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ARHGDIG

Gene
ARHGDIG
Protein
Rho GDP-dissociation inhibitor 3
Organism
Bos taurus
Length
225 amino acids
Function
Inhibits GDP/GTP exchange reaction of RhoB. Interacts specifically with the GDP- and GTP-bound forms of post-translationally processed Rhob and Rhog proteins, both of which show a growth-regulated expression in mammalian cells. Stimulates the release of the GDP-bound but not the GTP-bound RhoB protein. Also inhibits the GDP/GTP exchange of RhoB but shows less ability to inhibit the dissociation of prebound GTP (By similarity).
Similarity
Belongs to the Rho GDI family.
Mass
25.007 kDa
Sequence
MLGLDACELGAQLLELLRLALCARVLLTDKEGGQLPPEEALDEAVPEYRAPGKKSLLEIQQLDPDDESLVKYKRALLGPVLPAVDPSLPNVQVTRLTLISEQAPGPIVMDLTGELAALKNQVFVLKEGVDYKVKITFKVNKEIVSGLKCLHHTYRHGLRVDKAVYMVGSYGPSAQEYEFVTPVEEAPRGALVRGAYVVTSFFTDDDRTAHLSWEWGLYVCQDWER

Gene
ARHGDIG
Protein
Rho GDP-dissociation inhibitor 3
Organism
Homo sapiens
Length
225 amino acids
Function
Inhibits GDP/GTP exchange reaction of RhoB. Interacts specifically with the GDP- and GTP-bound forms of post-translationally processed Rhob and Rhog proteins, both of which show a growth-regulated expression in mammalian cells. Stimulates the release of the GDP-bound but not the GTP-bound RhoB protein. Also inhibits the GDP/GTP exchange of RhoB but shows less ability to inhibit the dissociation of prebound GTP.
Similarity
Belongs to the Rho GDI family.
Mass
25.098 kDa
Sequence
MLGLDACELGAQLLELLRLALCARVLLADKEGGPPAVDEVLDEAVPEYRAPGRKSLLEIRQLDPDDRSLAKYKRVLLGPLPPAVDPSLPNVQVTRLTLLSEQAPGPVVMDLTGDLAVLKDQVFVLKEGVDYRVKISFKVHREIVSGLKCLHHTYRRGLRVDKTVYMVGSYGPSAQEYEFVTPVEEAPRGALVRGPYLVVSLFTDDDRTHHLSWEWGLCICQDWKD

Gene
Arhgdig
Protein
Rho GDP-dissociation inhibitor 3
Organism
Mus musculus
Length
225 amino acids
Function
Inhibits GDP/GTP exchange reaction of RhoB. Interacts specifically with the GDP- and GTP-bound forms of post-translationally processed Rhob and Rhog proteins, both of which show a growth-regulated expression in mammalian cells. Stimulates the release of the GDP-bound but not the GTP-bound RhoB protein. Also inhibits the GDP/GTP exchange of RhoB but shows less ability to inhibit the dissociation of prebound GTP.
Similarity
Belongs to the Rho GDI family.
Mass
25.296 kDa
Sequence
MLGLDACELGEQLLELLRLALCARVLLADKDGESTPSDEVLDEIVPEYQAPGKKSMLAIWQLDPGDVSLVKYKQALLGPLPPIMDPSLPNVQVTRLTLLTEQAPGPIIMDLTGDLDALKNQVFVLKEGIEYKVKITFKVNKEIVSGLKCLHHTYRRGLRVDKAIFMVGSYGPRAQEYEFVTSVEEAPRGALARGLYVVRSLFTDDDRLNHLSWEWHLHVCQDWKD