPTRNFASLKINSVSKDIKSIAIINNEVQEDLVPQAYLNAKENNPSPPKDISVNTAKDLLPLNLLHINVVTSEGYFYTYGLDPDRGGDCILLHQYFLLD

ATG18

Autophagy-related protein 18

558 amino acids

The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Necessary for proper vacuole morphology. Plays an important role in osmotically-induced vacuole fragmentation. Required for cytoplasm to vacuole transport (Cvt) vesicle formation, pexophagy and starvation-induced autophagy. Involved in correct ATG9 trafficking to the pre-autophagosomal structure. Might also be involved in premeiotic DNA replication (By similarity).

Belongs to the WD repeat SVP1 family.

61.694 kDa

MLQTSSSSATASLQQQLSKQYANSFSNDGSSFSSKNNQQYSEIVNYISFNQDASCITIGLKNGYKIFNCQPNFGRSFQFKNDESTGIVEMLYCTSLLATVAQGEEIGSSPRKLKIINTKTKSTICDLIFPSTILQVKLTNTRLIVVLEDQIYLYDITTMKLLHTIETSPNLSGLSAISYDDSNSYLAYPSPPKTITHDSLLASGINTNGGSNSTQNNISSVSNTPNRVGDVIIFNLTSLQPISVIEAHKSTIASMAFSNNGLYLATASDKGTIVRIFEVATGTKLYQFRRGTYPTKIYSLRFSADDKYVLATSSSLTVHIFRLGEEEALETKHKKKKIPAVATILEEETEGSQSNEQTKSIKRNSEEFEDIRDDGDDSDVDDEDGDIDDESLEVIPAKQRKLSQGSTNSYTSVNSEDVQSNSPKTEPLIDQNRLSMARIIRRSSQTLGRKAAQKMGDFLPSRFSSILEPTRNFASLKINAHSKDTKSVAVMNNVLQQDLIPQTYLASDNASAKQDFMEVSLFHIYVVTTEGMLYTYGLDPERGGDCILLNSHCILDEY

ATG18

Autophagy-related protein 18

558 amino acids

The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Necessary for proper vacuole morphology. Plays an important role in osmotically-induced vacuole fragmentation. Required for cytoplasm to vacuole transport (Cvt) vesicle formation, pexophagy and starvation-induced autophagy. Involved in correct ATG9 trafficking to the pre-autophagosomal structure. Might also be involved in premeiotic DNA replication (By similarity).

Belongs to the WD repeat SVP1 family.

61.146 kDa

MLIDYPPTINFINFNQTGSCISIATDDGFSIYNCDPFGKFYSQKNYSIVEMLFSTSLLAVVGLGDQPALSQRRLTMINTKTYSIICEVTFPSAILSVKMNKSRLVVLLRDQIYIYDINNMRLLHTIETTSNKLGIISISSSPSPDHNMYLAYPSPPKFINSDIKSNLTTNNISIASSSSSQVEPPLNPQQRSNFSGNTLETIQDGKSYDGSNNSNNGNNNNNNNNNNNNNNNNNNNNNNNNNNSNNEENSNSKSFQQTGITGSSNSTIMKNGDVILFDLQTLQPTMVIEAHKGPIAALTLSFDGSLLATASEKGTIIRVFNVETGAKIYQFRRGTYPTEVYSLAFSKDNQFLAATSSSKTVHIFKLGKIMETSSDDNNNNTDDDSLNAGNIDSEIVTNLSSESLTESQSKDPHVDTSRSTVGRMIRKSSQQLSRQAAKKLGQIFPLKVASILESSRHFASFKLPTTGSGGGNSTGAGGQIKSISCFGEEIELDSSEYPELFNQGQDTTSNISQSKNPKLMKMQPIRIVSSDGNYYNYILDPERGGDCLLLSQYSILTN

ATG18

Autophagy-related protein 18

543 amino acids

The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Necessary for proper vacuole morphology. Plays an important role in osmotically-induced vacuole fragmentation. Involved in correct ATG9 trafficking to the pre-autophagosomal structure. Might also be involved in premeiotic DNA replication (By similarity). Required for cytoplasm to vacuole transport (Cvt) vesicle formation, autophagy, glucose-induced micropexophagy and ethanol-induced macropexophagy. Required for the involution of the vacuole that occurs during micropexophagy. Involved in the recruitment of ATG2 to punctate structures when cells are grown on glucose.

Belongs to the WD repeat SVP1 family.

59.893 kDa

MSQPTDEADKSTGNAQVTHESINFANFNQDSTCVSVGYQSGYKIFNVEPFTKCLSLADTSIGIVEMLFSSSLVAIVGLGELPDSSPRKLKVFNTKRRSIICELTFPTSILAVKMNRERMVVLLEDTIYIYDINTMRILHTIETPSNPEGLIALSSSTENNILAYPSPPKLPNRQETSTKGTTNDNDRSHLENIPENVNANSSNLRNGDVIIFNSHTLQPISVIEAHKAQLSAIALSSDGTLLATASNKGTIVRVFDVETGVKLYQFRRGTYPTKIYCLSFSQDNRFVCASSATETVHIFRLGQDEANNTMPSRWSKNQKLALQRYKQSMKQXQGSKPSSLVDSDSDPDVDELVENDNSDDDELEEDIDDELAEERFNSSLTVPRRVSSTTSLGSYGSQESIGDKIEPHVDSARRSVARMIRRTSQSLGRKAAEKMGPYLHPKFSSLLEPNRHFASLKVPASKDTKTVVAIGNSVGQGELLQLGEHEDVDNSSSTSDSTFHQKLLHVMVVSSEGFFYNFGLDTERGGDCTLLSQYSLLTDVNDG

ATG18

Autophagy-related protein 18

537 amino acids

The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Necessary for proper vacuole morphology. Plays an important role in osmotically-induced vacuole fragmentation. Required for cytoplasm to vacuole transport (Cvt) vesicle formation, pexophagy and starvation-induced autophagy. Involved in correct ATG9 trafficking to the pre-autophagosomal structure. Might also be involved in premeiotic DNA replication (By similarity).

Belongs to the WD repeat SVP1 family.

58.032 kDa

MSRTGMPVINFINFNQTGTCISMGTSEGLKIFNCDPFGRFYSDEDGGCGIVEMLFSTSLLAVVGIGDNPSMSPRRLRILNTKRHSVICEVTFPTTILAVKMNRSRLVVLLQEQIYIYDINSMRLLYTIETSSNPRGLISMSPSLENNYLAYPSPPKVINSGIKSNANTNNIGISARSSIAEGGSEYLDKGTEPLTDSSKAGADLNSVKASTETTISPGKEHSAGSGLNATSSSGTVKNGDVIFFNLQTLQPTMVIEAHKGEIAALALSKDGTLLATASEKGTIIRVFSVETCTKVYQFRRGTYPTRIYSLNFSDDNEFLAASSSNKTVHIFKLGKPNAENSSAAATNSDDDEGEADSDDGADDDGVGDSDDTRSTVSIESFDNGSHQTREPIVDSSRKTVGRMIRKSSQNLSRKAAKALGSYFPKKVTSILEPRRHFASLKIPIESGSNLKTICTIGEPLTLDISDYPELFSGSRTMAQSASISANSSDSSLTRNSNFVKMIPIRVVSSEGYMYNYVLDPERGGDCLLLSQYPLLMD

ATG18

Autophagy-related protein 18

526 amino acids

The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Necessary for proper vacuole morphology. Plays an important role in osmotically-induced vacuole fragmentation. Required for cytoplasm to vacuole transport (Cvt) vesicle formation, pexophagy and starvation-induced autophagy. Involved in correct ATG9 trafficking to the pre-autophagosomal structure. Might also be involved in premeiotic DNA replication (By similarity).

Belongs to the WD repeat SVP1 family.

57.675 kDa

MSELPVTHLNFNQDTSCVALGLMTGYKIVNIQLKFGKCCCYNDDSINLIEMLYTTSLIVMTPLGNEIGSSPRELKIKNTKTNSTICSLFFPTTILNIKLTRDHLIVVLENQIYIYEIKTMKLLQTIKTDSNPLGLCAVSYDQETNLLAFPSPPKAKDALASMRSSSGNAKSTHAAGTSHNSHNGANKGTVFKGDLILFDLNKFQPIMAISAHKNDIAAVAFSADGTLISTASHKGTIVRVFDTNTGVKLFQFRRGSYPTKIYSLQFSLDNKYVLATSSSMTVHIFRLGEDEALETKHKKRIKTINEEPSAVAAAAIAAAREASNNGGETTTTTTAAAATSGPRENGGEDDDSDSMDDDLDVDDDDDNEDDCDDDDDETPVKQRKLSQGSSNSYASINSEDINSPVIDQNRLSVARIIRRQSQNLGRKAAQKMGDYLPSRFSSILEPTRHFASIKVEAKHKDVKSIATINNSQHDIISLQYDSRDNMDANLLQINVVTSEGMLYIYGLDSERGGDCILLNLYSLIDE

ATG18

Autophagy-related protein 18

525 amino acids

The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Necessary for proper vacuole morphology. Plays an important role in osmotically-induced vacuole fragmentation. Required for cytoplasm to vacuole transport (Cvt) vesicle formation, pexophagy and starvation-induced autophagy. Involved in correct ATG9 trafficking to the pre-autophagosomal structure. Might also be involved in premeiotic DNA replication (By similarity).

Belongs to the WD repeat SVP1 family.

57.936 kDa

MASPNPLAFEAATAAHEVAASYVTEHKPRKNDNINFANFNQDFSCVSVGYSNGYKIYNCEPFGQCYSKSDGSIGIVEMLFSSSLLAIVGMGEQHSLSPRRLKIINTKRQTTICELTFPGAILAVKLNRERLVVLLEETIYIYDINNMRLLHTIETPSNPNGLIALSPSSENNYLAYPSPQKLAPNPQTEVTLHSNPQTVRNGDVIIFDAKTLQPTSVIEAHRTSLAAIALSKDGLLLATASDKGTIIRVFSVATGIKLYQFRRGTYPTKIYSLAFSPDNRFVIASSATETVHIFRLGEEEAANTIKSANKKARLTKAQVPNPLETSPDIYPHNQHTSSDEDEELNEDEEDLDGDEDEDLEDDAHVPVSLQRGRSSSSTGSFHSSESMTDKLKEPLVDNSRKSVARMLRRTSQSLGRKAAEKMGTYLPPKFSSILEPNRHFASLKVPASKETKTVVGVGSKIWDDLIPSVYLKDDANSITETSEDLVNKKLVHIMVITSEGFFYKFGLDPERGGDCVLLHQQSLFG

ATG18

Autophagy-related protein 18

513 amino acids

Component of the PI(3,5)P2 regulatory complex that regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (By similarity). Plays an important role in osmotically-induced vacuole fragmentation (By similarity). Required for cytoplasm to vacuole transport (Cvt) vesicle formation, pexophagy and starvation-induced autophagy (By similarity). Involved in correct ATG9 trafficking to the pre-autophagosomal structure (By similarity). With ATG2, protects ATG8 from ATG4-mediated cleavage (By similarity).

Belongs to the WD repeat SVP1 family.

57.117 kDa

MSDLPIINFINFNQNGTCISIGTSQGFKIFNCEPFGRFYQDDEGGCGIVEMLFSTSLLAVVGMGENPAMSPRRLRMLNTKRHSVICEVTFPTTILSIKMNKTRLAVLLQEQIYIYDISNMRLLHTIETSMNAQGLMSMSPNSENNYLVYPSPPKVINSEIKDHATTNNINIKKSDAAEDPLRKDHFAYDPSDHSHPQSTTESTSNNHNRTYSSGNNNNTNSNPNKIIKNGDVIVFNLQTLQPTMVIEAHKGEIAALKLSADGTLLATASEKGTIIRVFNVENGSKVYQFRRGTYSTKISSLSFSKDNQFLAVCSSSKTVHIFKLGEKIIDNTKPNELNSDDDMDDDLLPQFENGDDEEEVDEETLDEEATSLNSSHSNKEPIVDSSRSTVGRMIRKSSQRLSRKAAKTLGAYFPIKVSSILEPSRHFASLKISTTTNQPIKAIAAIDDPISLNTNEYPDLFDTSNQADHQNTDGLKMIPVRVLSSEGYMYKYILDPERGGDCILLEQYSLLSE

ATG18

Autophagy-related protein 18

505 amino acids

The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Necessary for proper vacuole morphology. Plays an important role in osmotically-induced vacuole fragmentation. Required for cytoplasm to vacuole transport (Cvt) vesicle formation, pexophagy and starvation-induced autophagy. Involved in correct ATG9 trafficking to the pre-autophagosomal structure. Might also be involved in premeiotic DNA replication (By similarity).

Belongs to the WD repeat SVP1 family.

55.55 kDa

MPNKAVSIYYLNFNQTGTCISMGTSNGFLIFNCAPFGKFYSEDSGGYGIVEMLFSTSLLALVGIGDQPMLSPRRLRIINTKKHSIICEVTFPTKILSVKMNRSRIVVVLKEQIYIYDINNMRLLHTIEIAPNPEGLVALSCNTDTNLLAYPSPPKVISSDINPNVNTNTINIARSKSEELIANSKDNNLQNKFGTTLEGQQNIDEDKAANGYQVDQNTDTAENDINSGDVIIYDMSTLQPLMVIEAHKGEIAALNFSFDGSLIATASEKGTIIRVFSTSSGAKLYQFRRGTYPTKIYSLSFSQDNRFLSVTCSSKTVHIFKLTKTGEERTSGGADDADSDDSGNENDGDNNSVGNGDVSSLLSDNDIESTREPYVDASRKTMGRMIRNSSQKLSRRAAKTLGQLFPIKVTSILEPSRHFASLKLPTDSNISGNVKTLCSIGNEMEVDKVEYPELFDGQDQGDRTKVTMLPIRVISSEGYLYNYVLDPERGGDCLLLSQYSTAIDQ

ATG18

Autophagy-related protein 18

500 amino acids

The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Necessary for proper vacuole morphology. Plays an important role in osmotically-induced vacuole fragmentation. Required for cytoplasm to vacuole transport (Cvt) vesicle formation, pexophagy and starvation-induced autophagy. Involved in correct ATG9 trafficking to the pre-autophagosomal structure. Might also be involved in premeiotic DNA replication (By similarity).

Belongs to the WD repeat SVP1 family.

55.515 kDa

MSNLPIINFINFNQNGSCISMGTSQGFKIFNCEPFGRFYQDEEGGCGIVEMLFSTSLLAVVGMGDNPAMSPRRLRMLNTKRHSVICEVTFPTTILSVKMNKSRLAVLLQEQIYIYDISNMRLLHTIETSMNAQGIMSMSPNSENNYLVYPSPPKVINSEIKDHATTNNINIKKTDAVDDTIKKDYSLQVPSDITGQQQQQQPGVDPATSNNTANKIIKNGDVIVFNLQTLQPTMVIEAHKGEIAALKLSADGTLLATASEKGTIIRVFNVENGSKVYQFRRGTYPTKISSLSFSKDNQFLAVCSSSKTVHIFKLGKNTVDNKSNELNSDDEIEDDLVPRYGDEDEEDEEIDEEATSINSNHSSKEPVVDAKRSTVGRMIRKSSQRLSRKAARTLGAYFPIKVSSILEPSRHFASLKITTSSNQPIKAIAAIDDPIELSIKEYPDLFEKNASNNGDYQNSDTLTMVPIRVVSSEGFMYKYISDPERGGDCILLEQYSLLSD

ATG18

Autophagy-related protein 18

500 amino acids

The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). May negatively regulate FAB1 activity by sequestering or masking VAC7 from FAB1. Necessary for proper vacuole morphology. Plays an important role in osmotically-induced vacuole fragmentation. Required for cytoplasm to vacuole transport (Cvt) vesicle formation, pexophagy and starvation-induced autophagy. Involved in correct ATG9 trafficking to the pre-autophagosomal structure. Might also be involved in premeiotic DNA replication. With ATG2, protects ATG8 from ARG4-mediated cleavage (By similarity).

Belongs to the WD repeat SVP1 family.

55.102 kDa

MSDSSPTINFINFNQTGTCISLGTSKGFKIFNCEPFGKFYSEDSGGYAIVEMLFSTSLLALVGIGDQPALSPRRLRIINTKKHSIICEVTFPTSILSVKMNKSRLVVLLQEQIYIYDINTMRLLHTIETNPNPRGLMAMSPSVANSYLVYPSPPKVINSEIKAHATTNNITLSVGGNTETSFKRDQQDAGHSDISDLDQYSSFTKRDDADPTSSNGGNSSIIKNGDVIVFNLETLQPTMVIEAHKGEIAAMAISFDGTLMATASDKGTIIRVFDIETGDKIYQFRRGTYATRIYSISFSEDSQYLAVTGSSKTVHIFKLGHSMSNNKLDSDDSNMEEAAADDSSLDTTSIDALSDEENPTRLAREPYVDASRKTMGRMIRYSSQKLSRRAARTLGQIFPIKVTSLLESSRHFASLKLPVETNSHVMTISSIGSPIDIDTSEYPELFETGNSASTESYHEPVMKMVPIRVVSSDGYLYNFVMDPERGGDCLILSQYSILMD

ATG18

Autophagy-related protein 18

500 amino acids

The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). May negatively regulate FAB1 activity by sequestering or masking VAC7 from FAB1. Necessary for proper vacuole morphology. Plays an important role in osmotically-induced vacuole fragmentation. Required for cytoplasm to vacuole transport (Cvt) vesicle formation, pexophagy and starvation-induced autophagy. Involved in correct ATG9 trafficking to the pre-autophagosomal structure. Might also be involved in premeiotic DNA replication. With ATG2, protects ATG8 from ATG4-mediated cleavage.

Belongs to the WD repeat SVP1 family.

55.102 kDa

MSDSSPTINFINFNQTGTCISLGTSKGFKIFNCEPFGKFYSEDSGGYAIVEMLFSTSLLALVGIGDQPALSPRRLRIINTKKHSIICEVTFPTSILSVKMNKSRLVVLLQEQIYIYDINTMRLLHTIETNPNPRGLMAMSPSVANSYLVYPSPPKVINSEIKAHATTNNITLSVGGNTETSFKRDQQDAGHSDISDLDQYSSFTKRDDADPTSSNGGNSSIIKNGDVIVFNLETLQPTMVIEAHKGEIAAMAISFDGTLMATASDKGTIIRVFDIETGDKIYQFRRGTYATRIYSISFSEDSQYLAVTGSSKTVHIFKLGHSMSNNKLDSDDSNMEEAAADDSSLDTTSIDALSDEENPTRLAREPYVDASRKTMGRMIRYSSQKLSRRAARTLGQIFPIKVTSLLESSRHFASLKLPVETNSHVMTISSIGSPIDIDTSEYPELFETGNSASTESYHEPVMKMVPIRVVSSDGYLYNFVMDPERGGDCLILSQYSILMD

ATG18

Autophagy-related protein 18

469 amino acids

The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Necessary for proper vacuole morphology. Plays an important role in osmotically-induced vacuole fragmentation. Required for cytoplasm to vacuole transport (Cvt) vesicle formation, pexophagy and starvation-induced autophagy. Involved in correct ATG9 trafficking to the pre-autophagosomal structure. Might also be involved in premeiotic DNA replication (By similarity).

Belongs to the WD repeat SVP1 family.

50.451 kDa

MATATLNFITFNQDHGCLAVGTSRGFRIYHTEPFSKIFSSEDGNVSIIEMLFSTSLVALILSPRHLIIQNTKRGSVICELTFPSAVLAVRLNRKRLAVVLEDEIYLYDIANMSLLFTIATSPNPSAICALSPSSENCFLAYPLPKPREDKDDKRPSHAPPLPTYIPPTSGDVLIFDAITLKAVNVIEAHRSPLSCIAINSEGTLLATASETGTIIRVFTVPKGQKLYQFRRGTYPSTIYSMSFNLSSTLLCVSSTSDTVHIFRLGGPNNGASGAAGAGSAGEVLAASPGQDITGSPRADRWSRSRSYDSGNESPGSGSEANDIAGSPSPRDRPTAANRRQSGSFSNILRRSSQIMGRSVAGVVGSYLPQTVTEMWEPARDFAFIKIPKSSAARQHNNPGATPSLPIAGEPLRSVVAMSSSSPQVMVVTSDGKFYVYNINMETGGEGYLVRQYSILENDDKHDSSSTYES

ATG18

Autophagy-related protein 18

459 amino acids

Component of the PI(3,5)P2 regulatory complex that regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (By similarity). Plays an important role in osmotically-induced vacuole fragmentation (By similarity). Required for cytoplasm to vacuole transport (Cvt) vesicle formation, pexophagy and starvation-induced autophagy (By similarity). Involved in correct ATG9 trafficking to the pre-autophagosomal structure (By similarity). With ATG2, protects ATG8 from ATG4-mediated cleavage (By similarity). Autophagy is required for proper vegetative growth, asexual/sexual reproduction, and full virulence (PubMed:28894236). Autophagy is particularly involved in the biosynthesis of deoxynivalenol (DON), an important virulence determinant (PubMed:28894236).

Belongs to the WD repeat SVP1 family.

49.247 kDa

MTSPALNFITFNQDHSCLAVGTSKGFRIYHTDPFSRIFSSDDGNIAIIEMLFSTSLVALILSPRHLIIQNTKRASTICELTFPSAVLAVRLNRKRLAVVLEEEIYLYDISNMSLLHTIATSPNPSAICALSPSSENCFIAYPLPKPREDPDANRPAHAPPQSTFVAPTSGEVLIFDTLSLKAVNVIEAHRSPLCCICLNNEGTLLATASETGTIIRVFSVPKGKKLYQFRRGTYPSTIYSMSFNLSSTLLCVSSTSDTIHIFRLGAPPGNTTPAGAPIESPASQRQDRWSRARSYDDSESPGASAADSPKNEPAELNGPGAGNNQGGHTRGSGSFSSMLRRSSQIMGRGVAGVMGSYLPQSVTEMWEPLRDFAYIKIPKSAAASGASRTLRDAPGGPLRSVVAMSSSSPQVMVVTSDGGFYVYNIDMEHGGEGYLVKQFSVNHSVLEGDDKSDASGYGS

ATG18

Autophagy-related protein 18

453 amino acids

The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Necessary for proper vacuole morphology. Plays an important role in osmotically-induced vacuole fragmentation. Required for cytoplasm to vacuole transport (Cvt) vesicle formation, pexophagy and starvation-induced autophagy. Involved in correct ATG9 trafficking to the pre-autophagosomal structure. Might also be involved in premeiotic DNA replication (By similarity).

Belongs to the WD repeat SVP1 family.

47.807 kDa

MSSSSLPTKSSNALLSVNFNQDHSCIAVGTRDGYSITNCEPFGRVYTNNAGPTSLVEMLFCTSLVALVATSDTDPKSNASPRRLQIVNTKRQSVICELLFPTAILGVKLNRRRLVVVLEQEIYIYDISNMKLLHTIETSPNPMAICALSPSSENCFLAYPSPVASPTSPFSNSGASSSAEANTTAGDVLIFDLLSLSVTNVIQAHKTPISALALNATGTLLATASDKGTVIRVFSIPAAQKLHQFRRGSYAARIYSLNFNAVSTLLAVSSDTETVHIFKLSSGAGAGAKGRSSSNGGESPSLNSFDGSSDSSSPPGSTTNATRGGYEAFMGKHKAAKSNGISGTLRRRSMALGRGITGSVGGYLPNSLTEMWEPSRDFAFLKLPSQGVSSVVALSSTTPHVMVVTSEGYFYSYAIDLEHGGECILMKQYSLIDPDLDTTSTARSDTATPSLAD

atg18

Autophagy-related protein 18

436 amino acids

The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Necessary for proper vacuole morphology. Plays an important role in osmotically-induced vacuole fragmentation. Required for cytoplasm to vacuole transport (Cvt) vesicle formation, pexophagy and starvation-induced autophagy. Involved in correct atg9 trafficking to the pre-autophagosomal structure. Might also be involved in premeiotic DNA replication (By similarity).

Belongs to the WD repeat SVP1 family.

47.359 kDa

MAMNFVTFNQDYSYLAVGSVSPPSATSKGFRIFTTDPFAKSYETKEGNIAIIEMLFSTSLVALILSPRRLQITNTKRQSTICELTFPTTVLAVRLNRKRLVIVLEDQIYLYDIQTMKLLYTIQTSPNPNAICALSPSSDNCYLAYPLPQKAPPSSFNPPSHTPPGTTHVSPTSGEVLIFDTLKLEAINVIEAHRSPLACITLNSDGTLLATASDKGTIIRVFSVPDGHKLYQFRRGSMPSRIFSMSFNTTSTLLCVSSSTETIHLFKLSHPTSSPDTSPSSPVGRDRSLSQSSSGYSPDRGDLTGDVGSSDFPARKHNGTLMGMIRRTSQNVGSTVAAKVGGYLPKGVSEMWEPTRDFAWFKLPKPSQTSGGSGNNGPLRSVVAMSSNTPQVMVVTSDGNFYVFSIDLSKGGEGTLTKQYSVLESNDRLGYSVTDY

atg18

Autophagy-related protein 18

434 amino acids

The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Necessary for proper vacuole morphology. Plays an important role in osmotically-induced vacuole fragmentation. Required for cytoplasm to vacuole transport (Cvt) vesicle formation, pexophagy and starvation-induced autophagy. Involved in correct atg9 trafficking to the pre-autophagosomal structure. Might also be involved in premeiotic DNA replication (By similarity).

Belongs to the WD repeat SVP1 family.

46.985 kDa

MNYVTFNQDYSCLAVGTAKGFRIYHTEPFSKIFTGDNENVTIIEMLFSTSLVAIKQSPRHIVIQNTKRGTVICELTFPSAVLAVRLNRKRFAVLLEEEIYLYDIQNMGLLYTISTSANPNAICSLSASSDNCYLAYPLPKPREETGDKRPAHAPPLSPYVAPTSGEVLIFDAKSLKAVNVIEAHRAPLSCIALNNDGTLLATASETGTIIRVFSVPDGQKLYQFRRGTYPSSIFSLSFNMSSTLLCVSSNSDTIHIFRLGGPVTGLPESPQSPGDKDKWRRSRSFDSENGSPPAGISPGSEMADVPAEKSKSSGTFGSMIRRSSQMVGKGVAGVVGGYLPQAVTEMWEPARDFAFIKLPKGGMGVTPRSGPVKSVVAMSSSSPQVMVVTSDGGFYIYSIDMETGGEGVLVKQYSVLESDDSLEPPPINYVSYRT

atg18

Autophagy-related protein 18

429 amino acids

The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Necessary for proper vacuole morphology. Plays an important role in osmotically-induced vacuole fragmentation. Required for cytoplasm to vacuole transport (Cvt) vesicle formation, pexophagy and starvation-induced autophagy. Involved in correct ATG9 trafficking to the pre-autophagosomal structure. Might also be involved in premeiotic DNA replication (By similarity).

Belongs to the WD repeat SVP1 family.

46.877 kDa

MTMNFVTFNQDYSYLAVATSKGFRIFTTDPFAKSYETKDGNIAIIEMLFSTSLVALILSPRRLQITNTKRQSTICELTFPTTVLAVKLNRKRLVIVLEDQIYLYDIQTMKLLYTIETSPNPNALCALSPSSENCYLAYPLPQKAAPSSFNPPAHAPPGNTHVSPTSGEVLIFDTLKLEAINVIEAHRSPLACITLNSDGTLIATASDKGTIIRVFSVPDGHKLYQFRRGSIPSRIFSMSFNTTSTLLCVSSSTETIHLFKLSQPSQLQETSSANTSSTGRRRSLSSLSQSPEREATEEDNGSSDLASRKHNGTLMGMLRRTSQNVGGAFAAKVGGYLPKGVSEMWEPARDFAWIKIPKPNQGQGPNANTGPLRSVVAMSSNTPQVMVVTSDGNFYVFSIDLSKGGEGTLTKQYSVLESNDRLGYSVADY

atg18

Autophagy-related protein 18

429 amino acids

The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Necessary for proper vacuole morphology. Plays an important role in osmotically-induced vacuole fragmentation. Required for cytoplasm to vacuole transport (Cvt) vesicle formation, pexophagy and starvation-induced autophagy. Involved in correct atg9 trafficking to the pre-autophagosomal structure. Might also be involved in premeiotic DNA replication (By similarity).

Belongs to the WD repeat SVP1 family.

46.744 kDa

MAMNFVTFNQDYSYLAVATSKGFRIFTTDPFAKSYETKEGNIAIIEMLFSTSLVALILSPRRLQITNTKRQSTICELTFPTTVLAVKLNRKRLVIVLEDQIYLYDIQTMKLLYTIQTSPNPNAICALSPSSDNCYLAYPLPQKAPPSSFNPPSHTPPGSTHVSPTSGEVLIFDTLKLEAINVIEAHRSPLACITLNSDGTLLATASDKGTIIRVFSVPDGHKLYQFRRGSMPSRIFSMSFNTTSTLLCVSSSTETIHLFKLSHPTSSPDASPSSPVGRDRSLSQSSSGYSPDRGDLTGDVGSSDFPARKHNGTLMGMIRRTSQNVGSTVAAKVGGYLPKGVSEMWEPTRDFAWFKLPKPNQTSGGSVNNGPLRSVVAMSSNTPQVMVVTSDGNFYVFSIDLSKGGEGTLTKQYSVLESNDRLGYSVTDY

atg18

Autophagy-related protein 18

427 amino acids

The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Necessary for proper vacuole morphology. Plays an important role in osmotically-induced vacuole fragmentation. Required for cytoplasm to vacuole transport (Cvt) vesicle formation, pexophagy and starvation-induced autophagy. Involved in correct atg9 trafficking to the pre-autophagosomal structure. Might also be involved in premeiotic DNA replication (By similarity).

Belongs to the WD repeat SVP1 family.

46.1 kDa

MAMNFVTFNQDYSYLAVATSKGFQIFTTEPFAKSYEAKEGNIAVIEMLFSTSLVALILSPRRLQIQNTKRQCTICELTFPTTVLAVKLNRKRLVIVLEDQIYLYDIQTMKLLSTIDTSPNPNAICALAPSSENCYMAYPLPQKAPAAASTPAHAPPGTTHVSPTTGDVLIFDAVKLEAINVIEAHRSPLALIALNSDGTLLATASDKGTIIRIFSVPDGHKLYQFRRGSMPSRIYSMSFNTTSTLLCVSSSTETVHIFKLAQQGPSSDGSSSHSPPSRDHGSPPNTYGYAHEEDEAVGDAGSDSSLRKHNGTLMGMIRRTSQNVGGAVAARMGGYLPKGVSEMWEPARDFAWIKLPRSNPGPGGNTGAGPLRSVVAMSSNTPQVMVVTSDGNFYVFNIDLSKGGEGTLTKQYSVVDSTDRLGYTTEY

ATG18

Autophagy-related protein 18

423 amino acids

The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Necessary for proper vacuole morphology. Plays an important role in osmotically-induced vacuole fragmentation. Required for cytoplasm to vacuole transport (Cvt) vesicle formation, pexophagy and starvation-induced autophagy. Involved in correct ATG9 trafficking to the pre-autophagosomal structure. Might also be involved in premeiotic DNA replication (By similarity).

Belongs to the WD repeat SVP1 family.

45.262 kDa

MSRLAKRHPDLLSCNFNQDYSCIAVGHKKGYTILNCDPFGKVHSNNDQGATGIVEMLFCTSLVALVGAAENQPSNSPRKLQIVNTKRQSTICELIFPTSVLAVKMNRKRLIVVLENEIYIYDISTMKLLHTIETGPNPNAVCALSSSSERSYLAYPSPVPSASSTPLSSSAIPAPPPAPTTGDVLLFDTISLTALNVIQAHKTPIAALALNSTGTMLATASDKGTVVRVFSVPDAKKLWQFRRGSSSARIFSINFNLMSTLLAVSSDTSTIHIYRLASSRKGGKDADDASTEEARSPTPSETPLASSPPLAGGKLDSHSAASSLRRRSYHLGKSFVGGVGGYLPKSVSEMWEPQRDFAFIKLRGNHGRTVVAMSATVPQVMVISSEGLFQAYNIDLENGGECSLMKEFALLGSEDFGNGSNGI

ATG18

Autophagy-related protein 18

423 amino acids

The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Necessary for proper vacuole morphology. Plays an important role in osmotically-induced vacuole fragmentation. Required for cytoplasm to vacuole transport (Cvt) vesicle formation, pexophagy and starvation-induced autophagy. Involved in correct ATG9 trafficking to the pre-autophagosomal structure. Might also be involved in premeiotic DNA replication (By similarity).

Belongs to the WD repeat SVP1 family.

45.276 kDa

MSRLAKRHPDLLSCNFNQDYSCIAVGHKKGYTILNCDPFGKVHSNNDQGATGIVEMLFCTSLVALVGAAENQPSNSPRKLQIVNTKRQSTICELIFPTSVLAVKMNRKRLIVVLENEIYIYDISTMKLLHTIETGPNPNAVCALSSSSERSYLAYPSPVPSASSTPLSSSAIPAPPPAPTTGDVLLFDTISLTALNVIQAHKTPIAALALNSTGTMLATASDKGTVVRVFSVPDAKKLWQFRRGSSSARIFSINFNLMSTLLAVSSDTSTIHIYRLASSRKGGKDADDASTEEARSPTPSETPLASSPPLAAGKLDSHSAASSLRRRSYHLGKSFVGGVGGYLPKSVSEMWEPQRDFAFIKLRGNHGRTVVAMSATVPQVMVISSEGLFQAYNIDLENGGECSLMKEFALLGSEDFGNGSNGI

atg18

Autophagy-related protein 18

423 amino acids

The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Necessary for proper vacuole morphology. Plays an important role in osmotically-induced vacuole fragmentation. Required for cytoplasm to vacuole transport (Cvt) vesicle formation, pexophagy and starvation-induced autophagy. Involved in correct atg9 trafficking to the pre-autophagosomal structure. Might also be involved in premeiotic DNA replication (By similarity).

Belongs to the WD repeat SVP1 family.

45.7 kDa

MNYVTFNQDYTCLAVGTAKGFRIYHTDPFSKIFTGDNENVTIIEMLFSTSLVAIKQSPRHIVIQNTKRGTVICELTFPSAVLAVRLNRKRFAVLLEEEIYLYDIQNMGLLYTISTSANPNAICALSASSENCYLAYPLPKPREETGDKRPAHAPPLSPYVAPTSGEVLIFDAKSLKAVNVVEAHRAPLSCIALNNDGTLLATASETGTIIRVFSVPDGQKLYQFRRGTYPSTIFSLSFNMSSTLLCVSSNSDTIHIFRLGGPVTGMPESPRSPNGKDKWKRSRSFDSDNGSPPAGTSPGSEMADVPVEKSKSTGTFGSMIRRSSQMMGKSVAGVVGGYLPQAVTEMWEPARDFAFIKLPKGGMGATSRSGPLKSVVAISSSSPQVMVVTSDGGFYIYSIDMEAGGEGVLVKQYSGRRQSRAAS

atg18

Autophagy-related protein 18

417 amino acids

The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Necessary for proper vacuole morphology. Plays an important role in osmotically-induced vacuole fragmentation. Required for cytoplasm to vacuole transport (Cvt) vesicle formation, pexophagy and starvation-induced autophagy. Involved in correct atg9 trafficking to the pre-autophagosomal structure. Might also be involved in premeiotic DNA replication (By similarity).

Belongs to the WD repeat SVP1 family.

45.374 kDa

MAMNFVTFNQDYSYLAVATSKGFRIFTTDPFAKSYETKEGHIAIIEMLFSTSLVALILSPRRLQITNTKRQSTICELTFPTTVLAVKLNRKRLVIVLEDQIYLYDIQTMKLLYTIQTSPNPNAICALSPSSDNCYLAYPLPQKAPPSSFTPPSHAPPGNTHVSPTSGEVLIFDSLKLEAINVIEAHRSPLACITLNSDGTLLATASDKGTIIRVFSVPDGHKLYQFRRGSMPSRIFSMSFNTTSTLLCVSSSTETIHLFKLSQQTSSSRDTSPSSSTPAGRDRAFSQSSLGHSPDRSDVSGEPDSSEFPARKHNGTLMGIIRRTSQNVGSTVAAKVGGYLPKGVSEMWEPARDFAWIKLPKPSQNAGGSGNNGPLRSVVAMSNNTPQVMVITSDGNFYVFSIDLSKGGEGTLTKQYS

ATG18

Autophagy-related protein 18

417 amino acids

The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Necessary for proper vacuole morphology. Plays an important role in osmotically-induced vacuole fragmentation. Required for cytoplasm to vacuole transport (Cvt) vesicle formation, pexophagy and starvation-induced autophagy. Involved in correct ATG9 trafficking to the pre-autophagosomal structure. Might also be involved in premeiotic DNA replication (By similarity).

Belongs to the WD repeat SVP1 family.

45.539 kDa

MSMNFVTFNQDYSYLAVGTSKGFRIFTTDPFGKSYETKEGNIAILEMLFSTSLVAVILSPRRLQIMNTKRQSVICELTFPTTVLAIRLNRKRLVIVLEDQIYIYDIQTMKLVYTIETSPNPNAICALAPSSDNCYLAYPLPQKAPPPSFSPPSHGPPSNTHIPPTSGEVLIFDAYKLEAVNVVEAHKSPLSFLALNSEGTLLATASDKGTIIRVFSVPAAHKLYQFRRGSMPSRIYSMSFNITSTLLCVSSATETIHIFKLGQQQGLSKTSSPSRKLESSRGSGDESAVESASSEMSSRKHNGTFMGMIRRTSQNVGNSFAATVGGYLPKGVTEMWEPERDFAWIKLPKSNGGNGGSGPVRSVVAMSSNTPQVMVVTSEGNFYVFNIDLSKGGEGTLVKQYSVLDSSDRMGSTDLDY

atg18

Autophagy-related protein 18

415 amino acids

The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Necessary for proper vacuole morphology. Plays an important role in osmotically-induced vacuole fragmentation. Required for cytoplasm to vacuole transport (Cvt) vesicle formation, pexophagy and starvation-induced autophagy. Involved in correct atg9 trafficking to the pre-autophagosomal structure. Might also be involved in premeiotic DNA replication (By similarity).

Belongs to the WD repeat SVP1 family.

45.142 kDa

MSMNFVTFNQDYSYLAVATSKGFRIFTTDPFAKSYETKEGNIAIIEMLFSTSLVALILSPRRLQITNTKRQSTICELTFPTTVLAVKLNRKRLVIVLEDQIYLYDIQTMKLLYTIETSPNPNALCALSPSSDNCYLAYPLPQKAPPSTFQPPAHAPPGTTHVTPTSGEVLIFDTLKLEAINVIEAHRSPLACITLNSDGTLIATASDKGTIIRVFSVPDGRKLYQFRRGSIPSRIYSMSFNTTSTLLCVSSSTETIHLFKLSLQSQSPDATPSSSLTAADRRSSQSSLGQLSDADDRVGDMGSSELASRKHNGTLMGMIRRTSQNVGSTFAAKVGGYLPKGVSEMWEPARDFAWIKLPKSNPGPGANGNNGPLRSVVAMSANTPQVMVVTSDGNFYVFNIDLSKGGEGTLTKQYS

atg18

Autophagy-related protein 18

414 amino acids

The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Necessary for proper vacuole morphology. Plays an important role in osmotically-induced vacuole fragmentation. Required for cytoplasm to vacuole transport (Cvt) vesicle formation, pexophagy and starvation-induced autophagy. Involved in correct atg9 trafficking to the pre-autophagosomal structure. Might also be involved in premeiotic DNA replication (By similarity).

Belongs to the WD repeat SVP1 family.

45.085 kDa

MAMNFVTFNQDYSYLAVATSKGFRIFTTDPFAKSYETKEGNIAIIEMLFSTSLVALILSPRRLQITNTKRQSTICELTFPTTVLAVKLNRKRLVIVLEDQIYLYDIQTMKLLYTIETSPNPNAICALSPSSDNCYLAYPLPQKAPPSSFNPPSHAPPGSTHVSPTTGEVLIFDALKLEAINVIEAHRSPLACITLNSDGTLIATASDKGTIIRVFSVPDGHKLYQFRRGSIPSRIYSMSFNTTSTLLCVSSSTETIHLFKLSHQTSSREGSPSSALSRERAASQSSLGTSPDPDDPTDDMESSEIASRKHNGTLMGMIRRTSQNVGSSFAAKVGGYLPKGVSEMWEPARDFAWIKLPKTNQTAGANGNAGSLRSVVAMSNNTPQVMVVTSDGNFYVFNIDLSKGGEGTLTKQYS

ATG18

Autophagy-related protein 18

414 amino acids

The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Necessary for proper vacuole morphology. Plays an important role in osmotically-induced vacuole fragmentation. Required for cytoplasm to vacuole transport (Cvt) vesicle formation, pexophagy and starvation-induced autophagy. Involved in correct ATG9 trafficking to the pre-autophagosomal structure. Might also be involved in premeiotic DNA replication (By similarity).

Belongs to the WD repeat SVP1 family.

45.103 kDa

MNFVTFNQDHSHLGVGTSNGYRVYTTDPFNKQSESREGDVSSLEMLFSTSLVALTLSPRVLRIQNTKGKRHSTICEMTFRTAILAMRLNRKRLVVVLESELYIYDISNMQMLRTEKTSPNPNAICALSASSENNYLIYPLPTKAAPATFQPPSHAPPKSDHIAPTSGEILIYDATKMEAVNVIEAHNSPLSCIALNNDGTLLATASEKGTIIRVFSIPDAQKLYQFRRGSIPARIFSMSFNSTSTLLSVSSATETVHIFRLGAPNTSRSNSISSGPTTLLSTSHQRSSSRTSEDISDEFGSSTADMAASERKPLNPTFASMIRRTSQTVGKSFAATVGGYLPSAVAEIWEPSRDFAWVKVPRSPNAASAGPVRTVVALSNNGPQIMVVTSEGNYYVFNVDLEKGGEGTLYKQYS

atg18

Autophagy-related protein 18

413 amino acids

The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Necessary for proper vacuole morphology. Plays an important role in osmotically-induced vacuole fragmentation. Required for cytoplasm to vacuole transport (Cvt) vesicle formation, pexophagy and starvation-induced autophagy. Involved in correct atg9 trafficking to the pre-autophagosomal structure. Might also be involved in premeiotic DNA replication (By similarity).

Belongs to the WD repeat SVP1 family.

44.983 kDa

MAMNFVTFNQDYSYLAVATAKGFRIFTTDPFAKSYETKEGNIAIIEMLFSTSLVALILSPRRLQITNTKRQSTICELTFPTTVLAVKLNRKRLVIVLEDQIYLYDIQTMKLLYTIETSPNPSAICALSPSSDNCYLAYPLPHKAPPTSFTPPSHAPPGNTHISPTSGEVLIFDTLKLEAINVIEAHRSPLACITLNSDGTLIATASDKGTIIRVFSVPDGHKLYQFRRGSIPSRIYSMSFNTTSTLLCVSSSTETIHLFKLSQGQSSESSLPSPSAPQRSMSQSSLSNSPDEDETSGDKDSSEFHSRKHNGTLMGMLRRTSQTVGSSFAAKVGGYLPKGVSEMWEPARDFAWIKLPKSNPGPGGNGNTGPLRSVVAMSNNTPQVMVVTSDGNFYVFSIDLSKGGEGTLTKQYS

ATG18

Autophagy-related protein 18

400 amino acids

The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Necessary for proper vacuole morphology. Plays an important role in osmotically-induced vacuole fragmentation. Required for cytoplasm to vacuole transport (Cvt) vesicle formation, pexophagy and starvation-induced autophagy. Involved in correct ATG9 trafficking to the pre-autophagosomal structure. Might also be involved in premeiotic DNA replication (By similarity).

Belongs to the WD repeat SVP1 family.

43.336 kDa

MAMNFVTFNQDYSYLAVGNIAILEMLFSTSLVALILSPRRLQITNTKRQSTICELTFPTTVLAVRLNRKRLVIVLEDQIYLYDIQTMKLLYTIETSPNPNAICALSPSSENCYLAYPLPQKAPPSSFTPPSHAPPSSAHISPTSGEVLIFDTLKLEAINVVEAHKSPLSCLAINTEGTLLATASDKGTIIRVFSVPDAQKLYQFRRGSMPSRIFSMSFNITSTLLCVSSATETIHIFKLGHQDPSEDLPTSPIGTDSRKTNSTPRERAFSQGSSTLSGGDNSPTDGDPSDISSRKHNGTLMGMIRRTSQNVGNSFAATVGGYLPKGVTEIWEPARDFAWIRLPKTAGYGGPGSNAGPVRSVVAMSSNTPQVMVVTSDGNFYVYNVDLSKGGEGTLTKQYS

ATG18

Autophagy-related protein 18

400 amino acids

The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Necessary for proper vacuole morphology. Plays an important role in osmotically-induced vacuole fragmentation. Required for cytoplasm to vacuole transport (Cvt) vesicle formation, pexophagy and starvation-induced autophagy. Involved in correct ATG9 trafficking to the pre-autophagosomal structure. Might also be involved in premeiotic DNA replication (By similarity).

Belongs to the WD repeat SVP1 family.

43.565 kDa

MSDSINFVSFNQDYSCVSVGTPQGYKIYNCDPFGKCFSKADGGMGIVEMLFCTSLIAVVGMGDQPQNSPRRLKIVNTKRQSTICELTFPTAVLGVRLNRQRLVVLLQDQIYIYDISNMKLVHTIETSPNPGAVCALSASSSDNNNYLVYPFPAPSSTAFNPGENNINDSSPNRKGDVTIFDCNSLQPVNVVEAHKTPLACLSLNSDGTLLATASDKGTIIRVFSVPKAQKLYEFRRGTYPAQIFSINFNLASNLMAVSSATETVHIFQLEAGVSSTPEVPQDTELAIPTRTPQQKGMASVFRKSSRSLGKGLAGAVGSYLPQTFTGMWEPLRDFAFIKQTSLPGTRSVVSVTSTNPPQVLVVTLEGYFYQYTLDLEKGGECDLIRQYSLLDNVEGSLYGP

ATG18

Autophagy-related protein 18

394 amino acids

The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Necessary for proper vacuole morphology. Plays an important role in osmotically-induced vacuole fragmentation. Required for cytoplasm to vacuole transport (Cvt) vesicle formation, pexophagy and starvation-induced autophagy. Involved in correct ATG9 trafficking to the pre-autophagosomal structure. Might also be involved in premeiotic DNA replication (By similarity).

Belongs to the WD repeat SVP1 family.

42.509 kDa

MADLSNTKLNYVTFNQDHSCLAVATSRGFRIYHTDPFSKIFNSDEGNVTIIEMLFSTSLVAMVRSPRHLVIQNTKRGSIICDLTFPTAVLAVRLNRKTLAVVLEEEIYVYDIGNMALKHTIATSPNPNAIFALSPMSDRSYIAYPMPKPREDQGERRPAHAPPLSEYVPPTSGALMVFDTTAGKAVNVIEAHKMPLCCIALNHEGTKVATASERGTIVRVHSVPEGHKLFEFRRGTIPSTIYNMSFNLSSTLLCVSSSSETVHIFRLASAQNANAGGAGPAALETPGSPRANRWSRSKSIDGSEYSPSGDSDSSPRGETPEAGPSGPSAARRQSGTFGSMLRRSSQIVSRSVAGAVVPYLPQSVAEMWEPQRDFASVKIPKPTNAGDALLGPCL

atg18

Autophagy-related protein 18

373 amino acids

The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Necessary for proper vacuole morphology. Plays an important role in osmotically-induced vacuole fragmentation. Required for cytoplasm to vacuole transport (Cvt) vesicle formation, pexophagy and starvation-induced autophagy. Involved in correct atg9 trafficking to the preautophagosomal structure. Might also be involved in premeiotic DNA replication (By similarity). Required for the recruitment of the atg5-atg12/atg16 complex to the preautophagosomal structure.

Belongs to the WD repeat SVP1 family.

41.109 kDa

MHFFVRKYRGKAALLSIGTFDGYKIYNCDPFGKCFHKIQGATSIVEMLFSTSLVALVEKDDGNNRKLKLINTKKSTTICELTFPTPLLAVKLNRKRLLAVLEEQIYVYDISNMLLLHTIETTSNVFAVCALSPNSENCYLAYPDSRDHEPRTEGESSSPNVSNSAVSGQVILWDVINCKQITKIEAHKDSLACLAFNSDGTMLATASDNGRIIRVFAIPSGQRLYQFRRGSLPAQIYSIAFHPDSSLLTVTSSTQTVHIFRLKEVYSNLERQGLLPSSPPPKESLLRRSSRSLIGTVGGYLPQSVSGMLDPERDFAYAHIPGDKVTSIAAFGPDNTIVNVATYDGNLYSFRVNLRTGGECAMVNHFCVGLTAA

atg18

Autophagy-related protein 18

372 amino acids

May be involved in cytoplasm to vacuole transport and autophagy.

Belongs to the WD repeat SVP1 family.

40.577 kDa

MNVGGKFNEGILFLNFNQDFSCIAVGTPEGYKIFNSDPYTLYYSQSNGGAGLVEMLFSTSLVSIVGSGDGNTSQRRLLINNIKNNIPICDLNFVTAILSVKMNRKRIVVIMETKIHIYDINNMKLLETREIASNPKGLCALSPSNTNYIVYPASQNNGNILVMDVLTLETVNLIQAHKSQISALALSQDGTLLATASDKGTVIRVFALPYANKSLSFRRGSIPAIIHSMTFSLDGRYLCVSSDTGTIHIFKIDFSSSNSSSFHQAQPSSSPSGGMMGLNFGGLTSKMSSYLPEVISQVWEPSRDFAHIKIPPGIPSICALMQNNKTAMVLTADSLYMQYNFDESVGGELKLAKEFSLLMEPDLDNDVTAKIL