Protein
Rho GDP-dissociation inhibitor 3
Function
Inhibits GDP/GTP exchange reaction of RhoB. Interacts specifically with the GDP- and GTP-bound forms of post-translationally processed Rhob and Rhog proteins, both of which show a growth-regulated expression in mammalian cells. Stimulates the release of the GDP-bound but not the GTP-bound RhoB protein. Also inhibits the GDP/GTP exchange of RhoB but shows less ability to inhibit the dissociation of prebound GTP (By similarity).
Similarity
Belongs to the Rho GDI family.
Sequence
MLGLDACELGAQLLELLRLALCARVLLTDKEGGQLPPEEALDEAVPEYRAPGKKSLLEIQQLDPDDESLVKYKRALLGPVLPAVDPSLPNVQVTRLTLISEQAPGPIVMDLTGELAALKNQVFVLKEGVDYKVKITFKVNKEIVSGLKCLHHTYRHGLRVDKAVYMVGSYGPSAQEYEFVTPVEEAPRGALVRGAYVVTSFFTDDDRTAHLSWEWGLYVCQDWER