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ATG16

Gene
atg16
Protein
Autophagy-related protein 16
Organism
Xenopus tropicalis
Length
622 amino acids
Function
Plays an essential role in autophagy: interacts with ATG12-ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C), to produce a membrane-bound activated form of LC3 named LC3-II. Thereby, controls the elongation of the nascent autophagosomal membrane.
Similarity
Belongs to the WD repeat ATG16 family.
Mass
69.723 kDa
Sequence
MAAGCRGPACPSWRLHISRELRRRDREQRQVFEELISQYKRLLEKSDLQSVLADKLQAEKYEQQSRHDSSPGPDGMRNDMLLQDMAQMRIKHQEELTELHKKRGELAQTVIELNNQMQQKDKEIQANEEKIAKYLQTIQDLETECQDLRNKLQELERANQTLKDEYDALQITFTALEDKLRKTTEDNQELVSRWMAEKAQEANRLNAENEKDSKRRQARLQKELAEAAKEPLSFEHDDDIEVLNDNADPVGDSAGAQATGRNISKRNSQPAVGGLLDSITNIFGLSESPSLSHRSDSSRRRSLNSFPASPDCADTPGAGNREVRVPATAVYSFDAHDGEVNAVRFSPGSRLLATGGMDRRVKLWDVIGNKCEAKGSLTGSNAGITSIEFDSAGSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLWDLRSKVCIKTVFAGSSCNDIVCTEQCVMSGHFDKKIRFWDIRTECIVRELELQGRITALDLNPERTQLLSCSRDDLIKITDLRANAVQQTFSAPGFKCGSDWTRVIFSPDGSYVSAGSAEGTLYFWNVLTGKVERMFSKQHSSSINAVAWSPSGTHVVSVDKGSRGVLWSDF

Gene
ATG16
Protein
Autophagy-related protein 16
Organism
Arabidopsis thaliana
Length
509 amino acids
Function
May play a role in autophagy.
Similarity
Belongs to the WD repeat ATG16 family.
Mass
56.427 kDa
Sequence
MVQEEKAMEAINDALRALRKRHLLEEGAHAPAISALSKPLISQGSEWKEKTEKLETELQQCYKAQSRLSEQLVIEVAESRTSKAILQEKELLINDLQKELTQRREDCTRLQEELEEKTKTVDVLIAENLEIRSQLEEMTSRVQKAETENKMLIDRWMLQKMQDAERLNEANDLYEEMLAKLKANGLETLARQQVDGIVRRNEDGTDHFVESTIPSTCANRIHAHEGGCGSIVFEYNSGTLFTGGQDRAVKMWDTNSGTLIKSLYGSLGNILDMAVTHDNKSVIAATSSNNLFVWDVSSGRVRHTLTGHTDKVCAVDVSKFSSRHVVSAAYDRTIKLWDLHKGYCTNTVLFTSNCNAICLSIDGLTVFSGHMDGNLRLWDIQTGKLLSEVAGHSSAVTSVSLSRNGNRILTSGRDNVHNVFDTRTLEICGTLRASGNRLASNWSRSCISPDDDYVAAGSADGSVHVWSLSKGNIVSILKEQTSPILCCSWSGIGKPLASADKNGYVCTWT

Gene
ATG16
Protein
Autophagy protein 16
Organism
Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
Length
204 amino acids
Function
Stabilizes the ATG5-ATG12 conjugate which is necessary for autophagy. The ATG5-ATG12/ATG16 complex is required for efficient promotion of ATG8-conjugation to phosphatidylethanolamine and ATG8 localization to the pre-autophagosomal structure (PAS). Recruits also ATG3 to the PAS. Involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress (By similarity).
Similarity
Belongs to the ATG16 family.
Mass
22.465 kDa
Sequence
MSSLPDWRDEYLASIKEAEKNSPVNRDLVEACSQLQDRVAALEAERDALKASGASAGQSASDPASQSGDAAQSAVVARLRLDLAEALGTQERLQSRLGLAESELERLRAKTAEDAKTIRTLNTQCVSLSTKVKDRNEELQGKSKLVENVQDELIALTLQLNVMEQQKAKIQAENDQLVERWMKRMGQEAEAMNLANEPKFAKRG

Gene
atg16
Protein
Autophagy protein 16
Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)
Length
202 amino acids
Function
Stabilizes the atg5-atg12 conjugate which is necessary for autophagy. The atg5-atg12/atg16 complex is required for efficient promotion of ATG8-conjugation to phosphatidylethanolamine and ATG8 localization to the pre-autophagosomal structure (PAS). Recruits also ATG3 to the PAS. Involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress (By similarity).
Similarity
Belongs to the ATG16 family.
Mass
23.118 kDa
Sequence
MAHWREEYAAALAARDRREKANVAIYNAYSQLADRTASSMIAVSDLQSDAQRSALSTPVADPRQQQPSPASGPSPQDIILAIRADLAEAQRSRSELEEQLARVTTELEKLRRRNIQNGKRISSMESEITHLQLRLKDRDEELREKAKLLEGFQDEIATFELQLNMAEERSNRLQKENQELIDRWMARMGKEADAMNDAYQFS

Gene
ATG16
Protein
Autophagy-related protein 16
Organism
Gibberella zeae (strain PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084)
Length
198 amino acids
Function
Stabilizes the ATG5-ATG12 conjugate (By similarity). The ATG5-ATG12/ATG16 complex is required for efficient promotion of ATG8-conjugation to phosphatidylethanolamine and ATG8 localization to the pre-autophagosomal structure (PAS) (By similarity). Recruits also ATG3 to the PAS (By similarity). Involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress (By similarity). Autophagy is required for proper vegetative growth, asexual/sexual reproduction, and full virulence (PubMed:28894236). Autophagy is particularly involved in the biosynthesis of deoxynivalenol (DON), an important virulence determinant (PubMed:28894236).
Similarity
Belongs to the ATG16 family.
Mass
22.848 kDa
Sequence
MPNWRDQYLSGIKDAELNNPVNMELVQTCSQMADRISALEAEKNGLETLVTTNGKTTARPTEPSTNDPAVAQLKQDLAEALRSKGVAEKRLRSSEEELLQLRSKHKTNTRSIRDLTADKNSLTTRLKDREYELREKRKFIEQVQDEMIALNLQMSMAEKERDKVKKENKELVDRWMKRMAQEAEAMNLANEPIFKKGR

Gene
ATG16
Protein
Autophagy-related protein 16
Organism
Pichia angusta
Length
188 amino acids
Function
Stabilizes the ATG5-ATG12 conjugate which is necessary for autophagy. The ATG5-ATG12/ATG16 complex is required for efficient promotion of ATG8-conjugation to phosphatidylethanolamine and ATG8 localization to the pre-autophagosomal structure (PAS). Recruits also ATG3 to the PAS. Involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress (By similarity).
Similarity
Belongs to the ATG16 family.
Mass
21.924 kDa
Sequence
MSWKNDLLAKLAQRDKSMETQKDVFLSFQFLSTRIASLERQLDTVQRDDSKKTVLDLLGEIDQLKQKLDLAEDSLKHETAKNKELVKELSTVKNNLNILTDGYKKLQERHLRLQEESKIKFQNLESLNDDILSLNIENNLLNDRMAKLKQENESLIERWMKRVKQEAEVLNDANEALSRSEKSLKPEG

Gene
ATG16
Protein
Autophagy protein 16
Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968)
Length
183 amino acids
Function
Stabilizes the ATG5-ATG12 conjugate which is necessary for autophagy. The ATG5-ATG12/ATG16 complex is required for efficient promotion of ATG8-conjugation to phosphatidylethanolamine and ATG8 localization to the pre-autophagosomal structure (PAS). Recruits also ATG3 to the PAS. Involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress (By similarity).
Similarity
Belongs to the ATG16 family.
Mass
21.537 kDa
Sequence
MSDDTEWSEDILNRLNVRDQYEKKDSRYFKAFSQLSQEARTNDQASNNDKSIEYNKLLKENNQLKKDNEILTTSLNQTTISLEKSDLKINQLLKSQDQLERHNTSLNNKIKHLNLEIIEKNKSVEILNDELLLNEIQTNVLNDKITRLSDENKKLVERWIEKAKSDAEKLNDANEFLESVNRK

Gene
atg16
Protein
Autophagy protein 16
Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)
Length
172 amino acids
Function
Stabilizes the atg5-atg12 conjugate which is necessary for autophagy. The atg5-atg12/atg16 complex is required for efficient promotion of ATG8-conjugation to phosphatidylethanolamine and ATG8 localization to the pre-autophagosomal structure (PAS). Recruits also atg3 to the PAS. Involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress (By similarity).
Similarity
Belongs to the ATG16 family.
Mass
19.213 kDa
Sequence
MAHWRNEYSAALAARDRREKANVALYNASDRTSRIASTGAQGAQYLTGTGDKHTAIPAAGKSLAGPSVPDILAATRADLSEAQRARSELQARLTELSTELEKLRKRSTQDSRRIHVLESEDFQDELASLNLQLNMAEERSSRLQRENRELIDRWMARIGREAEAMNDASKFS

Gene
ATG16
Protein
Autophagy-related protein 16
Organism
Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)
Length
169 amino acids
Function
Stabilizes the ATG5-ATG12 conjugate which is necessary for autophagy. The ATG5-ATG12/ATG16 complex is required for efficient promotion of ATG8-conjugation to phosphatidylethanolamine and ATG8 localization to the pre-autophagosomal structure (PAS). Recruits also ATG3 to the PAS. Involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress (By similarity).
Similarity
Belongs to the ATG16 family.
Mass
19.487 kDa
Sequence
MTEDWGGDILARLKLRDDLESRDSKYFEAFDLLRRKKVIKGTSGDPDVAAENERLIEKLNNLAIEVEKKDSQISKLKRQLSVAEKTIKSHQNKLENLALEVQEKNKNIEIVNDEVLMNQIQTAVLQKKLGELTKENETLVKRWMDRVSSEAQQMNDANQFLESMRKTSG

Gene
ATG16
Protein
Autophagy-related protein 16
Organism
Saccharomyces cerevisiae (strain YJM789)
Length
150 amino acids
Function
Stabilizes the ATG5-ATG12 conjugate and mediates the formation of the 350 kDa complex, which is necessary for autophagy. The ATG5-ATG12/ATG16 complex is required for efficient promotion of ATG8-conjugation to phosphatidylethanolamine and ATG8 localization to the pre-autophagosomal structure (PAS). Recruits also ATG3 to the PAS. Involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress (By similarity).
Similarity
Belongs to the ATG16 family.
Mass
17.222 kDa
Sequence
MGNFIITERKKAKEERSNPQTDSMDDLLIRRLTDRNDKEAHLNELFQDNSGAIGGNIVSHDDALLNTLAILQKELKSKEQEIRRLKEVIALKNKNTERLNDELISGTIENNVLQQKLSDLKKEHSQLVARWLKKTEKETEAMNSEIDGTK

Gene
ATG16
Protein
Autophagy protein 16
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
150 amino acids
Function
Stabilizes the ATG5-ATG12 conjugate and mediates the formation of the 350 kDa complex, which is necessary for autophagy. The ATG5-ATG12/ATG16 complex is required for efficient promotion of ATG8-conjugation to phosphatidylethanolamine and ATG8 localization to the pre-autophagosomal structure (PAS). Recruits also ATG3 to the PAS. Involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress.
Similarity
Belongs to the ATG16 family.
Mass
17.222 kDa
Sequence
MGNFIITERKKAKEERSNPQTDSMDDLLIRRLTDRNDKEAHLNELFQDNSGAIGGNIVSHDDALLNTLAILQKELKSKEQEIRRLKEVIALKNKNTERLNDELISGTIENNVLQQKLSDLKKEHSQLVARWLKKTEKETEAMNSEIDGTK

Gene
atg16
Protein
Autophagy protein 16
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Length
143 amino acids
Function
Stabilizes the atg5-atg12 conjugate and mediates the formation of the 350 kDa complex, which is necessary for autophagy. The atg5-atg12/atg16 complex is required for efficient promotion of atg8-conjugation to phosphatidylethanolamine and atg8 localization to the preautophagosomal structure (PAS). Involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress. Required for meiotic chromosome segregation.
Similarity
Belongs to the ATG16 family.
Mass
16.892 kDa
Sequence
MELIKKIQDRDAAEKAYYDVIEPYSELLEFSFHKEFVSEEKVTQRTASSDSLNTIASENNDENVINLEEFRQLKRNCDLYQRNLQKLQLLFKQQSQKNTLLEKQLSLQTELNQEKDKRVKILQDELWALQLEVAALERKSPNA

Gene
ATG16
Protein
Autophagy protein 16
Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
Length
126 amino acids
Function
Stabilizes the ATG5-ATG12 conjugate which is necessary for autophagy. The ATG5-ATG12/ATG16 complex is required for efficient promotion of ATG8-conjugation to phosphatidylethanolamine and ATG8 localization to the pre-autophagosomal structure (PAS). Recruits also ATG3 to the PAS. Involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress (By similarity).
Similarity
Belongs to the ATG16 family.
Mass
15.057 kDa
Sequence
MELPLLDKLKVRDLVDKRFSHLFETVSLLSGDNEEDNEDQLRLKNSIKNLREHLTEKEEEIRQLHDVISVKNRDAERLNDELISINIENNLLQERLTHIQAEYDTLIERWLLKAQREADIMNTRLK

Gene
ATG16
Protein
Autophagy-related protein 16
Organism
Kluyveromyces marxianus (strain DMKU3-1042 / BCC 29191 / NBRC 104275)
Length
126 amino acids
Function
Stabilizes the ATG5-ATG12 conjugate (By similarity). The ATG5-ATG12/ATG16 complex is required for efficient promotion of ATG8-conjugation to phosphatidylethanolamine and ATG8 localization to the pre-autophagosomal structure (PAS) (PubMed:26442587). Recruits also ATG3 to the PAS (By similarity). Involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress (By similarity).
Similarity
Belongs to the ATG16 family.
Mass
15.068 kDa
Sequence
MEYELLESIRARDLVDKRFSQLFEEVPLVPKLEKAGEGDTNVKESSIKNLKDYLKLRDEEVYKLKDILKLKNRDTERLNDELLSANIESNLLQERLEKLQQEYDRLIERWLLKAQKEADTMNSHFK

Gene
ATG16
Protein
Autophagy protein 16
Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
Length
124 amino acids
Function
Stabilizes the ATG5-ATG12 conjugate which is necessary for autophagy. The ATG5-ATG12/ATG16 complex is required for efficient promotion of ATG8-conjugation to phosphatidylethanolamine and ATG8 localization to the pre-autophagosomal structure (PAS). Recruits also ATG3 to the PAS. Involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress (By similarity).
Similarity
Belongs to the ATG16 family.
Mass
14.39 kDa
Sequence
MDLHQLYLDRLRQRDRIEGNFCYLFEAAVVLETAQPPQDSRDLVAKSLREELHAHEQEIHKLKDIVHLRSKDAEKLNDEIISLNIENSLLQDKLTALQAEYDKLIQRWLAKAQSEADAMNQGLA

Gene
ATG16
Protein
Autophagy-related protein 16
Organism
Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294)
Length
123 amino acids
Function
Stabilizes the ATG5-ATG12 conjugate which is necessary for autophagy. The ATG5-ATG12/ATG16 complex is required for efficient promotion of ATG8-conjugation to phosphatidylethanolamine and ATG8 localization to the pre-autophagosomal structure (PAS). Recruits also ATG3 to the PAS. Involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress (By similarity).
Similarity
Belongs to the ATG16 family.
Mass
14.616 kDa
Sequence
MDSLFVERLAQRDEVEGRFCELFKEVQIMVGPQLEDESMERKLIVALKSDLVEKDLRIGELEEILQLRNKDYERLNDELISLNIENNILRDKLQNMTEENSKLVKRWLNKVQQEADAMNENLH

Gene
ATG16
Protein
Autophagy protein 16
Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)
Length
108 amino acids
Function
Stabilizes the ATG5-ATG12 conjugate which is necessary for autophagy. The ATG5-ATG12/ATG16 complex is required for efficient promotion of ATG8-conjugation to phosphatidylethanolamine and ATG8 localization to the pre-autophagosomal structure (PAS). Recruits also ATG3 to the PAS. Involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress (By similarity).
Similarity
Belongs to the ATG16 family.
Mass
12.553 kDa
Sequence
MLAERDTLEKNYCELFEVPVDGRSNDGDAMLLQEALRGKDNEIRMLEERLAVSSKNVERLNDELLGANLEANVLGQKLQDLQQEHDKLLERWMQRVRVEVDKMNAQLE

Gene
ATG16
Protein
Autophagy protein 16
Organism
Yarrowia lipolytica (strain CLIB 122 / E 150)
Length
94 amino acids
Function
Stabilizes the ATG5-ATG12 conjugate which is necessary for autophagy. The ATG5-ATG12/ATG16 complex is required for efficient promotion of ATG8-conjugation to phosphatidylethanolamine and ATG8 localization to the pre-autophagosomal structure (PAS). Recruits also ATG3 to the PAS. Involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress (By similarity).
Similarity
Belongs to the ATG16 family.
Mass
10.776 kDa
Sequence
MQLNVTHRTNAERLEKHNRELETALAKKTEEHKEQAKALLLLQDDMLANQIQLNVLEQKTEALQQENETLVQRLVAKAAADADKMNDANAFLER