Protein
Disintegrin and metalloproteinase domain-containing protein 2
Organism
Oryctolagus cuniculus
Function
Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein (By similarity).
Sequence
MLRVLFLLCGLSGLRTKENSERLHVQVTVPEKMRSVTSEGFETEVVYNIVIEGKTYTLNLMQKLFLPRDFRVYGYDSTGIMKDLEQQFQNFCYYQGFVEGYPNSMVIVSTCTGLRGLLQFENVTYGIEPLESSIGFEHVIYQVKNKNESISLYAEKEVEFRDLPYKVQSVQPREFSQYIEMHVVVEKNLYKHMGSDTAVVSQKIFQLIGLTNAVFTSFNITIILSSLELWIDENKISTTGDANELLYRFLKWKKSYLVLRPHDVAFLLVYREIAKYVGATFQGKMCDINYSGGVALHPKTISLESLAIILAQLLSLSMGIAYDDINKCKCPGSVCIMNPEAIHSSGVKIFSNCSIEDFSRFISKQKSQCLQNLPRLEPFYKQDAVCGNSIVEAGEMCDCGTAEECGRAVPICCNSATCRLEVGSQCAEGECCENCTFKERGQSCRPPVGECDLFEYCNGTSALCPDDIVIQNGHPCGENQWICVDGSCISPPEQCKSIFGEEVEGGTPECYEELNAMADIILGICGITHDGYKKCESGNRKCGKLMCKHTTENIIDIKNATIIYANVSGSICLSLEYKPDHLDAAKMWVPNGAVCGSNKICRDKACVETTYVNLGCTLQNCNNQGICNSLQHCHCNPTFLPPNCSAVDERWAGGSVDSGNFQGGGVPGIGGLTSVGTPPFIPGVPGVRRYMEDVYQTAKPTRWPFFLLIPFFIILGALIAILVKVQFQRKKWKTEDYTSDEQFESDSELKE