The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Necessary for proper vacuole morphology. Plays an important role in osmotically-induced vacuole fragmentation. Required for cytoplasm to vacuole transport (Cvt) vesicle formation, pexophagy and starvation-induced autophagy. Involved in correct ATG9 trafficking to the pre-autophagosomal structure. Might also be involved in premeiotic DNA replication (By similarity).

Belongs to the WD repeat SVP1 family.

423 amino acids

MSRLAKRHPDLLSCNFNQDYSCIAVGHKKGYTILNCDPFGKVHSNNDQGATGIVEMLFCTSLVALVGAAENQPSNSPRKLQIVNTKRQSTICELIFPTSVLAVKMNRKRLIVVLENEIYIYDISTMKLLHTIETGPNPNAVCALSSSSERSYLAYPSPVPSASSTPLSSSAIPAPPPAPTTGDVLLFDTISLTALNVIQAHKTPIAALALNSTGTMLATASDKGTVVRVFSVPDAKKLWQFRRGSSSARIFSINFNLMSTLLAVSSDTSTIHIYRLASSRKGGKDADDASTEEARSPTPSETPLASSPPLAAGKLDSHSAASSLRRRSYHLGKSFVGGVGGYLPKSVSEMWEPQRDFAFIKLRGNHGRTVVAMSATVPQVMVISSEGLFQAYNIDLENGGECSLMKEFALLGSEDFGNGSNGI

45.3 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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